메뉴 건너뛰기




Volumn 21, Issue 27, 2015, Pages 3854-3866

Dry powder formulation of plasmid DNA and siRNA for inhalation

Author keywords

DNA; Dry powder; Pulmonary delivery; SiRNA; Spray drying; Spray freeze drying; Supercritical fluid

Indexed keywords

NUCLEIC ACID; PLASMID DNA; SMALL INTERFERING RNA; DNA; POWDER;

EID: 84947747408     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/1381612821666150820105916     Document Type: Article
Times cited : (28)

References (138)
  • 1
    • 0024411916 scopus 로고
    • Progress toward human gene therapy
    • Friedmann T. Progress toward human gene therapy. Science 1989; 244: 1275-81.
    • (1989) Science , vol.244 , pp. 1275-1281
    • Friedmann, T.1
  • 2
    • 0026718123 scopus 로고
    • Human gene therapy comes of age
    • Miller AD. Human gene therapy comes of age. Nature 1992; 357: 455-60.
    • (1992) Nature , vol.357 , pp. 455-460
    • Miller, A.D.1
  • 3
    • 22244459917 scopus 로고    scopus 로고
    • Gene therapy: Twenty-first century medicine
    • Verma IM, Weitzman MD. Gene therapy: twenty-first century medicine. Annu Rev Biochem 2005; 74: 711-38.
    • (2005) Annu Rev Biochem , vol.74 , pp. 711-738
    • Verma, I.M.1    Weitzman, M.D.2
  • 4
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/ shRNA therapeutics in clinical trials
    • Burnett JC, Rossi JJ, Tiemann K. Current progress of siRNA/ shRNA therapeutics in clinical trials. Biotechnol J 2011; 6: 1130- 46.
    • (2011) Biotechnol J , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 5
    • 80052228547 scopus 로고    scopus 로고
    • Nucleic acid aptamers: Clinical applications and promising new horizons
    • Ni X, Castanares M, Mukherjee A, Lupold SE. Nucleic acid aptamers: clinical applications and promising new horizons. Curr Med Chem 2011; 18: 4206-14.
    • (2011) Curr Med Chem , vol.18 , pp. 4206-4214
    • Ni, X.1    Castanares, M.2    Mukherjee, A.3    Lupold, S.E.4
  • 7
    • 33846914204 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: RNA aptamers
    • Que-Gewirth NS, Sullenger BA. Gene therapy progress and prospects: RNA aptamers. Gene Ther 2007; 14: 283-91.
    • (2007) Gene Ther , vol.14 , pp. 283-291
    • Que-Gewirth, N.S.1    Sullenger, B.A.2
  • 8
    • 11944267365 scopus 로고
    • Antisense oligonucleotides: A new therapeutic principle
    • Uhlmann E, Peyman A. Antisense oligonucleotides: a new therapeutic principle. Chem Rev 1990; 90: 543-84.
    • (1990) Chem Rev , vol.90 , pp. 543-584
    • Uhlmann, E.1    Peyman, A.2
  • 9
    • 0036787671 scopus 로고    scopus 로고
    • siRNA-mediated gene silencing in vitro and in vivo
    • Xia H, Mao Q, Paulson HL, Davidson BL. siRNA-mediated gene silencing in vitro and in vivo. Nat Biotechnol 2002; 20: 1006-10.
    • (2002) Nat Biotechnol , vol.20 , pp. 1006-1010
    • Xia, H.1    Mao, Q.2    Paulson, H.L.3    Davidson, B.L.4
  • 10
    • 33750809978 scopus 로고    scopus 로고
    • Prospects of RNA interference therapy in respiratory viral diseases: Update 2006
    • Barik S, Bitko V. Prospects of RNA interference therapy in respiratory viral diseases: update 2006. Expert Opin Biol Ther 2006; 6: 1151-60.
