Mucoadhesive vs. mucopenetrating particulate drug delivery

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 98, Issue , 2016, Pages 76-89

  Netsomboon, Kesinee ^a   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Firm mucus; Loose mucus; Mucoadhesion; Mucopenetration; Polymers

Indexed keywords

ALGINIC ACID; CELLULOSE DERIVATIVE; CHITOSAN; LIPOSOME; MUCIN; MUCOLYTIC AGENT; PECTIN; POLYACRYLIC ACID; ACRYLIC ACID RESIN; CARBOPOL 940; CELLULOSE; GLUCURONIC ACID; HEXURONIC ACID;

ARTICLE; COMPARATIVE STUDY; DISULFIDE BOND; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; HUMAN; IN VIVO STUDY; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; MUCOADHESION; MUCOADHESIVE PARTICLE; MUCOPENETRATING PARTICULATE; MUCOSA; MUCOUS CELL; MUCUS; NONHUMAN; PARTICLE SIZE; PHOSPHOLIPID BILAYER; SURFACE AREA; VIRUS PARTICLE; WATER FLOW; ZETA POTENTIAL; ADHESION; ANIMAL; CHEMISTRY; METABOLISM;

ACRYLIC RESINS; ADHESIVENESS; ALGINATES; ANIMALS; CELLULOSE; CHITOSAN; DRUG DELIVERY SYSTEMS; GLUCURONIC ACID; HEXURONIC ACIDS; HUMANS; MUCOUS MEMBRANE; PECTINS;

EID: 84948703300     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.11.003     Document Type: Review

References (125)

1. T. Kessler, and D. Dartt Neural stimulation of conjunctival goblet cell mucous secretion in rats D. Sullivan, Lacrimal Gland, Tear Film, and Dry Eye Syndromes Advances in Experimental Medicine and Biology vol. 350 1994 Springer US 393 398
2. B. Deplancke, and H.R. Gaskins Microbial modulation of innate defense: goblet cells and the intestinal mucus layer Am. J. Clin. Nutr. 73 6 2001 1131S 1141S PubMed PMID: 11393191. Epub 2001/06/08.eng
3. S.S. Spicer, B.A. Schulte, and L.W. Chakrin Ultrastructural and histochemical observations of respiratory epithelium and gland Exp. Lung Res. 4 2 1983 137 156 PubMed PMID: 6840046. Epub 1983/02/01.eng
4. W. Kahle, H. Leonhardt, and W. Platzer Internal Organs 1993 Druckhaus Götz GmbH Stuttgart, Germany
5. J.d. Neves, R. Palmeira-de-Oliveira, A. Palmeira-de-Oliveira, F. Rodrigues, and B. Sarmento Vaginal Mucosa and Drug Delivery Mucoadhesive Materials and Drug Delivery Systems 2014 John Wiley & Sons, Ltd. 99 132
6. L. Serra, J. Doménech, and N. Peppas Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents Eur. J. Pharm. Biopharm.: Official Journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik eV 71 71 3 2009 519 528 PubMed PMID: PMC2680154
7. M.V. Johansson, D. Ambort, T. Pelaseyed, A. Schütte, J. Gustafsson, and A. Ermund Composition and functional role of the mucus layers in the intestine Cell. Mol. Life Sci. 68 22 2011 3635 3641
8. K. Moghissi, O.W. Neuhaus, and C.S. Stevenson Composition and properties of human cervical mucus. I. Electrophoretic separation and identification of proteins J. Clin. Invest. 39 9 1960 1358 1363 PubMed PMID: PMC293380
9. S.J. Coles, K.R. Bhaskar, D.D. O'Sullivan, K.H. Neill, and L.M. Reid Airway mucus: composition and regulation of its secretion by neuropeptides in vitro Ciba Found. Symp. 109 1984 40 60 PubMed PMID: 6083850. Epub 1984/01/01.eng
