Environmental control of microRNAs in the nervous system: Implications in plasticity and behavior

Neuroscience and Biobehavioral Reviews

Volumn 60, Issue , 2016, Pages 121-138

  Codocedo, Juan F ^a   Inestrosa, Nibaldo C ^a,b,c  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c UNIVERSIDAD DE MAGALLANES   (Chile)

Author keywords

Behavior; Environmental factors; MicroRNAs; Neuropathologies; Plasticity; Signaling pathways; Stress

Indexed keywords

ALCOHOL; COCAINE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MICRORNA; MORPHINE; NICOTINE; PLACEBO; RESVERATROL; RETINOIC ACID; SATURATED FATTY ACID; VITAMIN; VITAMIN B GROUP;

ALCOHOLISM; ALZHEIMER DISEASE; ANXIETY DISORDER; AUDITORY SYSTEM; BEHAVIOR; CHRONIC STRESS; COCAINE DEPENDENCE; DEPRESSION; DIET SUPPLEMENTATION; ENVIRONMENTAL STRESS; HEARING IMPAIRMENT; HUMAN; MENTAL STRESS; NERVE CELL PLASTICITY; NEUROPATHIC PAIN; NEUROPROTECTION; NONHUMAN; OLFACTORY SYSTEM; PHYSICAL STRESS; PRIORITY JOURNAL; REVIEW; RNA SYNTHESIS; SCHIZOPHRENIA; SENSORY STIMULATION; SOMATOSENSORY SYSTEM; SPINAL CORD INJURY; SUICIDAL BEHAVIOR; TOBACCO DEPENDENCE; TOUCH; VISUAL SYSTEM; ANIMAL; GENOTYPE ENVIRONMENT INTERACTION; METABOLISM; NERVOUS SYSTEM; PHYSIOLOGY;

ANIMALS; GENE-ENVIRONMENT INTERACTION; HUMANS; MICRORNAS; NERVOUS SYSTEM; NEURONAL PLASTICITY;

EID: 84949784281     PISSN: 01497634     EISSN: 18737528     Source Type: Journal    
DOI: 10.1016/j.neubiorev.2015.10.010     Document Type: Review

References (207)

1. Androulidaki A., Iliopoulos D., Arranz A., Doxaki C., Schworer S., Zacharioudaki V., Margioris A.N., Tsichlis P.N., Tsatsanis C. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 2009, 31:220-231. 10.1016/j.immuni.2009.06.024.
2. Annibali D., Gioia U., Savino M., Laneve P., Caffarelli E., Nasi S. A new module in neural differentiation control: two microRNAs upregulated by retinoic acid, miR-9 and -103, target the differentiation inhibitor ID2. PLoS ONE 2012, 7:1-12. 10.1371/journal.pone.0040269.
3. Ashraf S.I., McLoon A.L., Sclarsic S.M., Kunes S. Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 2006, 124:191-205. 10.1016/j.cell.2005.12.017.
4. Ashraf S.I., McLoon A.L., Sclarsic S.M., Kunes S. Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila. Cell 2006, 126:812. 10.1016/j.cell.2006.08.013.
5. Baek D., Villén J., Shin C., Camargo F.D., Gygi S.P., Bartel D.P. The impact of microRNAs on protein output. Nature 2008, 455:64-71. 10.1038/nature07242.
6. Balaraman S., Winzer-Serhan U.H., Miranda R.C. Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells. Alcohol. Clin. Exp. Res. 2012, 36:1669-1677. 10.1111/j.1530-0277.2012.01793.x.
7. Banerjee S., Neveu P., Kosik K.S. A coordinated local translational control point at the synapse involving relief from silencing and MOV10 degradation. Neuron 2009, 64:871-884. 10.1016/j.neuron.2009.11.023.
8. Barbato C., Pezzola S., Caggiano C., Antonelli M., Frisone P., Ciotti M.T., Ruberti F. A lentiviral sponge for miR-101 regulates RanBP9 expression and amyloid precursor protein metabolism in hippocampal neurons. Front. Cell. Neurosci. 2014, 8:37. 10.3389/fncel.2014.00037.
9. Barbierato M., Zusso M., Skaper S.D., Giusti P. MicroRNAs: emerging role in the endogenous μ opioid system. CNS Neurol. Disord. Drug Targets 2015, 14:239-250.
10. Barco A., Alarcon J.M., Kandel E.R. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 2002, 108:689-703.
11. Baskerville S., Bartel D.P. Microarray profiling of microRNAs reveals frequent coexpression with neighboring miRNAs and host genes. RNA 2005, 11:241-247. 10.1261/rna.7240905.
12. Baudry A., Mouillet-Richard S., Schneider B., Launay J.-M., Kellermann O. miR-16 targets the serotonin transporter: a new facet for adaptive responses to antidepressants. Science 2010, 329:1537-1541. 10.1126/science.1193692.
13. Beckett E.L., Yates Z., Veysey M., Duesing K., Lucock M. The role of vitamins and minerals in modulating the expression of microRNA. Nutr. Res. Rev. 2014, 27:94-106. 10.1017/S0954422414000043.
14. Berezikov E., Chung W.-J., Willis J., Cuppen E., Lai E.C. Mammalian mirtron genes. Mol. Cell 2007, 28:328-336. 10.1016/j.molcel.2007.09.028.
15. Bergh C., Udumyan R., Fall K., Almroth H., Montgomery S. Stress resilience and physical fitness in adolescence and risk of coronary heart disease in middle age. Heart 2015, 101:623-629. 10.1136/heartjnl-2014-306703.
16. Bigagli E., Luceri C., Scartabelli T., Dolara P., Casamenti F., Pellegrini-Giampietro D.E., Giovannelli L. Long-term neuroglial cocultures as a brain aging model: hallmarks of senescence, MicroRNA expression profiles, and comparison with in vivo models. J. Gerontol. A. Biol. Sci. Med. Sci. 2015, glu231. 10.1093/gerona/glu231.
17. Bowes A., Dawson A., Jepson R., McCabe L. Physical activity for people with dementia: a scoping study. BMC Geriatr. 2013, 13:129. 10.1186/1471-2318-13-129.
18. Cao L., Feng C., Li L., Zuo Z. Contribution of microRNA-203 to the isoflurane preconditioning-induced neuroprotection. Brain Res. Bull. 2012, 88:525-528. 10.1016/j.brainresbull.2012.05.009.
19. Caputo F., Vignoli T., Leggio L., Addolorato G., Zoli G., Bernardi M. Alcohol use disorders in the elderly: a brief overview from epidemiology to treatment options. Exp. Gerontol. 2012, 47:411-416. 10.1016/j.exger.2012.03.019.
20. Chandrasekar V., Dreyer J.-L. Regulation of MiR-124 Let-7d, and MiR-181a in the accumbens affects the expression, extinction, and reinstatement of cocaine-induced conditioned place preference. Neuropsychopharmacology 2011, 36:1149-1164. 10.1038/npp.2010.250.
