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Volumn 37-38, Issue , 2016, Pages 3-15

Exploring and exploiting the systemic effects of deregulated replication licensing

Author keywords

Cancer; Cdc6; Cdt1; Replication licensing factors; Replication stress

Indexed keywords

CELL CYCLE PROTEIN 6; CYCLIN E; MYC PROTEIN; REPLICATION FACTOR A; REPLICATION LICENSING FACTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CTCF; TRANSCRIPTION FACTOR E2F; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84953432545     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2015.12.002     Document Type: Review
Times cited : (37)

References (131)
  • 1
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis T.D., Gorgoulis V.G., Bartek J. An oncogene-induced DNA damage model for cancer development. Science 2008, 319:1352-1355. 10.1126/science.1140735.
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 2
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis V.G., Vassiliou L.V., Karakaidos P., Zacharatos P., Kotsinas A., Liloglou T., et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 2005, 434:907-913. 10.1038/nature03485.
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1    Vassiliou, L.V.2    Karakaidos, P.3    Zacharatos, P.4    Kotsinas, A.5    Liloglou, T.6
  • 3
    • 33845235459 scopus 로고    scopus 로고
    • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
    • Bartkova J., Rezaei N., Liontos M., Karakaidos P., Kletsas D., Issaeva N., et al. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 2006, 444:633-637. 10.1038/nature05268.
    • (2006) Nature , vol.444 , pp. 633-637
    • Bartkova, J.1    Rezaei, N.2    Liontos, M.3    Karakaidos, P.4    Kletsas, D.5    Issaeva, N.6
  • 5
    • 0032489041 scopus 로고    scopus 로고
    • Polymerases and the replisome machines within machines
    • Baker T.A., Bell S.P. Polymerases and the replisome machines within machines. Cell 1998, 92:295-305.
    • (1998) Cell , vol.92 , pp. 295-305
    • Baker, T.A.1    Bell, S.P.2
  • 6
    • 0023956135 scopus 로고
    • Termination of DNA replication in Escherichia coli requires a transacting factor
    • Hill T.M., Kopp B.J., Kuempe1 P.K. Termination of DNA replication in Escherichia coli requires a transacting factor. J. Bacteriol. 1988, 170:662-668.
    • (1988) J. Bacteriol. , vol.170 , pp. 662-668
    • Hill, T.M.1    Kopp, B.J.2    Kuempe1, P.K.3
  • 7
    • 0023663881 scopus 로고
    • The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity
    • Greider C.W., Blackburn E.H. The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 1987, 51:887-898.
    • (1987) Cell , vol.51 , pp. 887-898
    • Greider, C.W.1    Blackburn, E.H.2
  • 8
    • 77649165394 scopus 로고    scopus 로고
    • Maintaining genome stability at the replication fork
    • Branzei D., Foiani M. Maintaining genome stability at the replication fork. Nat. Rev. Mol. Cell Biol. 2010, 11:208-219. 10.1038/nrm2852.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 208-219
    • Branzei, D.1    Foiani, M.2
  • 10
    • 34547912489 scopus 로고    scopus 로고
    • A database of oriC regions in bacterial genomes
    • Gao F., Zhang C.-T., Dori C. A database of oriC regions in bacterial genomes. Bioinformatics 2007, 23:1866-1867.
    • (2007) Bioinformatics , vol.23 , pp. 1866-1867
    • Gao, F.1    Zhang, C.-T.2    Dori, C.3
  • 11
    • 17044410835 scopus 로고    scopus 로고
    • Eukaryotic origins of DNA replication: could you please be more specific?
    • Cvetic C., Walter J.C. Eukaryotic origins of DNA replication: could you please be more specific?. Semin. Cell Dev. Biol. 2005, 16:343-353. 10.1016/j.semcdb.2005.02.009.
    • (2005) Semin. Cell Dev. Biol. , vol.16 , pp. 343-353
    • Cvetic, C.1    Walter, J.C.2
  • 12
    • 77957168933 scopus 로고    scopus 로고
    • Replication origins: many choices for appropriate answers
    • Mechali M., Eukaryotic D.N.A. replication origins: many choices for appropriate answers. Nat. Rev. Mol. Cell Biol. 2010, 11:728-738.
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 728-738
    • Mechali, M.1    Eukaryotic, D.N.A.2
  • 14
    • 80052523848 scopus 로고    scopus 로고
    • Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features
    • Cayrou C., Coulombe P., Vigneron A., Stanojcic S., Ganier O., Peiffer I., et al. Genome-scale analysis of metazoan replication origins reveals their organization in specific but flexible sites defined by conserved features. Genome Res. 2011, 21:1438-1449. 10.1101/gr.121830.111.
    • (2011) Genome Res. , vol.21 , pp. 1438-1449
    • Cayrou, C.1    Coulombe, P.2    Vigneron, A.3    Stanojcic, S.4    Ganier, O.5    Peiffer, I.6
  • 16
    • 0242610832 scopus 로고    scopus 로고
    • Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells
    • Feng D., Tu Z., Wu W., Liang C. Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells. Cancer Res. 2003, 63:7356-7364.
    • (2003) Cancer Res. , vol.63 , pp. 7356-7364
    • Feng, D.1    Tu, Z.2    Wu, W.3    Liang, C.4
  • 17
    • 60749084686 scopus 로고    scopus 로고
    • Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells
    • Liu P., Slater D.M., Lenburg M., Nevis K., Cook J.G., Vaziri C. Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells. Cell Cycle 2009, 8:125-136.
    • (2009) Cell Cycle , vol.8 , pp. 125-136
    • Liu, P.1    Slater, D.M.2    Lenburg, M.3    Nevis, K.4    Cook, J.G.5    Vaziri, C.6
  • 18
    • 23044445699 scopus 로고    scopus 로고
    • Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation
    • Machida Y.J., Teer J.K., Dutta A. Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation. J. Biol. Chem. 2005, 280:27624-27630.
    • (2005) J. Biol. Chem. , vol.280 , pp. 27624-27630
    • Machida, Y.J.1    Teer, J.K.2    Dutta, A.3
  • 19
    • 67649329182 scopus 로고    scopus 로고
    • Origin licensing and p53 status regulate Cdk2 activity during G(1)
    • Nevis K.R., Cordeiro-Stone M., Cook J.G. Origin licensing and p53 status regulate Cdk2 activity during G(1). Cell Cycle 2009, 8:1952-1963.
    • (2009) Cell Cycle , vol.8 , pp. 1952-1963
    • Nevis, K.R.1    Cordeiro-Stone, M.2    Cook, J.G.3
  • 20
    • 40549130342 scopus 로고    scopus 로고
    • CDC6: from DNA replication to cell cycle checkpoints and oncogenesis
    • Borlado L.R., Méndez J. CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 2008, 29:237-243. 10.1371/journal.pone.0137259.
