Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 97, Issue , 2015, Pages 257-264

  Pereira De Sousa, Irene ^a   Cattoz, Beatrice ^b   Wilcox, Matthew D ^c   Griffiths, Peter C ^b   Dalgliesh, Robert ^d   Rogers, Sarah ^d   Bernkop Schnürch, Andreas ^a  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b UNIVERSITY OF GREENWICH   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d RUTHERFORD APPLETON LABORATORY   (United Kingdom)

Author keywords

Bromelain; Diffusion; Enzyme functionalization; Mucus permeating nanoparticles; Oral drug delivery; Papain

Indexed keywords

BROMELAIN; NANOPARTICLE; PAPAIN; POLYACRYLIC ACID; PROTEINASE; ACRYLIC ACID RESIN; CARBOPOL 940; DRUG CARRIER; MUCIN; PEPTIDE HYDROLASE;

ARTICLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENZYME ACTIVITY; GELATION; HUMAN; HUMAN CELL; MUCUS; NEUTRON SCATTERING; NUCLEAR MAGNETIC RESONANCE; ZETA POTENTIAL; ANIMAL; CACO 2 CELL LINE; CHEMISTRY; COMPARATIVE STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; METABOLISM; PARTICLE SIZE; PIG;

ACRYLIC RESINS; ANIMALS; BROMELAINS; CACO-2 CELLS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MUCINS; MUCUS; NANOPARTICLES; PAPAIN; PARTICLE SIZE; PEPTIDE HYDROLASES; SWINE;

EID: 84946723956     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.01.008     Document Type: Article

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