10. L. Szentkuti, and K. Lorenz The thickness of the mucus layer in different segments of the rat intestine Histochem. J. 27 6 1995 466 472
11. I.A. Brownlee, M.E. Havler, P.W. Dettmar, A. Allen, and J.P. Pearson Colonic mucus: secretion and turnover in relation to dietary fibre intake Proc. Nutr. Soc. 62 1 2003 245 249 PubMed PMID: 12756974. Epub 2003/05/22.eng
12. R.A. Cone Barrier properties of mucus Adv. Drug Deliv. Rev. 61 2 2009 75 85
13. A. Rubinstein, and B. Tirosh Mucus gel thickness and turnover in the gastrointestinal tract of the rat: response to cholinergic stimulus and implication for mucoadhesion Pharm. Res. 11 6 1994 794 799 PubMed PMID: 7937516. Epub 1994/06/01.eng
14. M.E.V. Johansson Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in vivo labeling of mucin glycoproteins PLoS ONE 7 7 2012 e41009
15. H. Zhang, M.-A. Shahbazi, P.V. Almeida, and H.A. Santos Mucus as a barrier for biopharmaceuticals and drug delivery systems J.d. Neves, B. Sarmento, Mucosal Delivery of Biopharmaceuticals: Biology, Challenges and Strategies vol. 19 2014 Springer New York
16. C. Atuma, V. Strugala, A. Allen, and L. Holm The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo Am. J. Physiol. Gastrointest. Liver Physiol. 280 5 2001 G922 G929 PubMed PMID: 11292601. Epub 2001/04/09.eng
17. L.M. Ensign, R. Cone, and J. Hanes Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers Adv. Drug Deliv. Rev. 64 6 2012 557 570
18. D.J. Smith, E.A. Gaffney, and J.R. Blake Modelling mucociliary clearance Respir. Physiol. Neurobiol. 163 1-3 2008 178 188
19. V. Strugala, A. Allen, P.W. Dettmar, and J.P. Pearson Colonic mucin: methods of measuring mucus thickness Proc. Nutr. Soc. 62 01 2003 237 243
20. H. Lennernäs, Ö. Ahrenstedt, and A.L. Ungell Intestinal drug absorption during induced net water absorption in man; a mechanistic study using antipyrine, atenolol and enalaprilat Br. J. Clin. Pharmacol. 37 6 1994 589 596 PubMed PMID: 7917779. Pubmed Central PMCID: PMC1364820. Epub 1994/06/01.eng
21. H. Takeuchi, H. Yamamoto, and Y. Kawashima Mucoadhesive nanoparticulate systems for peptide drug delivery Adv. Drug Deliv. Rev. 47 1 2001 39 54
22. S.K. Lai, Y.-Y. Wang, and J. Hanes Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues Adv. Drug Deliv. Rev. 61 2 2009 158 171
23. S.K. Lai, D.E. O'Hanlon, S. Harrold, S.T. Man, Y.-Y. Wang, and R. Cone Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus Proc. Natl. Acad. Sci. U.S.A. 104 5 2007 1482 1487 PubMed PMID: PMC1785284
24. K. Maisel, L. Ensign, M. Reddy, R. Cone, and J. Hanes Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse J. Control. Release 197 2015 48 57
25. R. Shaikh, T.R.R. Singh, M.J. Garland, A.D. Woolfson, and R.F. Donnelly Mucoadhesive drug delivery systems J. Pharm. Bioallied Sci. 3 1 2011 89 100
26. R.C. Rowe, P.J. Sheskey, and S. Owen Handbook of Pharmaceutical Excipients fifth ed. 2006 The Pharmaceutical Press and the American Pharmacists Association London, UK
27. S.A. Mortazavi An in vitro assessment of mucus/mucoadhesive interactions Int. J. Pharm. 124 2 1995 173 182