    • (2008) Carcinogenesis , vol.29 , pp. 237-243
    • Borlado, L.R.1    Méndez, J.2
  • 21
    • 0037847620 scopus 로고    scopus 로고
    • GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast
    • Takayama Y., Kamimura Y., Okawa M., Muramatsu S., Sugino A., Araki H. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev. 2003, 17:1153-1165. 10.1101/gad.1065903.
    • (2003) Genes Dev. , vol.17 , pp. 1153-1165
    • Takayama, Y.1    Kamimura, Y.2    Okawa, M.3    Muramatsu, S.4    Sugino, A.5    Araki, H.6
  • 22
    • 84874695795 scopus 로고    scopus 로고
    • Helicase activation and establishment of replication forks at chromosomal origins of replication
    • Tanaka S., Araki H. Helicase activation and establishment of replication forks at chromosomal origins of replication. Cold Spring Harbor Perspect. Biol. 2013, 5(12):a010371. 10.1101/cshperspect.a010371.
    • (2013) Cold Spring Harbor Perspect. Biol. , vol.5 , Issue.12 , pp. a010371
    • Tanaka, S.1    Araki, H.2
  • 25
    • 34548500580 scopus 로고    scopus 로고
    • Cdc6 stability is regulated by the huwe1 ubiquitin ligase after DNA damage
    • Hall J.R., Kow E., Nevis K.R., Lu C.K., Luce K.S., Zhong Q., et al. Cdc6 stability is regulated by the huwe1 ubiquitin ligase after DNA damage. Mol. Biol. Cell 2007, 18:3340-3350. 10.1091/mbc.E07-02-0173.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 3340-3350
    • Hall, J.R.1    Kow, E.2    Nevis, K.R.3    Lu, C.K.4    Luce, K.S.5    Zhong, Q.6
  • 26
    • 66849093505 scopus 로고    scopus 로고
    • Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells
    • Sugimoto N., Yoshida K., Tatsumi Y., Yugawa T., Narisawa-Saito M., Waga S., Kiyono T., et al. Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells. J. Cell Sci. 2009, 122:1184-1191. 10.1242/jcs.041889.
    • (2009) J. Cell Sci. , vol.122 , pp. 1184-1191
    • Sugimoto, N.1    Yoshida, K.2    Tatsumi, Y.3    Yugawa, T.4    Narisawa-Saito, M.5    Waga, S.6    Kiyono, T.7
  • 27
    • 20344396122 scopus 로고    scopus 로고
    • Preventing re-replication of chromosomal DNA
    • Blow J.J., Dutta A. Preventing re-replication of chromosomal DNA. Nat. Rev. Mol. Cell Biol. 2005, 6:476-486. 10.1038/nrm1663.
    • (2005) Nat. Rev. Mol. Cell Biol. , vol.6 , pp. 476-486
    • Blow, J.J.1    Dutta, A.2
  • 28
    • 84901000531 scopus 로고    scopus 로고
    • DNA replication and oncogene-induced replicative stress
    • Hills S.A., Diffley J.F. DNA replication and oncogene-induced replicative stress. Curr. Biol. 2014, 24:R435-R444. 10.1016/j.cub.2014.04.012.
    • (2014) Curr. Biol. , vol.24 , pp. R435-R444
    • Hills, S.A.1    Diffley, J.F.2
  • 29
    • 79951468998 scopus 로고    scopus 로고
    • Prevention of DNA re-replication in eukaryotic cells
    • Truong L.N., Wu X. Prevention of DNA re-replication in eukaryotic cells. J. Mol. Cell. Biol. 2011, 3:13-22. 10.1093/jmcb/mjq052.
    • (2011) J. Mol. Cell. Biol. , vol.3 , pp. 13-22
    • Truong, L.N.1    Wu, X.2
  • 31
    • 67649295460 scopus 로고    scopus 로고
    • Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy
    • Ullah Z., Lee C.Y., DePamphilis M.L. Cip/Kip cyclin-dependent protein kinase inhibitors and the road to polyploidy. Cell Div. 2009, 4:10. 10.1186/1747-1028-4-10.
    • (2009) Cell Div. , vol.4 , pp. 10
    • Ullah, Z.1    Lee, C.Y.2    DePamphilis, M.L.3
  • 32
    • 13444254305 scopus 로고    scopus 로고
    • A novel E2 box-GATA element modulates Cdc6 transcription during human cells polyploidization
    • Vilaboa N., Bermejo R., Martinez P., Bornstein R., Calés C. A novel E2 box-GATA element modulates Cdc6 transcription during human cells polyploidization. Nucleic Acids Res. 2004, 32:6454-6467. 10.1093/nar/gkh981.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 6454-6467
    • Vilaboa, N.1    Bermejo, R.2    Martinez, P.3    Bornstein, R.4    Calés, C.5
  • 33
    • 4644292460 scopus 로고    scopus 로고
    • Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1
    • Karakaidos P., Taraviras S., Vassiliou L.V., Zacharatos P., Kastrinakis N.G., Kougiou D., et al. Overexpression of the replication licensing regulators hCdt1 and hCdc6 characterizes a subset of non-small-cell lung carcinomas: synergistic effect with mutant p53 on tumor growth and chromosomal instability-evidence of E2F-1 transcriptional control over hCdt1. Am. J. Pathol. 2004, 165:1351-1365.
    • (2004) Am. J. Pathol. , vol.165 , pp. 1351-1365
    • Karakaidos, P.1    Taraviras, S.2    Vassiliou, L.V.3    Zacharatos, P.4    Kastrinakis, N.G.5    Kougiou, D.6
  • 34
    • 36348944160 scopus 로고    scopus 로고
    • Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior
    • Liontos M., Koutsami M., Sideridou M., Evangelou K., Kletsas D., Levy B., et al. Deregulated overexpression of hCdt1 and hCdc6 promotes malignant behavior. Cancer Res. 2007, 67:10899-10909. 10.1158/0008-5472.CAN-07-2837.
    • (2007) Cancer Res. , vol.67 , pp. 10899-10909
    • Liontos, M.1    Koutsami, M.2    Sideridou, M.3    Evangelou, K.4    Kletsas, D.5    Levy, B.6
  • 35
    • 84904446222 scopus 로고    scopus 로고
    • Minichromosome maintenance (MCM) family as potential diagnostic and prognostic tumor markers for human gliomas
    • Hua C., Zhao G., Li Y., Bie L. Minichromosome maintenance (MCM) family as potential diagnostic and prognostic tumor markers for human gliomas. BMC Cancer 2014, 14:526. 10.1186/1471-2407-14-526.