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 1151-1160
    • Barik, S.1    Bitko, V.2
  • 11
    • 84860348641 scopus 로고    scopus 로고
    • The promise, pitfalls and progress of RNAinterference- based antiviral therapy for respiratory viruses
    • DeVincenzo JP. The promise, pitfalls and progress of RNAinterference- based antiviral therapy for respiratory viruses. Antivir Ther 2012; 17: 213-25.
    • (2012) Antivir Ther , vol.17 , pp. 213-225
    • DeVincenzo, J.P.1
  • 12
    • 0037027911 scopus 로고    scopus 로고
    • Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis
    • Ferrari S, Geddes DM, Alton EW. Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis. Adv Drug Deliv Rev 2002; 54: 1373-93.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1373-1393
    • Ferrari, S.1    Geddes, D.M.2    Alton, E.W.3
  • 13
    • 2942530436 scopus 로고    scopus 로고
    • Inhibition of influenza virus production in virus-infected mice by RNA interference
    • Ge Q, Filip L, Bai A, Nguyen T, Eisen HN, Chen J. Inhibition of influenza virus production in virus-infected mice by RNA interference. Proc Natl Acad Sci USA 2004; 101: 8676-81.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8676-8681
    • Ge, Q.1    Filip, L.2    Bai, A.3    Nguyen, T.4    Eisen, H.N.5    Chen, J.6
  • 14
    • 0037418322 scopus 로고    scopus 로고
    • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    • Ge Q, McManus MT, Nguyen T, et al. RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc Natl Acad Sci USA 2003; 100: 2718-23.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2718-2723
    • Ge, Q.1    McManus, M.T.2    Nguyen, T.3
  • 15
    • 33745755929 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: Cystic fibrosis
    • Griesenbach U, Geddes DM, Alton EW. Gene therapy progress and prospects: cystic fibrosis. Gene Ther 2006; 13: 1061-7.
    • (2006) Gene Ther , vol.13 , pp. 1061-1067
    • Griesenbach, U.1    Geddes, D.M.2    Alton, E.W.3
  • 16
    • 0242694530 scopus 로고    scopus 로고
    • Current status of gene therapy for lung cancer and head and neck cancer
    • Moon C, Oh Y, Roth JA. Current status of gene therapy for lung cancer and head and neck cancer. Clin Cancer Res 2003; 9: 5055- 67.
    • (2003) Clin Cancer Res , vol.9 , pp. 5055-5067
    • Moon, C.1    Oh, Y.2    Roth, J.A.3
  • 18
    • 70349338939 scopus 로고    scopus 로고
    • Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease
    • Seguin RM, Ferrari N. Emerging oligonucleotide therapies for asthma and chronic obstructive pulmonary disease. Expert Opin Investig Drugs 2009; 18: 1505-17.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 1505-1517
    • Seguin, R.M.1    Ferrari, N.2
  • 19
    • 84866935335 scopus 로고    scopus 로고
    • Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology
    • Zarogouldis P, Karamanos NK, Porpodis K, et al. Vectors for inhaled gene therapy in lung cancer. Application for nano oncology and safety of bio nanotechnology. Int J Mol Sci 2012; 13: 10828- 62.
    • (2012) Int J Mol Sci , vol.13 , pp. 10828-10862
    • Zarogouldis, P.1    Karamanos, N.K.2    Porpodis, K.3
  • 20
    • 77950873888 scopus 로고    scopus 로고
    • Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis
    • Senoo T, Hattori N, Tanimoto T, et al. Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis. Thorax 2010; 65: 334-40.
    • (2010) Thorax , vol.65 , pp. 334-340
    • Senoo, T.1    Hattori, N.2    Tanimoto, T.3
  • 21
    • 84883403406 scopus 로고    scopus 로고
    • Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation
    • Goh FY, Cook KL, Upton N, et al. Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation. J Immunol 2013; 191: 2691-9.
