Identification of novel factors involved in or regulating initiation of DNA replication by a genome-wide phenotypic screen in Saccharomyces cerevisiae

Cell Cycle

Volumn 9, Issue 21, 2010, Pages 4399-4410

  Ma, Lijuan ^a,b   Zhai, Yuanliang ^b   Feng, Daorong ^b   Chan, Tsz Choi ^b   Lu, Yongjun ^a   Fu, Xinrong ^b   Wang, Jiafeng ^a,b   Chen, Yanhong ^a   Li, Jianna ^a   Xu, Ke ^b   Liang, Chun ^a,b  

^a SUN YAT SEN UNIVERSITY   (China)

^b HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Budding yeast; CTF1; CTF18; DNA replication initiation; Phenotypic screen; Plasmid loss

Indexed keywords

ADK1P PROTEIN; CDC60P PROTEIN; CTF18P PROTEIN; CTF1P PROTEIN; CTF3P PROTEIN; CTF4P PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE S PHASE; DNA REPLICATION; GENE OVEREXPRESSION; NONHUMAN; PHENOTYPE; PLASMID; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE;

EUKARYOTA; SACCHAROMYCES CEREVISIAE; SACCHAROMYCETALES;

EID: 78349285501     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.21.13679     Document Type: Article

References (53)

