-
1
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965;37:614-636.
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
2
-
-
0030887851
-
Aging and cancer: The double-edged sword of replicative senescence
-
Campisi J. Aging and cancer: the double-edged sword of replicative senescence. J Am Geriatr Soc 1997;45:482-488.
-
(1997)
J Am Geriatr Soc
, vol.45
, pp. 482-488
-
-
Campisi, J.1
-
3
-
-
17144419374
-
Aging of fibroblasts
-
Kaul SC, Wadhwa R (eds). Kluwer Academic Publishers: Dordrecht, The Netherlands
-
Kletsas D. Aging of fibroblasts. In: Kaul SC, Wadhwa R (eds). Aging of Cells In and Outside the Body. Kluwer Academic Publishers: Dordrecht, The Netherlands, 2003, pp 27-46.
-
(2003)
Aging of Cells in and Outside the Body
, pp. 27-46
-
-
Kletsas, D.1
-
4
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
Dimri GP, Lee X, Basile G, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 1995;92:9363-9367.
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
-
5
-
-
0033730616
-
Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
-
Kurz DJ, Decary S, Hong Y, et al. Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 2000;113(Part 20): 3613-3622.
-
(2000)
J Cell Sci
, vol.113
, Issue.PART 20
, pp. 3613-3622
-
-
Kurz, D.J.1
Decary, S.2
Hong, Y.3
-
6
-
-
0037007075
-
Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
-
Minamino T, Miyauchi H, Yoshida T, et al. Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 2002;105:1541-1544.
-
(2002)
Circulation
, vol.105
, pp. 1541-1544
-
-
Minamino, T.1
Miyauchi, H.2
Yoshida, T.3
-
7
-
-
0033539169
-
Microarray analysis of replicative senescence
-
Shelton DN, Chang E, Whittier PS, et al. Microarray analysis of replicative senescence. Curr Biol 1999;9:939-945.
-
(1999)
Curr Biol
, vol.9
, pp. 939-945
-
-
Shelton, D.N.1
Chang, E.2
Whittier, P.S.3
-
8
-
-
0037370003
-
Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype
-
Schnabl B, Purbeck CA, Choi YH, et al. Replicative senescence of activated human hepatic stellate cells is accompanied by a pronounced inflammatory but less fibrogenic phenotype. Hepatology 2003;37:653-664.
-
(2003)
Hepatology
, vol.37
, pp. 653-664
-
-
Schnabl, B.1
Purbeck, C.A.2
Choi, Y.H.3
-
9
-
-
0031899980
-
Endothelial adhesion molecules in health and disease
-
Cotran RS, Mayadas-Norton T. Endothelial adhesion molecules in health and disease. Pathol Biol (Paris) 1998;46:164-170.
-
(1998)
Pathol Biol (Paris)
, vol.46
, pp. 164-170
-
-
Cotran, R.S.1
Mayadas-Norton, T.2
-
10
-
-
0026607620
-
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques
-
Poston RN, Haskard DO, Coucher JR, et al. Expression of intercellular adhesion molecule-1 in atherosclerotic plaques. Am J Pathol 1992;140:665-673.
-
(1992)
Am J Pathol
, vol.140
, pp. 665-673
-
-
Poston, R.N.1
Haskard, D.O.2
Coucher, J.R.3
-
12
-
-
0034890066
-
IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury
-
Burne MJ, Elghandour A, Haq M J, et al. IL-1 and TNF independent pathways mediate ICAM-1/VCAM-1 up-regulation in ischemia reperfusion injury. J Leukoc Biol 2001;70:192-198.
-
(2001)
J Leukoc Biol
, vol.70
, pp. 192-198
-
-
Burne, M.J.1
Elghandour, A.2
Haq, M.J.3
-
13
-
-
0027318186
-
Increased PMN adherence on endothelial cells after hypoxia: Involvement of PAF, CD18/CD11b, and ICAM-1
-
Arnould T, Michiels C, Remacle J. Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. Am J Physiol 1993;264:C1102-C1110.
-
(1993)
Am J Physiol
, vol.264
-
-
Arnould, T.1
Michiels, C.2
Remacle, J.3
-
14
-
-
0032969290
-
Radiation-induced normal tissue injury: Role of adhesion molecules in leukocyte-endothelial cell interactions
-
Quarmby S, Kumar P, Kumar S. Radiation-induced normal tissue injury: role of adhesion molecules in leukocyte-endothelial cell interactions. Int J Cancer 1999;82:385-395.