    • (2013) J Immunol , vol.191 , pp. 2691-2699
    • Goh, F.Y.1    Cook, K.L.2    Upton, N.3
  • 22
    • 28244480458 scopus 로고    scopus 로고
    • Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis
    • Perl M, Chung CS, Lomas-Neira J, et al. Silencing of Fas, but not caspase-8, in lung epithelial cells ameliorates pulmonary apoptosis, inflammation, and neutrophil influx after hemorrhagic shock and sepsis. Am J Pathol 2005; 167: 1545-59.
    • (2005) Am J Pathol , vol.167 , pp. 1545-1559
    • Perl, M.1    Chung, C.S.2    Lomas-Neira, J.3
  • 23
    • 82955233645 scopus 로고    scopus 로고
    • Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense
    • Moschos SA, Frick M, Taylor B, et al. Uptake, efficacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol Ther 2011; 19: 2163-8.
    • (2011) Mol Ther , vol.19 , pp. 2163-2168
    • Moschos, S.A.1    Frick, M.2    Taylor, B.3
  • 24
    • 59849128456 scopus 로고    scopus 로고
    • Targeting the lung using siRNA and antisense based oligonucleotides
    • Moschos SA, Spinks K, Williams AE, Lindsay MA. Targeting the lung using siRNA and antisense based oligonucleotides. Curr Pharm Des 2008; 14: 3620-7.
    • (2008) Curr Pharm Des , vol.14 , pp. 3620-3627
    • Moschos, S.A.1    Spinks, K.2    Williams, A.E.3    Lindsay, M.A.4
  • 25
    • 54949095836 scopus 로고    scopus 로고
    • Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation
    • Robbins M, Judge A, Ambegia E, et al. Misinterpreting the therapeutic effects of small interfering RNA caused by immune stimulation. Hum Gene Ther 2008; 19: 991-9.
    • (2008) Hum Gene Ther , vol.19 , pp. 991-999
    • Robbins, M.1    Judge, A.2    Ambegia, E.3
  • 26
    • 77952688315 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus
    • DeVincenzo J, Lambkin-Williams R, Wilkinson T, et al. A randomized, double-blind, placebo-controlled study of an RNAi-based therapy directed against respiratory syncytial virus. Proc Natl Acad Sci USA 2010; 107: 8800-5.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 8800-8805
    • DeVincenzo, J.1    Lambkin-Williams, R.2    Wilkinson, T.3
  • 27
    • 78349243640 scopus 로고    scopus 로고
    • Viral load drives disease in humans experimentally infected with respiratory syncytial virus
    • DeVincenzo JP, Wilkinson T, Vaishnaw A, et al. Viral load drives disease in humans experimentally infected with respiratory syncytial virus. Am J Respir Crit Care Med 2010; 182: 1305-14.
    • (2010) Am J Respir Crit Care Med , vol.182 , pp. 1305-1314
    • DeVincenzo, J.P.1    Wilkinson, T.2    Vaishnaw, A.3
  • 28
    • 60649098297 scopus 로고    scopus 로고
    • Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence
    • Mizuno T, Mohri K, Nasu S, Danjo K, Okamoto H. Dual imaging of pulmonary delivery and gene expression of dry powder inhalant by fluorescence and bioluminescence. J Control Release 2009; 134: 149-54.
    • (2009) J Control Release , vol.134 , pp. 149-154
    • Mizuno, T.1    Mohri, K.2    Nasu, S.3    Danjo, K.4    Okamoto, H.5
  • 29
    • 0037309687 scopus 로고    scopus 로고
    • Pulmonary gene delivery by chitosan-pDNA complex powder prepared by a supercritical carbon dioxide process
    • Okamoto H, Nishida S, Todo H, Sakakura Y, Iida K, Danjo K. Pulmonary gene delivery by chitosan-pDNA complex powder prepared by a supercritical carbon dioxide process. J Pharm Sci 2003; 92: 371-80.