21. Chandrasekar V., Dreyer J.-L. microRNAs miR-124, let-7d and miR-181a regulate cocaine-induced plasticity. Mol. Cell. Neurosci. 2009, 42:350-362. 10.1016/j.mcn.2009.08.009.
22. Chatterjee S., Bartlett S.E. Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders. CNS Neurol. Disord. Drug Targets 2010, 9:60-76.
23. Chendrimada T.P., Gregory R.I., Kumaraswamy E., Norman J., Cooch N., Nishikura K., Shiekhattar R. TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing. Nature 2005, 436:740-744. 10.1038/nature03868.
24. Cheung W.M., Chu P.W., Lung C.H., Ip N.Y. Expression of retinoid receptors during the retinoic acid-induced neuronal differentiation of human embryonal carcinoma cells. J. Neurochem. 2000, 75:34-40.
25. Choi H.-J., Lee J.H., Park S.-Y., Cho J.H., Han J.-S. STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells. Exp. Mol. Med. 2009, 41:94-101. 10.3858/emm.2009.41.2.012.
26. Choi S.-W., Friso S., Keyes M.K., Mason J.B. Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br. J. Nutr. 2005, 93:31-35.
27. Codocedo J.F., Inestrosa N.C. Wnt5a regulates expression of ROCK2 and SYNGAP1 through Mir-101b in rat hippocampal neurons. Program No. 223.16/C11. 2013 Neuroscience Meeting Planner 2013, (Online).
28. Codocedo J.F., Montecinos-Oliva C., Inestrosa N.C. Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers. Front. Cell. Neurosci. 2015, 9:227. 10.3389/fncel.2015.00227.
29. Codocedo J.F., Ríos J.A., Godoy J.A., Inestrosa N.C. Are microRNAs the molecular link between metabolic syndrome and Alzheimer's disease?. Mol. Neurobiol. 2015, 10.1007/s12035-015-9201-7.
30. Daniel E. Noise and hearing loss: a review. J. Sch. Health 2007, 77:225-231. 10.1111/j.1746-1561.2007.00197.x.
31. Darcq E., Warnault V., Phamluong K., Besserer G.M., Liu F., Ron D. MicroRNA-30a-5p in the prefrontal cortex controls the transition from moderate to excessive alcohol consumption. Mol. Psychiatry 2014, 1-11. 10.1038/mp.2014.120.
32. Das E., Bhattacharyya N.P. MicroRNA-432 contributes to dopamine cocktail and retinoic acid induced differentiation of human neuroblastoma cells by targeting NESTIN and RCOR1 genes. FEBS Lett. 2014, 588:1706-1714. 10.1016/j.febslet.2014.03.015.
33. Das S., Sadanandappa M.K., Dervan A., Larkin A., Lee J.A., Sudhakaran I.P., Priya R., Heidari R., Holohan E.E., Pimentel A., Gandhi A., Ito K., Sanyal S., Wang J.W., Rodrigues V., Ramaswami M. Plasticity of local GABAergic interneurons drives olfactory habituation. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E646-E654. 10.1073/pnas.1106411108.
34. Davis T.H., Cuellar T.L., Koch S.M., Barker A.J., Harfe B.D., McManus M.T., Ullian E.M. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus. J. Neurosci. 2008, 28:4322-4330. 10.1523/JNEUROSCI. 4815-07.2008.
35. Denli A.M., Tops B.B.J., Plasterk R.H.a, Ketting R.F., Hannon G.J. Processing of primary microRNAs by the Microprocessor complex. Nature 2004, 432:231-235. 10.1038/nature03049.
36. Doench J.G., Sharp P.A. Specificity of microRNA target selection in translational repression. Genes Dev. 2004, 18:504-511. 10.1101/gad.1184404.
37. Dome P., Lazary J., Kalapos M.P., Rihmer Z. Smoking, nicotine and neuropsychiatric disorders. Neurosci. Biobehav. Rev. 2010, 34:295-342. 10.1016/j.neubiorev.2009.07.013.
38. Dumortier O., Hinault C., Van Obberghen E. MicroRNAs and Metabolism Crosstalk in Energy Homeostasis. Cell Metab. 2013, 1-13. 10.1016/j.cmet.2013.06.004.
39. Eipper-Mains J.E., Kiraly D.D., Palakodeti D., Mains R.E., Eipper B.A., Graveley B.R. microRNA-Seq reveals cocaine-regulated expression of striatal microRNAs. RNA 2011, 17:1529-1543. 10.1261/rna.2775511.
40. Evangelisti C., Florian M.C., Massimi I., Dominici C., Giannini G., Galardi S., Buè M.C., Massalini S., McDowell H.P., Messi E., Gulino A., Farace M.G., Ciafrè S.A. MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. FASEB J. 2009, 23:4276-4287. 10.1096/fj.09-134965.
41. Fabian M.R., Sonenberg N., Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annu. Rev. Biochem. 2010, 79:351-379. 10.1146/annurev-biochem-060308-103103.
42. Fiore R., Khudayberdiev S., Christensen M., Siegel G., Flavell S.W., Kim T.-K., Greenberg M.E., Schratt G. Mef2- mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels. EMBO J. 2009, 28:697-710. 10.1038/emboj.2009.10.
43. Forstner A.J., Degenhardt F., Schratt G., Nöthen M.M. MicroRNAs as the cause of schizophrenia in 22q11.2 deletion carriers, and possible implications for idiopathic disease: a mini-review. Front. Mol. Neurosci. 2013, 6:47. 10.3389/fnmol.2013.00047.
44. Frucht C.S., Santos-Sacchi J., Navaratnam D.S. MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neurosci. Lett. 2011, 493:44-48. 10.1016/j.neulet.2011.02.017.
45. Frucht C.S., Uduman M., Duke J.L., Kleinstein S.H., Santos-Sacchi J., Navaratnam D.S. Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. PLoS ONE 2010, 5:e11502. 10.1371/journal.pone.0011502.
46. Gapp K., Jawaid A., Sarkies P., Bohacek J., Pelczar P., Prados J., Farinelli L., Miska E., Mansuy I.M. Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice. Nat. Neurosci. 2014, 17:667-669. 10.1038/nn.3695.
47. Gapp K., von Ziegler L., Tweedie-Cullen R.Y., Mansuy I.M. Early life epigenetic programming and transmission of stress-induced traits in mammals: how and when can environmental factors influence traits and their transgenerational inheritance?. Bioessays 2014, 36:491-502. 10.1002/bies.201300116.
48. Gariballa S., Ullegaddi R. Riboflavin status in acute ischaemic stroke. Eur. J. Clin. Nutr. 2007, 61:1237-1240. 10.1038/sj.ejcn.1602666.
49. Geekiyanage H., Chan C. MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease. J Neurosci. 2011, 31:14820-14830. 10.1523/JNEUROSCI. 3883-11.2011.
50. Giannotti G., Caffino L., Calabrese F., Racagni G., Riva M.A., Fumagalli F. Prolonged abstinence from developmental cocaine exposure dysregulates BDNF and its signaling network in the medial prefrontal cortex of adult rats. Int. J. Neuropsychopharmacol. 2014, 17:625-634. 10.1017/S1461145713001454.