    • (2014) BMC Cancer , vol.14 , pp. 526
    • Hua, C.1    Zhao, G.2    Li, Y.3    Bie, L.4
  • 36
    • 84880398062 scopus 로고    scopus 로고
    • Over Expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis
    • Das M., Prasad S.B., Yadav S.S., Govardhan H.B., Pandey L.K., Singh S., et al. Over Expression of minichromosome maintenance genes is clinically correlated to cervical carcinogenesis. PLoS ONE 2013, 8(7):e69607. 10.1371/journal.pone.0069607.
    • (2013) PLoS ONE , vol.8 , Issue.7 , pp. e69607
    • Das, M.1    Prasad, S.B.2    Yadav, S.S.3    Govardhan, H.B.4    Pandey, L.K.5    Singh, S.6
  • 37
    • 77957796717 scopus 로고    scopus 로고
    • Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion
    • Lau K.M., Chan Q.K., Pang J.C., Li K.K., Yeung W.W., Chung N.Y., et al. Minichromosome maintenance proteins 2, 3 and 7 in medulloblastoma: overexpression and involvement in regulation of cell migration and invasion. Oncogene 2010, 29:5475-5489. 10.1038/onc.2010.287.
    • (2010) Oncogene , vol.29 , pp. 5475-5489
    • Lau, K.M.1    Chan, Q.K.2    Pang, J.C.3    Li, K.K.4    Yeung, W.W.5    Chung, N.Y.6
  • 38
    • 84905841925 scopus 로고    scopus 로고
    • E2F transcription factors and digestive system malignancies: how much do we know?
    • Evangelou K., Havaki S., Kotsinas A. E2F transcription factors and digestive system malignancies: how much do we know?. World J. Gastroenterol.: WJG 2014, 20:10212-10216. 10.3748/wjg.v20.i29.10212.
    • (2014) World J. Gastroenterol.: WJG , vol.20 , pp. 10212-10216
    • Evangelou, K.1    Havaki, S.2    Kotsinas, A.3
  • 39
    • 27544431579 scopus 로고    scopus 로고
    • Involvement of E2F transcription factor family in cancer
    • Tsantoulis P.K., Gorgoulis V.G. Involvement of E2F transcription factor family in cancer. Eur. J. Cancer 2005, 41:2403-2414. 10.1016/j.ejca.2005.08.005.
    • (2005) Eur. J. Cancer , vol.41 , pp. 2403-2414
    • Tsantoulis, P.K.1    Gorgoulis, V.G.2
  • 40
    • 0036467506 scopus 로고    scopus 로고
    • Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes
    • Ho A., Dowdy S.F. Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genes. Curr. Opin. Genet. Dev. 2002, 12:47-52.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 47-52
    • Ho, A.1    Dowdy, S.F.2
  • 41
    • 84870581925 scopus 로고    scopus 로고
    • Estrogen-induced upregulation and 3'-UTR shortening of CDC6
    • Akman B.H., Can T., Erson-Bensan A.E. Estrogen-induced upregulation and 3'-UTR shortening of CDC6. Nucleic Acids Res. 2012, 40:10679-10688. 10.1093/nar/gks855.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 10679-10688
    • Akman, B.H.1    Can, T.2    Erson-Bensan, A.E.3
  • 42
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis
    • Greenblatt M.S., Bennett W.P., Hollstein M., Harris C.C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 1994, 54:4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 44
    • 84862820018 scopus 로고    scopus 로고
    • Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis
    • De Munnik S.A., Bicknell L.S., Aftimos S., Al-Aama J.Y., van Bever Y., Bober M.B., et al. Meier-Gorlin syndrome genotype-phenotype studies: 35 individuals with pre-replication complex gene mutations and 10 without molecular diagnosis. Eur. J. Hum. Genet. 2012, 20:598-606. 10.1038/ejhg.2011.269.
    • (2012) Eur. J. Hum. Genet. , vol.20 , pp. 598-606
    • De Munnik, S.A.1    Bicknell, L.S.2    Aftimos, S.3    Al-Aama, J.Y.4    van Bever, Y.5    Bober, M.B.6
  • 45
    • 84857815874 scopus 로고    scopus 로고
    • Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency
    • Gineau L., Cognet C., Kara N., Lach F.P., Dunne J., Veturi U., et al. Partial MCM4 deficiency in patients with growth retardation, adrenal insufficiency, and natural killer cell deficiency. J. Clin. Invest. 2012, 122:821-832. 10.1172/JCI61014.
    • (2012) J. Clin. Invest. , vol.122 , pp. 821-832
    • Gineau, L.1    Cognet, C.2    Kara, N.3    Lach, F.P.4    Dunne, J.5    Veturi, U.6
  • 46
    • 84857875264 scopus 로고    scopus 로고
    • MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans
    • Hughes C.R., Guasti L., Meimaridou E., Chuang C.H., Schimenti J.C., King P.J., et al. MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans. J. Clin. Invest. 2012, 122:814-820. 10.1172/JCI60224.
    • (2012) J. Clin. Invest. , vol.122 , pp. 814-820
    • Hughes, C.R.1    Guasti, L.2    Meimaridou, E.3    Chuang, C.H.4    Schimenti, J.C.5    King, P.J.6
  • 47
    • 84871607211 scopus 로고    scopus 로고
    • Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome
    • Capo-Chichi J.-M., Kumar Bharti S., Sommers J.A., Chouery E., Patry L., Rouleau G.A., et al. Identification and biochemical characterization of a novel mutation in DDX11 causing Warsaw breakage syndrome. Hum. Mutat. 2013, 34:103-107. 10.1002/humu.22226.
    • (2013) Hum. Mutat. , vol.34 , pp. 103-107
    • Capo-Chichi, J.-M.1    Kumar Bharti, S.2    Sommers, J.A.3    Chouery, E.4    Patry, L.5    Rouleau, G.A.6
  • 48
    • 78349285501 scopus 로고    scopus 로고
    • Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae
    • Ma L., Zhai Y., Feng D., Chan T.C., Lu Y., Fu X., et al. Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae. Cell Cycle 2010, 9:4399-4410.
    • (2010) Cell Cycle , vol.9 , pp. 4399-4410
    • Ma, L.1    Zhai, Y.2    Feng, D.3    Chan, T.C.4    Lu, Y.5    Fu, X.6
  • 50
    • 33845269825 scopus 로고    scopus 로고
    • Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
    • Di Micco R., Fumagalli M., Cicalese A., Piccinin S., Gasparini P., Luise C., et al. Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 2006, 444:638-642.