28. A. Makhlof, M. Werle, Y. Tozuka, and H. Takeuchi A mucoadhesive nanoparticulate system for the simultaneous delivery of macromolecules and permeation enhancers to the intestinal mucosa J. Control. Release 149 1 2011 81 88
29. M.D.A. El-Hameed, and I.W. Kellaway Preparation and in vitro characterisation of mucoadhesive polymeric microspheres as intra-nasal delivery systems Eur. J. Pharm. Biopharm. 44 1 1997 53 60
30. B. Kriwet, E. Walter, and T. Kissel Synthesis of bioadhesive poly(acrylic acid) nano- and microparticles using an inverse emulsion polymerization method for the entrapment of hydrophilic drug candidates J. Control. Release 56 1-3 1998 149 158
31. Y. Akiyama, N. Nagahara, T. Kashihara, S. Hirai, and H. Toguchi In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative Pharm. Res. 12 3 1995 397 405
32. A. Bernkop-Schnürch, C. Egger, M. Elhassan Imam, and A.H. Krauland Preparation and in vitro characterization of poly(acrylic acid)-cysteine microparticles J. Control. Release 93 1 2003 29 38
33. S. Dünnhaupt, J. Barthelmes, J. Hombach, D. Sakloetsakun, V. Arkhipova, and A. Bernkop-Schnürch Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa Int. J. Pharm. 408 1-2 2011 191 199
34. W.J. Cho, S.H. Oh, and J.H. Lee Alginate film as a novel post-surgical tissue adhesion barrier J. Biomater. Sci. Polym. Ed. 21 6 2010 701 713 PubMed PMID: 20482979. Epub 2010/05/21.eng
35. J.D. Smart The basics and underlying mechanisms of mucoadhesion Adv. Drug Deliv. Rev. 57 11 2005 1556 1568
36. M.J. Martín, A.C. Calpena, F. Fernández, M. Mallandrich, P. Gálvez, and B. Clares Development of alginate microspheres as nystatin carriers for oral mucosa drug delivery Carbohydr. Polym. 117 2015 140 149
37. E. Deat-Laine, V. Hoffart, G. Garrait, J.F. Jarrige, J.M. Cardot, and M. Subirade Efficacy of mucoadhesive hydrogel microparticles of whey protein and alginate for oral insulin delivery Pharm. Res. 30 3 2013 721 734 PubMed PMID: 23093377. Epub 2012/10/25.eng
38. S.N. Pawar, and K.J. Edgar Alginate derivatization: a review of chemistry, properties and applications Biomaterials 33 11 2012 3279 3305
39. S.N. Pawar, and K.J. Edgar Chemical modification of alginates in organic solvent systems Biomacromolecules 12 11 2011 4095 4103
40. J.-S. Yang, Y.-J. Xie, and W. He Research progress on chemical modification of alginate: a review Carbohydr. Polym. 84 1 2011 33 39
41. V. Grabovac, D. Guggi, and A. Bernkop-Schnürch Comparison of the mucoadhesive properties of various polymers Adv. Drug Deliv. Rev. 57 11 2005 1713 1723
42. M. Sar Investigation of various parameters influencing the duration of mucoadhesion of some polymer containing discs DARU J. Pharm. Sci. 10 3 2002 98 104
43. H.H. Sigurdsson, T. Loftsson, and C.-M. Lehr Assessment of mucoadhesion by a resonant mirror biosensor Int. J. Pharm. 325 1-2 2006 75 81
44. N. Suwannateep, W. Banlunara, S.P. Wanichwecharungruang, K. Chiablaem, K. Lirdprapamongkol, and J. Svasti Mucoadhesive curcumin nanospheres: biological activity, adhesion to stomach mucosa and release of curcumin into the circulation J. Control. Release 151 2 2011 176 182