51. Glanzman D.L. Olfactory habituation: fresh insights from flies. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:14711-14712. 10.1073/pnas.1111230108.
52. Gregory R.I., Yan K.-P., Amuthan G., Chendrimada T., Doratotaj B., Cooch N., Shiekhattar R. The Microprocessor complex mediates the genesis of microRNAs. Nature 2004, 432:235-240. 10.1038/nature03120.
53. Grønbaek M. The positive and negative health effects of alcohol- and the public health implications. J Intern Med. 2009, 265:407-420. 10.1111/j.1365-2796.2009.02082.x.
54. Hammond S.M., Boettcher S., Caudy A.A., Kobayashi R., Hannon G.J. Argonaute2, a link between genetic and biochemical analyses of RNAi. Science 2001, 293:1146-1150. 10.1126/science.1064023.
55. Haramati S., Navon I., Issler O., Ezra-Nevo G., Gil S., Zwang R., Hornstein E., Chen A. MicroRNA as repressors of stress-induced anxiety: the case of amygdalar miR-34. J. Neurosci. 2011, 31:14191-14203. 10.1523/JNEUROSCI. 1673-11.2011.
56. Hasegawa J., Obara T., Tanaka K., Tachibana M. High-density presynaptic transporters are required for glutamate removal from the first visual synapse. Neuron 2006, 50:63-74. 10.1016/j.neuron.2006.02.022.
57. Havens M.A., Reich A.A., Duelli D.M., Hastings M.L. Biogenesis of mammalian microRNAs by a non-canonical processing pathway. Nucleic Acids Res. 2012, 1-15. 10.1093/nar/gks026.
58. He X., Huang Y., Li B., Gong C.-X., Schuchman E.H. Deregulation of sphingolipid metabolism in Alzheimer's disease. Neurobiol. Aging 2010, 31:398-408. 10.1016/j.neurobiolaging.2008.05.010.
59. Hébert S.S., Horré K., Nicolaï L., Papadopoulou A.S., Mandemakers W., Silahtaroglu A.N., Kauppinen S., Delacourte A., De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:6415-6420. 10.1073/pnas.0710263105.
60. Hensch T.K. Critical period plasticity in local cortical circuits. Nat. Rev. Neurosci. 2005, 6:877-888. 10.1038/nrn1787.
61. Hogan E.M., Casserly A.P., Scofield M.D., Mou Z., Zhao-Shea R., Johnson C.W., Tapper A.R., Gardner P.D. miRNAome analysis of the mammalian neuronal nicotinic acetylcholine receptor gene family. RNA 2014, 20:1890-1899. 10.1261/rna.034066.112.
62. Hollander J.A., Im H.-I., Amelio A.L., Kocerha J., Bali P., Lu Q., Willoughby D., Wahlestedt C., Conkright M.D., Kenny P.J. Striatal microRNA controls cocaine intake through CREB signalling. Nature 2010, 466:197-202. 10.1038/nature09202.
63. Hollins S.L., Zavitsanou K., Walker F.R., Cairns M.J. Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure. Transl. Psychiatry 2014, 4:e452. 10.1038/tp.2014.99.
64. Hu B., Guo Y., Chen C., Li Q., Niu X., Guo S., Zhang A., Wang Y., Deng Z. Repression of SIRT1 promotes the differentiation of mouse induced pluripotent stem cells into neural stem cells. Cell. Mol. Neurobiol. 2014, 34:905-912. 10.1007/s10571-014-0071-8.
65. Huang W., Li M.D. Nicotine modulates expression of miR-140, which targets the 3'-untranslated region of dynamin 1 gene (Dnm1). Int. J. Neuropsychopharmacol. 2009, 12:537-546. 10.1017/S1461145708009528.
66. Hutchison M., Berman K.S., Cobb M.H. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J. Biol. Chem. 1998, 273:28625-28632. 10.1074/jbc.273.44.28625.
67. Hutvágner G., Zamore P.D. RNAi: nature abhors a double-strand. Curr. Opin. Genet. Dev. 2002, 12:225-232. 10.1016/S0959-437X(02)00290-3.
68. Hwang Y.Y., Li M.D. Proteins differentially expressed in response to nicotine in five rat brain regions: identification using a 2-DE/MS-based proteomics approach. Proteomics 2006, 6:3138-3153. 10.1002/pmic.200500745.
69. Im H.-I., Hollander J.A., Bali P., Kenny P.J. MeCP2 controls BDNF expression and cocaine intake through homeostatic interactions with microRNA-212. Nat. Neurosci. 2010, 13:1120-1127. 10.1038/nn.2615.
70. Imbard A., Benoist J.-F., Blom H.J. Neural tube defects, folic acid and methylation. Int. J. Environ. Res. Public Health 2013, 10:4352-4389. 10.3390/ijerph10094352.
71. Impey S., Davare M., Lasiek A., Fortin D., Ando H., Varlamova O., Obrietan K., Soderling T.R., Goodman R.H., Wayman G.A. An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling. Mol. Cell. Neurosci. 2010, 43:146-156. 10.1016/j.mcn.2009.10.005.
72. Improgo M.R.D., Scofield M.D., Tapper A.R., Gardner P.D. From smoking to lung cancer: the CHRNA5/A3/B4 connection. Oncogene 2010, 29:4874-4884. 10.1038/onc.2010.256.
73. Inestrosa N.C., Arenas E. Emerging roles of Wnts in the adult nervous system. Nat. Rev. Neurosci. 2010, 11:77-86. 10.1038/nrn2755.
74. Issler O., Chen A. Determining the role of microRNAs in psychiatric disorders. Nat. Rev. Neurosci. 2015, 16:201-212. 10.1038/nrn3879.
75. Issler O., Haramati S., Paul E.D., Maeno H., Navon I., Zwang R., Gil S., Mayberg H.S., Dunlop B.W., Menke A., Awatramani R., Binder E.B., Deneris E.S., Lowry C.A., Chen A. MicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity. Neuron 2014, 83:344-360. 10.1016/j.neuron.2014.05.042.
76. Jang J.Y., Lee S.H., Kim M., Ryu J.S. Characteristics of neuropathic pain in patients with spinal cord injury. Ann. Rehabil. Med. 2014, 38:327-334. 10.5535/arm.2014.38.3.327.
77. Jeanblanc J., He D.-Y., Carnicella S., Kharazia V., Janak P.H., Ron D. Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J. Neurosci. 2009, 29:13494-13502. 10.1523/JNEUROSCI.;1; 2243-09.2009.
78. Jeanblanc J., Logrip M.L., Janak P.H., Ron D. BDNF-mediated regulation of ethanol consumption requires the activation of the MAP kinase pathway and protein synthesis. Eur. J. Neurosci. 2013, 37:607-612. 10.1111/ejn.12067.
79. Kalhan S.C., Marczewski S.E. Methionine, homocysteine, one carbon metabolism and fetal growth. Rev. Endocr. Metab. Disord. 2012, 13:109-119. 10.1007/s11154-012-9215-7.
80. Kandel E.R. The molecular biology of memory storage: a dialogue between genes and synapses. Science. 2001, 294:1030-1038. 10.1126/science.1067020.