-
(1999)
Int J Cancer
, vol.82
, pp. 385-395
-
-
Quarmby, S.1
Kumar, P.2
Kumar, S.3
-
15
-
-
0033454739
-
Regulation of intercellular adhesion molecule-1 (CD54) gene expression
-
Roebuck KA, Finnegan A. Regulation of intercellular adhesion molecule-1 (CD54) gene expression. J Leukoc Biol 1999;66:876-888.
-
(1999)
J Leukoc Biol
, vol.66
, pp. 876-888
-
-
Roebuck, K.A.1
Finnegan, A.2
-
16
-
-
0032945057
-
Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappa B independent pathway
-
Takizawa K, Kamijo R, Ito D, et al. Synergistic induction of ICAM-1 expression by cisplatin and 5-fluorouracil in a cancer cell line via a NF-kappa B independent pathway. Br J Cancer 1999;80:954-963.
-
(1999)
Br J Cancer
, vol.80
, pp. 954-963
-
-
Takizawa, K.1
Kamijo, R.2
Ito, D.3
-
17
-
-
0035146094
-
Activation of NF-kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium
-
Sun B, Fan H, Honda T, et al. Activation of NF-kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium. J Mol Cell Cardiol 2001;33:109-119.
-
(2001)
J Mol Cell Cardiol
, vol.33
, pp. 109-119
-
-
Sun, B.1
Fan, H.2
Honda, T.3
-
18
-
-
0032222420
-
Nuclear factor kappa B dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium
-
Hallahan DE, Virudachalam S, Kuchibhotla J. Nuclear factor kappa B dominant negative genetic constructs inhibit X-ray induction of cell adhesion molecules in the vascular endothelium. Cancer Res 1998;58:5484-5488.
-
(1998)
Cancer Res
, vol.58
, pp. 5484-5488
-
-
Hallahan, D.E.1
Virudachalam, S.2
Kuchibhotla, J.3
-
19
-
-
0037388676
-
p53 activates ICAM-1 (CD54) expression in an NF-κB-independent manner
-
Gorgoulis VG, Zacharatos P, Kotsinas A, et al. p53 activates ICAM-1 (CD54) expression in an NF-κB-independent manner. EMBO J 2003;22:1567-1578.
-
(2003)
EMBO J
, vol.22
, pp. 1567-1578
-
-
Gorgoulis, V.G.1
Zacharatos, P.2
Kotsinas, A.3
-
20
-
-
0036260527
-
Does p53 affect organismal aging?
-
Donehower LA. Does p53 affect organismal aging? J Cell Physiol 2002;192:23-33.
-
(2002)
J Cell Physiol
, vol.192
, pp. 23-33
-
-
Donehower, L.A.1
-
21
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 2002;415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
-
22
-
-
0035800755
-
Age-associated differences in cardiovascular inflammatory gene induction during endotoxic stress
-
Saito H, Papaconstantinou J. Age-associated differences in cardiovascular inflammatory gene induction during endotoxic stress. J Biol Chem 2001;276:29307-29312.
-
(2001)
J Biol Chem
, vol.276
, pp. 29307-29312
-
-
Saito, H.1
Papaconstantinou, J.2
-
23
-
-
1842856178
-
Chronic in vivo exposure to glucocorticoids prolongs cellular lifespan: The case of Cushing's syndrome-patients' fibroblasts
-
Pratsinis H, Tsagarakis S, Zervolea I, et al. Chronic in vivo exposure to glucocorticoids prolongs cellular lifespan: the case of Cushing's syndrome-patients' fibroblasts. Exp Gerontol 2002;37:1237-1245.
-
(2002)
Exp Gerontol
, vol.37
, pp. 1237-1245
-
-
Pratsinis, H.1
Tsagarakis, S.2
Zervolea, I.3
-
24
-
-
0034021808
-
p53, p21(WAF1/ CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells
-
Hsieh JK, Kletsas D, Clunn G, et al. p53, p21(WAF1/ CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2000;20:973-981.
