메뉴 건너뛰기




Volumn 8, Issue 1, 2009, Pages 125-136

Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells

Author keywords

Cyclin D1; DNA replication; G1 progression; Licensing; Pre RC

Indexed keywords

CELL CYCLE PROTEIN 6; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; MINICHROMOSOME MAINTENANCE PROTEIN 7; PROTEIN E7; RETINOBLASTOMA PROTEIN; RNA POLYMERASE II; CCND1 PROTEIN, HUMAN; CDC6 PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DNA BINDING PROTEIN; MCM7 PROTEIN, HUMAN; NUCLEAR PROTEIN;

EID: 60749084686     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.1.7528     Document Type: Article
Times cited : (52)

References (53)
  • 1
    • 0035997368 scopus 로고    scopus 로고
    • DNA replication in eukaryotic cells
    • Bell SP, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 2002; 71:333-74.
    • (2002) Annu Rev Biochem , vol.71 , pp. 333-374
    • Bell, S.P.1    Dutta, A.2
  • 2
    • 18344384065 scopus 로고    scopus 로고
    • DNA replication and progression through S phase
    • Takeda DY, Dutta A. DNA replication and progression through S phase. Oncogene 2005; 24:2827-43.
    • (2005) Oncogene , vol.24 , pp. 2827-2843
    • Takeda, D.Y.1    Dutta, A.2
  • 3
    • 22744445013 scopus 로고    scopus 로고
    • Pumps, paradoxes and ploughshares: Mechanism of the MCM2-7 DNA helicase
    • Takahashi TS, Wigley DB, Walter JC. Pumps, paradoxes and ploughshares: mechanism of the MCM2-7 DNA helicase. Trends Biochem Sci 2005; 30:437-44.
    • (2005) Trends Biochem Sci , vol.30 , pp. 437-444
    • Takahashi, T.S.1    Wigley, D.B.2    Walter, J.C.3
  • 5
    • 0032528027 scopus 로고    scopus 로고
    • E2F3 activity is regulated during the cell cycle and is required for the induction of S phase
    • Leone G, DeGregori J, Yan Z, Jakoi L, Ishida S, Williams RS, et al. E2F3 activity is regulated during the cell cycle and is required for the induction of S phase. Genes Dev 1998; 12:2120-30.
    • (1998) Genes Dev , vol.12 , pp. 2120-2130
    • Leone, G.1    DeGregori, J.2    Yan, Z.3    Jakoi, L.4    Ishida, S.5    Williams, R.S.6
  • 6
    • 2942722811 scopus 로고    scopus 로고
    • Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
    • Frolov MV, Dyson NJ. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci 2004; 117:2173-81.
    • (2004) J Cell Sci , vol.117 , pp. 2173-2181
    • Frolov, M.V.1    Dyson, N.J.2
  • 8
    • 0031951182 scopus 로고    scopus 로고
    • Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes
    • Lundberg AS, Weinberg RA. Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexes. Mol Cell Biol 1998; 18:753-61.
    • (1998) Mol Cell Biol , vol.18 , pp. 753-761
    • Lundberg, A.S.1    Weinberg, R.A.2
  • 9
    • 12644284504 scopus 로고    scopus 로고
    • The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2
    • Kitagawa M, Higashi H, Jung HK, Suzuki-Takahashi I, Ikeda M, Tamai K, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. Embo J 1996; 15:7060-9.
    • (1996) Embo J , vol.15 , pp. 7060-7069
    • Kitagawa, M.1    Higashi, H.2    Jung, H.K.3    Suzuki-Takahashi, I.4    Ikeda, M.5    Tamai, K.6
  • 11
    • 25144525540 scopus 로고    scopus 로고
    • CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis
    • Mailand N, Diffley JF. CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysis. Cell 2005; 122:915-26.
    • (2005) Cell , vol.122 , pp. 915-926
    • Mailand, N.1    Diffley, J.F.2
  • 12
    • 33845877445 scopus 로고    scopus 로고
    • A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice
    • Shima N, Alcaraz A, Liachko I, Buske TR, Andrews CA, Munroe RJ, et al. A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice. Nat Genet 2007; 39:93-8.
