메뉴 건너뛰기




Volumn 68, Issue 22, 2011, Pages 3635-3641

Composition and functional role of the mucus layers in the intestine

Author keywords

Colon; Commensal bacteria; MUC2; Mucin; Mucus; Small intestine

Indexed keywords

MUCIN; MUCIN 2;

EID: 82155175676     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0822-3     Document Type: Review
Times cited : (430)

References (35)
  • 2
    • 77953770453 scopus 로고    scopus 로고
    • The future of mucosal immunology: Studying an integrated system-wide organ
    • Gill N, Wlodarska M, Finlay BB (2010) The future of mucosal immunology: studying an integrated system-wide organ. Nat Immunol 11:558-560
    • (2010) Nat Immunol , vol.11 , pp. 558-560
    • Gill, N.1    Wlodarska, M.2    Finlay, B.B.3
  • 4
    • 3042842452 scopus 로고    scopus 로고
    • Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes
    • DOI 10.1093/glycob/cwh066
    • Lang T, Alexandersson M, Hansson GC, Samuelsson T (2004) Bioinformatic identification of polymerizing and transmembrane mucins in the puffer fish Fugu rubripes. Glycobiology 14:521-527 (Pubitemid 38868266)
    • (2004) Glycobiology , vol.14 , Issue.6 , pp. 521-527
    • Lang, T.1    Alexandersson, M.2    Hansson, G.C.3    Samuelsson, T.4
  • 5
    • 0036302192 scopus 로고    scopus 로고
    • Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis
    • DOI 10.1053/gast.2002.34157
    • Vinall LE, King M, Novelli M, Green CA, Daniels G, Hilkens J, Sarner M, Swallow DM (2002) Altered expression and allelic association of the hypervariable membrane mucin MUC1 in Helicobacter pylori gastritis. Gastroenterology 123:41-49 (Pubitemid 34747524)
    • (2002) Gastroenterology , vol.123 , Issue.1 , pp. 41-49
    • Vinall, L.E.1    King, M.2    Novelli, M.3    Green, C.A.4    Daniels, G.5    Hilkens, J.6    Sarner, M.7    Swallow, D.M.8
  • 6
    • 0034843704 scopus 로고    scopus 로고
    • Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins
    • Axelsson MA, Karlsson NG, Steel DM, Ouwendijk J, Nilsson T, Hansson GC (2001) Neutralization of pH in the Golgi apparatus causes redistribution of glycosyltransferases and changes in the O-glycosylation of mucins. Glycobiology 11:633-644 (Pubitemid 32785269)
    • (2001) Glycobiology , vol.11 , Issue.8 , pp. 633-644
    • Axelsson, M.A.B.1    Karlsson, N.G.2    Steel, D.M.3    Ouwendijk, J.4    Nilsson, T.5    Hansson, G.C.6
  • 7
    • 0037177858 scopus 로고    scopus 로고
    • Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection
    • DOI 10.1074/jbc.M112287200
    • Olson FJ, Johansson ME, Klinga-Levan K, Bouhours D, Enerbäck L, Hansson GC, Karlsson NG (2002) Blood group A glycosyltransferase occurring as alleles with high sequence difference is transiently induced during a Nippostrongylus brasiliensis parasite infection. J Biol Chem 277:15044-15052 (Pubitemid 34952581)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.17 , pp. 15044-15052
    • Olson, F.J.1    Johansson, M.E.V.2    Klinga-Levan, K.3    Bouhours, D.4    Enerback, L.5    Hansson, G.C.6    Karlsson, N.G.7
  • 8
    • 0037252356 scopus 로고    scopus 로고
    • Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus brasiliensis
    • DOI 10.1023/A:1022589015687
    • Holmén JM, Olson FJ, Karlsson H, Hansson GC (2002) Two glycosylation alterations of mouse intestinal mucins due to infection caused by the parasite Nippostrongylus brasiliensis. Glycoconj J 19:67-75 (Pubitemid 36408002)
    • (2002) Glycoconjugate Journal , vol.19 , Issue.1 , pp. 67-75
    • Holmen, J.M.1    Olson, F.J.2    Karlsson, H.3    Hansson, G.C.4
  • 12
    • 30044448792 scopus 로고    scopus 로고
    • Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
    • DOI 10.1038/nsmb1035
    • Macao B, Johansson DG, Hansson GC, Härd T (2006) Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat Struct Mol Biol 13:71-76 (Pubitemid 43049405)
    • (2006) Nature Structural and Molecular Biology , vol.13 , Issue.1 , pp. 71-76
    • Macao, B.1    Johansson, D.G.A.2    Hansson, G.C.3    Hard, T.4
  • 13
    • 40449109105 scopus 로고    scopus 로고
    • The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine
    • DOI 10.1042/BJ20071068
    • Malmberg EK, Pelaseyed T, Petersson AC, Seidler UE, De Jonge H, Riordan JR, Hansson GC (2008) The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem J 410:283-289 (Pubitemid 351346186)
    • (2008) Biochemical Journal , vol.410 , Issue.2 , pp. 283-289
    • Malmberg, E.K.1    Pelaseyed, T.2    Petersson, A.C.3    Seidler, U.E.4    De Jonge, H.5    Riordan, J.R.6    Hansson, G.C.7
  • 14
    • 80054039442 scopus 로고    scopus 로고
    • CFTR anion channel modulates expression of human transmembrane mucin MUC3 via the PDZ protein GOPC
    • Pelaseyed T, Hansson GC (2011) CFTR anion channel modulates expression of human transmembrane mucin MUC3 via the PDZ protein GOPC. J Cell Sci 124:3074-3083