    • (2003) J Pharm Sci , vol.92 , pp. 371-380
    • Okamoto, H.1    Nishida, S.2    Todo, H.3    Sakakura, Y.4    Iida, K.5    Danjo, K.6
  • 30
    • 84862668679 scopus 로고    scopus 로고
    • Controlled pulmonary drug and gene delivery using polymeric nano-carriers
    • Beck-Broichsitter M, Merkel OM, Kissel T. Controlled pulmonary drug and gene delivery using polymeric nano-carriers. J Control Release 2012; 161: 214-24.
    • (2012) J Control Release , vol.161 , pp. 214-224
    • Beck-Broichsitter, M.1    Merkel, O.M.2    Kissel, T.3
  • 33
    • 84855977468 scopus 로고    scopus 로고
    • Pulmonary gene delivery using polymeric nonviral vectors
    • Merkel OM, Zheng M, Debus H, Kissel T. Pulmonary gene delivery using polymeric nonviral vectors. Bioconjug Chem 2012; 23: 3- 20.
    • (2012) Bioconjug Chem , vol.23 , pp. 3-20
    • Merkel, O.M.1    Zheng, M.2    Debus, H.3    Kissel, T.4
  • 35
    • 84898024686 scopus 로고    scopus 로고
    • Advances in metered dose inhaler technology: Hardware development
    • Stein SW, Sheth P, Hodson PD, Myrdal PB. Advances in metered dose inhaler technology: hardware development. AAPS Pharm- SciTech 2014; 15: 326-38.
    • (2014) AAPS Pharm- SciTech , vol.15 , pp. 326-338
    • Stein, S.W.1    Sheth, P.2    Hodson, P.D.3    Myrdal, P.B.4
  • 36
    • 79251640422 scopus 로고    scopus 로고
    • A review of major chlorofluorocarbons and their halocarbon alternatives in the air
    • Kim K-H, Shon Z-H, Nguyen HT, Jeon EC. A review of major chlorofluorocarbons and their halocarbon alternatives in the air. Atmos Environ 2011; 45: 1369-82.
    • (2011) Atmos Environ , vol.45 , pp. 1369-1382
    • Kim, K.-H.1    Shon, Z.-H.2    Nguyen, H.T.3    Jeon, E.C.4
  • 37
    • 28444482423 scopus 로고    scopus 로고
    • An overview of environmental hazards and exposure risk of hydrofluorocarbons (HFCs)
    • Tsai WT. An overview of environmental hazards and exposure risk of hydrofluorocarbons (HFCs). Chemosphere 2005; 61: 1539-47.
    • (2005) Chemosphere , vol.61 , pp. 1539-1547
    • Tsai, W.T.1
  • 38
    • 0032790248 scopus 로고    scopus 로고
    • Drug-surfactant-propellant interactions in HFA-formulations
    • Vervaet C, Byron PR. Drug-surfactant-propellant interactions in HFA-formulations. Int J Pharm 1999; 186: 13-30.
    • (1999) Int J Pharm , vol.186 , pp. 13-30
    • Vervaet, C.1    Byron, P.R.2
  • 39
    • 84898037878 scopus 로고    scopus 로고
    • Advances in metered dose inhaler technology: Formulation development
    • Myrdal PB, Sheth P, Stein SW. Advances in metered dose inhaler technology: formulation development. AAPS PharmSciTech 2014; 15: 434-55.
    • (2014) AAPS PharmSciTech , vol.15 , pp. 434-455
    • Myrdal, P.B.1    Sheth, P.2    Stein, S.W.3
  • 41
    • 0035719828 scopus 로고    scopus 로고
    • The lung as a route for systemic delivery of therapeutic proteins and peptides
    • Agu RU, Ugwoke MI, Armand M, Kinget R, Verbeke N. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir Res 2001; 2: 198-209.
