N-linked glycosylation of protease-activated receptor-1 second extracellular loop: A critical determinant for ligand-induced receptor activation and internalization

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18781-18793

  Soto, Antonio G ^a,b   Trejo, JoAnn ^a  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CRITICAL DETERMINANT; EXTRACELLULAR; EXTRACELLULAR LOOPS; G PROTEIN; LIGAND DOCKING; N-LINKED GLYCOSYLATION; PROTEASE-ACTIVATED RECEPTOR-1; RECEPTOR ACTIVATION; RECEPTOR SIGNALING; RECEPTOR TRAFFICKING; SIGNAL TERMINATION; WILD TYPES;

CELL MEMBRANES; ESTERIFICATION; LIGANDS; SIGNALING;

GLYCOSYLATION;

ASPARAGINE; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN;

AMINO TERMINAL SEQUENCE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; GENE MUTATION; GLYCOSYLATION; HELA CELL; HUMAN; HUMAN CELL; INTERNALIZATION; MOLECULAR DOCKING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TRANSPORT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL MEMBRANE; GLYCOSYLATION; GTP-BINDING PROTEINS; HELA CELLS; HUMANS; LIGANDS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, PAR-1; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; THROMBIN;

EID: 77953301324     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.111088     Document Type: Article

References (50)

1. Coughlin, S. R. (2005) J. Thromb. Haemost. 3, 1800-1814
2. Arora, P., Ricks, T. K., and Trejo, J. (2007) J. Cell Sci. 120, 921-928
3. Coughlin, S. R. (2000) Nature 407, 258-264
4. Vu, T. K., Hung, D. T., Wheaton, V. I., and Coughlin, S. R. (1991) Cell 64, 1057-1068
5. Benka, M. L., Lee, M., Wang, G. R., Buckman, S., Burlacu, A., Cole, L., DePina, A., Dias, P., Granger, A., and Grant, B. (1995) FEBS Lett. 363, 49-52
6. Majumdar, M., Seasholtz, T. M., Buckmaster, C., Toksoz, D., and Brown, J. H. (1999) J. Biol. Chem. 274, 26815-26821
7. Baffy, G., Yang, L., Raj, S., Manning, D. R., and Williamson, J. R. (1994) J. Biol. Chem. 269, 8483-8487
8. Offermanns, S., Toombs, C. F., Hu, Y. H., and Simon, M. I. (1997) Nature 389, 183-186
9. Lagerström, M. C., and Schiöth, H. B. (2008) Nat. Rev. Drug Discov. 7, 339-357
10. Rosenbaum, D. M., Rasmussen, S. G., and Kobilka, B. K. (2009) Nature 459, 356-363
11. Parthier, C., Reedtz-Runge, S., Rudolph, R., and Stubbs, M. T. (2009) Trends Biochem. Sci. 34, 303-310
12. Gerszten, R. E., Chen, J., Ishii, M., Ishii, K., Wang, L., Nanevicz, T., Turck, C. W., Vu, T. K., and Coughlin, S. R. (1994) Nature 368, 648-651
13. Lerner, D. J., Chen, M., Tram, T., and Coughlin, S. R. (1996) J. Biol. Chem. 271, 13943-13947
14. Landolt-Marticorena, C., and Reithmeier, R. A. (1994) Biochem. J. 302, 253-260
15. Compton, S. J. (2003) Drug Dev. Res. 59, 350-354
16. Compton, S. J., Sandhu, S., Wijesuriya, S. J., and Hollenberg, M. D. (2002) Biochem. J. 368, 495-505
17. Vouret-Craviari, V., Grall, D., Chambard, J. C., Rasmussen, U. B., Pouysségur, J., and Van Obberghen-Schilling, E. (1995) J. Biol. Chem. 270, 8367-8372
18. Kuliopulos, A., Covic, L., Seeley, S. K., Sheridan, P. J., Helin, J., and Costello, C. E. (1999) Biochemistry 38, 4572-4585
19. Mize, G. J., Harris, J. E., Takayama, T. K., and Kulman, J. D. (2008) Protein Expr. Purif. 57, 280-289