81. Karayiorgou M., Morris M.A., Morrow B., Shprintzen R.J., Goldberg R., Borrow J., Gos A., Nestadt G., Wolyniec P.S., Lasseter V.K. Schizophrenia susceptibility associated with interstitial deletions of chromosome 22q11. Proc. Natl. Acad. Sci. U.S.A. 1995, 92:7612-7616. 10.1073/pnas.92.17.7612.
82. Kawasaki H., Taira K. Retraction: Hes1 is a target of microRNA-23 during retinoic-acid-induced neuronal differentiation of NT2 cells. Nature 2003, 426:100. 10.1038/nature02141.
83. Kelleher R.J., Govindarajan A., Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron 2004, 10.1016/j.neuron.2004.09.013.
84. Kenny P.J. Epigenetics, microRNA, and addiction. Dialogues Clin. Neurosci. 2014, 16:335-344.
85. Kerek R., Geoffroy A., Bison A., Martin N., Akchiche N., Pourié G., Helle D., Guéant J.-L., Bossenmeyer-Pourié C., Daval J.-L. Early methyl donor deficiency may induce persistent brain defects by reducing Stat3 signaling targeted by miR-124. Cell Death Dis. 2013, 4:e755. 10.1038/cddis.2013.278.
86. Khvorova A., Reynolds A., Jayasena S.D. Functional siRNAs and miRNAs exhibit strand bias. Cell 2003, 115:209-216. 10.1016/S0092-8674(03)00801-8.
87. Kim H.S., Shen Q., Nam S.W. Histone deacetylases and their regulatory microRNAs in hepatocarcinogenesis. J. Korean Med. Sci. 2015, 30:1375-1380. 10.3346/jkms.2015.30.10.1375.
88. Kirby E.D., Muroy S.E., Sun W.G., Covarrubias D., Leong M.J., Barchas L.A., Kaufer D. Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2. Elife 2013, 2:e00362. 10.7554/eLife.00362.
89. Kirino E. Escitalopram for the management of major depressive disorder: a review of its efficacy, safety, and patient acceptability. Patient Prefer. Adherence 2012, 6:853-861. 10.2147/PPA.S22495.
90. Kocerha J., Faghihi M.A., Lopez-Toledano M.A., Huang J., Ramsey A.J., Caron M.G., Sales N., Willoughby D., Elmen J., Hansen H.F., Orum H., Kauppinen S., Kenny P.J., Wahlestedt C. MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:3507-3512. 10.1073/pnas.0805854106.
91. Krol J., Busskamp V., Markiewicz I., Stadler M.B., Ribi S., Richter J., Duebel J., Bicker S., Fehling H.J., Schübeler D., Oertner T.G., Schratt G., Bibel M., Roska B., Filipowicz W. Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell 2010, 141:618-631. 10.1016/j.cell.2010.03.039.
92. Landgraf P., Rusu M., Sheridan R., Sewer A., Iovino N., Aravin A., Pfeffer S., Rice A., Kamphorst A.O., Landthaler M., Lin C., Socci N.D., Hermida L., Fulci V., Chiaretti S., Foà R., Schliwka J., Fuchs U., Novosel A., Müller R.-U., Schermer B., Bissels U., Inman J., Phan Q., Chien M., Weir D.B., Choksi R., De Vita G., Frezzetti D., Trompeter H.-I., Hornung V., Teng G., Hartmann G., Palkovits M., Di Lauro R., Wernet P., Macino G., Rogler C.E., Nagle J.W., Ju J., Papavasiliou F.N., Benzing T., Lichter P., Tam W., Brownstein M.J., Bosio A., Borkhardt A., Russo J.J., Sander C., Zavolan M., Tuschl T. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 2007, 129:1401-1414. 10.1016/j.cell.2007.04.040.
93. Laneve P., Di Marcotullio L., Gioia U., Fiori M.E., Ferretti E., Gulino A., Bozzoni I., Caffarelli E. The interplay between microRNAs and the neurotrophin receptor tropomyosin-related kinase C controls proliferation of human neuroblastoma cells. Proc. Natl. Acad. Sci. 2007, 104:7957-7962. 10.1073/pnas.0700071104.
94. Lee S.J., Liyanage U., Bickel P.E., Xia W., Lansbury P.T., Kosik K.S. A detergent-insoluble membrane compartment contains A beta in vivo. Nat. Med. 1998, 4:730-734. 10.1038/nm0698-730.
95. Lee Y., Samaco R.C., Gatchel J.R., Thaller C., Orr H.T., Zoghbi H.Y. miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis. Nat. Neurosci. 2008, 11:1137-1139. 10.1038/nn.2183.
96. Levy D.A., Hopkins R.O., Squire L.R. Impaired odor recognition memory in patients with hippocampal lesions. Learn. Mem. 2004, 11:794-796. 10.1101/lm.82504.
97. Lewis M.A., Quint E., Glazier A.M., Fuchs H., De Angelis M.H., Langford C., van Dongen S., Abreu-Goodger C., Piipari M., Redshaw N., Dalmay T., Moreno-Pelayo M.A., Enright A.J., Steel K.P. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat. Genet. 2009, 41:614-618. 10.1038/ng.369.
98. Lewohl J.M., Nunez Y.O., Dodd P.R., Tiwari G.R., Harris R.A., Mayfield R.D. Up-regulation of microRNAs in brain of human alcoholics. Alcohol. Clin. Exp. Res. 2011, 35:1928-1937. 10.1111/j.1530-0277.2011.01544.x.
99. Li B., Zhong L., Yang X., Andersson T., Huang M., Tang S.-J. WNT5A signaling contributes to Aβ-induced neuroinflammation and neurotoxicity. PLoS ONE 2011, 6:e22920. 10.1371/journal.pone.0022920.
100. Li Y., Kong D., Wang Z., Sarkar F.H. Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm. Res. 2010, 27:1027-1041. 10.1007/s11095-010-0105-y.
101. Liebhaber G.M., Riemann E., Baumeister F.A.M. Ketogenic diet in Rett syndrome. J. Child Neurol. 2003, 18:74-75.
102. Lin C.-H., Jackson A.L., Guo J., Linsley P.S., Eisenman R.N. Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO J. 2009, 28:3157-3170. 10.1038/emboj.2009.254.
103. Lin Q., Wei W., Coelho C.M., Li X., Baker-Andresen D., Dudley K., Ratnu V.S., Boskovic Z., Kobor M.S., Sun Y.E., Bredy T.W. The brain-specific microRNA miR-128b regulates the formation of fear-extinction memory. Nat. Neurosci. 2011, 14:1115-1117. 10.1038/nn.2891.
104. Liu H., Tian T., Qin S., Li W., Zhang X., Wang X., Gao Y., Huang G. Folic acid deficiency enhances abeta accumulation in APP/PS1 mice brain and decreases amyloid-associated miRNAs expression. J. Nutr. Biochem. 2015, 10.1016/j.jnutbio.2015.07.020.