    • (2001) Respir Res , vol.2 , pp. 198-209
    • Agu, R.U.1    Ugwoke, M.I.2    Armand, M.3    Kinget, R.4    Verbeke, N.5
  • 42
    • 0036373350 scopus 로고    scopus 로고
    • The role of particle properties in pharmaceutical powder inhalation formulations
    • Chew NY, Chan HK. The role of particle properties in pharmaceutical powder inhalation formulations. J Aerosol Med 2002; 15: 325- 30.
    • (2002) J Aerosol Med , vol.15 , pp. 325-330
    • Chew, N.Y.1    Chan, H.K.2
  • 43
    • 84902381555 scopus 로고    scopus 로고
    • That's cool!--Nebulization of thermolabile proteins with a cooled vibrating mesh nebulizer
    • Hertel S, Pohl T, Friess W, Winter G. That's cool!--Nebulization of thermolabile proteins with a cooled vibrating mesh nebulizer. Eur J Pharm Biopharm 2014; 87: 357-65.
    • (2014) Eur J Pharm Biopharm , vol.87 , pp. 357-365
    • Hertel, S.1    Pohl, T.2    Friess, W.3    Winter, G.4
  • 44
    • 0038581578 scopus 로고    scopus 로고
    • Stability analysis for long-term storage of naked DNA: Impact on nonviral in vivo gene transfer
    • Walther W, Stein U, Voss C, Schmidt T, Schleef M, Schlag PM. Stability analysis for long-term storage of naked DNA: impact on nonviral in vivo gene transfer. Anal Biochem 2003; 318: 230-5.
    • (2003) Anal Biochem , vol.318 , pp. 230-235
    • Walther, W.1    Stein, U.2    Voss, C.3    Schmidt, T.4    Schleef, M.5    Schlag, P.M.6
  • 45
    • 0038826781 scopus 로고    scopus 로고
    • Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers
    • Newhouse MT, Hirst PH, Duddu SP, et al. Inhalation of a dry powder tobramycin PulmoSphere formulation in healthy volunteers. Chest 2003; 124: 360-6.
    • (2003) Chest , vol.124 , pp. 360-366
    • Newhouse, M.T.1    Hirst, P.H.2    Duddu, S.P.3
  • 46
    • 70249104706 scopus 로고    scopus 로고
    • Delivery of antibiotics to the respiratory tract: An update
    • Traini D, Young PM. Delivery of antibiotics to the respiratory tract: an update. Expert Opin Drug Deliv 2009; 6: 897-905.
    • (2009) Expert Opin Drug Deliv , vol.6 , pp. 897-905
    • Traini, D.1    Young, P.M.2
  • 48
    • 84908259448 scopus 로고    scopus 로고
    • Emerging inhalation aerosol devices and strategies: Where are we headed?
    • Zhou QT, Tang P, Leung SS, Chan JG, Chan HK. Emerging inhalation aerosol devices and strategies: where are we headed? Adv Drug Deliv Rev 2014; 75: 3-17.
    • (2014) Adv Drug Deliv Rev , vol.75 , pp. 3-17
    • Zhou, Q.T.1    Tang, P.2    Leung, S.S.3    Chan, J.G.4    Chan, H.K.5
  • 49
    • 77952744763 scopus 로고    scopus 로고
    • Formulation strategy and use of excipients in pulmonary drug delivery
    • Pilcer G, Amighi K. Formulation strategy and use of excipients in pulmonary drug delivery. Int J Pharm 2010; 392: 1-19.
    • (2010) Int J Pharm , vol.392 , pp. 1-19
    • Pilcer, G.1    Amighi, K.2
  • 50
    • 0019732965 scopus 로고
    • Retention of microspheres in the rat lung after intratracheal instillation
    • Snipes MB, Clem MF. Retention of microspheres in the rat lung after intratracheal instillation. Environ Res 1981; 24: 33-41.
    • (1981) Environ Res , vol.24 , pp. 33-41
    • Snipes, M.B.1    Clem, M.F.2
  • 51
    • 84880446740 scopus 로고    scopus 로고
    • Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique
    • Okuda T, Kito D, Oiwa A, Fukushima M, Hira D, Okamoto H. Gene silencing in a mouse lung metastasis model by an inhalable dry small interfering RNA powder prepared using the supercritical carbon dioxide technique. Biol Pharm Bull 2013; 36: 1183-91.