45. D. Rahmat, C. Müller, J. Barthelmes, G. Shahnaz, R. Martien, and A. Bernkop-Schnürch Thiolated hydroxyethyl cellulose: design and in vitro evaluation of mucoadhesive and permeation enhancing nanoparticles Eur. J. Pharm. Biopharm. 83 2 2013 149 155
46. A. Sosnik, J. das Neves, and B. Sarmento Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review Prog. Polym. Sci. 39 12 2014 2030 2075
47. A. Sundar Raj, S. Rubila, R. Jayabalan, and T. Ranganathan A review on pectin: chemistry due to general properties of pectin and its pharmaceutical uses Sci. Rep. 1 550 2012
48. Y. Li, H. Zhao, L.-R. Duan, H. Li, Q. Yang, and H.-H. Tu Preparation, characterization and evaluation of bufalin liposomes coated with citrus pectin Colloids Surf. A 444 2014 54 62
49. H.S. Mahajan, B.V. Tatiya, and P.P. Nerkar Ondansetron loaded pectin based microspheres for nasal administration: in vitro and in vivo studies Powder Technol. 221 0 2012 168 176
50. R. Sharma, M. Ahuja, and H. Kaur Thiolated pectin nanoparticles: preparation, characterization and ex vivo corneal permeation study Carbohydr. Polym. 87 2 2012 1606 1610
51. I.A. Sogias, A.C. Williams, and V.V. Khutoryanskiy Why is chitosan mucoadhesive? Biomacromolecules 9 7 2008 1837 1842 PubMed PMID: 18540644. Epub 2008/06/11.eng
52. J. Xu, S. Strandman, J.X.X. Zhu, J. Barralet, and M. Cerruti Genipin-crosslinked catechol-chitosan mucoadhesive hydrogels for buccal drug delivery Biomaterials 0 2015
53. W. Chaiyasan, S.P. Srinivas, and W. Tiyaboonchai Mucoadhesive chitosan-dextran sulfate nanoparticles for sustained drug delivery to the ocular surface J. Ocul. Pharmacol. Ther.: Off. J. Assoc. Ocul. Pharmacol. Ther. 29 2 2013 200 207 PubMed PMID: 23356788. Pubmed Central PMCID: PMC3601816. Epub 2013/01/30.eng
54. C. Muller, B.N. Ma, R. Gust, and A. Bernkop-Schnurch Thiopyrazole preactivated chitosan: combining mucoadhesion and drug delivery Acta Biomater. 9 5 2013 6585 6593 PubMed PMID: 23321304. Epub 2013/01/17.eng
55. C.K.S. Pillai, W. Paul, and C.P. Sharma Chitin and chitosan polymers: chemistry, solubility and fiber formation Prog. Polym. Sci. 34 7 2009 641 678
56. W.-F. Lai, and M.C.-M. Lin Nucleic acid delivery with chitosan and its derivatives J. Control. Release 134 3 2009 158 168
57. P. He, S.S. Davis, and L. Illum In vitro evaluation of the mucoadhesive properties of chitosan microspheres Int. J. Pharm. 166 1 1998 75 88
58. S. Dhawan, A.K. Singla, and V.R. Sinha Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods AAPS PharmSciTech 5 4 2004 e67 PubMed PMID: 15760064. Pubmed Central PMCID: PMC2750492. Epub 2005/03/12.eng
59. A. Bernkop-Schnürch, C. Humenberger, and C. Valenta Basic studies on bioadhesive delivery systems for peptide and protein drugs Int. J. Pharm. 165 2 1998 217 225
60. A. Bernkop-Schnürch, and S. Dünnhaupt Chitosan-based drug delivery systems Eur. J. Pharm. Biopharm. 81 3 2012 463 469
61. H.L. Luessen, B.J. de Leeuw, M.W. Langemeyer, A.B. de Boer, J.C. Verhoef, and H.E. Junginger Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo Pharm. Res. 13 11 1996 1668 1672 PubMed PMID: 8956332. Epub 1996/11/01.eng