105. Liu R., Guo X., Park Y., Wang J., Huang X., Hollenbeck A., Blair A., Chen H. Alcohol consumption. Types of alcohol, and Parkinson's disease. PLoS ONE 2013, 8:e66452. 10.1371/journal.pone.0066452.
106. Lo R., Weksberg R. Biological and biochemical modulation of DNA methylation. Epigenomics 2014, 6:593-602. 10.2217/epi.14.49.
107. Long J.M., Lahiri D.K. MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochem. Biophys. Res. Commun. 2011, 404:889-895. 10.1016/j.bbrc.2010.12.053.
108. Lopez M.S., Dempsey R.J., Vemuganti R. Resveratrol neuroprotection in stroke and traumatic CNS injury. Neurochem. Int. 2015, 89:75-82. 10.1016/j.neuint.2015.08.009.
109. Lu Y., Cao D.-L., Jiang B.-C., Yang T., Gao Y.-J. MicroRNA-146a-5p attenuates neuropathic pain via suppressing TRAF6 signaling in the spinal cord. Brain Behav. Immun. 2015, 49:119-129. 10.1016/j.bbi.2015.04.018.
110. Lugli G., Larson J., Martone M.E., Jones Y., Smalheiser N.R. Dicer and eIF2c are enriched at postsynaptic densities in adult mouse brain and are modified by neuronal activity in a calpain-dependent manner. J. Neurochem. 2005, 94:896-905. 10.1111/j.1471-4159.2005.03224.x.
111. Lugli G., Torvik V.I., Larson J., Smalheiser N.R. Expression of microRNAs and their precursors in synaptic fractions of adult mouse forebrain. J. Neurochem. 2008, 106:650-661. 10.1111/j.1471-4159.2008.05413.x.
112. Maciotta S., Meregalli M., Torrente Y. The involvement of microRNAs in neurodegenerative diseases. Front. Cell. Neurosci. 2013, 7:265. 10.3389/fncel.2013.00265.
113. Macrae I.J., Zhou K., Li F., Repic A., Brooks A.N., Cande W.Z., Adams P.D., Doudna J.A. Structural basis for double-stranded RNA processing by Dicer. Science 2006, 311:195-198. 10.1126/science.1121638.
114. Maesako M., Uemura K., Kubota M., Kuzuya A., Sasaki K., Asada M., Watanabe K., Hayashida N., Ihara M., Ito H., Shimohama S., Kihara T., Kinoshita A. Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice. Neurobiol. Aging 2012, 33. 1011.e11-1011.23. 10.1016/j.neurobiolaging.2011.10.028.
115. Maesako M., Uemura K., Kubota M., Kuzuya A., Sasaki K., Hayashida N., Asada-Utsugi M., Watanabe K., Uemura M., Kihara T., Takahashi R., Shimohama S., Kinoshita A. Exercise is more effective than diet control in preventing high fat diet-induced β-amyloid deposition and memory deficit in amyloid precursor protein transgenic mice. J. Biol. Chem. 2012, 287:23024-23033. 10.1074/jbc.M112.367011.
116. Mansoori N., Tripathi M., Alam R., Luthra K., Sharma S., Lakshmy R., Kalaivani M., Mukhopadhyay A.K. Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia. Am. J. Alzheimers Dis. Other Demen. 2014, 29:38-44. 10.1177/1533317513505131.
117. Maya-Vetencourt J.F., Pizzorusso T. Molecular mechanisms at the basis of plasticity in the developing visual cortex: epigenetic processes and gene programs. J. Exp. Neurosci. 2013, 7:75-83. 10.4137/JEN.S12958.TYPE.
118. McCann C., Holohan E.E., Das S., Dervan A., Larkin A., Lee J.A., Rodrigues V., Parker R., Ramaswami M. The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:E655-E662. 10.1073/pnas.1107198108.
119. McNeill E., Van Vactor D. MicroRNAs shape the neuronal landscape. Neuron 2012, 75:363-379. 10.1016/j.neuron.2012.07.005.
120. Meerson A., Cacheaux L., Goosens K.A., Sapolsky R.M., Soreq H., Kaufer D. Changes in brain microRNAs contribute to cholinergic stress reactions. J. Mol. Neurosci. 2009, 40:47-55. 10.1007/s12031-009-9252-1.
121. Melinder C., Udumyan R., Hiyoshi A., Brummer R.J., Montgomery S. Decreased stress resilience in young men significantly increases the risk of subsequent peptic ulcer disease-a prospective study of 233 093 men in Sweden. Aliment. Pharmacol. Ther. 2015, 41:1005-1015. 10.1111/apt.13168.
122. Mellios N., Sugihara H., Castro J., Banerjee A., Le C., Kumar A., Crawford B., Strathmann J., Tropea D., Levine S.S., Edbauer D., Sur M. miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity. Nat. Neurosci. 2011, 14:1240-1242. 10.1038/nn.2909.
123. Meltzer H.Y., Rajagopal L., Huang M., Oyamada Y., Kwon S., Horiguchi M. Translating the N-methyl-d-aspartate receptor antagonist model of schizophrenia to treatments for cognitive impairment in schizophrenia. Int. J. Neuropsychopharmacol. 2013, 16:2181-2194. 10.1017/S1461145713000928.
124. Mencía A., Modamio-Høybjør S., Redshaw N., Morín M., Mayo-Merino F., Olavarrieta L., Aguirre L.A., del Castillo I., Steel K.P., Dalmay T., Moreno F., Moreno-Pelayo M.A. Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat. Genet. 2009, 41:609-613. 10.1038/ng.355.
125. Misner D.L., Jacobs S., Shimizu Y., de Urquiza A.M., Solomin L., Perlmann T., De Luca L.M., Stevens C.F., Evans R.M. Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:11714-11719. 10.1073/pnas.191369798.
126. Misso G., Teresa M., Martino D., Rosa G., De, Farooqi A.A., Lombardi A., Campani V., Zarone M.R., Gullà A., Tagliaferri P., Tassone P., Caraglia M. Mir-34: a new weapon against cancer?. Mol. Ther. Nucleic Acids 2014, 10.1038/mtna.2014.47.
127. Nahrendorf M., Swirski F.K. Lifestyle effects on hematopoiesis and atherosclerosis. Circ. Res. 2015, 116:884-894. 10.1161/CIRCRESAHA.116.303550.
128. Navaratnam D.S., Su H.S., Scott S.P., Oberholtzer J.C. Proliferation in the auditory receptor epithelium mediated by a cyclic AMP-dependent signaling pathway. Nat. Med. 1996, 2:1136-1139.
129. Nieto-Diaz M., Esteban F.J., Reigada D., Muñoz-Galdeano T., Yunta M., Caballero-López M., Navarro-Ruiz R., Del Águila A., Maza R.M. MicroRNA dysregulation in spinal cord injury: causes, consequences and therapeutics. Front. Cell. Neurosci. 2014, 8:53. 10.3389/fncel.2014.00053.
130. Nunez Y.O., Truitt J.M., Gorini G., Ponomareva O.N., Blednov Y.A., Harris R.A., Mayfield R.D. Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence. BMC Genomics 2013, 14:725. 10.1186/1471-2164-14-725.