    • (2006) Nature , vol.444 , pp. 638-642
    • Di Micco, R.1    Fumagalli, M.2    Cicalese, A.3    Piccinin, S.4    Gasparini, P.5    Luise, C.6
  • 51
    • 79955525482 scopus 로고    scopus 로고
    • Nucleotide deficiency promotes genomic instability in early stages of cancer development
    • Bester A.C., Roniger M., Oren Y.S., Im M.M., Sarni D., Chaoat M., et al. Nucleotide deficiency promotes genomic instability in early stages of cancer development. Cell 2011, 145:435-446. 10.1016/j.cell.2011.03.044.
    • (2011) Cell , vol.145 , pp. 435-446
    • Bester, A.C.1    Roniger, M.2    Oren, Y.S.3    Im, M.M.4    Sarni, D.5    Chaoat, M.6
  • 53
    • 84881480253 scopus 로고    scopus 로고
    • Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress
    • Jones R.M., Mortusewicz O., Afzal I., Lorvellec M., Garcia P., Helleday T., et al. Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress. Oncogene 2012, 32:3744-3753. 10.1038/onc.2012.387.
    • (2012) Oncogene , vol.32 , pp. 3744-3753
    • Jones, R.M.1    Mortusewicz, O.2    Afzal, I.3    Lorvellec, M.4    Garcia, P.5    Helleday, T.6
  • 54
    • 0029822745 scopus 로고    scopus 로고
    • Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc
    • Vlach J., Hennecke S., Alevizopoulos K., Conti D., Amati B. Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996, 15:6595-6604.
    • (1996) EMBO J. , vol.15 , pp. 6595-6604
    • Vlach, J.1    Hennecke, S.2    Alevizopoulos, K.3    Conti, D.4    Amati, B.5
  • 55
    • 33750472654 scopus 로고    scopus 로고
    • Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision
    • Davidson I.F., Li A., Blow J.J. Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol. Cell 2006, 24:433-443. 10.1016/j.molcel.2006.09.010.
    • (2006) Mol. Cell , vol.24 , pp. 433-443
    • Davidson, I.F.1    Li, A.2    Blow, J.J.3
  • 56
    • 84876188716 scopus 로고    scopus 로고
    • Transcription-replication encounters, consequences and genomic instability
    • Helmrich A., Ballarino M., Nudler E., Tora L. Transcription-replication encounters, consequences and genomic instability. Nat. Struct. Mol. Biol. 2013, 20:412-418. 10.1038/nsmb.2543.
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 412-418
    • Helmrich, A.1    Ballarino, M.2    Nudler, E.3    Tora, L.4
  • 57
    • 0037623356 scopus 로고    scopus 로고
    • A p53-dependent checkpoint pathway prevents re-replication
    • Vaziri C., Saxena S., Jeon Y., Lee C., Murata K., Machida Y., et al. A p53-dependent checkpoint pathway prevents re-replication. Mol. Cell 2003, 11:997-1008.
    • (2003) Mol. Cell , vol.11 , pp. 997-1008
    • Vaziri, C.1    Saxena, S.2    Jeon, Y.3    Lee, C.4    Murata, K.5    Machida, Y.6
  • 58
    • 3042687608 scopus 로고    scopus 로고
    • Deregulation of cyclin E in human cells interferes with pre-replication complex assembly
    • Ekholm-Reed S., Méndez J., Tedesco D., Zetterberg A., Stillman B., Reed S.I. Deregulation of cyclin E in human cells interferes with pre-replication complex assembly. J. Cell Biol. 2004, 165:789-800. 10.1083/jcb.200404092.
    • (2004) J. Cell Biol. , vol.165 , pp. 789-800
    • Ekholm-Reed, S.1    Méndez, J.2    Tedesco, D.3    Zetterberg, A.4    Stillman, B.5    Reed, S.I.6
  • 59
    • 84903757525 scopus 로고    scopus 로고
    • Sources of DNA double-strand breaks and models of recombinational DNA repair
    • Mehta A., Haber J.E. Sources of DNA double-strand breaks and models of recombinational DNA repair. Cold Spring Harbor Perspect. Biol. 2014, 6:a016428. 10.1101/cshperspect.a016428.
    • (2014) Cold Spring Harbor Perspect. Biol. , vol.6 , pp. a016428
    • Mehta, A.1    Haber, J.E.2
  • 60
    • 64249120749 scopus 로고    scopus 로고
    • A single S phase double-strand break influences replicon dynamics and triggers a Mre11-Tel1/ATM-mediated mechanism controlling terminal fork integrity
    • Doksani Y., Bermejo R., Fiorani S., Haber J.E., Foiani M. A single S phase double-strand break influences replicon dynamics and triggers a Mre11-Tel1/ATM-mediated mechanism controlling terminal fork integrity. Cell 2009, 137:247-258. 10.1016/j.cell.2009.02.016.
    • (2009) Cell , vol.137 , pp. 247-258
    • Doksani, Y.1    Bermejo, R.2    Fiorani, S.3    Haber, J.E.4    Foiani, M.5
  • 61
    • 84896715928 scopus 로고    scopus 로고
    • The role of microhomology in genomic structural variation
    • Ottaviani D., LeCain M., Sheer D. The role of microhomology in genomic structural variation. Trends Genet. 2014, 30:85-94. 10.1016/j.tig.2014.01.001.
    • (2014) Trends Genet. , vol.30 , pp. 85-94
    • Ottaviani, D.1    LeCain, M.2    Sheer, D.3
  • 62
    • 37349109667 scopus 로고    scopus 로고
    • A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders
    • Lee J.A., Carvalho C.M., Lupski J.R. A DNA replication mechanism for generating nonrecurrent rearrangements associated with genomic disorders. Cell 2007, 131:123547.
    • (2007) Cell , vol.131 , pp. 123547
    • Lee, J.A.1    Carvalho, C.M.2    Lupski, J.R.3
  • 63
    • 67649878596 scopus 로고    scopus 로고
    • Replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans
    • Zhang F., Khajavi M., Connolly A.M., Towne C.F., Batish S.D., Lupski J.R., The D.N.A. replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans. Nat. Genet. 2009, 41:849-853. 10.1038/ng.399.
    • (2009) Nat. Genet. , vol.41 , pp. 849-853
    • Zhang, F.1    Khajavi, M.2    Connolly, A.M.3    Towne, C.F.4    Batish, S.D.5    Lupski, J.R.6    The, D.N.A.7
  • 64
    • 84921932554 scopus 로고    scopus 로고
    • DNA replication stress as a hallmark of cancer
    • Macheret M., Halazonetis T.D. DNA replication stress as a hallmark of cancer. Annu. Rev. Pathol. 2015, 10:425-448. 10.1146/annurev-pathol-012414-040424.