    • (2007) Nat Genet , vol.39 , pp. 93-98
    • Shima, N.1    Alcaraz, A.2    Liachko, I.3    Buske, T.R.4    Andrews, C.A.5    Munroe, R.J.6
  • 13
    • 0037179866 scopus 로고    scopus 로고
    • Cell type-specific responses of human cells to inhibition of replication licensing
    • Shreeram S, Sparks A, Lane DP, Blow JJ. Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene 2002; 21:6624-32.
    • (2002) Oncogene , vol.21 , pp. 6624-6632
    • Shreeram, S.1    Sparks, A.2    Lane, D.P.3    Blow, J.J.4
  • 14
    • 23044445699 scopus 로고    scopus 로고
    • Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation
    • Machida YJ, Teer JK, Dutta A. Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation. J Biol Chem 2005; 280:27624-30.
    • (2005) J Biol Chem , vol.280 , pp. 27624-27630
    • Machida, Y.J.1    Teer, J.K.2    Dutta, A.3
  • 15
    • 0027587793 scopus 로고
    • Cell cycle checkpoints, genetic instability and cancer
    • Weinert T, Lydall D. Cell cycle checkpoints, genetic instability and cancer. Seminars in cancer biology 1993; 4:129-40.
    • (1993) Seminars in cancer biology , vol.4 , pp. 129-140
    • Weinert, T.1    Lydall, D.2
  • 16
    • 0034616913 scopus 로고    scopus 로고
    • 1 cell cycle arrest in response to DNA damage
    • 1 cell cycle arrest in response to DNA damage. Cell 2000; 102:55-66.
    • (2000) Cell , vol.102 , pp. 55-66
    • Agami, R.1    Bernards, R.2
  • 17
    • 0034142325 scopus 로고    scopus 로고
    • Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53
    • Chehab NH, Malikzay A, Appel M, Halazonetis TD. Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev 2000; 14:278-88.
    • (2000) Genes Dev , vol.14 , pp. 278-288
    • Chehab, N.H.1    Malikzay, A.2    Appel, M.3    Halazonetis, T.D.4
  • 18
  • 19
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • Sancar A, Lindsey-Boltz LA, Unsal-Kacmaz K, Linn S. Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. Annu Rev Biochem 2004; 73:39-85.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 20
    • 0042347451 scopus 로고    scopus 로고
    • Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae
    • Dziak R, Leishman D, Radovic M, Tye BK, Yankulov K. Evidence for a role of MCM (mini-chromosome maintenance)5 in transcriptional repression of sub-telomeric and Ty-proximal genes in Saccharomyces cerevisiae. J Biol Chem 2003; 278:27372-81.
    • (2003) J Biol Chem , vol.278 , pp. 27372-27381
    • Dziak, R.1    Leishman, D.2    Radovic, M.3    Tye, B.K.4    Yankulov, K.5
  • 21
    • 0037815412 scopus 로고    scopus 로고
    • Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1
    • Fitch MJ, Donato JJ, Tye BK. Mcm7, a subunit of the presumptive MCM helicase, modulates its own expression in conjunction with Mcm1. J Biol Chem 2003; 278:25408-16.
    • (2003) J Biol Chem , vol.278 , pp. 25408-25416
    • Fitch, M.J.1    Donato, J.J.2    Tye, B.K.3
  • 23
    • 0035920202 scopus 로고    scopus 로고
    • Multiple mechanisms regulate subcellular localization of human CDC6
    • Delmolino LM, Saha P, Dutta A. Multiple mechanisms regulate subcellular localization of human CDC6. J Biol Chem 2001; 276:26947-54.
    • (2001) J Biol Chem , vol.276 , pp. 26947-26954
    • Delmolino, L.M.1    Saha, P.2    Dutta, A.3
  • 24
    • 0035853152 scopus 로고    scopus 로고
    • Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFNgamma
    • DaFonseca CJ, Shu F, Zhang JJ. Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFNgamma. Proc Natl Acad Sci USA 2001; 98:3034-9.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 3034-3039
    • DaFonseca, C.J.1    Shu, F.2    Zhang, J.J.3
  • 25
    • 0032401780 scopus 로고    scopus 로고
    • Ser727-dependent recruitment of MCM5 by Stat1alpha in IFNgamma-induced transcriptional activation
    • Zhang JJ, Zhao Y, Chait BT, Lathem WW, Ritzi M, Knippers R, et al. Ser727-dependent recruitment of MCM5 by Stat1alpha in IFNgamma-induced transcriptional activation. Embo J 1998; 17:6963-71.