131. Nunez-Iglesias J., Liu C.-C., Morgan T.E., Finch C.E., Zhou X.J. Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation. PLoS One 2010, 5:e8898. 10.1371/journal.pone.0008898.
132. O'Carroll D., Schaefer A. General principals of miRNA biogenesis and regulation in the brain. Neuropsychopharmacology 2013, 38:39-54. 10.1038/npp.2012.87.
133. Ohtsuka T., Ishibashi M., Gradwohl G., Nakanishi S., Guillemot F., Kageyama R. Hes1 and Hes5 as notch effectors in mammalian neuronal differentiation. EMBO J. 1999, 18:2196-2207. 10.1093/emboj/18.8.2196.
134. Okada C., Yamashita E., Lee S.J., Shibata S., Katahira J., Nakagawa A., Yoneda Y., Tsukihara T. A high-resolution structure of the pre-microRNA nuclear export machinery. Science 2009, 326:1275-1279. 10.1126/science.1178705.
135. Opie R.S., O'Neil A., Itsiopoulos C., Jacka F.N. The impact of whole-of-diet interventions on depression and anxiety: a systematic review of randomised controlled trials. Public Health Nutr. 2014, 1-20. 10.1017/S1368980014002614.
136. Parasramka M.A., Ho E., Williams D.E., Dashwood R.H. MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol. Carcinog. 2012, 51:213-230. 10.1002/mc.20822.
137. Patel M., Cai Q., Ding D., Salvi R., Hu Z., Hu B.H. The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma. PLoS ONE 2013, 8:e58471. 10.1371/journal.pone.0058471.
138. Pietrzykowski A.Z., Friesen R.M., Martin G.E., Puig S.I., Nowak C.L., Wynne P.M., Siegelmann H.T., Treistman S.N. Posttranscriptional regulation of BK channel splice variant stability by miR-9 underlies neuroadaptation to alcohol. Neuron 2008, 59:274-287. 10.1016/j.neuron.2008.05.032.
139. Pietrzykowski A.Z., Martin G.E., Puig S.I., Knott T.K., Lemos J.R., Treistman S.N. Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density. J. Neurosci. 2004, 24:8322-8332. 10.1523/JNEUROSCI.;1; 1536-04.2004.
140. Pugh E.N., Nikonov S., Lamb T.D. Molecular mechanisms of vertebrate photoreceptor light adaptation. Curr. Opin. Neurobiol. 1999, 9:410-418. 10.1016/S0959-4388(99)80062-2.
141. Putignano E., Lonetti G., Cancedda L., Ratto G., Costa M., Maffei L., Pizzorusso T. Developmental downregulation of histone posttranslational modifications regulates visual cortical plasticity. Neuron 2007, 53:747-759. 10.1016/j.neuron.2007.02.007.
142. Qiu S., Feng Y., LeSage G., Zhang Y., Stuart C., He L., Li Y., Caudle Y., Peng Y., Yin D. Chronic morphine-induced microRNA-124 promotes microglial immunosuppression by modulating P65 and TRAF6. J. Immunol. 2015, 194:1021-1030. 10.4049/jimmunol.1400106.
143. Quinn R.K., Brown A.L., Goldie B.J., Levi E.M., Dickson P.W., Smith D.W., Cairns M.J., Dayas C.V. Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats. Transl. Psychiatry 2015, 5:e503. 10.1038/tp.2014.144.
144. Rajasethupathy P., Fiumara F., Sheridan R., Betel D., Puthanveettil S.V., Russo J.J., Sander C., Tuschl T., Kandel E. Characterization of small RNAs in Aplysia reveals a role for miR-124 in constraining synaptic plasticity through CREB. Neuron 2009, 63:803-817. 10.1016/j.neuron.2009.05.029.
145. Raman M., Earnest S., Zhang K., Zhao Y., Cobb M.H. TAO kinases mediate activation of p38 in response to DNA damage. EMBO J. 2007, 26:2005-2014. 10.1038/sj.emboj.7601668.
146. Rodgers A.B., Morgan C.P., Bronson S.L., Revello S., Bale T.L. Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. J. Neurosci. 2013, 33:9003-9012. 10.1523/JNEUROSCI.;1; 0914-13.2013.
147. Ron D., Messing R.O. Signaling pathways mediating alcohol effects. Curr. Top. Behav. Neurosci. 2013, 13:87-126. 10.1007/7854_2011_161.
148. Ronksley P.E., Brien S.E., Turner B.J., Mukamal K.J., Ghali W.A. Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 2011, 342:d671.
149. Ross S.A., Davis C.D. The emerging role of microRNAs and nutrition in modulating health and disease. Annu. Rev. Nutr. 2014, 34:305-336. 10.1146/annurev-nutr-071813-105729.
150. Ruepp A., Kowarsch A., Schmidl D., Buggenthin F., Brauner B., Dunger I., Fobo G., Frishman G., Montrone C., Theis F.J. PhenomiR: a knowledgebase for microRNA expression in diseases and biological processes. Genome Biol. 2010, 11:R6. 10.1186/gb-2010-11-1-r6.
151. Russo S.J., Nestler E.J. The brain reward circuitry in mood disorders. Nat. Rev. Neurosci. 2013, 14:609-625. 10.1038/nrn3381.
152. Sacerdote P., Franchi S., Moretti S., Castelli M., Procacci P., Magnaghi V., Panerai A.E. Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain. J. Neuroimmune Pharmacol. 2013, 8:202-211. 10.1007/s11481-012-9428-2.
153. Sakai A., Suzuki H. Nerve injury-induced upregulation of miR-21 in the primary sensory neurons contributes to neuropathic pain in rats. Biochem. Biophys. Res. Commun. 2013, 435:176-181. 10.1016/j.bbrc.2013.04.089.
154. Samsom J.N., Wong A.H.C. Schizophrenia and depression co-morbidity: what we have learned from animal models. Front. Psychiatry 2015, 6:13. 10.3389/fpsyt.2015.00013.
155. Sathyan P., Golden H.B., Miranda R.C. Competing interactions between micro-RNAs determine neural progenitor survival and proliferation after ethanol exposure: evidence from an ex vivo model of the fetal cerebral cortical neuroepithelium. J. Neurosci. 2007, 27:8546-8557. 10.1523/JNEUROSCI.;1; 1269-07.2007.
156. Schaefer A., Im H.-I., Venø M.T., Fowler C.D., Min A., Intrator A., Kjems J., Kenny P.J., O'Carroll D., Greengard P. Argonaute 2 in dopamine 2 receptor-expressing neurons regulates cocaine addiction. J. Exp. Med. 2010, 207:1843-1851. 10.1084/jem.20100451.
157. Schmidt U., Keck M.E., Buell D.R. miRNAs and other non-coding RNAs in posttraumatic stress disorder: a systematic review of clinical and animal studies. J. Psychiatr. Res. 2015, 10.1016/j.jpsychires.2015.03.014.
158. Selbach M., Schwanhäusser B., Thierfelder N., Fang Z., Khanin R., Rajewsky N. Widespread changes in protein synthesis induced by microRNAs. Nature 2008, 455:58-63. 10.1038/nature07228.
