Mucoadhesive drug delivery systems

Journal of Pharmacy and Bioallied Sciences

Volumn 3, Issue 1, 2011, Pages 89-100

  Shaikh, Rahamatullah ^a   Raj Singh, Thakur ^a   Garland, Martin ^a   Woolfson, A ^a   Donnelly, Ryan ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Mucoadhesion; mucoadhesive drug delivery systems; mucoadhesive materials

Indexed keywords

AMPHOTERICIN; BENZYDAMINE; BENZYL NICOTINATE; CARBOMER; CHITOSAN; CHLORPROMAZINE; CIPROFLOXACIN; DICLOFENAC; FENTANYL; FLUORESCEIN; INSULIN; MACROGOL; METRONIDAZOLE; MICONAZOLE; MORPHINE; POLYACRYLIC ACID; POLYMACON; POLYMER; POLYVINYL ALCOHOL; POVIDONE; PROPRANOLOL; PSEUDOMONIC ACID; PUERARIN; QUININE; RAMOSETRON; SULFADICRAMIDE; TERAMEPROCOL; THEOPHYLLINE; UNINDEXED DRUG; ZINC OXIDE;

ADSORPTION; CHEEK MUCOSA; CONTROLLED DRUG RELEASE; CORNEA; CROSS LINKING; DIFFUSION; DIFFUSION COEFFICIENT; DRUG ADMINISTRATION ROUTE; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; HUMAN; HYDROPHILICITY; MOLECULAR WEIGHT; MUCOADHESION; MUCOADHESIVE DRUG DELIVERY SYSTEM; NONHUMAN; NOSE MUCOSA; PAIN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RECTUM MUCOSA; REVIEW; THEORY; THERMODYNAMICS; VAGINA MUCOSA; WETTABILITY;

EID: 79952930235     PISSN: None     EISSN: 09757406     Source Type: Journal    
DOI: 10.4103/0975-7406.76478     Document Type: Review

References (113)

1. Good WR. Transdermal nitro-controlled delivery of nitroglycerin via the transdermal route. Drug Dev Ind Pharm 1983;9:647-70. (Pubitemid 13058875)
2. Henriksen I, Green KL, Smart JD, Smistad G, Karlsen J. Bioadhesion of Hydrated Chitosans: An in vitro and in vivo Study. Int J Pharm 1996;145:231-40. (Pubitemid 27063004)
3. Leung SH, Robinson JR. The Contribution of anionic polymer structural features related to mucoadhesion. J Control Release 1988;5:223-31. (Pubitemid 18038211)
4. Longer MA, Robinson JR. Fundamental aspects of bioadhesion. Pharmacy Int 1986;7:114-7. (Pubitemid 17183045)
5. McBain JW, Hopkins DG. On adhesives and adhesive action. J Phys Chem 1925;29:188-204.
6. Pritchard WH. In: (3rd edition ed.),D. Alder, Editor, Aspects of adhesion 6, London University Press, London (1970), pp. ll-23.
7. Wake WC. Adhesion and the Formulation of Adhesives. London: Applied Science Publishers; 1982.
8. Deraguin BV, Smilga VP. Adhesion: Fundamentals and Practice. London: McLaren; 1969.
9. Jimenez-Castellanos MR, Zia, H, Rhodes CT. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1993;19:143-94.
10. Duchene D, Touchard F, Peppas NA. Pharmaceutical and medical aspects of bioadhesive systems for drug administration. Drug Dev Ind Pharm 1988;14:283-18.
11. Peppas NA, Buri PA. Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues. J Control Release 1985;2:257-75. (Pubitemid 16195943)
12. Reinhart CP, Peppas NA. Solute diffusion in swollen membranes ii. influence of crosslinking on diffusion properties. J Memb Sci 1984;18:227-39.
13. Ahuja A, Khar RK, Ali J. Mucoadhesive drug delivery systems. Drug Dev Ind Pharm 1997;23:489-515. (Pubitemid 27241128)
14. Huntsberger JR. Mechanisms of adhesion. J Pain Technol 1967;39:199-211.
15. Kinloch AJ. The science of adhesion I. Surface and interfacial aspects. J Material Sci 1980;15:2141.
16. Yang X, Robinson JR. Bioadhesion in Mucosal Drug Delivery. In: Okano T, editor. Biorelated Polymers and Gels. London: Academic Press; 1998.