    • (2015) Annu. Rev. Pathol. , vol.10 , pp. 425-448
    • Macheret, M.1    Halazonetis, T.D.2
  • 65
    • 84922089150 scopus 로고    scopus 로고
    • Interplay between genetic and epigenetic factors governs common fragile site instability in cancer
    • Ozeri-Galai E., Tur-Sinai M., Bester A.C., Kerem B. Interplay between genetic and epigenetic factors governs common fragile site instability in cancer. Cell Mol. Life Sci. 2014, 71:4495-4506. 10.1007/s00018-014-1719-8.
    • (2014) Cell Mol. Life Sci. , vol.71 , pp. 4495-4506
    • Ozeri-Galai, E.1    Tur-Sinai, M.2    Bester, A.C.3    Kerem, B.4
  • 66
    • 84912016575 scopus 로고    scopus 로고
    • Replication fork recovery and regulation of common fragile sites stability
    • Franchitto A., Pichierri P. Replication fork recovery and regulation of common fragile sites stability. Cell Mol. Life Sci. 2014, 71:4507-4517. 10.1007/s00018-014-1718-9.
    • (2014) Cell Mol. Life Sci. , vol.71 , pp. 4507-4517
    • Franchitto, A.1    Pichierri, P.2
  • 67
    • 79952281751 scopus 로고    scopus 로고
    • 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
    • Lukas C., Savic V., Bekker-Jensen S., Doil C., Neumann B., Pedersen R.S., et al. 53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress. Nat. Cell Biol. 2011, 13:243-253. 10.1038/ncb2201.
    • (2011) Nat. Cell Biol. , vol.13 , pp. 243-253
    • Lukas, C.1    Savic, V.2    Bekker-Jensen, S.3    Doil, C.4    Neumann, B.5    Pedersen, R.S.6
  • 69
    • 84873310832 scopus 로고    scopus 로고
    • Identification of early replicating fragile sites that contribute to genome instability
    • Barlow J.H., Faryabi R.B., Callén E., Wong N., Malhowski A., Chen H.T., et al. Identification of early replicating fragile sites that contribute to genome instability. Cell 2013, 152:620-632. 10.1016/j.cell.2013.01.006.
    • (2013) Cell , vol.152 , pp. 620-632
    • Barlow, J.H.1    Faryabi, R.B.2    Callén, E.3    Wong, N.4    Malhowski, A.5    Chen, H.T.6
  • 70
    • 84922005439 scopus 로고    scopus 로고
    • Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?
    • Georgakilas A.G., Tsantoulis P., Kotsinas A., Michalopoulos I., Townsend P., Gorgoulis V.G. Are common fragile sites merely structural domains or highly organized "functional" units susceptible to oncogenic stress?. Cell Mol. Life Sci. 2014, 71:4519-4544. 10.1007/s00018-014-1717-x.
    • (2014) Cell Mol. Life Sci. , vol.71 , pp. 4519-4544
    • Georgakilas, A.G.1    Tsantoulis, P.2    Kotsinas, A.3    Michalopoulos, I.4    Townsend, P.5    Gorgoulis, V.G.6
  • 71
    • 84856809222 scopus 로고    scopus 로고
    • Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins
    • Sideridou M., Zakopoulou R., Evangelou K., Liontos M., Kotsinas A., Rampakakis E., et al. Cdc6 expression represses E-cadherin transcription and activates adjacent replication origins. J. Cell Biol. 2011, 195:1123-1140. 10.1083/jcb.201108121.
    • (2011) J. Cell Biol. , vol.195 , pp. 1123-1140
    • Sideridou, M.1    Zakopoulou, R.2    Evangelou, K.3    Liontos, M.4    Kotsinas, A.5    Rampakakis, E.6
  • 72
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273:5858-5868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 73
    • 77951935474 scopus 로고    scopus 로고
    • Mechanism of p53 stabilization by ATM after DNA damage
    • Cheng Q., Chen J. Mechanism of p53 stabilization by ATM after DNA damage. Cell Cycle 2010, 9:472-478.
    • (2010) Cell Cycle , vol.9 , pp. 472-478
    • Cheng, Q.1    Chen, J.2
  • 74
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y., Xiong Y., Yarbrough W.G. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998, 92:725-734.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 76
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M., Blasco M.A., Serrano M. Cellular senescence in cancer and aging. Cell 2007, 130:223-233.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 77
    • 84881481725 scopus 로고    scopus 로고
    • Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer
    • Velimezi G., Liontos M., Vougas K., Roumeliotis T., Bartkova J., Sideridou M., et al. Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer. Nat. Cell Biol. 2013, 15:967-977. 10.1038/ncb2795.
    • (2013) Nat. Cell Biol. , vol.15 , pp. 967-977
    • Velimezi, G.1    Liontos, M.2    Vougas, K.3    Roumeliotis, T.4    Bartkova, J.5    Sideridou, M.6
  • 78
    • 79953167422 scopus 로고    scopus 로고
    • Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome
    • Bicknell L.S., Walker S., Klingseisen A., Stiff T., Leitch A., Kerzendorfer C., et al. Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nat. Genet. 2011, 43:350-355. 10.1038/ng.776.
    • (2011) Nat. Genet. , vol.43 , pp. 350-355
    • Bicknell, L.S.1    Walker, S.2    Klingseisen, A.3    Stiff, T.4    Leitch, A.5    Kerzendorfer, C.6
  • 79
    • 84875989545 scopus 로고    scopus 로고
    • Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome
    • Stiff T., Alagoz M., Alcantara D., Outwin E., Brunner H.G., Bongers E.M., et al. Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome. PLoS Genet. 2013, 9(3):e1003360. 10.1371/journal.pgen.1003360.
    • (2013) PLoS Genet. , vol.9 , Issue.3 , pp. e1003360
    • Stiff, T.1    Alagoz, M.2    Alcantara, D.3    Outwin, E.4    Brunner, H.G.5    Bongers, E.M.6
  • 81
    • 84870701350 scopus 로고    scopus 로고
    • A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis
    • Bagley B.N., Keane T.M., Maklakova V.I., Marshall J.G., Lester R.A., Cancel M.M., et al. A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis. PLoS Genet. 2012, 8(11):e1003034. 10.1371/journal.pgen.1003034.
    • (2012) PLoS Genet. , vol.8 , Issue.11 , pp. e1003034
    • Bagley, B.N.1    Keane, T.M.2    Maklakova, V.I.3    Marshall, J.G.4    Lester, R.A.5    Cancel, M.M.6
  • 82
    • 33845877445 scopus 로고    scopus 로고
    • A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
    • Shima N., Alcaraz A., Liachko I., Buske T.R., Andrews C.A., Munroe R.J., et al. A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat. Genet. 2007, 39:93-98.