62. H. Takeuchi, Y. Matsui, H. Yamamoto, and Y. Kawashima Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats J. Control. Release 86 2-3 2003 235 242 PubMed PMID: 12526820. Epub 2003/01/16.eng
63. M. Abdel Mouez, N.M. Zaki, S. Mansour, and A.S. Geneidi Bioavailability enhancement of verapamil HCl via intranasal chitosan microspheres Eur. J. Pharm. Sci. 51 0 2014 59 66
64. J. Iqbal, G. Shahnaz, G. Perera, F. Hintzen, F. Sarti, and A. Bernkop-Schnürch Thiolated chitosan: development and in vivo evaluation of an oral delivery system for leuprolide Eur. J. Pharm. Biopharm. 80 1 2012 95 102
65. G. Shahnaz, A. Vetter, J. Barthelmes, D. Rahmat, F. Laffleur, and J. Iqbal Thiolated chitosan nanoparticles for the nasal administration of leuprolide: bioavailability and pharmacokinetic characterization Int. J. Pharm. 428 1-2 2012 164 170
66. S. Dünnhaupt, J. Barthelmes, C.C. Thurner, C. Waldner, D. Sakloetsakun, and A. Bernkop-Schnürch S-protected thiolated chitosan: synthesis and in vitro characterization Carbohydr. Polym. 90 2 2012 765 772
67. S.K. Lai, J.S. Suk, A. Pace, Y.-Y. Wang, M. Yang, and O. Mert Drug carrier nanoparticles that penetrate human chronic rhinosinusitis mucus Biomaterials 32 26 2011 6285 6290
68. X. Li, D. Chen, C. Le, C. Zhu, Y. Gan, and L. Hovgaard Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake Int. J. Nanomed. 6 2011 3151 3162 PubMed PMID: PMC3235033
69. M. TobÍo, A. Sánchez, A. Vila, I. Soriano, C. Evora, and J.L. Vila-Jato The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration Colloids Surf. B 18 3-4 2000 315 323
70. V. Bourganis, T. Karamanidou, E. Samaridou, K. Karidi, O. Kammona, and C. Kiparissides On the synthesis of mucus permeating nanocarriers Eur. J. Pharm. Biopharm. 0 2015
71. O. Mert, S.K. Lai, L. Ensign, M. Yang, Y.-Y. Wang, and J. Wood A poly(ethylene glycol)-based surfactant for formulation of drug-loaded mucus penetrating particles J. Control. Release 157 3 2012 455 460
72. J.S. Suk, A.J. Kim, K. Trehan, C.S. Schneider, L. Cebotaru, and O.M. Woodward Lung gene therapy with highly compacted DNA nanoparticles that overcome the mucus barrier J. Control. Release 178 2014 8 17
73. L. Inchaurraga, N. Martín-Arbella, V. Zabaleta, G. Quincoces, I. Peñuelas, and J.M. Irache In vivo study of the mucus-permeating properties of PEG-coated nanoparticles following oral administration Eur. J. Pharm. Biopharm. 0 2014
74. S.S. Olmsted, J.L. Padgett, A.I. Yudin, K.J. Whaley, T.R. Moench, and R.A. Cone Diffusion of macromolecules and virus-like particles in human cervical mucus Biophys. J. 81 4 2001 1930 1937
75. B. Michen, and T. Graule Isoelectric points of viruses J. Appl. Microbiol. 109 2 2010 388 397 PubMed PMID: 20102425. Epub 2010/01/28.eng
76. I. Pereira de Sousa, C. Steiner, M. Schmutzler, M.D. Wilcox, G.J. Veldhuis, and J.P. Pearson Mucus permeating carriers: formulation and characterization of highly densely charged nanoparticles Eur. J. Pharm. Biopharm. 0 2015
77. J. Rohrer, A. Partenhauser, S. Hauptstein, C. Gallati, B. Matuszczak, M. Abdulkarim, et al., Mucus permeating thiolated SEDDS, 2015.
