RNAi: Nature abhors a double-strand

Current Opinion in Genetics and Development

Volumn 12, Issue 2, 2002, Pages 225-232

  Hutvágner, György ^a   Zamore, Phillip D ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORDYCEPIN; DOUBLE STRANDED RNA; ENDONUCLEASE; RIBONUCLEASE; RNA;

FUNGUS; NEMATODE; NONHUMAN; PLANT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; RNA DEGRADATION; RNA STRUCTURE; TRYPANOSOMA;

FUNGI; NEMATODA; TRYPANOSOMA;

EID: 0036532120     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(02)00290-3     Document Type: Review

References (70)

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
2. Suppression of gene expression by homologous transgenes
3. RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plants
4. Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway
5. Double-stranded RNA induces mRNA degradation in Trypanosoma brucei
6. Specific interference by ingested dsRNA
7. Virus resistance and gene silencing in plants can be induced by simultaneous expression of sense and antisense RNA
8. Silencing of developmental genes in hydra
9. Double-stranded RNA specifically disrupts gene expression during planarian regeneration
10. Total silencing by intron-spliced hairpin RNAs
11. Specific interference with gene function by double-stranded RNA in early mouse development
12. Specific and heritable genetic interference by double-stranded RNA in Arabidopsis thaliana
13. Specific double-stranded RNA interference in undifferentiated mouse embryonic stem cells
14. Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference
15. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
16. Duplexes of 21-nucleotide RNAs mediate RNA interference in mammalian cell culture
17. A species of small antisense RNA in posttranscriptional gene silencing in plants
18. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
19. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
20. Role for a bidentate ribonuclease in the initiation step of RNA interference
21. ATP requirements and small interfering RNA structure in the RNA interference pathway
22. Argonaute2, a link between genetic and biochemical analyses of RNAi
23. RNA interference is mediated by 21- and 22-nucleotide RNAs
24. Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila
25. Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
26. Distinct roles for RDE-1 and RDE-4 during RNA interference in Caenorhabditis elegans
27. Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
28. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
29. Functional anatomy of a dsRNA trigger. Differential requirement for the two trigger strands in RNA interference
30. Evidence that processed small dsRNAs may mediate sequence-specific mRNA degradation during RNAi in Drosophila embryos
31. RNAi as random degradative PCR. siRNA primers convert mRNA into dsRNAs that are degraded to generate new siRNAs
32. Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase
33. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance
34. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus
35. On the role of RNA amplification in dsRNA-triggered gene silencing
36. Genetic requirements for inheritance of RNAi in C. elegans
37. RNA-based silencing strategies in plants
38. Listening to the silent genes: Transgene silencing, gene regulation and pathogen control
39. Aubergine enhances oskar translation in the Drosophila ovary
40. AGO1 defines a novel locus of Arabidopsis controlling leaf development
41. A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal
42. The PINHEAD/ZWILLE gene acts pleiotropically in Arabidopsis development and has overlapping functions with the ARGONAUTE1 gene
43. Domains in gene silencing and cell differentiation proteins: The novel PAZ domain and redefinition of the Piwi domain
44. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals
45. EGO-1 is related to RNA-directed RNA polymerase and functions in germ-line development and RNA interference in C. elegans
46. Genetic and molecular characterization of sting, a gene involved in crystal formation and meiotic drive in the male germ line of Drosophila melanogaster
47. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
48. A role for the RNase III enzyme DCR-1 in RNA interference and germ line development in C. elegans
49. SHORT INTEGUMENT (SIN1), a gene required for ovule development in Arabidopsis, also controls flowering time
50. Maternal effects of the short integument mutation on embryo development in Arabidopsis
51. Disruption of an RNA helicase/RNase III gene in Arabidopsis causes unregulated cell division in floral meristems
52. Control of developmental timing in animals
53. Identification of novel genes coding for small expressed RNAs
54. An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans
55. An extensive class of small RNAs in Caenorhabditis elegans
56. Detailed characterization of the posttranscriptional gene-silencing-related small RNA in a GUS gene-silenced tobacco
57. The rde-1 gene, RNA interference, and transposon silencing in C. elegans
58. Mut-7 of C. elegans, required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNaseD
59. Transgene and transposon silencing in chlamydomonas reinhardtii by a DEAH-Box RNA helicase
60. RNA interference in Trypanosoma brucei: Cloning of small interfering RNAs provides evidence for retroposon-derived 24-26 nt RNAs
61. A counterdefensive strategy of plant viruses: Suppression of posttranscriptional gene silencing
62. Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanism
63. Virus-encoded suppressor of posttranscriptional gene silencing targets a maintenance step in the silencing pathway
64. Suppression of post-transcriptional gene silencing by a plant viral protein localized in the nucleus
65. Viral suppressors of RNA silencing
66. HC-Pro suppression of transgene silencing eliminates the small RNAs but not transgene methylation or the mobile signal
67. Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
68. Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
69. Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi
70. Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III