    • (2007) Nat. Genet. , vol.39 , pp. 93-98
    • Shima, N.1    Alcaraz, A.2    Liachko, I.3    Buske, T.R.4    Andrews, C.A.5    Munroe, R.J.6
  • 83
    • 34247150402 scopus 로고    scopus 로고
    • CD56brightCD16- killer Ig-like receptor-NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation
    • Romagnani C., Juelke K., Falco M., Morandi B., D'Agostino A., Costa R., et al. CD56brightCD16- killer Ig-like receptor-NK cells display longer telomeres and acquire features of CD56dim NK cells upon activation. J. Immunol. 2007, 178:4947-4955.
    • (2007) J. Immunol. , vol.178 , pp. 4947-4955
    • Romagnani, C.1    Juelke, K.2    Falco, M.3    Morandi, B.4    D'Agostino, A.5    Costa, R.6
  • 84
    • 0035902454 scopus 로고    scopus 로고
    • Evidence that replication fork components catalyze establishment of cohesion between sister chromatids
    • Carson D.R., Christman M.F. Evidence that replication fork components catalyze establishment of cohesion between sister chromatids. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:8270-8275.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 8270-8275
    • Carson, D.R.1    Christman, M.F.2
  • 85
    • 0042337435 scopus 로고    scopus 로고
    • The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA
    • Bermudez V.P., Maniwa Y., Tappin I., Ozato K., Yokomori K., Hurwitz J. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:10237-10242.
    • (2003) Proc. Natl. Acad. Sci. U.S.A. , vol.100 , pp. 10237-10242
    • Bermudez, V.P.1    Maniwa, Y.2    Tappin, I.3    Ozato, K.4    Yokomori, K.5    Hurwitz, J.6
  • 86
    • 80052607856 scopus 로고    scopus 로고
    • Mammalian ChlR1 has a role in heterochromatin organization
    • Inoue A., Hyle J., Lechner M.S., Lahti J.M. Mammalian ChlR1 has a role in heterochromatin organization. Exp. Cell Res. 2011, 317:2522-2535. 10.1016/j.yexcr.2011.08.006.
    • (2011) Exp. Cell Res. , vol.317 , pp. 2522-2535
    • Inoue, A.1    Hyle, J.2    Lechner, M.S.3    Lahti, J.M.4
  • 87
    • 51049121966 scopus 로고    scopus 로고
    • Studies with the human cohesin establishment factor ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1
    • Farina A., Shin J.H., Kim D.H., Bermudez V.P., Kelman Z., Seo Y.S., et al. Studies with the human cohesin establishment factor ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. J. Biol. Chem. 2008, 283:20925-20936. 10.1074/jbc.M802696200.
    • (2008) J. Biol. Chem. , vol.283 , pp. 20925-20936
    • Farina, A.1    Shin, J.H.2    Kim, D.H.3    Bermudez, V.P.4    Kelman, Z.5    Seo, Y.S.6
  • 88
    • 76049096485 scopus 로고    scopus 로고
    • Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1
    • van der Lelij P., Chrzanowska K.H., Godthelp B.C., Rooimans M.A., Oostra A.B., Stumm M., et al. Warsaw breakage syndrome, a cohesinopathy associated with mutations in the XPD helicase family member DDX11/ChlR1. Am. J. Hum. Genet. 2010, 86:262-266. 10.1016/j.ajhg.2010.01.008.
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 262-266
    • van der Lelij, P.1    Chrzanowska, K.H.2    Godthelp, B.C.3    Rooimans, M.A.4    Oostra, A.B.5    Stumm, M.6
  • 89
    • 84862908251 scopus 로고    scopus 로고
    • Biochemical characterization of Warsaw breakage syndrome helicase
    • Wu Y., Sommers J.A., Khan I., de Winter J.P., Brosh R.M. Biochemical characterization of Warsaw breakage syndrome helicase. J. Biol. Chem. 2012, 287:1007-1021. 10.1074/jbc.M111.276022.
    • (2012) J. Biol. Chem. , vol.287 , pp. 1007-1021
    • Wu, Y.1    Sommers, J.A.2    Khan, I.3    de Winter, J.P.4    Brosh, R.M.5
  • 90
    • 84868225511 scopus 로고    scopus 로고
    • The DEAD/DEAH box helicase DDX11, is essential for the survival of advanced melanomas
    • Bhattacharya C., Wang X., Becker D. The DEAD/DEAH box helicase DDX11, is essential for the survival of advanced melanomas. Mol. Cancer 2012, 11:82.
    • (2012) Mol. Cancer , vol.11 , pp. 82
    • Bhattacharya, C.1    Wang, X.2    Becker, D.3
  • 92
    • 84924550820 scopus 로고    scopus 로고
    • Neuronal cell cycle: the neuron itself and its circumstances
    • Frade J.M., Ovejero-Benito M.C. Neuronal cell cycle: the neuron itself and its circumstances. Cell Cycle 2015, 14:712-720. 10.1080/15384101.2015.1004937.
    • (2015) Cell Cycle , vol.14 , pp. 712-720
    • Frade, J.M.1    Ovejero-Benito, M.C.2
  • 93
    • 1542381057 scopus 로고    scopus 로고
    • Cell cycle regulation of neuronal apoptosis in development and disease
    • Becker E.B., Bonni A. Cell cycle regulation of neuronal apoptosis in development and disease. Prog. Neurobiol. 2004, 72:1-25.
    • (2004) Prog. Neurobiol. , vol.72 , pp. 1-25
    • Becker, E.B.1    Bonni, A.2
  • 94
    • 0034923671 scopus 로고    scopus 로고
    • Neuronal apoptosis at the G1/S cell cycle checkpoint
    • Liu D.X., Greene L.A. Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res. 2001, 305:217-228.
    • (2001) Cell Tissue Res. , vol.305 , pp. 217-228
    • Liu, D.X.1    Greene, L.A.2
  • 95
    • 33947317590 scopus 로고    scopus 로고
    • Conditional neuronal simian virus 40T antigen expression induces Alzheimer-like tau and amyloid pathology in mice
    • Park K.H., Hallows J.L., Chakrabarty P., Davies P., Vincent I. Conditional neuronal simian virus 40T antigen expression induces Alzheimer-like tau and amyloid pathology in mice. J. Neurosci. 2007, 27:2969-2978.