17. Gu JM, Robinson JR, Leung SH. Binding of acrylic polymers to mucin/ epithelial surfaces: Structure-property relationships. Crit Rev Ther Drug Carrier Syst 1988;5:21-67.
18. Smart JD, Nicholls TJ, Green KL, Rogers DJ, Cook JD. Lectins in Drug Delivery: A study of the acute local irritancy of the lectins fromSolanum tuberosum and helix pomatia. Eur J Pharm Sci 1999;9:93-8. (Pubitemid 29430198)
19. Naisbett B, Woodley J. The potential use of tomato lectin for oral drug delivery. Int J Pharm 1994;107:223-30.
20. Nicholls TJ, Green KL, Rogers DJ, Cook, JD, Wolowacz S, Smart JD. Lectins in ocular drug delivery. An investigation of lectin binding sites on the corneal and conjunctival surfaces. Int J Pharm 1996;138:175-83. (Pubitemid 26281174)
21. Hornof M, Weyenberg W, Ludwig A, Bernkop-Schnurch A. A mucoadhesive ophthalmic insert based on thiolated poly(acrylic) acid: Development and in vivo evaluation in human volunteers. J Control Release 2003;89:419-28. (Pubitemid 36555901)
22. Albrecht K, Zirm EJ, Palmberger TF, Schlocker W, Bernkop-Schnurch A. Preparation of thiomer microparticles and in vitro evaluation of parameters influencing their mucoadhesive properties. Drug Dev Ind Pharm 2006;32:1149-57. (Pubitemid 44721729)
23. Peppas NA, Little MD, Huang Y. Bioadhesive Controlled Release Systems. In: Wise DL, editor. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker; 2000. p. 255-69.
24. Gurny R, Meyer JM, Peppas NA. Bioadhesive intraoral release systems: Design, testing and analysis. Biomaterials 1984;5:336-40. (Pubitemid 15195092)
25. Gudeman L, Peppas NA. Preparation and characterisation of ph- sensitive, interpenetrating networks of poly(vinyl alcohol) and poly(acrylic acid). J Appl Polym Sci 1995;55:919-28.
26. McCarron PA, Woolfson AD, Donnelly RF, Andrews GP, Zawislak A, Price JH. Influence of plasticiser type and storage conditions on the properties of poly(methyl vinyl ether-co-maleic anhydride) bioadhesive films. J Appl Polym Sci 2004;91:1576-89. (Pubitemid 38107399)
27. Park H, Robinson JR. Physicochemical properties of water soluble polymers important to mucin/epithelium adhesion. J Control Release 1985;2:47-7.
28. Blanco Fuente H, AnguianoIgea S, OteroEspinar FJ, BlancoMendez J. Invitro bioadhesion of carbopol hydrogels. Int J Pharm 1996;142:169-74.
29. Donnelly RF, McCarron PA, Tunney MM, Woolfson AD. Potential of photodynamic therapy in treatment of fungal infections of the mouth. design and characterisation of a mucoadhesive patch containing toluidine Blue O. J Photochem Photobiol B 2007;86:59-69. (Pubitemid 44835462)
30. Smart JD. An in vitro assessment of some mucoadhesive dosage forms. Int J Pharm 1991;73:69-74.
31. Kamath KR, Park K. Mucosal Adhesive Preparations. In: Swarbrick J, Boylan JC, editors. Encyclopedia of Pharmaceutical Technology. New York: Marcel Dekker; 1992. p.133.
32. Lehr CM, Poelma FG. An Estimate of turnover time of intestinal mucus gel layer in the Rat in situ Loop. Int J Pharm 1991;70:235.
33. Park K, Park H. Test methods of bioadhesion, Bioadhesive drug delivery systems. In: Lenaerts V, Gurney R, editors. Florida, Boca Raton: CRC Press; 1990.