    • (2013) Biol Pharm Bull , vol.36 , pp. 1183-1191
    • Okuda, T.1    Kito, D.2    Oiwa, A.3    Fukushima, M.4    Hira, D.5    Okamoto, H.6
  • 52
    • 0033043629 scopus 로고    scopus 로고
    • Protein inhalation powders: Spray drying vs spray freeze drying
    • Maa YF, Nguyen PA, Sweeney T, Shire SJ, Hsu CC. Protein inhalation powders: spray drying vs spray freeze drying. Pharm Res 1999; 16: 249-54.
    • (1999) Pharm Res , vol.16 , pp. 249-254
    • Maa, Y.F.1    Nguyen, P.A.2    Sweeney, T.3    Shire, S.J.4    Hsu, C.C.5
  • 53
    • 52449131110 scopus 로고    scopus 로고
    • The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations
    • Adi H, Traini D, Chan HK, Young PM. The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations. J Pharm Sci 2008; 97: 2780-8.
    • (2008) J Pharm Sci , vol.97 , pp. 2780-2788
    • Adi, H.1    Traini, D.2    Chan, H.K.3    Young, P.M.4
  • 54
    • 0034750024 scopus 로고    scopus 로고
    • Use of solid corrugated particles to enhance powder aerosol performance
    • Chew NY, Chan HK. Use of solid corrugated particles to enhance powder aerosol performance. Pharm Res 2001; 18: 1570-7.
    • (2001) Pharm Res , vol.18 , pp. 1570-1577
    • Chew, N.Y.1    Chan, H.K.2
  • 55
    • 79955603054 scopus 로고    scopus 로고
    • Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery
    • Kwok PC, Tunsirikongkon A, Glover W, Chan HK. Formation of protein nano-matrix particles with controlled surface architecture for respiratory drug delivery. Pharm Res 2011; 28: 788-96.
    • (2011) Pharm Res , vol.28 , pp. 788-796
    • Kwok, P.C.1    Tunsirikongkon, A.2    Glover, W.3    Chan, H.K.4
  • 56
    • 42049094490 scopus 로고    scopus 로고
    • Pharmaceutical particle engineering via spray drying
    • Vehring R. Pharmaceutical particle engineering via spray drying. Pharm Res 2008; 25: 999-1022.
    • (2008) Pharm Res , vol.25 , pp. 999-1022
    • Vehring, R.1
  • 57
    • 0028260848 scopus 로고
    • Production of spray dried salbutamol sulphate for use in dry powder aerosol formulation
    • Chawla A, Taylor KMG, Newton JM, Johnson MCR. Production of spray dried salbutamol sulphate for use in dry powder aerosol formulation. Int J Pharm 1994; 108: 233-40.
    • (1994) Int J Pharm , vol.108 , pp. 233-240
    • Chawla, A.1    Taylor, K.M.G.2    Newton, J.M.3    Johnson, M.C.R.4
  • 58
    • 0141798534 scopus 로고    scopus 로고
    • Statistical modeling of protein spray drying at the lab scale
    • Prinn KB, Costantino HR, Tracy M. Statistical modeling of protein spray drying at the lab scale. AAPS PharmSciTech 2002; 3: E4.
    • (2002) AAPS PharmSciTech , vol.3
    • Prinn, K.B.1    Costantino, H.R.2    Tracy, M.3
  • 59
    • 84856544900 scopus 로고    scopus 로고
    • Optimization of a spray drying process to prepare dry powder microparticles containing plasmid nanocomplex
    • Mohajel N, Najafabadi AR, Azadmanesh K, et al. Optimization of a spray drying process to prepare dry powder microparticles containing plasmid nanocomplex. Int J Pharm 2012; 423: 577-85.