    • (2007) J. Neurosci. , vol.27 , pp. 2969-2978
    • Park, K.H.1    Hallows, J.L.2    Chakrabarty, P.3    Davies, P.4    Vincent, I.5
  • 96
    • 68749118423 scopus 로고    scopus 로고
    • Neural cell cycle dysregulation and central nervous system diseases
    • Wang W., Bu B., Xie M., Zhang M., Yu Z., Tao D. Neural cell cycle dysregulation and central nervous system diseases. Prog. Neurobiol. 2009, 89:1-17.
    • (2009) Prog. Neurobiol. , vol.89 , pp. 1-17
    • Wang, W.1    Bu, B.2    Xie, M.3    Zhang, M.4    Yu, Z.5    Tao, D.6
  • 97
    • 77949884756 scopus 로고    scopus 로고
    • Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease
    • Bonda D.J., Evans T.A., Santocanale C., Llosá J.C., Viña J., Bajic V., et al. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging (Albany, NY) 2009, 1:382-388.
    • (2009) Aging (Albany, NY) , vol.1 , pp. 382-388
    • Bonda, D.J.1    Evans, T.A.2    Santocanale, C.3    Llosá, J.C.4    Viña, J.5    Bajic, V.6
  • 98
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R., Weinberg R.A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119:1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 99
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery J.P., Acloque H., Huang R.Y., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 100
    • 48249153426 scopus 로고    scopus 로고
    • The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome
    • Fu Y., Sinha M., Peterson C.L., Weng Z. The insulator binding protein CTCF positions 20 nucleosomes around its binding sites across the human genome. PLoS Genet. 2008, 4(7):e1000138.
    • (2008) PLoS Genet. , vol.4 , Issue.7 , pp. e1000138
    • Fu, Y.1    Sinha, M.2    Peterson, C.L.3    Weng, Z.4
  • 101
    • 84862671835 scopus 로고    scopus 로고
    • Cdc6: a multi-functional molecular switch with critical role in carcinogenesis
    • Petrakis T.G., Vougas K., Gorgoulis V.G. Cdc6: a multi-functional molecular switch with critical role in carcinogenesis. Transcription 2012, 3:124-129. 10.4161/trns.20301.
    • (2012) Transcription , vol.3 , pp. 124-129
    • Petrakis, T.G.1    Vougas, K.2    Gorgoulis, V.G.3
  • 102
    • 78449300594 scopus 로고    scopus 로고
    • CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression
    • Sun X., Cheng G., Hao M., Zheng J., Zhou X., Zhang J., et al. CXCL12/CXCR4/CXCR7 chemokine axis and cancer progression. Cancer Metastasis Rev. 2010, 29(4):709-722. 10.1007/s10555-010-9256-x.
    • (2010) Cancer Metastasis Rev. , vol.29 , Issue.4 , pp. 709-722
    • Sun, X.1    Cheng, G.2    Hao, M.3    Zheng, J.4    Zhou, X.5    Zhang, J.6
  • 105
    • 84941421013 scopus 로고    scopus 로고
    • The DNA damage response and immune signaling alliance: is it good or bad? Nature decides when and where
    • Pateras I.S., Havaki S., Nikitopoulou X., Vougas K., Townsend P.A., Panayiotidis M.I., et al. The DNA damage response and immune signaling alliance: is it good or bad? Nature decides when and where. Pharmacol. Ther. 2015, 154:36-56. 10.1016/j.pharmthera.201506.011.
    • (2015) Pharmacol. Ther. , vol.154 , pp. 36-56
    • Pateras, I.S.1    Havaki, S.2    Nikitopoulou, X.3    Vougas, K.4    Townsend, P.A.5    Panayiotidis, M.I.6
  • 106
    • 38549139593 scopus 로고    scopus 로고
    • Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation
    • Edmunds J.W., Mahadevan L.C., Clayton A.L. Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J. 2008, 27:406-420.
    • (2008) EMBO J. , vol.27 , pp. 406-420
    • Edmunds, J.W.1    Mahadevan, L.C.2    Clayton, A.L.3
  • 107
    • 0032969563 scopus 로고    scopus 로고
    • AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes
    • Neuwald A.F., Aravind L., Spouge J.L., Koonin E.V. AAA+: a class of chaperone-like ATPases associated with the assembly, operation, and disassembly of protein complexes. Genome Res. 1999, 9:27-43.
    • (1999) Genome Res. , vol.9 , pp. 27-43
    • Neuwald, A.F.1    Aravind, L.2    Spouge, J.L.3    Koonin, E.V.4
  • 109
    • 84865015653 scopus 로고    scopus 로고
    • Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies
    • Steckel M., Molina-Arcas M., Weigelt B., Marani M., Warne P.H., Kuznetsov H., et al. Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. Cell Res. 2012, 22:1227-1245. 10.1038/cr.2012.82.
    • (2012) Cell Res. , vol.22 , pp. 1227-1245
    • Steckel, M.1    Molina-Arcas, M.2    Weigelt, B.3    Marani, M.4    Warne, P.H.5    Kuznetsov, H.6
  • 110
    • 77956534350 scopus 로고    scopus 로고
    • Consorzio interuniversitario nazionale per bio-oncologia (CINBO) tyrosine kinase inhibitors
    • Natoli C., Perrucci B., Perrotti F., Falchi L., Iacobelli S. Consorzio interuniversitario nazionale per bio-oncologia (CINBO) tyrosine kinase inhibitors. Curr. Cancer Drug Targets 2010, 10:462-483.
    • (2010) Curr. Cancer Drug Targets , vol.10 , pp. 462-483
    • Natoli, C.1    Perrucci, B.2    Perrotti, F.3    Falchi, L.4    Iacobelli, S.5
  • 111
    • 0036718795 scopus 로고    scopus 로고
    • ATPases as drug targets: learning from their structure
    • Chene P. ATPases as drug targets: learning from their structure. Nat. Rev. Drug Discov. 2002, 1:665-673.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 665-673
    • Chene, P.1
  • 112
    • 84969290027 scopus 로고    scopus 로고
    • Schrödinger, LLC, New York, NY
    • Schrödinger, LLC SiteMap. Version 3.4 2015, Schrödinger, LLC, New York, NY.
    • (2015) SiteMap. Version 3.4
  • 113
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: next generation
    • Hanahan D., Weinberg R.A. Hallmarks of cancer: next generation. Cell 2011, 144:646-674. 10.1016/j.cell.2011.02.013.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 114
    • 52549115459 scopus 로고    scopus 로고
    • Replication licensing and cancer-a fatal entanglement?
    • Blow J.J., Gillespie P.J. Replication licensing and cancer-a fatal entanglement?. Nat. Rev. Cancer 2008, 8:799-806. 10.1038/nrc2500.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 799-806
    • Blow, J.J.1    Gillespie, P.J.2
  • 115
    • 15244358503 scopus 로고    scopus 로고
    • Systematic discovery of regulatory motifs in human promoters and 3'UTRs by comparison of several mammals
    • Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., et al. Systematic discovery of regulatory motifs in human promoters and 3'UTRs by comparison of several mammals. Nature 2005, 434:338-345.