-
(2000)
Arterioscler Thromb Vasc Biol
, vol.20
, pp. 973-981
-
-
Hsieh, J.K.1
Kletsas, D.2
Clunn, G.3
-
25
-
-
0033912463
-
A novel in vitro model of conditionally immortalized human vascular smooth muscle cells. A tool for aging studies
-
Pratsinis H, Demoliou-Mason C, Hughes A, et al. A novel in vitro model of conditionally immortalized human vascular smooth muscle cells. A tool for aging studies. Ann NY Acad Sci 2000;908:321-323.
-
(2000)
Ann NY Acad Sci
, vol.908
, pp. 321-323
-
-
Pratsinis, H.1
Demoliou-Mason, C.2
Hughes, A.3
-
26
-
-
0033543728
-
A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
-
Komarov PG, Komarova EA, Kondratov RV, et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733-1737.
-
(1999)
Science
, vol.285
, pp. 1733-1737
-
-
Komarov, P.G.1
Komarova, E.A.2
Kondratov, R.V.3
-
27
-
-
0030772376
-
Novel inhibitors of cytokine-induced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo
-
Pierce JW, Schoenleber R, Jesmok G, et al. Novel inhibitors of cytokine-induced Ikappa Balpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo. J Biol Chem 1997;272:21096-21103.
-
(1997)
J Biol Chem
, vol.272
, pp. 21096-21103
-
-
Pierce, J.W.1
Schoenleber, R.2
Jesmok, G.3
-
28
-
-
0029097154
-
A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association
-
Stary HC, Chandler AB, Dinsmore RE, et al. A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 1995;92:1355-1374.
-
(1995)
Circulation
, vol.92
, pp. 1355-1374
-
-
Stary, H.C.1
Chandler, A.B.2
Dinsmore, R.E.3
-
29
-
-
0035884487
-
Chemoprotection from p53-dependent apoptosis: Potential clinical applications of the p53 inhibitors
-
Komarova EA, Gudkov AV. Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors. Biochem Pharmacol 2001;62:657-667.
-
(2001)
Biochem Pharmacol
, vol.62
, pp. 657-667
-
-
Komarova, E.A.1
Gudkov, A.V.2
-
30
-
-
0028030392
-
Consistent responses of the human vascular smooth muscle cell in culture: Implications for restenosis
-
Munro E, Chan P, Patel M, et al. Consistent responses of the human vascular smooth muscle cell in culture: implications for restenosis. J Vasc Surg 1994;20:482-487.
-
(1994)
J Vasc Surg
, vol.20
, pp. 482-487
-
-
Munro, E.1
Chan, P.2
Patel, M.3
-
31
-
-
0031969967
-
Proliferation and the monoclonal origins of atherosclerotic lesions
-
Schwartz SM, Murry CE. Proliferation and the monoclonal origins of atherosclerotic lesions. Annu Rev Med 1998;49:437-460.
-
(1998)
Annu Rev Med
, vol.49
, pp. 437-460
-
-
Schwartz, S.M.1
Murry, C.E.2
-
32
-
-
0028365839
-
The transforming activity of simian virus 40 large tumor antigen
-
Manfredi JJ, Prives C. The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta 1994;1198:65-83.
-
(1994)
Biochim Biophys Acta
, vol.1198
, pp. 65-83
-
-
Manfredi, J.J.1
Prives, C.2
-
33
-
-
0031875104
-
Co-expression of p53 and MDM2 in human atherosclerosis: Implications for the regulation of cellularity of atherosclerotic lesions
-
Ihling C, Haendeler J, Menzel G, et al. Co-expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions. J Pathol 1998;185:303-312.
-
(1998)
J Pathol
, vol.185
, pp. 303-312
-
-
Ihling, C.1
Haendeler, J.2
Menzel, G.3
-
34
-
-
0035253719
-
Cellular senescence as a tumor-protection mechanism: The essential role of counting
-
Wright WE, Shay JW. Cellular senescence as a tumor-protection mechanism: the essential role of counting. Curr Opin Genet Dev 2001;11:98-103.
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 98-103
-
-
Wright, W.E.1
Shay, J.W.2
-
35
-
-
0036303126
-
Cellular senescence and tissue aging in vivo
-
Hornsby PJ. Cellular senescence and tissue aging in vivo. J Gerontol A Biol Sci Med Sci 2002;57: B251-B256.
-
(2002)
J Gerontol A Biol Sci Med Sci
, vol.57
-
-
Hornsby, P.J.1
-
36
-
-
0028898823
-
Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors
-
Oshima J, Campisi J, Tannock TC, et al. Regulation of c-fos expression in senescing Werner syndrome fibroblasts differs from that observed in senescing fibroblasts from normal donors. J Cell Physiol 1995;162:277-283.