    • (1998) Embo J , vol.17 , pp. 6963-6971
    • Zhang, J.J.1    Zhao, Y.2    Chait, B.T.3    Lathem, W.W.4    Ritzi, M.5    Knippers, R.6
  • 26
    • 26844432215 scopus 로고    scopus 로고
    • The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation
    • Snyder M, He W, Zhang JJ. The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation. Proc Natl Acad Sci USA 2005; 102:14539-44.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 14539-14544
    • Snyder, M.1    He, W.2    Zhang, J.J.3
  • 27
    • 0036427519 scopus 로고    scopus 로고
    • Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme
    • Holland L, Gauthier L, Bell-Rogers P, Yankulov K. Distinct parts of minichromosome maintenance protein 2 associate with histone H3/H4 and RNA polymerase II holoenzyme. Eur J Biochem 2002; 269:5192-202.
    • (2002) Eur J Biochem , vol.269 , pp. 5192-5202
    • Holland, L.1    Gauthier, L.2    Bell-Rogers, P.3    Yankulov, K.4
  • 29
    • 2942607401 scopus 로고    scopus 로고
    • Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae
    • Sawyer SL, Cheng IH, Chai W, Tye BK. Mcm10 and Cdc45 cooperate in origin activation in Saccharomyces cerevisiae. J Mol Biol 2004; 340:195-202.
    • (2004) J Mol Biol , vol.340 , pp. 195-202
    • Sawyer, S.L.1    Cheng, I.H.2    Chai, W.3    Tye, B.K.4
  • 30
    • 33645717628 scopus 로고    scopus 로고
    • GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks
    • Gambus A, Jones RC, Sanchez-Diaz A, Kanemaki M, van Deursen F, Edmondson RD, et al. GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks. Nat Cell Biol 2006; 8:358-66.
    • (2006) Nat Cell Biol , vol.8 , pp. 358-366
    • Gambus, A.1    Jones, R.C.2    Sanchez-Diaz, A.3    Kanemaki, M.4    van Deursen, F.5    Edmondson, R.D.6
  • 31
    • 33748590811 scopus 로고    scopus 로고
    • Interaction between HP1alpha and replication proteins in mammalian cells
    • Auth T, Kunkel E, Grummt F. Interaction between HP1alpha and replication proteins in mammalian cells. Exp Cell Res 2006; 312:3349-59.
    • (2006) Exp Cell Res , vol.312 , pp. 3349-3359
    • Auth, T.1    Kunkel, E.2    Grummt, F.3
  • 32
    • 34147093026 scopus 로고    scopus 로고
    • H2B ubiquitylation in transcriptional control: A FACT-finding mission
    • Laribee RN, Fuchs SM, Strahl BD. H2B ubiquitylation in transcriptional control: a FACT-finding mission. Genes Dev 2007; 21:737-43.
    • (2007) Genes Dev , vol.21 , pp. 737-743
    • Laribee, R.N.1    Fuchs, S.M.2    Strahl, B.D.3
  • 33
    • 0036859962 scopus 로고    scopus 로고
    • The role of the carboxy-terminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae
    • Gauthier L, Dziak R, Kramer DJ, Leishman D, Song X, Ho J, et al. The role of the carboxy-terminal domain of RNA polymerase II in regulating origins of DNA replication in Saccharomyces cerevisiae. Genetics 2002; 162:1117-29.
