-
1
-
-
36049033946
-
Hedgehog regulates smoothened activity by inducing a conformational switch
-
Zhao Y, Tong C, Jiang J, (2007) Hedgehog regulates smoothened activity by inducing a conformational switch. Nature 450: 252-258.
-
(2007)
Nature
, vol.450
, pp. 252-258
-
-
Zhao, Y.1
Tong, C.2
Jiang, J.3
-
2
-
-
79959804711
-
Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened
-
Chen Y, Sasai N, Ma G, Yue T, Jia J, et al. (2011) Sonic Hedgehog dependent phosphorylation by CK1alpha and GRK2 is required for ciliary accumulation and activation of smoothened. PLoS Biol 9: e1001083.
-
(2011)
PLoS Biol
, vol.9
-
-
Chen, Y.1
Sasai, N.2
Ma, G.3
Yue, T.4
Jia, J.5
-
3
-
-
84879414522
-
The mechanisms of Hedgehog signalling and its roles in development and disease
-
Briscoe J, Therond PP, (2013) The mechanisms of Hedgehog signalling and its roles in development and disease. Nat Rev Mol Cell Biol 14: 416-429.
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 416-429
-
-
Briscoe, J.1
Therond, P.P.2
-
4
-
-
79960084157
-
Sequential phosphorylation of smoothened transduces graded hedgehog signaling
-
Su Y, Ospina JK, Zhang J, Michelson AP, Schoen AM, et al. (2011) Sequential phosphorylation of smoothened transduces graded hedgehog signaling. Sci Signal 4: ra43.
-
(2011)
Sci Signal
, vol.4
-
-
Su, Y.1
Ospina, J.K.2
Zhang, J.3
Michelson, A.P.4
Schoen, A.M.5
-
5
-
-
11144237279
-
Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I
-
Jia J, Tong C, Wang B, Luo L, Jiang J, (2004) Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I. Nature 432: 1045-1050.
-
(2004)
Nature
, vol.432
, pp. 1045-1050
-
-
Jia, J.1
Tong, C.2
Wang, B.3
Luo, L.4
Jiang, J.5
-
6
-
-
11144248964
-
Extensive phosphorylation of Smoothened in Hedgehog pathway activation
-
Zhang C, Williams EH, Guo Y, Lum L, Beachy PA, (2004) Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A 101: 17900-17907.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17900-17907
-
-
Zhang, C.1
Williams, E.H.2
Guo, Y.3
Lum, L.4
Beachy, P.A.5
-
7
-
-
12344305145
-
Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction
-
Apionishev S, Katanayeva NM, Marks SA, Kalderon D, Tomlinson A, (2005) Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction. Nat Cell Biol 7: 86-92.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 86-92
-
-
Apionishev, S.1
Katanayeva, N.M.2
Marks, S.A.3
Kalderon, D.4
Tomlinson, A.5
-
8
-
-
0242361620
-
Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail
-
Jia J, Tong C, Jiang J, (2003) Smoothened transduces Hedgehog signal by physically interacting with Costal2/Fused complex through its C-terminal tail. Genes Dev 17: 2709-2720.
-
(2003)
Genes Dev
, vol.17
, pp. 2709-2720
-
-
Jia, J.1
Tong, C.2
Jiang, J.3
-
9
-
-
10744233219
-
Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
-
Lum L, Zhang C, Oh S, Mann RK, von Kessler DP, et al. (2003) Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 12: 1261-1274.
-
(2003)
Mol Cell
, vol.12
, pp. 1261-1274
-
-
Lum, L.1
Zhang, C.2
Oh, S.3
Mann, R.K.4
von Kessler, D.P.5
-
10
-
-
84868528041
-
Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2
-
Yang C, Chen W, Chen Y, Jiang J, (2012) Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2. Cell Res 22: 1593-1604.