    • (2012) Int J Pharm , vol.423 , pp. 577-585
    • Mohajel, N.1    Najafabadi, A.R.2    Azadmanesh, K.3
  • 60
    • 36549097687 scopus 로고
    • Fracture of polymer chains in extensional flow: Experiments with DNA, and a molecular-dynamics simulation
    • Reese HR, Zimm BH. Fracture of polymer chains in extensional flow: Experiments with DNA, and a molecular-dynamics simulation. J Chem Phys 1990; 92: 2650-62.
    • (1990) J Chem Phys , vol.92 , pp. 2650-2662
    • Reese, H.R.1    Zimm, B.H.2
  • 61
    • 0037355596 scopus 로고    scopus 로고
    • The effect of protective agents on the stability of plasmid DNA by the process of spray-drying
    • Kuo JH. The effect of protective agents on the stability of plasmid DNA by the process of spray-drying. J Pharm Pharmacol 2003; 55: 301-6.
    • (2003) J Pharm Pharmacol , vol.55 , pp. 301-306
    • Kuo, J.H.1
  • 62
    • 0037124544 scopus 로고    scopus 로고
    • A thermodynamic study of cationic polymer-plasmid DNA complexes by highly-sensitive differential scanning calorimetry
    • Kuo JH, Lo YL, Shau MD, Cherng JY. A thermodynamic study of cationic polymer-plasmid DNA complexes by highly-sensitive differential scanning calorimetry. J Control Release 2002; 81: 321-5.
    • (2002) J Control Release , vol.81 , pp. 321-325
    • Kuo, J.H.1    Lo, Y.L.2    Shau, M.D.3    Cherng, J.Y.4
  • 63
    • 84864403732 scopus 로고    scopus 로고
    • The use of artificial neural network to predict exergetic performance of spray drying process: A preliminary study
    • Aghbashlo M, Mobli H, Rafiee S, Madadlou A. The use of artificial neural network to predict exergetic performance of spray drying process: A preliminary study. Comput Electron Agr 2012; 88: 32-43.
    • (2012) Comput Electron Agr , vol.88 , pp. 32-43
    • Aghbashlo, M.1    Mobli, H.2    Rafiee, S.3    Madadlou, A.4
  • 64
  • 65
    • 15944418284 scopus 로고    scopus 로고
    • The use of amino acids to enhance the aerosolisation of spray-dried powders for pulmonary gene therapy
    • Li HY, Seville PC, Williamson IJ, Birchall JC. The use of amino acids to enhance the aerosolisation of spray-dried powders for pulmonary gene therapy. J Gene Med 2005; 7: 343-53.
    • (2005) J Gene Med , vol.7 , pp. 343-353
    • Li, H.Y.1    Seville, P.C.2    Williamson, I.J.3    Birchall, J.C.4
  • 66
    • 84903755570 scopus 로고    scopus 로고
    • Drying of a plasmid containing formulation: Chitosan as a protecting agent
    • Mohajel N, Najafabadi AR, Azadmanesh K, et al. Drying of a plasmid containing formulation: chitosan as a protecting agent. Daru 2012; 20: 22.
    • (2012) Daru , vol.20 , pp. 22
    • Mohajel, N.1    Najafabadi, A.R.2    Azadmanesh, K.3
  • 67
    • 23944455043 scopus 로고    scopus 로고
    • The use of absorption enhancers to enhance the dispersibility of spray-dried powders for pulmonary gene therapy
    • Li HY, Seville PC, Williamson IJ, Birchall JC. The use of absorption enhancers to enhance the dispersibility of spray-dried powders for pulmonary gene therapy. J Gene Med 2005; 7: 1035-43.