    • (2002) Genetics , vol.162 , pp. 1117-1129
    • Gauthier, L.1    Dziak, R.2    Kramer, D.J.3    Leishman, D.4    Song, X.5    Ho, J.6
  • 34
    • 0035949475 scopus 로고    scopus 로고
    • Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle
    • Weinreich M, Liang C, Chen HH, Stillman B. Binding of cyclin-dependent kinases to ORC and Cdc6p regulates the chromosome replication cycle. Proc Natl Acad Sci USA 2001; 98:11211-7.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11211-11217
    • Weinreich, M.1    Liang, C.2    Chen, H.H.3    Stillman, B.4
  • 35
    • 0035911969 scopus 로고    scopus 로고
    • Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication
    • Furstenthal L, Kaiser BK, Swanson C, Jackson PK. Cyclin E uses Cdc6 as a chromatin-associated receptor required for DNA replication. J Cell Biol 2001; 152:1267-78.
    • (2001) J Cell Biol , vol.152 , pp. 1267-1278
    • Furstenthal, L.1    Kaiser, B.K.2    Swanson, C.3    Jackson, P.K.4
  • 36
    • 7744234408 scopus 로고    scopus 로고
    • Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
    • Mimura S, Seki T, Tanaka S, Diffley JF. Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control. Nature 2004; 431:1118-23.
    • (2004) Nature , vol.431 , pp. 1118-1123
    • Mimura, S.1    Seki, T.2    Tanaka, S.3    Diffley, J.F.4
  • 37
    • 0030727157 scopus 로고    scopus 로고
    • Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation
    • Jallepalli PV, Brown GW, Muzi-Falconi M, Tien D, Kelly TJ. Regulation of the replication initiator protein p65cdc18 by CDK phosphorylation. Genes Dev 1997; 11:2767-79.
    • (1997) Genes Dev , vol.11 , pp. 2767-2779
    • Jallepalli, P.V.1    Brown, G.W.2    Muzi-Falconi, M.3    Tien, D.4    Kelly, T.J.5
  • 38
    • 34247268629 scopus 로고    scopus 로고
    • Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication
    • Honey S, Futcher B. Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication. Mol Biol Cell 2007; 18:1324-36.
    • (2007) Mol Biol Cell , vol.18 , pp. 1324-1336
    • Honey, S.1    Futcher, B.2
  • 39
    • 29244491689 scopus 로고    scopus 로고
    • CDK-dependent stabilization of Cdc6: Linking growth and stress signals to activation of DNA replication
    • Duursma AM, Agami R. CDK-dependent stabilization of Cdc6: linking growth and stress signals to activation of DNA replication. Cell Cycle 2005; 4:1725-8.
    • (2005) Cell Cycle , vol.4 , pp. 1725-1728
    • Duursma, A.M.1    Agami, R.2
  • 40
    • 0031962883 scopus 로고    scopus 로고
    • 1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts
    • 1 cyclin-dependent kinases are sufficient to initiate DNA synthesis in quiescent human fibroblasts. Curr Biol 1998; 8:65-8.
    • (1998) Curr Biol , vol.8 , pp. 65-68
    • Connell-Crowley, L.1    Elledge, S.J.2    Harper, J.W.3
  • 41
    • 34147099107 scopus 로고    scopus 로고
    • Autocatalytic phosphorylation of CDK2 at the activating Thr160
    • Abbas T, Jha S, Sherman NE, Dutta A. Autocatalytic phosphorylation of CDK2 at the activating Thr160. Cell Cycle 2007; 6:843-52.
    • (2007) Cell Cycle , vol.6 , pp. 843-852
    • Abbas, T.1    Jha, S.2    Sherman, N.E.3    Dutta, A.4
  • 42
    • 33646588731 scopus 로고    scopus 로고
    • Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation
    • Teer JK, Machida YJ, Labit H, Novac O, Hyrien O, Marheineke K, et al. Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation. J Biol Chem 2006; 281:6253-60.
    • (2006) J Biol Chem , vol.281 , pp. 6253-6260
    • Teer, J.K.1    Machida, Y.J.2    Labit, H.3    Novac, O.4    Hyrien, O.5    Marheineke, K.6
  • 43
    • 0035201229 scopus 로고    scopus 로고
    • 1-phase and are required to establish, but not maintain, the S-phase checkpoint
    • 1-phase and are required to establish, but not maintain, the S-phase checkpoint. Mol Biol Cell 2001; 12:3658-67.