1. Bell S, Dutta A. DNA replication in eukaryotic cells. Annu Rev Biochem 2002; 71:13-5.
2. Méndez J, Stillman B. Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins. Bioessays 2003; 25:1158-67.
3. Crampton A, Chang F, DL JP, Frisch R, Weinreich M. An ARS element inhibits DNA replication through a SIR2-dependent mechanism. Mol Cell 2008; 30:156-66. (Pubitemid 351626680)
4. Hartwell L, Mortimer R, Culotti J, Culotti M. Genetic Control of the Cell Division Cycle in Yeast: V Genetic Analysis of cdc Mutants. Genetics 1973; 74:267-86.
5. Moir D, Stewart S, Osmond B, Botstein D. Cold-sensitive cell-division-cycle mutants of yeast: isolation, properties and pseudoreversion studies. Genetics 1982; 100:547-63.
6. Liang C, Weinreich M, Stillman B. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell 1995; 81:667-76.
7. Donaldson A, Fangman W, Brewer B. Cdc7 is required throughout the yeast S phase to activate replication origins. Genes Dev 1998; 12:491-501.
8. Hartwell L. Three additional genes required for deoxyribonucleic acid synthesis in Saccharomyces cerevisiae. J Bacteriol 1973; 115:966-74.
9. Aparicio O, Weinstein D, Bell S. Components and dynamics of DNA replication complexes in S. cerevisiae: redistribution of MCM proteins and Cdc45p during S phase. Cell 1997; 91:59-69.
10. Tye B. Minichromosome maintenance as a genetic assay for defects in DNA replication. Methods 1999; 18:329-34. (Pubitemid 29443620)
11. Dumas L, Lussky J, McFarland E, Shampay J. New temperature-sensitive mutants of Saccharomyces cerevisiae affecting DNA replication. Mol Gen Genet 1982; 187:42-6.
12. Johnston L, Thomas A. The isolation of new DNA synthesis mutants in the yeast Saccharomyces cerevisiae. Mol Gen Genet 1982; 186:439-44. (Pubitemid 13231988)
13. Takayama Y, Kamimura Y, Okawa M, Muramatsu S, Sugino A, Araki H. GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast. Genes Dev 2003; 17:1153-65. (Pubitemid 36534989)
14. Merchant A, Kawasaki Y, Chen Y, Lei M, Tye B. A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae. Mol Cell Biol 1997; 17:3261-71.
15. Dowell S, Romanowski P, Diffley J. Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 1994; 265:1243-6.
16. Maine G, Sinha P, Tye B. Mutants of S. cerevisiae defective in the maintenance of minichromosomes. Genetics 1984; 106:365-85. (Pubitemid 14170925)
17. Kitada K, Johnston L, Sugino T, Sugino A. Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the G1/S cell cycle transition. Genetics 1992; 131:21-9.
18. Zhang Y, Yu Z, Fu X, Liang C. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell 2002; 109:849-60.
19. Kamimura Y, Masumoto H, Sugino A, Araki H. Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication. Mol Cell Biol 1998; 18:6102-9.
20. Kamimura Y, Tak Y, Sugino A, Araki H. Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae. EMBO J 2001; 20:2097-107. (Pubitemid 32397411)
21. Hardy C. Characterization of an essential Orc2p-associated factor that plays a role in DNA replication. Mol Cell Biol 1996; 16:1832-41.
22. Jang S, Elsasser S, Campbell J, Kim J. Identification of Cdc6 protein domains involved in interaction with Mcm2 protein and Cdc4 protein in budding yeast cells. Biochem J 2001; 354:655-61.
23. Kan J, Zou L, Zhang J, Wu R, Wang Z, Liang C. Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae. J Biol Chem 2008; 283:33803-7.
24. Bell S, Stillman B. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 1992; 357:128-34.
25. Du Y, Stillman B. Yph1p, an ORC-interacting protein: potential links between cell proliferation control, DNA replication and ribosome biogenesis. Cell 2002; 109:835-48. (Pubitemid 34785999)
26. Koshland D, Kent J, Hartwell L. Genetic analysis of the mitotic transmission of minichromosomes. Cell 1985; 40:393-403.
27. Hogan E, Koshland D. Addition of extra origins of replication to a minichromosome suppresses its mitotic loss in cdc6 and cdc14 mutants of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 1992; 89:3098-102.
28. Loo S, Fox C, Rine J, Kobayashi R, Stillman B, Bell S. The origin recognition complex in silencing, cell cycle progression and DNA replication. Mol Biol Cell 1995; 6:741-56.
29. Wang J, Wu R, Lu Y, Liang C. Ctf4p facilitates Mcm10p to promote DNA replication in budding yeast. Biochem Biophys Res Commun 2010; 395:336-41.
30. Hanna J, Kroll E, Lundblad V, Spencer F. Saccharomyces cerevisiae CTF18 and CTF4 are required for sister chromatid cohesion. Mol Cell Biol 2001; 21:3144-58.
31. Zhai Y, Yung P, Huo L, Liang C. Cdc14p resets the competency of replication licensing by dephosphorylating multiple initiation proteins during mitotic exit in budding yeast. J Cell Sci 2010; In press.
32. Rose M, Novick P, Thomas J, Botstein D, Fink G. A Saccharomyces cerevisiae genomic plasmid bank based on a centromere-containing shuttle vector. Gene 1987; 60:237-43. (Pubitemid 18043769)
33. 1 to S transition in S. cerevisiae. Cell 1994; 79:233-44.
34. Yuen K, Warren C, Chen O, Kwok T, Hieter P, Spencer F. Systematic genome instability screens in yeast and their potential relevance to cancer. Proc Natl Acad Sci USA 2007; 104:3925-30.
35. Kouprina N, Kroll E, Bannikov V, Bliskovsky V, Gizatullin R, Kirillov A, et al. CTF4 (CHL15) mutants exhibit defective DNA metabolism in the yeast Saccharomyces cerevisiae. Mol Cell Biol 1992; 12:5736-47.
36. Konrad M. Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae. J Biol Chem 1988; 263:19468-74.
37. Cheng X, Xu Z, Wang J, Zhai Y, Lu Y, Liang C. ATP-dependent pre-replicative complex assembly is facilitated by Adk1p in budding yeast. J Biol Chem. 2010; 285:29974-80.
38. Laha S, Das S, Hajra S, Sau S, Sinha P. The budding yeast protein Chl1p is required to preserve genome integrity upon DNA damage in S-phase. Nucleic Acids Res 2006; 34:5880-91.
39. Suter B, Tong A, Chang M, Yu L, Brown G, Boone C, et al. The origin recognition complex links replication, sister chromatid cohesion and transcriptional silencing in Saccharomyces cerevisiae. Genetics 2004; 167:579-91. (Pubitemid 38931849)
40. Honey S, Futcher B. Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication. Mol Biol Cell 2007; 18:1324-36.
41. Kroll E, Hyland K, Hieter P, Li J. Establishing genetic interactions by a synthetic dosage lethality phenotype. Genetics 1996; 143:95-102.
42. Skibbens R. Chl1p, a DNA helicase-like protein in budding yeast, functions in sister-chromatid cohesion. Genetics 2004; 166:33-42. (Pubitemid 38364700)
43. Ansbach A, Noguchi C, Klansek I, Heidlebaugh M, Nakamura T, Noguchi E. RFCCtf18 and the Swi1-Swi3 complex function in separate and redundant pathways required for the stabilization of replication forks to facilitate sister chromatid cohesion in Schizosaccharomyces pombe. Mol Biol Cell 2008; 19:595-607. (Pubitemid 351272148)
44. Chabes A, Stillman B. Constitutively high dNTP concentration inhibits cell cycle progression and the DNA damage checkpoint in yeast Saccharomyces cerevisiae. Proc Natl Acad Sci USA 2007; 104:1183-8.
45. Lengronne A, Schwob E. The yeast CDK inhibitor Sic1 prevents genomic instability by promoting replication origin licensing in late G(1). Mol Cell 2002; 9:1067-78.
46. Measday V, Hailey D, Pot I, Givan S, Hyland K, Cagney G, et al. Ctf3p, the Mis6 budding yeast homolog, interacts with Mcm22p and Mcm16p at the yeast outer kinetochore. Genes Dev 2002; 16:101-13.
47. Shimada K, Gasser S. The origin recognition complex functions in sister-chromatid cohesion in Saccharomyces cerevisiae. Cell 2007; 128:85-99. (Pubitemid 46048893)
48. Hohmann S, Thevelein J. The cell division cycle gene CDC60 encodes cytosolic leucyl-tRNA synthetase in Saccharomyces cerevisiae. Gene 1992; 120:43-9.
49. Janke C, Magiera M, Rathfelder N, Taxis C, Reber S, Maekawa H, et al. A versatile toolbox for PCR-based tagging of yeast genes: new fluorescent proteins, more markers and promoter substitution cassettes. Yeast 2004; 21:947-62.
50. Labib K, Tercero J, Diffley J. Uninterrupted MCM2-7 function required for DNA replication fork progression. Science 2000; 288:1643-7.
51. Sanchez-Diaz A, Kanemaki M, Marchesi V, Labib K. Rapid depletion of budding yeast proteins by fusion to a heat-inducible degron. Sci STKE 2004; 223:8.
52. Liang C, Stillman B. Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants. Genes Dev 1997; 11:3375-86. (Pubitemid 28024028)
53. Weinreich M, Liang C, Stillman B. The Cdc6p nucleotide-binding motif is required for loading mcm proteins onto chromatin. Proc Natl Acad Sci USA 1999; 96:441-6.