-
(1995)
J Cell Physiol
, vol.162
, pp. 277-283
-
-
Oshima, J.1
Campisi, J.2
Tannock, T.C.3
-
37
-
-
0034594895
-
p53 sends nucleotides to repair DNA
-
Lozano G, Elledge SJ. p53 sends nucleotides to repair DNA. Nature 2000;404:24-25.
-
(2000)
Nature
, vol.404
, pp. 24-25
-
-
Lozano, G.1
Elledge, S.J.2
-
38
-
-
0034114544
-
Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage
-
Webley K, Bond JA, Jones CJ, et al. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage. Mol Cell Biol 2000;20:2803-2808.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2803-2808
-
-
Webley, K.1
Bond, J.A.2
Jones, C.J.3
-
39
-
-
0028342664
-
Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen
-
Noda A, Ning Y, Venable SF, et al. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994;211:90-98.
-
(1994)
Exp Cell Res
, vol.211
, pp. 90-98
-
-
Noda, A.1
Ning, Y.2
Venable, S.F.3
-
41
-
-
0037204529
-
Between Scylla and Charybdis: p53 links tumor suppression and aging
-
Campisi J. Between Scylla and Charybdis: p53 links tumor suppression and aging. Mech Ageing Dev 2002;123:567-573.
-
(2002)
Mech Ageing Dev
, vol.123
, pp. 567-573
-
-
Campisi, J.1
-
42
-
-
0033552883
-
Atherosclerosis - An inflammatory disease
-
Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999;340:115-126.
-
(1999)
N Engl J Med
, vol.340
, pp. 115-126
-
-
Ross, R.1
-
43
-
-
0035571606
-
Immune mechanisms in atherosclerosis
-
Hansson GK. Immune mechanisms in atherosclerosis. Arterioscler Thromb Vasc Biol 2001;21:1876-1890.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 1876-1890
-
-
Hansson, G.K.1
-
44
-
-
0032978142
-
The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
-
Guevara NV, Kim HS, Antonova EI, et al. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 1999;5:335-339.
-
(1999)
Nat Med
, vol.5
, pp. 335-339
-
-
Guevara, N.V.1
Kim, H.S.2
Antonova, E.I.3
-
45
-
-
0031469636
-
Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue
-
Ihling C, Menzel G, Wellens E, et al. Topographical association between the cyclin-dependent kinases inhibitor P21, p53 accumulation, and cellular proliferation in human atherosclerotic tissue. Arterioscler Thromb Vasc Biol 1997;17:2218-2224.
-
(1997)
Arterioscler Thromb Vasc Biol
, vol.17
, pp. 2218-2224
-
-
Ihling, C.1
Menzel, G.2
Wellens, E.3
-
46
-
-
0032489850
-
Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques
-
Bennett MR, Macdonald K, Chan SW, et al. Cooperative interactions between RB and p53 regulate cell proliferation, cell senescence, and apoptosis in human vascular smooth muscle cells from atherosclerotic plaques. Circ Res 1998;82:704-712.
-
(1998)
Circ Res
, vol.82
, pp. 704-712
-
-
Bennett, M.R.1
Macdonald, K.2
Chan, S.W.3
-
47
-
-
0035146421
-
Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries
-
Fenton M, Barker S, Kurz DJ, et al. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 2001;21:220-226.
-
(2001)
Arterioscler Thromb Vasc Biol
, vol.21
, pp. 220-226
-
-
Fenton, M.1
Barker, S.2
Kurz, D.J.3
-
48
-
-
0037242639
-
A Darwinian-evolutionary concept of age-related diseases
-
Wick G, Berger P, Jansen-Durr P, et al. A Darwinian-evolutionary concept of age-related diseases. Exp Gerontol 2003;38:13-25.
-
(2003)
Exp Gerontol
, vol.38
, pp. 13-25
-
-
Wick, G.1
Berger, P.2
Jansen-Durr, P.3
-
49
-
-
0036829090
-
Cancer and aging: A model for the cancer promoting effects of the aging stroma
-
Krtolica A, Campisi J. Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 2002;34:1401-1414.
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 1401-1414
-
-
Krtolica, A.1
Campisi, J.2
|