Alcohol use disorders in the elderly: A brief overview from epidemiology to treatment options

Experimental Gerontology

Volumn 47, Issue 6, 2012, Pages 411-416

  Caputo, Fabio ^a   Vignoli, Teo ^b   Leggio, Lorenzo ^c,d   Addolorato, Giovanni ^d   Zoli, Giorgio ^a   Bernardi, Mauro ^e  

^a SS Annunziata Hospital   (Italy)

^b Department of Addiction Disease ^*  (Italy)

^c BROWN UNIVERSITY   (United States)

^d CATHOLIC UNIVERSITY   (Italy)

^e UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Alcohol related disease; Alcohol use disorders; Diagnosis and treatment of alcohol use disorders; Elderly; Pathogenesis of alcohol related damage

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; ANXIOLYTIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CARBAMAZEPINE; CEPHALOSPORIN; CHLORAMPHENICOL; CIMETIDINE; DIGOXIN; DNA; HEPARIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISONIAZID; KETOCONAZOLE; LITHIUM; METHOTREXATE; METRONIDAZOLE; NEUROLEPTIC AGENT; NITRATE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; ORAL ANTIDIABETIC AGENT; PARACETAMOL; PHENYTOIN; PROTON PUMP INHIBITOR; UNINDEXED DRUG; WARFARIN;

AGED; ALCOHOL USE DISORDER; ALCOHOLISM; BLOOD PRESSURE; CONTROLLED STUDY; DEMENTIA; DEPRESSION; DNA REPAIR; FEMALE; GERIATRICS; HUMAN; INCIDENCE; MALE; NEUROLOGICAL COMPLICATION; PATHOGENESIS; PREVALENCE; PRIORITY JOURNAL; PSYCHOTHERAPY; QUESTIONNAIRE; RELAPSE; REVIEW; TIGHT JUNCTION; TISSUE INJURY;

AGE FACTORS; AGED; ALCOHOL-RELATED DISORDERS; ALCOHOLISM; BIOLOGICAL MARKERS; HUMANS;

EID: 84861183511     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2012.03.019     Document Type: Review

References (41)

