Hedgehog signaling regulates transcription through Gli/Ci binding sites in the wingless enhancer

Mechanisms of Development

Volumn 68, Issue 1-2, 1997, Pages 149-156

  Von Ohlen, Tonia ^a   Hooper, Joan E ^a  

^a UNIVERSITY OF COLORADO   (United States)

Author keywords

Cubitus interruptus; Hedgehog signaling; Wingless promoter

Indexed keywords

ANIMAL CELL; ARTICLE; BINDING SITE; BLASTODERM; CELL POLARITY; DNA BINDING; DNA FLANKING REGION; DNA SEQUENCE; ENHANCER REGION; HEDGEHOG; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PROCESSING; TRANSCRIPTION REGULATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BINDING SITES; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; ENHANCER ELEMENTS (GENETICS); GENE EXPRESSION REGULATION, DEVELOPMENTAL; INSECT PROTEINS; LUCIFERASES; MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; RECEPTORS, CELL SURFACE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0031437362     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(97)00150-0     Document Type: Article

References (54)

1. Akimaru H., Chen Y., Dai P., Hou D., Nonka M., Smolik S.M., Armstrong S., Goodman R.H., Ishii S. Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature. 386:1997;735-738.
2. Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J.E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the Hedgehog signal. Cell. 86:1996;221-232.
3. Alexandre C., Jacinto A., Ingham P.W. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the Cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev. 10:1996;2003-2013.
4. Arias J., Alberts A.S., Brindle P., Claret F.X., Smeal T., Karin M., Feramisco J., Montminy M. Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature. 370:1994;226-229.
5. Aza-Blanc P., Ramirez-Weber F.-A., Laget M.-P., Schwartz C., Kornberg T.B. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell. 89:1997;1043-1053.
6. Baker N.E. Molecular cloning of sequences from wingless, a segment polarity gene in Drosophila: the spatial distribution of a transcript in embryos. EMBO J. 6:1987;1765-1773.
7. Bannister A.J., Kouzarides T. CPB-induced stimulation of c-Fos activity is abrogated by E1A. EMBO J. 14:1995;4758-4762.
8. Bejsovec A., Martinez-Arias A. Roles of wingless in patterning the larval epidermis of Drosophila. Development. 113:1991;471-485.
9. Bhattacharya S., Eckner R., Grossman S., Oldread E., Arany Z., D'Andrea A., Livingston D.M. Cooperation of Stat2 and p300/CBP in signalling induced by interferon-α Nature. 383:1996;344-347.
10. Bunch T.A., Grindblat Y., Goldstein L.S.B. Characterization and use of the Drosophila metallothionein promotor in cultured Drosophila melanogaster cells. Nucleic Acids Res. 16:1988;1043-1061.
11. Cadigan K.M., Grossniklaus U., Gehring W.J. Localized expression of sloppy paired protein maintains the polarity of Drosophila parasegments. Genes Dev. 8:1994;899-913.
12. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
13. Chu-LaGraff Q., Doe C.Q. Neuroblast specification and formation regulated by wingless in the Drosophila CNS. Science. 261:1993;1594-1597.
14. Dai P., Akimaru H., Tanaka Y., Hou D., Yasukawa T., Kanei-Ishii C., Takahashi T., Ishii S. CBP as a transcriptional coactivator of c-Myb. Genes Dev. 10:1996;528-540.
15. de Wet J.R., Wood K.V., DeLuca M., Helinski D.R., Subramani S. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:1987;725-737.
16. Eaton S., Kornberg T.B. Repression of ci-D in posterior compartments of Drosophila by engrailed. Genes Dev. 4:1990;1068-1077.
17. Forbes, A.J., Nakano, Y., Taylor, A.M. and Ingham, P.W., 1993. Genetic analysis of hedgehog signalling in the Drosophila embryo. Development (Suppl.), 115-124.
18. Grossniklaus U., Pearson R.K., Gehring W.J. The Drosophila sloppy paired locus encodes two proteins involved in segmentation that show homology to mammalian transcription factors. Genes Dev. 6:1992;1030-1051.
19. Han K., Levine M.S., Manley J.L. Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell. 56:1989;573-583.
20. Hidalgo A., Ingham P. Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched. Development. 110:1990;291-301.
21. Hoch M., Pankratz M.J. Control of gut development by forkhead and cell signaling molecules in Drosophila. Mech. Dev. 58:1996;3-14.
22. Hooper J.E. Distinct pathways for autocrine and paracrine Wingless signalling in Drosophila embryos. Nature. 372:1994;461-464.
23. Ingham P.W. Localized hedgehog activity controls spatial limits of wingless transcription in the Drosophila embryo. Nature. 366:1993;560-562.
24. Ingham P.W., Hidalgo A. Regulation of wingless transcription in the Drosophila embryo. Development. 117:1993;283-291.
25. Ingham P.W., Taylor A.M., Nakano Y. Role of the Drosophila patched gene in positional signalling. Nature. 353:1991;184-187.