34. McCarron PA, Donnelly RF, Zawislak A, Woolfson AD, Price JH, McClelland R. Evaluation of a Water-soluble Bioadhesive patch for photodynamic therapy of vulval lesions. Int J Pharm 2005;293:11-23. (Pubitemid 40381076)
35. McCarron PA, Donnelly RF, Zawislak A, Woolfson AD. Design and evaluation of a water-soluble bioadhesive patch formulation for cutaneous delivery of 5-aminolevulinic acid to superficial neoplastic lesions. Eur J Pharm Sci 2006;27:268-79. (Pubitemid 41831262)
36. Donnelly RF, McCarron PA, Zawislak AA, Woolfson AD. Design and physicochemical characterisation of a bioadhesive patch for dosecontrolled topical delivery of imiquimod. Int J Pharm 2006;307:318-25. (Pubitemid 41820430)
37. Hassan EE, Gallo JM. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm Res 1990;7:491-5. (Pubitemid 20322199)
38. Rossi S, Bonferoni MC, Lippoli G, Bertoni M, Ferrari F, Caramella C, et al. Influence of mucin type on polymer-mucin rheological interactions. Biometerials 1995;16:1073-9.
39. Hagerstrom H, Paulsson M, Edsman K. Evaluation of mucoadhesion for two polyelectrolyte gels in simulated physiological conditions using a rheological method. Eur J Pharm Sci 2000;9:301-9.
40. Rossi S, Ferrari F, Bonferoni MC, Caramella C. Characterization of chitosan hydrochloride-mucin rheological interaction: Influence of polymer concentration and polymer: Mucin weight ratio. Eur J Pharm Sci 2001;12:479-85. (Pubitemid 32166747)
41. Hagerstrom H, Edsman K. Limitations of the rheological mucoadhesion method: The effect of the choice of conditions and the rheological synergism parameter Eur J Pharm Sci 2003;18:349-57. (Pubitemid 36407695)
42. Ch'ng HS, Park H, Kelly P, Robinson JR. Bioadhesive polymers as platforms for oral controlled drug delivery. II Synthesis and evaluation of some swelling, water-insoluble bioadhesive polymers. J Pharm Sci 1985;74:399-05.
43. Davis SS. The design and evaluation of controlled release systems for the gastro-intestinal tract. J Control Release 1985;2:27-38. (Pubitemid 16195924)
44. Christian K, Karin A, Melanie G, Christian W, Paul D, Andreas BS. In vivo determination of the time and location of mucoadhesive drug delivery systems disintegration in the gastrointestinal tract. Magn Reson Imaging 2008;26:638-43.
45. Woolfson AD, McCafferty DF, Moss GP. Development and characterisation of a moisture-activated bioadhesive drug delivery system for percutaneous local anaesthesia. Int J Pharm 1998;169:83-94. (Pubitemid 28352601)
46. Salamat-Miller N, Chittchang M, Johnston TP. The use of mucoadhesive polymers in buccal drug delivery. Adv Drug Deliv Rev 2005;57:1666-91. (Pubitemid 41443474)
47. Ugwoke MI, Agu RU, Verbeke N, Kinget R. Nasal mucoadhesive drug delivery: Background, applications, trends and future perspectives. Adv Drug Deliv Rev 2005;57:1640-65. (Pubitemid 41443473)
48. Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv Drug Deliv Rev 2005;57:1595-639. (Pubitemid 41443472)
49. Valenta C. The use of mucoadhesive polymers in vaginal delivery, Adv Drug Deliv Rev 2005;57:1692-712. (Pubitemid 41444256)
50. Edsman K, Hagerstrom H. Pharmaceutical applications of mucoadhesion for the non-oral routes. J Pharm Pharmacol 2005:57:3-22. (Pubitemid 40030097)
51. Ponchel G, Touchard F, Duchene D, Peppas NA. Bioadhesive analysis of controlled release systems I. Fracture and interpenetration analysis in poly(acrylic acid)-containing systems. J Control Release 1987;5:129-41. (Pubitemid 17132061)
52. Nagai T, Konishi R. Buccal/gingival drug delivery systems. J Control Release 1987;6:353-60. (Pubitemid 18017744)
53. Sayin B, Somavarapu S, Li XW, Thanou M, Sesardic D, Alpar HO, Senel S. Mono-N-carboxymethyl chitosan (MCC) and N-trimethyl chitosan (TMC) nanoparticles for non-invasive vaccine delivery. Int J Pharm 2008;363:139-48.
54. Ango R, Kavimani S, Mullaicharam AR, Jayakar B. In vitro studies on buccal strips of glibenclamide using chitosan. Indian J Pharm Sci 1997;59:232-5. (Pubitemid 27504506)
55. Boyapally H, Nukala RK, Bhujbal P, Douroumis D. Controlled release from directly compressible theophylline buccal tablets. Colloids Surf B Biointerfaces 2010;77:227-33.