159. Sempere L.F., Freemantle S., Pitha-Rowe I., Moss E., Dmitrovsky E., Ambros V. Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation. Genome Biol. 2004, 5:R13. 10.1186/gb-2004-5-3-r13.
160. Serafini G., Pompili M., Hansen K.F., Obrietan K., Dwivedi Y., Shomron N., Girardi P. The involvement of microRNAs in major depression, suicidal behavior, and related disorders: a focus on miR-185 and miR-491-3p. Cell. Mol. Neurobiol. 2014, 34:17-30. 10.1007/s10571-013-9997-5.
161. Shi Y., Zhao X., Hsieh J., Wichterle H., Impey S., Banerjee S., Neveu P., Kosik K.S. MicroRNA regulation of neural stem cells and neurogenesis. J. Neurosci. 2010, 30:14931-14936. 10.1523/JNEUROSCI. 4280-10.2010.
162. Siegel G., Obernosterer G., Fiore R., Oehmen M., Bicker S., Christensen M., Khudayberdiev S., Leuschner P.F., Busch C.J.L., Kane C., Hübel K., Dekker F., Hedberg C., Rengarajan B., Drepper C., Waldmann H., Kauppinen S., Greenberg M.E., Draguhn A., Rehmsmeier M., Martinez J., Schratt G. A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis. Nat. Cell Biol. 2009, 11:705-716. 10.1038/ncb1876.
163. Siegel G., Saba R., Schratt G. microRNAs in neurons: manifold regulatory roles at the synapse. Curr. Opin. Genet. Dev. 2011, 21:491-497. 10.1016/j.gde.2011.04.008.
164. Smalheiser N.R., Lugli G., Lenon A.L., Davis J.M., Torvik V.I., Larson J. Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus. ASN Neuro 2010, 2:e00028. 10.1042/AN20090055.
165. Smalheiser N.R., Lugli G., Rizavi H.S., Torvik V.I., Turecki G., Dwivedi Y. MicroRNA expression is down-regulated and reorganized in prefrontal cortex of depressed suicide subjects. PLoS ONE 2012, 7:e33201. 10.1371/journal.pone.0033201.
166. Stone J.S., Cotanche D.A. Hair cell regeneration in the avian auditory epithelium. Int. J. Dev. Biol. 2007, 51:633-647. 10.1387/ijdb.072408js.
167. Strickland I.T., Richards L., Holmes F.E., Wynick D., Uney J.B., Wong L.-F. Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons. PLoS ONE 2011, 6:e23423. 10.1371/journal.pone.0023423.
168. Sudhakaran I.P., Hillebrand J., Dervan A., Das S., Holohan E.E., Hülsmeier J., Sarov M., Parker R., VijayRaghavan K., Ramaswami M. FMRP and Ataxin-2 function together in long-term olfactory habituation and neuronal translational control. Proc. Natl. Acad. Sci. U.S.A. 2014, 111:E99-E108. 10.1073/pnas.1309543111.
169. Szulwach K.E., Li X., Smrt R.D., Li Y., Luo Y., Lin L., Santistevan N.J., Li W., Zhao X., Jin P. Cross talk between microRNA and epigenetic regulation in adult neurogenesis. J. Cell Biol. 2010, 189:127-141. 10.1083/jcb.200908151.
170. Takemoto O., Tomimoto H., Yanagihara T. Induction of c-fos and c-jun gene products and heat shock protein after brief and prolonged cerebral ischemia in gerbils. Stroke 1995, 26:1639-1648.
171. Tapocik J.D., Barbier E., Flanigan M., Solomon M., Pincus A., Pilling A., Sun H., Schank J.R., King C., Heilig M. microRNA-206 in rat medial prefrontal cortex regulates BDNF expression and alcohol drinking. J. Neurosci. 2014, 34:4581-4588. 10.1523/JNEUROSCI.;1; 0445-14.2014.
172. Thompson S.M., Kallarackal A.J., Kvarta M.D., Van Dyke A.M., LeGates T.A., Cai X. An excitatory synapse hypothesis of depression. Trends Neurosci. 2015, 10.1016/j.tins.2015.03.003.
173. Tognini P., Putignano E., Coatti A., Pizzorusso T. Experience-dependent expression of miR-132 regulates ocular dominance plasticity. Nat. Neurosci. 2011, 14:1237-1239. 10.1038/nn.2920.
174. Tremblay F., Lavigne C., Jacques H., Marette A. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities. Diabetes 2001, 50:1901-1910.
175. Tripathi A.K., Dwivedi A., Pal M.K., Rastogi N., Gupta P., Ali S., Prabhu M.B.H., Kushwaha H.N., Ray R.S., Singh S.K., Duggal S., Narayan B., Mishra D.P. Attenuated neuroprotective effect of riboflavin under UV-B irradiation via miR-203/c-Jun signaling pathway in vivo and in vitro. J. Biomed. Sci. 2014, 21:39. 10.1186/1423-0127-21-39.
176. Uchida S., Nishida A., Hara K., Kamemoto T., Suetsugi M., Fujimoto M., Watanuki T., Wakabayashi Y., Otsuki K., McEwen B.S., Watanabe Y. Characterization of the vulnerability to repeated stress in Fischer 344 rats: possible involvement of microRNA-mediated down-regulation of the glucocorticoid receptor. Eur. J. Neurosci. 2008, 27:2250-2261. 10.1111/j.1460-9568.2008.06218.x.
177. Vangipuram S.D., Lyman W.D. Ethanol affects differentiation-related pathways and suppresses Wnt signaling protein expression in human neural stem cells. Alcohol. Clin. Exp. Res. 2012, 36:788-797. 10.1111/j.1530-0277.2011.01682.x.
178. Vetrivel K.S., Cheng H., Kim S.-H., Chen Y., Barnes N.Y., Parent A.T., Sisodia S.S., Thinakaran G. Spatial segregation of gamma-secretase and substrates in distinct membrane domains. J. Biol. Chem. 2005, 280:25892-25900. 10.1074/jbc.M503570200.
179. Vilardo E., Barbato C., Ciotti M., Cogoni C., Ruberti F. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. J Biol Chem. 2010, 285:18344-18351. 10.1074/jbc.M110.112664.
180. Vo N., Klein M.E., Varlamova O., Keller D.M., Yamamoto T., Goodman R.H., Impey S. A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:16426-16431. 10.1073/pnas.0508448102.
181. Volk N., Paul E.D., Haramati S., Eitan C., Fields B.K.K., Zwang R., Gil S., Lowry C.A., Chen A. MicroRNA-19b associates with Ago2 in the amygdala following chronic stress and regulates the adrenergic receptor beta 1. J. Neurosci. 2014, 34:15070-15082. 10.1523/JNEUROSCI.;1; 0855-14.2014.
182. von Hehn C.A., Baron R., Woolf C.J. Deconstructing the neuropathic pain phenotype to reveal neural mechanisms. Neuron 2012, 73:638-652. 10.1016/j.neuron.2012.02.008.
183. Wagner A.E., Piegholdt S., Ferraro M., Pallauf K., Rimbach G. Food derived microRNAs. Food Funct. 2015, 714-718. 10.1039/C4FO01119H.