26. Jiang J., Hoey T., Levine M. Autoregulation of a segmentation gene in Drosophila: combinatorial interactions of the even-skipped homeo box protein with a distal enhancer element. Genes Dev. 5:1991;265-277.
27. Johnson R.L., Grenier J.K., Scott M.P. patched overexpression alters wing disc size and pattern: transcriptional and post-transcriptional effects on hedgehog targets. Development. 121:1995;4161-4170.
28. Kwok R.P.S., Lundblad J.R., Chiriva J.C., Richards J.P., Bachinger H.P., Brennan R.G., Roberts S.G.E., Green M.R., Goodman R.H. Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature. 370:1994;223-226.
29. Lawrence P.A., Sanson B., Vincent J.P. Compartments, wingless and engrailed: patterning the ventral epidermis of Drosophila embryos. Development. 122:1996;4095-4103.
30. Lee J.J., von Kessler D.P., Parks S., Beachy P.A. Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell. 71:1992;33-50.
31. Li X., Noll M. Role of the gooseberry gene in Drosophila embryos: maintenance of wingless expression by a wingless-gooseberry autoregulatory loop. EMBO J. 12:1993;4499-4509.
32. Li X., Gutjahr T., Noll M. Separable regulatory elements mediate the establishment and maintenance of cell states by the Drosophila segment-polarity gene gooseberry. EMBO J. 12:1993;1427-1436.
33. Maniatis, T., Fritsch, E.F. and Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Martinez-Arias A., Baker N.E., Ingham P.W. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo. Development. 103:1988;157-170.
35. Miller, J.H. (1972) Experiments in Molecular Genetics, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
36. Motzny C.K., Homgren R. The Drosophila cubitus interruptus protein and its role in the wingless and hedgehog signal transduction pathways. Mech. Dev. 52:1995;137-150.
37. Noordermeer J., Johnston P., Rijsewijk F., Nusse R., Lawrence P.A. The consequences of ubiquitous expression of the wingless gene in the Drosophila embryo. Development. 116:1992;711-719.
38. Nüsslein-Volhard C., Weischaus E. Mutations affecting segment number and polarity in Drosophila. Nature. 287:1980;795-801.
39. Ogryzko V.V., Schiltz R.L., Russanova V., Howard B.H., Nakatani Y. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell. 87:1996;953-959.
40. Orenic T., Chidsey J., Holmgren R. Cell and cubitus interruptus Dominant; two segment polarity genes on the fourth chromosome in Drosophila. Dev. Biol. 124:1987;50-56.
41. Orenic T., Slusarski C., Kroll K., Holmgren R. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev. 4:1990;1053-1067.
42. Perrimon N. Hedgehog and beyond. Cell. 80:1995;517-520.
43. Preat T., Thérond P., Lamour-Isnard C., Limbourg-Bouchon B., Tricoire H., Erk I., Mariol M.-C., Busson D. A putative serine/threonine protein kinase encoded by the segment polarity fused gene of Drosophila. Nature. 347:1990;87-89.
44. Robbins D.J., Nybakken K.E., Kobyashi R., Sisson J.C., Bishop J.M., Thérond P.P. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein Costal2. Cell. 90:1997;225-234.
45. Schuske K., Hooper J., Scott M. patched overexpression causes a wingless phenocopy in Drosophila embryos. Dev. Biol. 164:1994;300-311.
46. Sisson J.C., Ho K.S., Suyama K., Scott M.P. Costal2, a novel kinesin related protein in the Hedgehog signaling pathway. Cell. 90:1997;235-245.
47. Spradling A.C., Rubin G.M. Transposition of cloned P elements into Drosophila germ line chromosomes. Science. 218:1982;341-347.
48. Stone D.M., Hynew M., Armanini M., Swanson T.A., Gu Q., Johnson R.L., Scott M.P., Pennica D., Goddard A., Phillips H., Noll M., Hooper J.E., de Sauvage F., Rosenthal A. The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature. 384:1996;129-134.
49. Tautz D., Pfeiffle C. A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback. Chromosoma. 98:1989;81-85.
50. Thérond P.P., Knight J.D., Kornberg T.B., Bishop J.M. Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc. Natl. Acad. Sci. USA. 63:1996;4224-4228.
51. Thummel C.S., Boulet A.M., Lipshitz H.D. Vectors for Drosophila P-element-mediated transformation and tissue culture transfection. Gene. 74:1988;445-450.
52. van den Heuvel M., Ingham P.W. smoothened encodes a receptor-like serpentine protein required for hedgehog signalling. Nature. 382:1996;547-551.
53. van den Heuvel, M., Klingensmith, J., Perrimon, N. and Nusse, R. (1993) Cell patterning in the Drosophila segment: engrailed and wingless distributions in segment polarity mutant embryos. Development (Suppl.), 105-114.
54. Von Ohlen T., Lessing D., Nusse R., Hooper J.E. Hedgehog signaling regulates transcription through Cubitus Interruptus, a sequence specific DNA binding protein. Proc. Natl. Acad. Sci. USA. 94:1997;2404-2409.