Inhibiting the Expression of DNA Replication-Initiation Proteins Induces Apoptosis in Human Cancer Cells

Cancer Research

Volumn 63, Issue 21, 2003, Pages 7356-7364

  Feng, Daorong ^a   Tu, Zheng ^a   Wu, Wenyan ^a   Liang, Chun ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; INITIATION FACTOR; MESSENGER RNA; PROTEIN HCDC45P; PROTEIN HCDC6P; PROTEIN HMCM2P; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER CHEMOTHERAPY; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; DNA REPLICATION; FLOW CYTOMETRY; GENE SILENCING; GENE TARGETING; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CELL CYCLE PROTEINS; CELL DIVISION; DNA REPLICATION; GENE SILENCING; HELA CELLS; HUMANS; MICE; MICE, NUDE; NEOPLASMS; NUCLEAR PROTEINS; OLIGONUCLEOTIDES, ANTISENSE; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0242610832     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Williams, R. S., Shohet, R. V., and Stillman, B. A human protein related to yeast Cdc6p. Proc. Natl. Acad. Sci. USA, 94: 142-147, 1997.
2. Williams, G. H., Romanowski, P., Morris, L., Madine, M., Mills, A. D., Stoeber, K., Marr, J., Laskey, R. A., and Coleman, N. Improved cervical smear assessment using antibodies against proteins that regulate DNA replication. Proc. Natl. Acad. Sci. USA, 95: 14932-14937, 1998.
3. Bell, S. P., and Stillman, B. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature (Lond.), 357: 128-134, 1992.
4. Gavin, K. A., Hidaka, M., and Stillman, B. Conserved initiator proteins in eukaryotes. Science (Wash. DC), 270: 1667-1671, 1995.
5. Muzi-Falconi, M., and Kelly, T. J. Orp1, a member of the Cdc18/Cdc6 family of S-phase regulators, is homologous to a component of the origin recognition complex. Proc. Natl. Acad. Sci. USA, 92: 12475-12479, 1995.
6. Gossen, M., Pak, D. T., Hansen, S. K., Acharya, J. K., and Botchan, M. R. A Drosophila homolog of the yeast origin recognition complex. Science (Wash. DC), 270: 1674-1677, 1995.
7. Ehrenhofer-Murray, A. E., Gossen, M., Pak, D. T., Botchan, M. R., and Rine, J. Separation of origin recognition complex functions by cross-species complementation. Science (Wash. DC), 270: 1671-1674, 1995.
8. Zhang, Y., Yu, Z., Fu, X., and Liang, C. Noc3p, a bHLH protein, plays an integral role in the initiation of DNA replication in budding yeast. Cell, 109: 849-860, 2002.
9. Liang, C., Weinreich, M., and Stillman, B. ORC and Cdc6p interact and determine the frequency of initiation of DNA replication in the genome. Cell, 81: 667-676, 1995.
10. Muzi-Falconi, M., Brown, G. W., and Kelly, T. J. cdc18+ regulates initiation of DNA replication in Schizosaccharomyces pombe. Proc. Natl. Acad. Sci. USA, 93: 1566-1570, 1996.
11. Coleman, T. R., Carpenter, P. B., and Dunphy, W. G. The Xenopus Cdc6 protein is essential for the initiation of a single round of DNA replication in cell-free extracts. Cell, 87: 53-63, 1996.
12. Yan, Z., DeGregori, J., Shohet, R., Leone, G., Stillman, B., Nevins, J. R., and Williams, R. S. Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. Proc. Natl. Acad. Sci. USA, 95: 3603-3608, 1998.
13. Whittaker, A. J., Royzman, I., and Orr-Weaver, T. L. Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts. Genes Dev., 14: 1765-1776, 2000.
14. Nishitani, H., Lygerou, Z., Nishimoto, T., and Nurse, P. The Cdt1 protein is required to license DNA for replication in fission yeast. Nature (Lond.), 404: 625-628, 2000.
15. Maiorano, D., Moreau, J., and Mechali, M. XCDT1 is required for the assembly of pre-replicative complexes in Xenopus laevis. Nature (Lond.), 404: 622-625, 2000.
16. Tanaka, S., and Diffley, J. F. X. Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase. Nat. Cell Biol., 4: 198-207, 2002.
17. Yan, H., Merchant, A. M., and Tye, B. K. Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast. Genes Dev., 7: 2149-2160, 1993.
18. Madine, M. A., Khoo, C. Y., Mills, A. D., and Laskey, R. A. MCM3 complex required for cell cycle regulation of DNA replication in vertebrate cells. Nature (Lond.), 375: 421-424, 1995.
19. Chong, J. P., Mahbubani, H. M., Khoo, C. Y., and Blow, J. J. Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature (Lond.), 375: 418-421, 1995.
20. Schulte, D., Burkhart, R., Musahl, C., Hu, B., Schlatterer, C., Hameister, H., and Knippers, R. Expression, phosphorylation and nuclear localization of the human P1 protein, a homologue of the yeast Mcm 3 replication protein. J. Cell Sci., 108: 1381-1389, 1995.