    • (2001) Mol Biol Cell , vol.12 , pp. 3658-3667
    • Labib, K.1    Kearsey, S.E.2    Diffley, J.F.3
  • 44
    • 0029082391 scopus 로고
    • 1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae
    • 1 is important for the onset of S phase and for preventing a 'reductional' anaphase in the budding yeast Saccharomyces cerevisiae. Embo J 1995; 14:3788-99.
    • (1995) Embo J , vol.14 , pp. 3788-3799
    • Piatti, S.1    Lengauer, C.2    Nasmyth, K.3
  • 46
    • 0033544931 scopus 로고    scopus 로고
    • Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae
    • Weinberger M, Trabold PA, Lu M, Sharma K, Huberman JA, Burhans WC. Induction by adozelesin and hydroxyurea of origin recognition complex-dependent DNA damage and DNA replication checkpoints in Saccharomyces cerevisiae. J Biol Chem 1999; 274:35975-84.
    • (1999) J Biol Chem , vol.274 , pp. 35975-35984
    • Weinberger, M.1    Trabold, P.A.2    Lu, M.3    Sharma, K.4    Huberman, J.A.5    Burhans, W.C.6
  • 47
    • 0037115462 scopus 로고    scopus 로고
    • ORC and the intra-S-phase checkpoint: A threshold regulates Rad53p activation in S phase
    • Shimada K, Pasero P, Gasser SM. ORC and the intra-S-phase checkpoint: a threshold regulates Rad53p activation in S phase. Genes Dev 2002; 16:3236-52.
    • (2002) Genes Dev , vol.16 , pp. 3236-3252
    • Shimada, K.1    Pasero, P.2    Gasser, S.M.3
  • 48
    • 0032513357 scopus 로고    scopus 로고
    • Roles for ORC in M phase and S phase
    • Dillin A, Rine J. Roles for ORC in M phase and S phase. Science 1998; 279:1733-7.
    • (1998) Science , vol.279 , pp. 1733-1737
    • Dillin, A.1    Rine, J.2
  • 49
    • 18644375649 scopus 로고    scopus 로고
    • Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
    • Takai H, Naka K, Okada Y, Watanabe M, Harada N, Saito S, et al. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. Embo J 2002; 21:5195-205.
    • (2002) Embo J , vol.21 , pp. 5195-5205
    • Takai, H.1    Naka, K.2    Okada, Y.3    Watanabe, M.4    Harada, N.5    Saito, S.6
  • 50
    • 24344435218 scopus 로고    scopus 로고
    • Apoptosis in budding yeast caused by defects in initiation of DNA replication
    • Weinberger M, Ramachandran L, Feng L, Sharma K, Sun X, Marchetti M, et al. Apoptosis in budding yeast caused by defects in initiation of DNA replication. J Cell Sci 2005; 118:3543-53.
    • (2005) J Cell Sci , vol.118 , pp. 3543-3553
    • Weinberger, M.1    Ramachandran, L.2    Feng, L.3    Sharma, K.4    Sun, X.5    Marchetti, M.6
  • 51
    • 37349025510 scopus 로고    scopus 로고
    • Reduced Mcm2 Expression Results in Severe Stem/ Progenitor Cell Deficiency and Cancer
    • Pruitt SC, Bailey KJ, Freeland A. Reduced Mcm2 Expression Results in Severe Stem/ Progenitor Cell Deficiency and Cancer. Stem Cells 2007.
    • (2007) Stem Cells
    • Pruitt, S.C.1    Bailey, K.J.2    Freeland, A.3
  • 52
    • 33746190649 scopus 로고    scopus 로고
    • Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1
    • Jagadeesh S, Banerjee PP. Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1. Biochem Biophys Res Commun 2006; 347:774-80.
    • (2006) Biochem Biophys Res Commun , vol.347 , pp. 774-780
    • Jagadeesh, S.1    Banerjee, P.P.2
  • 53
    • 33750053273 scopus 로고    scopus 로고
    • The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25a/Cdk2-independent mechanism
    • Liu P, Barkley LR, Day T, Bi X, Slater DM, Alexandrow MG, et al. The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25a/Cdk2-independent mechanism. J Biol Chem 2006.
    • (2006) J Biol Chem
    • Liu, P.1    Barkley, L.R.2    Day, T.3    Bi, X.4    Slater, D.M.5    Alexandrow, M.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.