-
(2012)
Cell Res
, vol.22
, pp. 1593-1604
-
-
Yang, C.1
Chen, W.2
Chen, Y.3
Jiang, J.4
-
11
-
-
0034669178
-
Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus
-
Wang G, Amanai K, Wang B, Jiang J, (2000) Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev 14: 2893-2905.
-
(2000)
Genes Dev
, vol.14
, pp. 2893-2905
-
-
Wang, G.1
Amanai, K.2
Wang, B.3
Jiang, J.4
-
12
-
-
0033859849
-
Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation
-
Wang QT, Holmgren RA, (2000) Nuclear import of cubitus interruptus is regulated by hedgehog via a mechanism distinct from Ci stabilization and Ci activation. Development 127: 3131-3139.
-
(2000)
Development
, vol.127
, pp. 3131-3139
-
-
Wang, Q.T.1
Holmgren, R.A.2
-
13
-
-
69449084098
-
The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling
-
Cheung HO, Zhang X, Ribeiro A, Mo R, Makino S, et al. (2009) The kinesin protein Kif7 is a critical regulator of Gli transcription factors in mammalian hedgehog signaling. Sci Signal 2: ra29.
-
(2009)
Sci Signal
, vol.2
-
-
Cheung, H.O.1
Zhang, X.2
Ribeiro, A.3
Mo, R.4
Makino, S.5
-
14
-
-
80052515585
-
The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation
-
Shi Q, Li S, Jia J, Jiang J, (2011) The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation. Development 138: 4219-4231.
-
(2011)
Development
, vol.138
, pp. 4219-4231
-
-
Shi, Q.1
Li, S.2
Jia, J.3
Jiang, J.4
-
15
-
-
79956308325
-
Mechanisms and functions of Hedgehog signalling across the metazoa
-
Ingham PW, Nakano Y, Seger C, (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12: 393-406.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 393-406
-
-
Ingham, P.W.1
Nakano, Y.2
Seger, C.3
-
16
-
-
70450221494
-
Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases
-
Cheng S, Maier D, Neubueser D, Hipfner DR, (2010) Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases. Dev Biol 337: 99-109.
-
(2010)
Dev Biol
, vol.337
, pp. 99-109
-
-
Cheng, S.1
Maier, D.2
Neubueser, D.3
Hipfner, D.R.4
-
17
-
-
34249950014
-
The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila
-
Molnar C, Holguin H, Mayor F Jr, Ruiz-Gomez A, de Celis JF, (2007) The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila. Proc Natl Acad Sci U S A 104: 7963-7968.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 7963-7968
-
-
Molnar, C.1
Holguin, H.2
Mayor Jr., F.3
Ruiz-Gomez, A.4
de Celis, J.F.5
-
18
-
-
77956805860
-
G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila
-
Chen Y, Li S, Tong C, Zhao Y, Wang B, et al. (2010) G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila. Genes Dev 24: 2054-2067.
-
(2010)
Genes Dev
, vol.24
, pp. 2054-2067
-
-
Chen, Y.1
Li, S.2
Tong, C.3
Zhao, Y.4
Wang, B.5
-
19
-
-
82855169173
-
Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling
-
Cheng S, Maier D, Hipfner DR, (2012) Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling. Development 139: 85-94.
-
(2012)
Development
, vol.139
, pp. 85-94
-
-
Cheng, S.1
Maier, D.2
Hipfner, D.R.3
-
20
-
-
33645714857
-
Phosphate-binding tag, a new tool to visualize phosphorylated proteins
-
Kinoshita E, Kinoshita-Kikuta E, Takiyama K, Koike T, (2006) Phosphate-binding tag, a new tool to visualize phosphorylated proteins. Mol Cell Proteomics 5: 749-757.