    • (2005) Nature , vol.434 , pp. 338-345
    • Xie, X.1    Lu, J.2    Kulbokas, E.J.3    Golub, T.R.4    Mootha, V.5    Lindblad-Toh, K.6
  • 117
    • 84903363884 scopus 로고    scopus 로고
    • PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase
    • Clijsters L., Wolthuis R. PIP-box-mediated degradation prohibits re-accumulation of Cdc6 during S phase. J. Cell Sci. 2014, 127:1336-1345. 10.1242/jcs.145862.
    • (2014) J. Cell Sci. , vol.127 , pp. 1336-1345
    • Clijsters, L.1    Wolthuis, R.2
  • 118
    • 0033556238 scopus 로고    scopus 로고
    • Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization
    • Petersen B.O., Lukas J., Sorensen C.S., Bartek J., Helin K. Phosphorylation of mammalian CDC6 by cyclin A/CDK2 regulates its subcellular localization. EMBO J. 1999, 18:396-410.
    • (1999) EMBO J. , vol.18 , pp. 396-410
    • Petersen, B.O.1    Lukas, J.2    Sorensen, C.S.3    Bartek, J.4    Helin, K.5
  • 119
    • 25144525540 scopus 로고    scopus 로고
    • CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
    • Mailand N., Diffley J.F. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005, 122:915-926.
    • (2005) Cell , vol.122 , pp. 915-926
    • Mailand, N.1    Diffley, J.F.2
  • 120
    • 0032865839 scopus 로고    scopus 로고
    • Phosphorylation controls timing of Cdc6p destruction: a biochemical analysis
    • Elsasser S., Chi Y., Yang P., Campbell J.L. Phosphorylation controls timing of Cdc6p destruction: a biochemical analysis. Mol. Biol. Cell 1999, 10:3263-3277.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 3263-3277
    • Elsasser, S.1    Chi, Y.2    Yang, P.3    Campbell, J.L.4
  • 121
    • 33646517986 scopus 로고    scopus 로고
    • Ubiquitylation phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis
    • Saha T., Ghosh S., Vassilev A., DePamphilis M.L. Ubiquitylation phosphorylation and Orc2 modulate the subcellular location of Orc1 and prevent it from inducing apoptosis. J. Cell Sci. 2006, 119:1371-1382. 10.1242/jcs.02851.
    • (2006) J. Cell Sci. , vol.119 , pp. 1371-1382
    • Saha, T.1    Ghosh, S.2    Vassilev, A.3    DePamphilis, M.L.4
  • 122
    • 84868546625 scopus 로고    scopus 로고
    • Mathematical modeling of gene regulatory networks in Xenopus development
    • Saka Y. Mathematical modeling of gene regulatory networks in Xenopus development. Methods Mol. Biol. 2012, 917:497-513. 10.1007/978-1-61779-992-1_28.
    • (2012) Methods Mol. Biol. , vol.917 , pp. 497-513
    • Saka, Y.1
  • 123
    • 16844370131 scopus 로고    scopus 로고
    • Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells
    • Fujii-Yamamoto H., Kim J.M., Arai K., Masai H. Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J. Biol. Chem. 2005, 280:12976-12987.
    • (2005) J. Biol. Chem. , vol.280 , pp. 12976-12987
    • Fujii-Yamamoto, H.1    Kim, J.M.2    Arai, K.3    Masai, H.4
  • 125
    • 0030727157 scopus 로고    scopus 로고
    • Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
    • Jallepalli P.V., Brown G.W., Muzi-Falconi M., Tien D., Kelly T.J. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev. 1997, 11:2767-2779.
    • (1997) Genes Dev. , vol.11 , pp. 2767-2779
    • Jallepalli, P.V.1    Brown, G.W.2    Muzi-Falconi, M.3    Tien, D.4    Kelly, T.J.5
  • 126
    • 0025242245 scopus 로고
    • CDC6 mRNA fluctuates periodically in the yeast cell cycle
    • Zhou C., Jong A. CDC6 mRNA fluctuates periodically in the yeast cell cycle. J. Biol. Chem. 1990, 265:19904-19909.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19904-19909
    • Zhou, C.1    Jong, A.2
  • 127
    • 0036773376 scopus 로고    scopus 로고
    • Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas
    • Gorgoulis V.G., Zacharatos P., Mariatos G., Kotsinas A., Bouda M., Kletsas D., et al. Transcription factor E2F-1 acts as a growth-promoting factor and is associated with adverse prognosis in non-small cell lung carcinomas. J. Pathol. 2002, 198:142-156.
    • (2002) J. Pathol. , vol.198 , pp. 142-156
    • Gorgoulis, V.G.1    Zacharatos, P.2    Mariatos, G.3    Kotsinas, A.4    Bouda, M.5    Kletsas, D.6
  • 128
    • 3242682558 scopus 로고    scopus 로고
    • Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas
    • Zacharatos P., Kotsinas A., Evangelou K., Karakaidos P., Vassiliou L.V., Rezaei N., et al. Distinct expression patterns of the transcription factor E2F-1 in relation to tumour growth parameters in common human carcinomas. J. Pathol. 2004, 203:744-753. 10.1002/path.1582.
    • (2004) J. Pathol. , vol.203 , pp. 744-753
    • Zacharatos, P.1    Kotsinas, A.2    Evangelou, K.3    Karakaidos, P.4    Vassiliou, L.V.5    Rezaei, N.6
  • 130
    • 0035976980 scopus 로고    scopus 로고
    • The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
    • Nishitani H., Taraviras S., Lygerou Z., Nishimoto T. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. J. Biol. Chem. 2001, 276:44905-44911.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44905-44911
    • Nishitani, H.1    Taraviras, S.2    Lygerou, Z.3    Nishimoto, T.4
  • 131
    • 84874967976 scopus 로고    scopus 로고
    • Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues
    • Georgakopoulou E., Tsimaratou K., Evangelou K., Fernandez M.P.J., Zoumpourlis V., Trougakos I.P., et al. Specific lipofuscin staining as a novel biomarker to detect replicative and stress-induced senescence. A method applicable in cryo-preserved and archival tissues. Aging (Albany, NY) 2013, 5:37-50.
    • (2013) Aging (Albany, NY) , vol.5 , pp. 37-50
    • Georgakopoulou, E.1    Tsimaratou, K.2    Evangelou, K.3    Fernandez, M.P.J.4    Zoumpourlis, V.5    Trougakos, I.P.6


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