56. Petelin M, Pavlica Z, Bizimoska S, Sentjurc M. In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetry. Int J Pharm 2004;270:83-91. (Pubitemid 38077090)
57. Rossi S, Maricello M, Bonferoni MC, Ferrari F, Sandri G, Dacarro C, et al. Thermally sensitive gels based on chitosan derivatives for the treatment of oral mucositis. Eur J Pharm Biopharm 2010;74:248-54.
58. Nafee NA, Ismail FA, Boraie NA, Mortada LM. Mucoadhesive buccal patches of miconazole nitrate: In vitro/in vivo performance and effect of ageing. Int J Pharm 2003;264:1-14. (Pubitemid 37297629)
59. Consuelo ID, Falson F, Guy R H, Jacques Y. Ex vivo evaluation of bioadhesive films for buccal delivery of fentanyl. J Control Release 2007;122:135-40. (Pubitemid 47361402)
60. Nasal Ointment Abvailable from: Http://www.Medicines.Org.Uk/ Emc/Medicine/2027/Spc/ Jun2010.htm.[Last cited on 2010 Aug 16].
61. Jain AK, Khar RK, Ahmed FJ, Diwan PV. Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier. Eur J Pharm Biopharm 2008;69:426-35.
62. Wu J, Wei W, Wang LY, Su ZG, Ma GH. A thermosensitive hydrogel based on quarternized chitosan and poly(ethylene glycol) for nasal drug delivery system. Biomaterials 2007;28:2220-32. (Pubitemid 46216447)
63. Luppi B, Bigucci F, Abruzzo A, Corace G, Cerchia T, Zecchi V. Freeze dried chitosan/pectin nasal inserts for antipsychotic drug delivery. Eur J Pharm Biopharm 2010;75:381-7.
64. Hornof M, Weyenberg W, Ludwig A, Bernkop-Schnurch A. Mucoadhesive ocular insert based on thiolated poly(acrylic acid): Development and in vivo evaluation in humans. J Control Release 2003;89:419-28. (Pubitemid 36555901)
65. Grezeskowiak E. Biopharmaceutical availability of sulphadicramide from ocular ointments in vitro. Eur J Pharm Sci 1998;6:247-53.
66. Qi H, Chen W, Huang C, Li L, Chen C, Li W, et al. Development of a poloxamer analogs / carbopol based in situ gelling and mucoadhesive ophthalmic delivery system for puerain. Int j pharm 2007;337:178-87. (Pubitemid 46756045)
67. Jain D, Carvalho E, Banerjee R. Biodegradable hybrid polymeric membranes for ocular drug delivery. Acta Biomater 2010;6:1370-9.
68. Lux A, Maier S, Dinslay S, Suverkrup R, Diestelhorst M. A comparative bioavailability study of three conventional eye drops versus a single lyophilisate. Br J Ophthalmol 2003;87:436-40. (Pubitemid 36399032)
69. Perioli L, Ambrogi V, Pagano C, Sw S, Rossi C. Fg90 Chitosan as a new polymer for metronidazole mucoadhesive tablets for vaginal administration. Int J Pharm 2009;337:120-7.
70. Khanna N, Dalby R, Tan M, Arnold S, Stern J, Frazer N. Phase I/II clinical safety studies of terameprocol vaginal ointment. Gyn Oncol 2007;107:554-62. (Pubitemid 350160872)
71. Kim Yt, Shin BK, Garripelli VK, Kim JK, Davaa E, et al. a Thermosensitive vaginal gel formulation with hpõcd for the ph dependent release and solubilsation of amphotericin b. Eur J Pharm Sci 2010;9:399-406.
72. Yoo JW, Dharmala K, Lee CH. The physicodynamic properties of mucoadhesive polymeric films developed as female controlled drug delivery system. Int J Pharm 2006;309:139-45. (Pubitemid 43129476)
73. Yahagi R, Machida Y, Onishi H. Mucoadhesive suppositories of ramosetron hydrochloride utilizing carbopol. Int J Pharm 2000;193:205-12. (Pubitemid 30001863)
74. Available from: Http://www.medicines.org.uk/emc/medicine/7162/ spc/Anusol+Ointment/#excipients/Jun2010.htm [Last accessed on 2010 Aug 02].