78. C. Müller, K. Leithner, S. Hauptstein, F. Hintzen, W. Salvenmoser, and A. Bernkop-Schnürch Preparation and characterization of mucus-penetrating papain/poly(acrylic acid) nanoparticles for oral drug delivery applications J. Nanopart. Res. 15 1 2012 1 13
79. C. Müller, G. Perera, V. König, and A. Bernkop-Schnürch Development and in vivo evaluation of papain-functionalized nanoparticles Eur. J. Pharm. Biopharm. 87 1 2014 125 131
80. S. Köllner, S. Dünnhaupt, C. Waldner, S. Hauptstein, I. Pereira de Sousa, and A. Bernkop-Schnürch Mucus permeating thiomer nanoparticles Eur. J. Pharm. Biopharm. 0 2015
81. I. Pereira de Sousa, B. Cattoz, M.D. Wilcox, P.C. Griffiths, R. Dalgliesh, and S. Rogers Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier Eur. J. Pharm. Biopharm. 0 2015
82. R. Bansil, and B.S. Turner Mucin structure, aggregation, physiological functions and biomedical applications Curr. Opin. Colloid Interface Sci. 11 2-3 2006 164 170
83. J.S. Crater, and R.L. Carrier Barrier properties of gastrointestinal mucus to nanoparticle transport Macromol. Biosci. 10 12 2010 1473 1483
84. C.R. Miller, B. Bondurant, S.D. McLean, K.A. McGovern, and D.F. O'Brien Liposome-cell interactions in vitro: effect of liposome surface charge on the binding and endocytosis of conventional and sterically stabilized liposomes Biochemistry 37 37 1998 12875 12883 PubMed PMID: 9737866. Epub 1998/09/16.eng
85. B. Loretz, M. Thaler, and A. Bernkop-Schnurch Role of sulfhydryl groups in transfection? A case study with chitosan-NAC nanoparticles Bioconjug. Chem. 18 4 2007 1028 1035 PubMed PMID: 17552491. Epub 2007/06/08.eng
86. S. Bonengel, F. Prufert, G. Perera, J. Schauer, and A. Bernkop-Schnurch Polyethylene imine-6-phosphogluconic acid nanoparticles - a novel zeta potential changing system Int. J. Pharm. 483 1-2 2015 19 25 PubMed PMID: 25623492. Epub 2015/01/28.eng
87. G. Perera, M. Zipser, S. Bonengel, W. Salvenmoser, and A. Bernkop-Schnürch Development of phosphorylated nanoparticles as zeta potential inverting systems Eur. J. Pharm. Biopharm. 0 2015
88. R.S. Bhatta, H. Chandasana, Y.S. Chhonker, C. Rathi, D. Kumar, and K. Mitra Mucoadhesive nanoparticles for prolonged ocular delivery of natamycin: in vitro and pharmacokinetics studies Int. J. Pharm. 432 1-2 2012 105 112
89. P.M. Dandagi, A.M. Belekar, V.S. Mastiholimath, A.P. Gadad, V.W. Sontake, and P.S. Salian An improvement of the efficacy of moxifloxacin HCl for the treatment of bacterial keratitis by the formulation of ocular mucoadhesive microspheres Sci. Pharm. 81 1 2013 259 280 PubMed PMID: 23641344. Pubmed Central PMCID: PMC3617656. Epub 2013/05/04.eng
90. Q.-R. Cao, Y. Liu, W.-J. Xu, B.-J. Lee, M. Yang, and J.-H. Cui Enhanced oral bioavailability of novel mucoadhesive pellets containing valsartan prepared by a dry powder-coating technique Int. J. Pharm. 434 1-2 2012 325 333
91. Y. Zhang, W. Wei, P. Lv, L. Wang, and G. Ma Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin Eur. J. Pharm. Biopharm. 77 1 2011 11 19
92. Y. Akiyama, N. Nagahara, E. Nara, M. Kitano, S. Iwasa, and I. Yamamoto Evaluation of oral mucoadhesive microspheres in man on the basis of the pharmacokinetics of furosemide and riboflavin, compounds with limited gastrointestinal absorption sites J. Pharm. Pharmacol. 50 2 1998 159 166