20. Tordai, A., Brass, L. F., and Gelfand, E. W. (1995) Biochem. Biophys. Res. Commun. 206, 857-862
21. Paing, M. M., Johnston, C. A., Siderovski, D. P., and Trejo, J. (2006) Mol. Cell. Biol. 26, 3231-3242
22. Trejo, J., Altschuler, Y., Fu, H. W., Mostov, K. E., and Coughlin, S. R. (2000) J. Biol. Chem. 275, 31255-31265
23. Russo, A., Soh, U. J., Paing, M. M., Arora, P., and Trejo, J. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 6393-6397
24. Paing, M. M., Stutts, A. B., Kohout, T. A., Lefkowitz, R. J., and Trejo, J. (2002) J. Biol. Chem. 277, 1292-1300
25. Ishii, K., Hein, L., Kobilka, B., and Coughlin, S. R. (1993) J. Biol. Chem. 268, 9780-9786
26. Jones, J., Krag, S. S., and Betenbaugh, M. J. (2005) Biochim. Biophys. Acta 1726, 121-137
27. Helenius, A. (1994) Mol. Biol. Cell 5, 253-265
28. Dennis, J. W., Lau, K. S., Demetriou, M., and Nabi, I. R. (2009) Traffic 10, 1569-1578
29. Brass, L. F., Pizarro, S., Ahuja, M., Belmonte, E., Blanchard, N., Stadel, J. M., and Hoxie, J. A. (1994) J. Biol. Chem. 269, 2943-2952
30. Taylor, S. J., Chae, H. Z., Rhee, S. G., and Exton, J. H. (1991) Nature 350, 516-518
31. Hains, M. D., Wing, M. R., Maddileti, S., Siderovski, D. P., and Harden, T. K. (2006) Mol. Pharmacol. 69, 2068-2075
32. Trejo, J., Hammes, S. R., and Coughlin, S. R. (1998) Proc. Natl. Acad. Sci. U.S.A. 95, 13698-13702
33. Booden, M. A., Eckert, L. B., Der, C. J., and Trejo, J. (2004) Mol. Cell. Biol. 24, 1990-1999
34. Wolfe, B. L., Marchese, A., and Trejo, J. (2007) J. Cell Biol. 177, 905-916
35. Hoe, M. H., and Hunt, R. C. (1992) J. Biol. Chem. 267, 4916-4923
36. Liu, X., Davis, D., and Segaloff, D. L. (1993) J. Biol. Chem. 268, 1513-1516
37. Compton, S. J., Renaux, B., Wijesuriya, S. J., and Hollenberg, M. D. (2001) Br. J. Pharmacol. 134, 705-718
38. Kornfeld, R., and Kornfeld, S. (1985) Annu. Rev. Biochem. 54, 631-664
39. Pioszak, A. A., Parker, N. R., Suino-Powell, K., and Xu, H. E. (2008) J. Biol. Chem. 283, 32900-32912
40. Hoare, S. R. (2005) Drug Discov. Today 10, 417-427
41. Ahn, K. H., Bertalovitz, A. C., Mierke, D. F., and Kendall, D. A. (2009) Mol. Pharmacol. 76, 833-842
42. Shi, L., and Javitch, J. A. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 440-445
43. Datta, A., and Stone, M. J. (2003) Protein Sci. 12, 2482-2491
44. Bokoch, M. P., Zou, Y., Rasmussen, S. G., Liu, C. W., Nygaard, R., Rosenbaum, D. M., Fung, J. J., Choi, H. J., Thian, F. S., Kobilka, T. S., Puglisi, J. D., Weis, W. I., Pardo, L., Prosser, R. S., Mueller, L., and Kobilka, B. K. (2010) Nature 463, 108-112
45. Trivedi, V., Boire, A., Tchernychev, B., Kaneider, N. C., Leger, A. J., O'Callaghan, K., Covic, L., and Kuliopulos, A. (2009) Cell 137, 332-343
46. Jacques, S. L., LeMasurier, M., Sheridan, P. J., Seeley, S. K., and Kuliopulos, A. (2000) J. Biol. Chem. 275, 40671-40678
47. Arora, P., Cuevas, B. D., Russo, A., Johnson, G. L., and Trejo, J. (2008) Oncogene 27, 4434-4445
48. Trejo, J., and Coughlin, S. R. (1999) J. Biol. Chem. 274, 2216-2224
49. Pagano, M., Clynes, M. A., Masada, N., Ciruela, A., Ayling, L. J., Wachten, S., and Cooper, D. M. (2009) Am. J. Physiol. Cell Physiol. 296, C607-C619
50. Luga, V., McLean, S., Le Roy, C., O'Connor-McCourt, M., Wrana, J. L., and Di Guglielmo, G. M. (2009) Biochem. J. 421, 119-131