21. Zou, L., Mitchell J., and Stillman B. CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication. Mol. Cell. Biol., 17: 553-563, 1997.
22. Saha, P., Thome, K. C., Yamaguchi, R., Hou, Z., Weremowicz, S., and Dutta, A. The human homolog of Saccharomyces cerevisiae CDC45. J. Biol. Chem., 273: 18205-18209, 1998.
23. Yoshida, K., Kuo, F., George, E. L., Sharpe, A. H., and Dutta, A. Requirement of CDC45 for postimplantation mouse development. Mol. Cell. Biol., 21: 4598-4603, 2001.
24. Walter, A. E., Turner, D. H., Kim, J., Lyttle, M. H., Muller, P., Mathews, D. H., and Zuker, M. Coaxial stacking of helixes enhances binding of oligoribonucleotides and improves predictions of RNA folding. Proc. Natl. Acad. Sci. USA, 91: 9218-9222, 1994.
25. Tu, G. C., Cao, Q. N., Zhou, F., and Israel, Y. Tetranucleotide GGGA motif in primary RNA transcripts. Novel target site for antisense design. J. Biol. Chem., 273: 25125-25131, 1998.
26. Ishiyama, M., Tominaga, H., Shiga, M., Sasamoto, K., Ohkura, Y., and Ueno, K. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol. Pharm. Bull., 19: 1518-1520, 1996.
27. Yu, L. R., Zeng, R., Shao, X. X., Wang, N., Xu, Y. H., and Xia, Q. C. Identification of differentially expressed proteins between human hepatoma and normal liver cell lines by two-dimensional electrophoresis and liquid chromatography-ion trap mass spectrometry. Electrophoresis, 21: 3058-3068, 2000.
28. Ji, L. L., Zhao, X. G., Chen, L., Zhang, M., and Wang, Z. T. Pyrrolizidine alkaloid clivorine inhibits human normal liver L-02 cells growth and activates p38 mitogen-activated protein kinase in L-02 cells. Toxicon, 40: 1685-1690, 2002.
29. Elbashir, S. M., Martinez, J., Patkaniowska, A., Lendeckel, W., and Tuschl, T. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J., 20: 6877-6888, 2001.
30. Raats, J. M., Gell, D., Vickers, L., Heasman, J., and Wylie, C. Modified mRNA rescue of maternal CK1/8 mRNA depletion in Xenopus oocytes. Antisense Nucleic Acid Drug Dev., 7: 263-277, 1997.
31. Lassus, P., Opitz-Araya, X., and Lazebnik, Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science (Wash. DC), 297: 1352-1354, 2002.
32. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol., 119, 493-501, 1992.
33. Koopman, G., Reutelingsperger, C. P., Kuijten, G. A., Keehnen, R. M., Pals, S. T., and van Oers, M. H. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood. 84: 1415-1420, 1994.
34. Ricci, G., Perticarari, S., Fragonas, E., Giolo, E., Canova, S., Pozzobon, C., Guaschino, S., and Presani, G. Apoptosis in human sperm: its correlation with semen quality and the presence of leukocytes. Hum. Reprod., 17: 2665-2672, 2002.
35. Prasanth, S. G., Prasanth, K. V., and Stillman, B. Orc6 involved in DNA replication, chromosome segregation, and cytokinesis. Science (Wash. DC). 297: 1026-1031, 2002.
36. Shreeram, S., Sparks, A., Lane, D. P., and Blow, J. J. Cell type-specific responses of human cells to inhibition of replication licensing. Oncogene, 21: 6624-6632, 2002.
37. Wang, H., Prasad, G., Buolamwini, J. K., and Zhang, R. Antisense anticancer oligonucleotide therapeutics. Curr. Cancer Drug Targets, 1: 177-196, 2001.
38. Wickstrom, E. Oligonucleotide treatment of ras-induced tumors in nude mice. Mol. Biotechnol., 18: 35-55, 2001.
39. Jansen, B., and Zangemeister-Wittke, U. Antisense therapy for cancer - the time of truth. Lancet Oncol., 3: 672-683, 2002.
40. Cho-Chung, Y. S. Antisense DNAs as targeted therapeutics for cancer: no longer a dream. Curr. Opin. Investig. Drugs, 3: 934-939, 2002.
41. McCaffrey, A. P., Meuse, L., Pham, T. T. T., Conklin, D. S., Hannon, G. J., and Kay, M. A. RNA interference in adult mice. Nature (Lond.), 418: 38-39, 2002.
42. Song, E., Lee, S. K., Wang, J., Ince, N., Ouyang, N., Min, J., Chen, J., Shankar, P., and Lieberman, J. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat. Med., 9: 347-351, 2003.
43. Hemann, M. T., Fridman, J. S., Zilfou, J. T., Hernando, E., Paddison, P. J., Cordon-Cardo, C., Hannon, G. J., and Lowe, S. W. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nat. Genet., 33: 396-400, 2003.
44. Merdan, T., Kopecek, J., and Kissel, T. Prospects for cationic polymers in gene and oligonucleotide therapy against cancer. Adv. Drug Deliv. Rev., 54: 715-758, 2002.
45. Chirila, T. V., Rakoczy, P. E., Garrett, K. L., Lou, X., and Constable, I. J. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides. Biomaterials. 23: 321-342, 2002.