    • (2011) J Cell Sci , vol.124 , pp. 3074-3083
    • Pelaseyed, T.1    Hansson, G.C.2
  • 19
    • 0033023242 scopus 로고    scopus 로고
    • Studies on the "insoluble" glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage
    • Herrmann A, Davies JR, Lindell G, Martensson S, Packer NH, Swallow DM, Carlstedt I (1999) Studies on the "insoluble" glycoprotein complex from human colon. Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage. J Biol Chem 274:15828-15836
    • (1999) J Biol Chem , vol.274 , pp. 15828-15836
    • Herrmann, A.1    Davies, J.R.2    Lindell, G.3    Martensson, S.4    Packer, N.H.5    Swallow, D.M.6    Carlstedt, I.7
  • 20
    • 0032563105 scopus 로고    scopus 로고
    • O-glycosylated MUC2 monomer and dimer from LS 174T cells are water- soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds
    • DOI 10.1074/jbc.273.30.18864
    • Axelsson MA, Asker N, Hansson GC (1998) O-glycosylated MUC2 monomer and dimer from LS 174T cells are water-soluble, whereas larger MUC2 species formed early during biosynthesis are insoluble and contain nonreducible intermolecular bonds. J Biol Chem 273:18864-18870 (Pubitemid 28366273)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.30 , pp. 18864-18870
    • Axelsson, M.A.B.1    Asker, N.2    Hansson, G.C.3
  • 22
    • 67650394385 scopus 로고    scopus 로고
    • Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein
    • Johansson ME, Thomsson KA, Hansson GC (2009) Proteomic analyses of the two mucus layers of the colon barrier reveal that their main component, the Muc2 mucin, is strongly bound to the Fcgbp protein. J Proteome Res 8:3549-3557
    • (2009) J Proteome Res , vol.8 , pp. 3549-3557
    • Johansson, M.E.1    Thomsson, K.A.2    Hansson, G.C.3
  • 23
    • 0038751861 scopus 로고    scopus 로고
    • An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway
    • DOI 10.1074/jbc.M210069200
    • Lidell ME, Johansson ME, Hansson GC (2003) An autocatalytic cleavage in the C terminus of the human MUC2 mucin occurs at the low pH of the late secretory pathway. J Biol Chem 278:13944-13951 (Pubitemid 36799936)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.16 , pp. 13944-13951
    • Lidell, M.E.1    Johansson, M.E.V.2    Hansson, G.C.3
  • 24
    • 4644353637 scopus 로고    scopus 로고
    • Inter-α-trypsin inhibitor, a covalent protein-glycosaminoglycan- protein complex
    • DOI 10.1074/jbc.R300039200
    • Zhuo L, Hascall VC, Kimata K (2004) Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein complex. J Biol Chem 279:38079-38082 (Pubitemid 39295949)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.37 , pp. 38079-38082
    • Zhuo, L.1    Hascall, V.C.2    Kimata, K.3
  • 25
    • 79952748335 scopus 로고    scopus 로고
    • The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions
    • Johansson ME, Larsson JM, Hansson GC (2011) The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proc Natl Acad Sci USA 108:4659-4665
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 4659-4665
    • Johansson, M.E.1    Larsson, J.M.2    Hansson, G.C.3
  • 26
    • 84855912506 scopus 로고    scopus 로고
    • Lactobacillus and Bifidobacterium species do not secrete proteases that can cleave the MUC2 mucin protein core which organizes the colon mucus layers
    • Subramani DB, Johansson MEV, Dahlén G, Hansson GC (2010) Lactobacillus and Bifidobacterium species do not secrete proteases that can cleave the MUC2 mucin protein core which organizes the colon mucus layers. Beneficial Microbes 1:343-350
    • (2010) Beneficial Microbes , vol.1 , pp. 343-350
    • Subramani, D.B.1    Johansson, M.E.V.2    Dahlén, G.3    Hansson, G.C.4
  • 30
    • 0032763888 scopus 로고    scopus 로고
    • Evolutionary considerations in relating oligosaccharide diversity to biological function
    • DOI 10.1093/glycob/9.8.747
    • Gagneux P, Varki A (1999) Evolutionary considerations in relating oligosaccharide diversity to biological function. Glycobiology 9:747-755 (Pubitemid 29376001)
    • (1999) Glycobiology , vol.9 , Issue.8 , pp. 747-755
    • Gagneux, P.1    Varki, A.2
  • 31
    • 0023721490 scopus 로고
    • Structural aspects of blood group glycosphingolipids in the gastrointestinal tract
    • Hansson GC (1988) Structural aspects of blood group glycosphingolipids in the gastrointestinal tract. Adv Exp Med Biol 228:465-494
    • (1988) Adv Exp Med Biol , vol.228 , pp. 465-494
    • Hansson, G.C.1
  • 32
    • 66249136714 scopus 로고    scopus 로고
    • A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn
    • Larsson JM, Karlsson H, Sjovall H, Hansson GC (2009) A complex, but uniform O-glycosylation of the human MUC2 mucin from colonic biopsies analyzed by nanoLC/MSn. Glycobiology 19:756-766
    • (2009) Glycobiology , vol.19 , pp. 756-766
    • Larsson, J.M.1    Karlsson, H.2    Sjovall, H.3    Hansson, G.C.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.