184. Wang W.-X., Huang Q., Hu Y., Stromberg A.J., Nelson P.T. Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter. Acta Neuropathol. 2011, 121:193-205. 10.1007/s00401-010-0756-0.
185. Wang C., Xu Y., Feng X., Ma J., Xie S., Zhang Y., Tang B.-S., Chan P. Linkage analysis and whole-exome sequencing exclude extra mutations responsible for the parkinsonian phenotype of spinocerebellar ataxia-2. Neurobiol. Aging. 2014, 10.1016/j.neurobiolaging.2014.07.039.
186. Wang G., Guo X., Hong W., Liu Q., Wei T., Lu C., Gao L., Ye D., Zhou Y., Chen J., Wang J., Wu M., Liu H., Kang J. Critical regulation of miR-200/ZEB2 pathway in Oct4/Sox2-induced mesenchymal-to-epithelial transition and induced pluripotent stem cell generation. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:2858-2863. 10.1073/pnas.1212769110.
187. Wang L.-L., Zhang Z., Li Q., Yang R., Pei X., Xu Y., Wang J., Zhou S.-F., Li Y. Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation. Hum. Reprod. 2009, 24:562-579. 10.1093/humrep/den439.
188. Wang X., Gocek E., Liu C.-G., Studzinski G.P. MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle 2009, 8:736-741.
189. Wang X., Zheng G., Dong D. Coordinated action of histone modification and microRNA regulations in human genome. Gene 2015, 570:277-281. 10.1016/j.gene.2015.06.046.
190. Wang Z.-H., Zhang J.-L., Duan Y.-L., Zhang Q.-S., Li G.-F., Zheng D.-L. MicroRNA-214 participates in the neuroprotective effect of resveratrol via inhibiting α-synuclein expression in MPTP-induced Parkinson's disease mouse. Biomed. Pharmacother. 2015, 74:252-256. 10.1016/j.biopha.2015.08.025.
191. Wayman G.A., Davare M., Ando H., Fortin D., Varlamova O., Cheng H.-Y.M., Marks D., Obrietan K., Soderling T.R., Goodman R.H., Impey S. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP. Proc. Natl. Acad. Sci. U.S.A. 2008, 105:9093-9098. 10.1073/pnas.0803072105.
192. Westholm J.O., Lai E.C. Mirtrons: microRNA biogenesis via splicing. Biochimie 2011, 93:1897-1904. 10.1016/j.biochi.2011.06.017.
193. Witte A.V., Kerti L., Margulies D.S., Flöel A. Effects of resveratrol on memory performance, hippocampal functional connectivity, and glucose metabolism in healthy older adults. J. Neurosci. 2014, 34:7862-7870. 10.1523/JNEUROSCI.;1; 0385-14.2014.
194. Wu D., Raafat M., Pak E., Hammond S., Murashov A.K. MicroRNA machinery responds to peripheral nerve lesion in an injury-regulated pattern. Neuroscience 2011, 190:386-397. 10.1016/j.neuroscience.2011.06.017.
195. Wu M.-F., Wang S.-G. Human TAO kinase 1 induces apoptosis in SH-SY5Y cells. Cell Biol. Int. 2008, 32:151-156. 10.1016/j.cellbi.2007.08.006.
196. Xu Y., Zhang X., Pu S., Wu J., Lv Y., Du D. Circulating microRNA expression profile: a novel potential predictor for chronic nervous lesions. Acta Biochim. Biophys. Sin. (Shanghai) 2014, 46:942-949. 10.1093/abbs/gmu090.
197. Yadav S., Pandey A., Shukla A., Talwelkar S.S., Kumar A., Pant A.B., Parmar D. miR-497 and miR-302b regulate ethanol-induced neuronal cell death through BCL2 protein and cyclin D2. J. Biol. Chem. 2011, 286:37347-37357. 10.1074/jbc.M111.235531.
198. Yu B., Zhou S., Qian T., Wang Y., Ding F., Gu X. Altered microRNA expression following sciatic nerve resection in dorsal root ganglia of rats. Acta Biochim. Biophys. Sin. (Shanghai) 2011, 43:909-915. 10.1093/abbs/gmr083.
199. Yu L., Tang H., Jiang X.H., Tsang L.L., Chung Y.W., Chan H.C. Involvement of calpain-I and microRNA34 in kanamycin-induced apoptosis of inner ear cells. Cell Biol. Int. 2010, 34:1219-1225. 10.1042/CBI20100515.
200. Zacharewicz E., Lamon S., Russell A.P. MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease. Front. Physiol. 2013, 4:266. 10.3389/fphys.2013.00266.
201. Zhang L., Hou D., Chen X., Li D., Zhu L., Zhang Y., Li J., Bian Z., Liang X., Cai X., Yin Y., Wang C., Zhang T., Zhu D., Zhang D., Xu J., Chen Q., Ba Y., Liu J., Wang Q., Chen J., Wang J., Wang M., Zhang Q., Zhang J., Zen K., Zhang C.-Y. Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA. Cell Res. 2012, 10.1038/cr.2011.174.
202. Zhang J., Gao Y., Yu M., Wu H., Ai Z., Wu Y., Liu H., Du J., Guo Z., Zhang Y. Retinoic acid induces embryonic stem cell differentiation by altering both encoding rna and microrna expression. PLoS ONE 2015, 10:e0132566. 10.1371/journal.pone.0132566.
203. Zhang Y., Wang Y., Wang L., Bai M., Zhang X., Zhu X. Dopamine receptor D2 and associated microRNAs are involved in stress susceptibility and resistance to Escitalopram treatment. Int. J. Neuropsychopharmacol. 2015, 18. 10.1093/ijnp/pyv025.
204. Zhao H., Xu J., Pang L., Zhang Y., Fan H., Liu L., Liu T., Yu F., Zhang G., Lan Y., Bai J., Li X., Xiao Y. Genome-wide DNA methylome reveals the dysfunction of intronic microRNAs in major psychosis. BMC Med. Genomics 2015, 8:62. 10.1186/s12920-015-0139-4.
205. Zhao Y.-N., Li W.-F., Li F., Zhang Z., Dai Y.-D., Xu A.-L., Qi C., Gao J.-M., Gao J. Resveratrol improves learning and memory in normally aged mice through microRNA-CREB pathway. Biochem. Biophys. Res. Commun. 2013, 435:597-602. 10.1016/j.bbrc.2013.05.025.
206. Zhou R., Yuan P., Wang Y., Hunsberger J.G., Elkahloun A., Wei Y., Damschroder-Williams P., Du J., Chen G., Manji H.K. Evidence for selective microRNAs and their effectors as common long-term targets for the actions of mood stabilizers. Neuropsychopharmacology 2009, 34:1395-1405. 10.1038/npp.2008.131.
207. Zongaro S., Hukema R., D'Antoni S., Davidovic L., Barbry P., Catania M.V., Willemsen R., Mari B., Bardoni B. The 3' UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse. Hum. Mol Genet. 2013, 22:1971-1982. 10.1093/hmg/ddt044.