75. Koffi AA, Agnely F, Ponchel G, Grossiord JL. Modulation of the rheological and mucoadhesive properties of thermosensitive poloxamer-based hydrogels intended for the rectal administration of quinine. Eur J Pharm Sci 2006;27:328-35. (Pubitemid 43143258)
76. Leede LG, Boer AG, Portzgen E, Feijen J, Breimer DD. Rate controlled rectal drug delivery in man with a hydrogel preparation. J Control Release 1986;4:17-24. (Pubitemid 16067604)
77. Anders R, Merkle HP. Evaluation of laminated mucoadhesive patches for buccal drug delivery. Int J Pharm 1989;49:231-40. (Pubitemid 19053414)
78. Woolfson AD, McCafferty DF, McCallion CR, McAdams ET, Anderson J. Moisture-activated, electrically-conducting bioadhesive hydrogels as interfaces for bio-electrodes: Effect of film hydration on cutaneous adherence in wet environments. J Appl Polym Sci 1995;58:1291-6.
79. Leung SHS, Robinson JA. Polyanionic polymers in bioadhesive and mucoadhesive drug delivery. ACS Symposium Series 1992;480:269-84.
80. Shojaei AH, Berner B, Xiaoling L. Transbuccal delivery of acyclovir: I. In vitro determination of routes of buccal transport. Pharm Res 1998;15:1182-8. (Pubitemid 28401707)
81. Al-Achi A, Greenwood R. Buccal administration of human insulin in streptozocin-diabetic rats. Res Commun Chem Pathol Pharmacol 1993;82:297-306. (Pubitemid 24017048)
82. Bouckaert S, Remon JP. In-vitro bioadhesion of a buccal, miconazole slow-release tablet. J Pharm Pharmacol 1993;45:504-7. (Pubitemid 23201429)
83. Perioli L, Ambrogi V, Giovagnoli S, Blasi P, Mancini A, Ricci M, et al. Influence of compression force on the behaviour of mucoadhesive buccal tablets. AAPS PharmSciTech 2008;9:274-81.
84. Shemer A, Amichai B, Trau H, Nathansohn N, Mizrahi B, Domb AJ. Efficacy of a mucoadhesive patch compared with an oral solution for treatment of aphthous stomatitis. Drugs R D 2008;9:29-35.
85. Medlicott NJ, Rathbone MJ, Tucker IJ, Holborow DW. Delivery systems for the administration of drugs to the periodontal pocket. Adv Drug Deliv Rev 1994;13:181-203. (Pubitemid 24032048)
86. Mizrahi B, Domb AJ. Mucoadhesive polymers for delivery of drugs to the oral cavity. Recent Pat Drug Deliv Formul 2008;2:108-19.
87. Andrews GP, Jones DS, Redpath JM, Woolfson AD. Characterisation of protein-containing binary polymeric gel systems designed for the treatment of periodontal disease. J Pharm Pharmacol 2004;56:S71-2.
88. Jones DS, Bruschi ML, de Freitas O, Gremiao MP, Lara EH, Andrews GP. Rheological, mechanical and mucoadhesive properties of thermoresponsive, bioadhesive binary mixtures composed of poloxamer 407 and carbopol 974P designed as platforms for implantable drug delivery systems for use in the oral cavity. Int J Pharm 2009;372:49-58.
89. 3M, 3M buccal drug delivery system [UKICRS Newsletter, 1998, Page 7.
90. Modi P, Mihic M, Lewin A. Evolving role of oral insulin in the treatment of diabetes using a novel rapidmist system. Diabetes Metab Res Rev 2002;18:38-42.
91. Nagai T, Machida Y. Bioadhesive dosage forms for nasal administration, Bioadhesive Drug Delivery Systems. In: Lenaerts V, Gurney R, editors. Florida; Boca Raton: CRC Press; 1990.
92. McInnes FJ, O'Mahony B, Lindsay B, Band J, Wilson CG, Hodges LA, et al. Nasal residence of insulin containing lyophilised nasal insert formulations, using gamma scintigraphy. Eur J Pharm Sci 2007;31:25-31. (Pubitemid 46601867)
93. Coucke D, Schotsaert M, Libert C, Pringels E, Vervaet C, Foreman P, et al. Spray-dried powders of starch and crosslinked poly(acrylic acid) as carriers for nasal delivery of inactivated influenza vaccine. Vaccine 2009;27:1279-86.