93. D. Chen, D. Xia, X. Li, Q. Zhu, H. Yu, and C. Zhu Comparative study of Pluronic® F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats Int. J. Pharm. 449 1-2 2013 1 9
94. Q. Zhu, T. Guo, D. Xia, X. Li, C. Zhu, and H. Li Pluronic F127-modified liposome-containing tacrolimus-cyclodextrin inclusion complexes: improved solubility, cellular uptake and intestinal penetration J. Pharm. Pharmacol. 65 8 2013 1107 1117
95. V. Zabaleta, G. Ponchel, H. Salman, M. Agueros, C. Vauthier, and J.M. Irache Oral administration of paclitaxel with pegylated poly(anhydride) nanoparticles: permeability and pharmacokinetic study Eur. J. Pharm. Biopharm. 81 3 2012 514 523 PubMed PMID: 22516136. Epub 2012/04/21.eng
96. S. GuhaSarkar, and R. Banerjee Intravesical drug delivery: challenges, current status, opportunities and novel strategies J. Control. Release 148 2 2010 147 159
97. J. Barthelmes, S. Dunnhaupt, S. Unterhofer, G. Perera, W. Schlocker, and A. Bernkop-Schnurch Thiolated particles as effective intravesical drug delivery systems for treatment of bladder-related diseases Nanomedicine 8 1 2013 65 75 PubMed PMID: 22812707. Epub 2012/07/21.eng (London, England)
98. L. Perioli, V. Ambrogi, C. Pagano, E. Massetti, and C. Rossi New solid mucoadhesive systems for benzydamine vaginal administration Colloids Surf. B 84 2 2011 413 420
99. K. Berginc, S. Suljaković, N. Škalko-Basnet, and A. Kristl Mucoadhesive liposomes as new formulation for vaginal delivery of curcumin Eur. J. Pharm. Biopharm. 87 1 2014 40 46
100. M.W. Jøraholmen, Ž. Vanić, I. Tho, and N. Škalko-Basnet Chitosan-coated liposomes for topical vaginal therapy: assuring localized drug effect Int. J. Pharm. 472 1-2 2014 94 101
101. Y. Cu, C.J. Booth, and W.M. Saltzman In vivo distribution of surface-modified PLGA nanoparticles following intravaginal delivery J. Control. Release 156 2 2011 258 264
102. M. Sund-Levander, C. Forsberg, and L.K. Wahren Normal oral, rectal, tympanic and axillary body temperature in adult men and women: a systematic literature review Scand. J. Caring Sci. 16 2 2002 122 128 PubMed PMID: 12000664. Epub 2002/05/10.eng
103. L.M. Collins, and C. Dawes The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa J. Dent. Res. 66 8 1987 1300 1302 PubMed PMID: 3476596. Epub 1987/08/01.eng
104. C. Dawes How much saliva is enough for avoidance of xerostomia? Caries Res. 38 3 2004 236 240 PubMed PMID: 15153694. Epub 2004/05/22.eng
105. R. Neelagiri, M.S. Reddy, and N.G.R. Rao Buccal patch as drug delivery system: an overview Int. J. Curr. Pharm. Res. 5 2 2013 40 47
106. A.H. Shojaei Buccal mucosa as a route for systemic drug delivery: a review J. Pharm. Pharm. Sci.: Publ. Can. Soc. Pharm. Sci. 1 1 1998 15 30 PubMed PMID: 10942969. Epub 2000/08/16.eng
107. A. Shahiwala Applications of polymers in buccal drug delivery A. Misra, A. Shahiwala, Applications of Polymers in Drug Delivery 2014 Smithers-Rapra 59 96
108. J. Lindemann, R. Leiacker, G. Rettinger, and T. Keck Nasal mucosal temperature during respiration Clin. Otolaryngol. Allied Sci. 27 3 2002 135 139 PubMed PMID: 12071984. Epub 2002/06/20.eng
109. A.G. Beule Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses GMS Curr. Top. Otorhinolaryngol. Head Neck Surg. 9 2010 Doc07 PubMed PMID: PMC3199822