-
(2006)
Mol Cell Proteomics
, vol.5
, pp. 749-757
-
-
Kinoshita, E.1
Kinoshita-Kikuta, E.2
Takiyama, K.3
Koike, T.4
-
21
-
-
79551500036
-
Less label, more free: approaches in label-free quantitative mass spectrometry
-
Neilson KA, Ali NA, Muralidharan S, Mirzaei M, Mariani M, et al. (2011) Less label, more free: approaches in label-free quantitative mass spectrometry. Proteomics 11: 535-553.
-
(2011)
Proteomics
, vol.11
, pp. 535-553
-
-
Neilson, K.A.1
Ali, N.A.2
Muralidharan, S.3
Mirzaei, M.4
Mariani, M.5
-
22
-
-
0033529667
-
Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression
-
Chen CH, von Kessler DP, Park W, Wang B, Ma Y, et al. (1999) Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell 98: 305-316.
-
(1999)
Cell
, vol.98
, pp. 305-316
-
-
Chen, C.H.1
von Kessler, D.P.2
Park, W.3
Wang, B.4
Ma, Y.5
-
23
-
-
81055129599
-
A mechanism for the evolution of phosphorylation sites
-
Pearlman SM, Serber Z, Ferrell JE Jr, (2011) A mechanism for the evolution of phosphorylation sites. Cell 147: 934-946.
-
(2011)
Cell
, vol.147
, pp. 934-946
-
-
Pearlman, S.M.1
Serber, Z.2
Ferrell Jr., J.E.3
-
24
-
-
79952784761
-
Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs
-
Huang CC, Tesmer JJ, (2011) Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs. J Biol Chem 286: 7715-7721.
-
(2011)
J Biol Chem
, vol.286
, pp. 7715-7721
-
-
Huang, C.C.1
Tesmer, J.J.2
-
25
-
-
33847660443
-
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases
-
Bischof J, Maeda RK, Hediger M, Karch F, Basler K, (2007) An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A 104: 3312-3317.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3312-3317
-
-
Bischof, J.1
Maeda, R.K.2
Hediger, M.3
Karch, F.4
Basler, K.5
-
26
-
-
0034682719
-
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
-
Denef N, Neubuser D, Perez L, Cohen SM, (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
-
(2000)
Cell
, vol.102
, pp. 521-531
-
-
Denef, N.1
Neubuser, D.2
Perez, L.3
Cohen, S.M.4
-
27
-
-
0036209874
-
Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins
-
Claing A, Laporte SA, Caron MG, Lefkowitz RJ, (2002) Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins. Prog Neurobiol 66: 61-79.
-
(2002)
Prog Neurobiol
, vol.66
, pp. 61-79
-
-
Claing, A.1
Laporte, S.A.2
Caron, M.G.3
Lefkowitz, R.J.4
-
28
-
-
84873735792
-
Decoding the phosphorylation code in Hedgehog signal transduction
-
Chen Y, Jiang J, (2013) Decoding the phosphorylation code in Hedgehog signal transduction. Cell Res 23: 186-200.
-
(2013)
Cell Res
, vol.23
, pp. 186-200
-
-
Chen, Y.1
Jiang, J.2
-
29
-
-
80051616441
-
Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin
-
Nobles KN, Xiao K, Ahn S, Shukla AK, Lam CM, et al. (2011) Distinct phosphorylation sites on the beta(2)-adrenergic receptor establish a barcode that encodes differential functions of beta-arrestin. Sci Signal 4: ra51.
-
(2011)
Sci Signal
, vol.4
-
-
Nobles, K.N.1
Xiao, K.2
Ahn, S.3
Shukla, A.K.4
Lam, C.M.5
-
31
-
-
77951230331
-
Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling
-
Busillo JM, Armando S, Sengupta R, Meucci O, Bouvier M, et al. (2010) Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling. J Biol Chem 285: 7805-7817.