94. Kharenko EA, Larionova NI, Demina NB. Mucoadhesive drug delivery systems (Review) 43, 4, Pharm Chem J 2009;43:200-8.
95. Pavis H, Wilcock A, Edgecombe J, Carr D, Manderson C, Church A, et al. Pilot study of nasal morphinechitosan for the relief of breakthrough pain in patients with cancer. J Pain Symp Manag 2002;24:598-602. (Pubitemid 36120449)
96. Tzachev CT, Mandajieva M, Minkov EH, Popov TA. Comparison of the clinical efficacy of standard and mucoadhesive- based nasal decongestants. Br J Clin Pharmacol 2002;53:107-9. (Pubitemid 34117747)
97. Sensoy D, Cevher E, Sarici A, Yilmaz M, Ozdamar A, Bergisadi N. Bioadhesive sulfacetamide sodium microspheres: Evaluation of their effectiveness in the treatment of bacterial keratitis caused by Staphylococcus aureus and Pseudomonas aeruginosa in a rabbit model. Eur J Pharm Biopharm 2009;72:487-95.
98. de la Fuente M, Seijo B, Alonso MJ. Bioadhesive hyaluronan-chitosan nanoparticles can transport genes across the ocular mucosa and transfect ocular tissue. Gene Therapy 2009;15:668-76. (Pubitemid 351524521)
99. Baeyens V, Felt-Baeyens O, Rougier S, Pheulpin S, Boisrame B, Gurnya R. Clinical evaluation of bioadhesive ophthalmic drug inserts (BODI®) for the treatment of external ocular infections in dogs. J Control Release 2002;85:163-8. (Pubitemid 35449462)
100. Batchelor H. Formulation strategies in mucosal-adhesive drug delivery CRS Newsletter 2005;22:4-5.
101. Robinson JR, Bologna WJ. Vaginal and reproductive- system treatments using a bioadhesive polymer. J Control Release 1994;28:87-94. (Pubitemid 24104034)
102. O'Hagan DT, Rafferty D, Wharton S, Illum L. Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system. Vaccine 1993;11:660-4. (Pubitemid 23142624)
103. Bonucci E, Ballanti P, Ramires PA, Richardson JL, Benedetti LM. Prevention of ovariectomy osteopenia in rats after vaginal administration of Hyaff 11 microspheres containing salmon calcitonin. Calcif Tissue Intl 1995;56:274-9.
104. Alam MA, Ahmad FJ, Khan ZI, Khar RK, Ali M. Development and evaluation of acid-buffering bioadhesive vaginal Tablet for Mixed vaginal Infections. AAPS PharmSciTech 2007;8:109.
105. Cevher E, Taha MA, Orlu M, Araman A. Evaluation of mechanical and mucoadhesive properties of clomiphene citrate gel formulations containing carbomers and their thiolated derivatives. Drug Deliv 2008;15:57-67.
106. Available from: Http://www.clinicaltrials.gov. [Laat accessed on 2010 Aug 02].
107. Francois M, Snoeckx E, Putteman P, Wouters F, Proost E De, Delaet U, et al. A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole. AAPS PharmSci 2003;5:E5.
108. Kim JK, Kim MS, Park JS, Kim CK. Thermo-reversible flurbiprofen liquid suppository with HP-beta-CD as a solubility enhancer: Improvement of rectal bioavailability. J Incl Phenom Macrocycl Chem 2009;64:265-72.
109. Woolfson AD, McCafferty DF, McCarron PA, Price JH. A Bioadhesive patch cervical drug delivery system for the administration of 5-fluorouracil to cervical tissue. J Control Release 1995;35:49-58.
110. Woolfson AD, McCafferty DF, Moss GP. Development and characterisation of a moisture-activated bioadhesive drug delivery system for percutaneous local anaesthesia. Int J Pharm 1998;169:83-94. (Pubitemid 28352601)
111. Donnelly RF, McCarron PA, Zawislak A, Woolfson AD. Photodynamic therapy of vulval neoplasias and dysplasias: Design and evaluation of bioadhesive photosensitiser delivery systems. In: Verlag M, editor. Saarbrücken: VDM Publication; 2009. p. 78-400.
112. Ahmed IS, Ayres JW. Bioavailability of riboflavin from a gastric retention formulation. Int J Pharm 2007;330:146-54. (Pubitemid 46097370)
113. Salman HH, Gamazo C, Agueros M, Irache JM. Bioadhesive capacity and immunoadjuvant properties of thiamine-coated nanoparticles. Vaccine 2007;48:8123-32. (Pubitemid 350046324)