1. Aalto M., Alho H., Halme J.T., Seppä K. The alcohol use disorders identification test (AUDIT) and its derivates in screening for heavy drinking among the elderly. Int. J. Geriatr. Psychiatry 2011, 26:881-885.
2. Addolorato G., Leggio L., Ferrulli A., Cardone S., Bedogni G., Caputo F., Gasbarrini G., Landolfi R., Baclofen Study Group Dose-response effect of baclofen in reducing daily alcohol intake in alcohol dependence: secondary analysis of a randomized, double-blind, placebo-controlled trial. Alcohol Alcohol. 2011, 46:312-317.
3. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, Text Revision. American Psychiatric Association, Washington DC. fourth ed.
4. Bagnardi V., Blangiardo M., La Vecchia C., Corrao G. A meta-analysis of alcohol drinking and cancer risk. Br. J. Cancer 2001, 85:1700-1705.
5. Blazer D.G., Wu L.T. The epidemiology of at-risk and binge drinking among middle-aged and elderly community adults: national survey on drug use and health. Am. J. Psychiatry 2009, 166:1162-1169.
6. Boe D.M., Vandivier W., Burnham E.L., Moss M. Alcohol abuse and pulmonary disease. J. Leukoc. Biol. 2009, 86:1097-1104.
7. Caputo F., Bernardi M. Medications acting on the GABA system in the treatment of alcoholic patients. Curr. Pharm. Des. 2010, 16:2118-2125.
8. Chen W.Y., Rosner B., Hankinson S.E., Colditz G.A., Willett W.C. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 2011, 306:1884-1890.
9. Costanzo S., Di Castelnuovo A., Donati M.B., Iacoviello L., de Gaetano G. Alcohol consumption and mortality in patients with cardiovascular disease: a meta-analysis. J. Am. Coll. Cardiol. 2010, 55:1339-1347.
10. Culberson J.W. Alcohol use in the elderly: beyond the CAGE. Part 2: screening instruments and treatment strategies. Geriatrics 2006, 61:20-26.
11. Diaz L.E., Montero A., Gonzalez-Gross M., Vallejo A.I., Romeo J., Marcos A. Influence of alcohol consumption on immunological status: a review. Eur. J. Clin. Nutr. 2002, 56:S50-S53.
12. Gramenzi A., Caputo F., Biselli M., Kuria F., Loggi E., Andreone P., Bernardi M. Review article: alcoholic liver disease - pathophysiological aspects and risk factors. Aliment. Pharmacol. Ther. 2006, 24:1151-1161.
13. Gunn A.M., Cheavens J.S. Psychiatric comorbidity and depression in older adults. Curr. Psychiatry Rep. 2008, 10:23-29.
14. Hall K.E., Proctor D.D., Fisher L., Rose S. American Gastroenterological Association future trends committee report: effects of aging of the population on gastroenterology practice, education, and research. Gastroenterology 2005, 129:1305-1338.
15. Johnson B.A. Medication treatment of different types of alcoholism. Am. J. Psychiatry 2010, 167:630-639.
16. Johnson-Greene D., McCaul M.E., Roger P. Screening for hazardous drinking using the Michigan Alcohol Screening Test-Geriatric Version (MAST-G) in elderly persons with acute cerebrovascular accidents. Alcohol. Clin. Exp. Res. 2009, 33:1555-1561.
17. Johnston J.J., McGovern S.J. Alcohol related falls: an interesting pattern of injuries. Emerg. Med. J. 2004, 21:185-188.
18. Koppes L.L.J., Dekker J.M., Hendriks H.F.J., Bouter L.M., Hene R.J. Moderate alcohol consumption lowers the risk of type 2 diabetes. A meta-analysis of prospective observational studies. Diabetes Care 2005, 28:719-725.
19. Lee H.S., Mericle A.A., Ayalon L., Areán P.A. Harm reduction among at-risk elderly drinkers: a site-specific analysis from the multi-site Primary Care Research in Substance Abuse and Mental Health for Elderly (PRISM-E) study. Int. J. Geriatr. Psychiatry 2008, 24:54-60.
20. Letizia M., Reinbolz M. Identification and managing acute alcohol withdrawal in the elderly. Geriatr. Nurs. 2005, 26:176-183.
21. Lieber C.S. Metabolism of alcohol. Clin. Liver Dis. 2005, 9:1-35.
22. Lobo E., Dufouil C., Marcos C., Quetglas B., Saz P., Gullar E., Lobo A., ZARADEMP Workgroup Is there an association between low-to-moderate alcohol consumption and risk of cognitive decline?. Am. J. Epidemiol. 2010, 172:708-716.
23. Moore A.A., Beck J.C., Babor T.F., Hays R.D., Reuben D.B. Beyond alcoholism: identifying older, at-risk drinkers in primary care. J. Stud. Alcohol 2002, 63:316-324.
24. Moore A.A., Whiteman E.J., Ward K.T. Risks of combined alcohol/medication use in older adults. Am. J. Geriatr. Pharmacother. 2007, 5:64-74.
25. Moriyama Y., Mimura M., Kato M., Kashima H. Primary alcoholic dementia and alcohol-related dementia. Psychogeriatrics 2006, 6:114-118.
26. Mukamal K.J., Chung H., Jenny N.S., Kuller L.H., Longstreth W.T., Mittleman M.A., Burke G.L., Cushman M., Psaty B.M., Siscovick D.S. Alcohol consumption and risk of coronary heart disease in older adults: the Cardiovascular Health Study. J. Am. Geriatr. Soc. 2006, 54:30-37.
27. Mundle G., Ackermann K., Munkes J., Steinle D., Mann K. Influence of age, alcohol consumption and abstinence on the sensitivity of carbohydrate-deficient transferrin, gamma-glutamyltransferase and mean corpuscular volume. Alcohol Alcohol. 1999, 34:760-766.
28. Newell-Price J., Bertagna X., Grossman A.B., Nieman L.K. Cushing's syndrome. Lancet 2006, 367:1605-1617.
29. Oslin D., Liberto J.G., O'Brien J., Krois S., Norbeck J. Naltrexone as an adjunctive treatment for older patients with alcohol dependence. Am. J. Geriatr. Psychiatry 1997, 5:324-332.
30. Paganini-Hill A. Lifestyle practices and cardiovascular disease mortality in the elderly: the leisure world cohort study. Cardiol. Res. Pract. 2011, 10.4061/2011/983764.
31. Piano M.R. Alcoholic cardiomyopathy: incidence, clinical characteristics, and pathophysiology. Chest 2002, 121:1638-1650.
32. Rehm J., Mathers C., Popova S., Thavorncharoensap M., Teerawattananon Y., Patra J. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet 2009, 373:2223-2233.
33. Rodgers B., Windsor T.D., Anstey K.J., Dear K.B., Jorm A., Christensen H. Non-linear relationships between cognitive function and alcohol consumption in young, middle-aged and older adults: the PATH Through Life Project. Addiction 2005, 100:1280-1290.
34. Satre D.D., Mertens J.R., Areán P.A., Weisner C. Five-year alcohol and drug treatment outcomes of older adults versus middle-aged and younger adults in a managed care program. Addiction 2004, 99:1286-1297.
35. Satre D.D., Blow F.C., Chi F.W., Weisner C. Gender differences in seven-year alcohol and drug treatment outcomes among older adults. Am. J. Addict. 2007, 16:216-221.
36. Scafato E. Alcohol and the elderly: the time to act is now!. Eur. J. Public Health 2010, 20:617-618.
37. Schuckit M.A. Alcohol use disorders. Lancet 2009, 373:492-501.
38. Seitz H.K., Stickel F. Alcoholic liver disease in the elderly. Clin. Geriatr. Med. 2007, 23:905-921.
39. Solfrizzi V., Frisardi V., Seripa D., Logroscino G., Imbimbo B.P., D'Onofrio G., Addante F., Sancarlo D., Cascavilla L., Pilotto A., Panza F. Mediterranean diet in predementia and dementia syndromes. Curr. Alzheimer Res. 2011, 8:520-542.
40. Szabo G., Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol. Clin. Exp. Res. 2009, 33:220-232.
41. Wakabayashi I., Araki Y. Influences of gender and age on relationships between alcohol drinking and atherosclerotic risk factors. Alcohol. Clin. Exp. Res. 2010, 34:S54-S60.