110. M.I. Ugwoke, R.U. Agu, N. Verbeke, and R. Kinget Nasal mucoadhesive drug delivery: background, applications, trends and future perspectives Adv. Drug Deliv. Rev. 57 11 2005 1640 1665
111. A. Pires, A. Fortuna, G. Alves, and A. Falcao Intranasal drug delivery: how, why and what for? J. Pharm. Pharm. Sci.: Publ. Can. Soc. Pharm. Sci. 12 3 2009 288 311 PubMed PMID: 20067706. Epub 2010/01/14.eng
112. E.R. McFadden Jr., B.M. Pichurko, H.F. Bowman, E. Ingenito, S. Burns, and N. Dowling Thermal mapping of the airways in humans J. Appl. Physiol. 58 2 1985 564 570 PubMed PMID: 3980358. Epub 1985/02/01.eng (Bethesda, MD)
113. M.S. Ali, and J.P. Pearson Upper airway mucin gene expression: a review Laryngoscope 117 5 2007 932 938
114. F. Girardin, S. Orgul, C. Erb, and J. Flammer Relationship between corneal temperature and finger temperature Arch. Ophthalmol. 117 2 1999 166 169 PubMed PMID: 10037559. Epub 1999/02/26.eng
115. H. Fujishima, I. Toda, M. Yamada, N. Sato, and K. Tsubota Corneal temperature in patients with dry eye evaluated by infrared radiation thermometry Brit. J. Ophthalmol. 80 1 1996 29 32 PubMed PMID: 8664227. Pubmed Central PMCID: PMC505379. Epub 1996/01/01.eng
116. N. Jordan, J. Newton, J. Pearson, and A. Allen A novel method for the visualization of the in situ mucus layer in rat and man Clin. Sci. 95 1 1998 97 106 PubMed PMID: 9662491. Epub 1998/07/15.eng (London, England: 1979)
117. J.L. Newton, N. Jordan, J. Pearson, G.V. Williams, A. Allen, and O.F.W. James The adherent gastric antral and duodenal mucus gel layer thins with advancing age in subjects infected with Helicobacter pylori Gerontology 46 3 2000 153 157
118. S.M. Kelly, J.R. Crampton, and J.O. Hunter Helicobacter pylori increases gastric antral juxtamucosal pH Dig. Dis. Sci. 38 1 1993 129 131 PubMed PMID: 8420744. Epub 1993/01/01.eng
119. M. Dawson, E. Krauland, D. Wirtz, and J. Hanes Transport of polymeric nanoparticle gene carriers in gastric mucus Biotechnol. Prog. 20 3 2004 851 857 PubMed PMID: 15176891. Epub 2004/06/05.eng
120. M. Derrien, M.W.J. van Passel, J.H.B. van de Bovenkamp, R.G. Schipper, W.M. de Vos, and J. Dekker Mucin-bacterial interactions in the human oral cavity and digestive tract Gut Microbes 1 4 2010 254 268 PubMed PMID: PMC3023607
121. S.G. Nugent, D. Kumar, D.S. Rampton, and D.F. Evans Intestinal luminal pH in inflammatory bowel disease: possible determinants and implications for therapy with aminosalicylates and other drugs Gut 48 4 2001 571 577 PubMed PMID: 11247905. Pubmed Central PMCID: PMC1728243. Epub 2001/03/15.eng
122. K. Matsuo, H. Ota, T. Akamatsu, A. Sugiyama, and T. Katsuyama Histochemistry of the surface mucous gel layer of the human colon Gut 40 6 1997 782 789 PubMed PMID: PMC1027204
123. M.A. McGuckin, D.J. Thornton, and J.A. Whitsett Mucins and mucus J. Mestecky, W. Strober, M.W. Russell, B.L. Kelsall, H. Cheroutre, B.N. Lambrecht, Mucosal Immunology vol. 1 2015 Academic Press 231 250
124. J. Cornish, J.C. Nickel, M. Vanderwee, and J.W. Costerton Ultrastructural visualization of human bladder mucous Urol. Res. 18 4 1990 263 266
125. S.A. McKinley, A. Chen, F. Shi, S. Wang, P.J. Mucha, and M.G. Forest Modeling neutralization kinetics of HIV by broadly neutralizing monoclonal antibodies in genital secretions coating the cervicovaginal mucosa PLoS ONE 9 6 2014 e100598 PubMed PMID: 24967706. Pubmed Central PMCID: PMC4072659. Epub 2014/06/27.eng