-
(2010)
J Biol Chem
, vol.285
, pp. 7805-7817
-
-
Busillo, J.M.1
Armando, S.2
Sengupta, R.3
Meucci, O.4
Bouvier, M.5
-
32
-
-
0028809192
-
Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2
-
Prossnitz ER, Kim CM, Benovic JL, Ye RD, (1995) Phosphorylation of the N-formyl peptide receptor carboxyl terminus by the G protein-coupled receptor kinase, GRK2. J Biol Chem 270: 1130-1137.
-
(1995)
J Biol Chem
, vol.270
, pp. 1130-1137
-
-
Prossnitz, E.R.1
Kim, C.M.2
Benovic, J.L.3
Ye, R.D.4
-
33
-
-
84896692442
-
PI4KIIIalpha is required for cortical integrity and cell polarity during Drosophila oogenesis
-
Tan J, Oh K, Burgess J, Hipfner DR, Brill JA, (2014) PI4KIIIalpha is required for cortical integrity and cell polarity during Drosophila oogenesis. J Cell Sci [Epub ahead of print.].
-
(2014)
J Cell Sci
-
-
Tan, J.1
Oh, K.2
Burgess, J.3
Hipfner, D.R.4
Brill, J.A.5
-
34
-
-
84863012620
-
USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization
-
Xia R, Jia H, Fan J, Liu Y, Jia J, (2012) USP8 promotes smoothened signaling by preventing its ubiquitination and changing its subcellular localization. PLoS Biol 10: e1001238.
-
(2012)
PLoS Biol
, vol.10
-
-
Xia, R.1
Jia, H.2
Fan, J.3
Liu, Y.4
Jia, J.5
-
35
-
-
33748751670
-
Trafficking of G protein-coupled receptors
-
Drake MT, Shenoy SK, Lefkowitz RJ, (2006) Trafficking of G protein-coupled receptors. Circ Res 99: 570-582.
-
(2006)
Circ Res
, vol.99
, pp. 570-582
-
-
Drake, M.T.1
Shenoy, S.K.2
Lefkowitz, R.J.3
-
36
-
-
84863012714
-
Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila
-
Li S, Chen Y, Shi Q, Yue T, Wang B, et al. (2012) Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila. PLoS Biol 10: e1001239.
-
(2012)
PLoS Biol
, vol.10
-
-
Li, S.1
Chen, Y.2
Shi, Q.3
Yue, T.4
Wang, B.5
-
37
-
-
33744788672
-
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
-
Corcoran RB, Scott MP, (2006) Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells. Proc Natl Acad Sci U S A 103: 8408-8413.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8408-8413
-
-
Corcoran, R.B.1
Scott, M.P.2
-
38
-
-
33646162635
-
GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling
-
Reiter E, Lefkowitz RJ, (2006) GRKs and beta-arrestins: roles in receptor silencing, trafficking and signaling. Trends Endocrinol Metab 17: 159-165.
-
(2006)
Trends Endocrinol Metab
, vol.17
, pp. 159-165
-
-
Reiter, E.1
Lefkowitz, R.J.2
-
39
-
-
34547608994
-
Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused
-
Claret S, Sanial M, Plessis A, (2007) Evidence for a novel feedback loop in the Hedgehog pathway involving Smoothened and Fused. Curr Biol 17: 1326-1333.
-
(2007)
Curr Biol
, vol.17
, pp. 1326-1333
-
-
Claret, S.1
Sanial, M.2
Plessis, A.3
-
40
-
-
79958243351
-
Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses
-
Zhou Q, Kalderon D, (2011) Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. Dev Cell 20: 802-814.
-
(2011)
Dev Cell
, vol.20
, pp. 802-814
-
-
Zhou, Q.1
Kalderon, D.2
-
41
-
-
0036665581
-
Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry
-
Chelius D, Bondarenko PV, (2002) Quantitative profiling of proteins in complex mixtures using liquid chromatography and mass spectrometry. J Proteome Res 1: 317-323.
-
(2002)
J Proteome Res
, vol.1
, pp. 317-323
-
-
Chelius, D.1
Bondarenko, P.V.2
|