    • (2005) J Gene Med , vol.7 , pp. 1035-1043
    • Li, H.Y.1    Seville, P.C.2    Williamson, I.J.3    Birchall, J.C.4
  • 68
    • 33646892850 scopus 로고    scopus 로고
    • Chitosan-modified dry powder formulations for pulmonary gene delivery
    • Li HY, Birchall J. Chitosan-modified dry powder formulations for pulmonary gene delivery. Pharm Res 2006; 23: 941-50.
    • (2006) Pharm Res , vol.23 , pp. 941-950
    • Li, H.Y.1    Birchall, J.2
  • 69
    • 84896691375 scopus 로고    scopus 로고
    • Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids
    • Liang W, Kwok PC, Chow MY, et al. Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids. Eur J Pharm Biopharm 2014; 86: 64-73.
    • (2014) Eur J Pharm Biopharm , vol.86 , pp. 64-73
    • Liang, W.1    Kwok, P.C.2    Chow, M.Y.3
  • 70
    • 84924039536 scopus 로고    scopus 로고
    • Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus
    • Liang W, Chow MY, Lau PN, et al. Inhalable dry powder formulations of siRNA and pH responsive peptides with antiviral activity against H1N1 influenza virus. Mol Pharm 2015; 12(3): 910-21.
    • (2015) Mol Pharm , vol.12 , Issue.3 , pp. 910-921
    • Liang, W.1    Chow, M.Y.2    Lau, P.N.3
  • 72
    • 84855837134 scopus 로고    scopus 로고
    • Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA
    • Jensen DK, Jensen LB, Koocheki S, et al. Design of an inhalable dry powder formulation of DOTAP-modified PLGA nanoparticles loaded with siRNA. J Control Release 2012; 157: 141-8.
    • (2012) J Control Release , vol.157 , pp. 141-148
    • Jensen, D.K.1    Jensen, L.B.2    Koocheki, S.3
  • 73
    • 84859106992 scopus 로고    scopus 로고
    • Constant size, variable density aerosol particles by ultrasonic spray freeze drying
    • D'Addio SM, Chan JG, Kwok PC, Prud'homme RK, Chan HK. Constant size, variable density aerosol particles by ultrasonic spray freeze drying. Int J Pharm 2012; 427: 185-91.
    • (2012) Int J Pharm , vol.427 , pp. 185-191
    • D'Addio, S.M.1    Chan, J.G.2    Kwok, P.C.3    Prud'homme, R.K.4    Chan, H.K.5
  • 74
    • 1042292677 scopus 로고    scopus 로고
    • Preparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: Effect of protective agents (polyethyleneimine and sugars) on the stability of DNA
    • Kuo JH, Hwang R. Preparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: effect of protective agents (polyethyleneimine and sugars) on the stability of DNA. J Pharm Pharmacol 2004; 56: 27-33.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 27-33
    • Kuo, J.H.1    Hwang, R.2
  • 75
    • 0034495318 scopus 로고    scopus 로고
    • Protein sprayfreeze drying. Effect of atomization conditions on particle size and stability
    • Costantino HR, Firouzabadian L, Hogeland K, et al. Protein sprayfreeze drying. Effect of atomization conditions on particle size and stability. Pharm Res 2000; 17: 1374-83.
    • (2000) Pharm Res , vol.17 , pp. 1374-1383
    • Costantino, H.R.1    Firouzabadian, L.2    Hogeland, K.3
  • 76
    • 0036281804 scopus 로고    scopus 로고
    • Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations
    • Webb SD, Golledge SL, Cleland JL, Carpenter JF, Randolph TW. Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations. J Pharm Sci 2002; 91: 1474-87.
    • (2002) J Pharm Sci , vol.91 , pp. 1474-1487
    • Webb, S.D.1    Golledge, S.L.2    Cleland, J.L.3    Carpenter, J.F.4    Randolph, T.W.5
  • 77
    • 28444436280 scopus 로고    scopus 로고
    • Spray freezing into liquid versus spray-freeze drying: Influence of atomization on protein aggregation and biological activity
    • Yu Z, Johnston KP, Williams RO, 3rd. Spray freezing into liquid versus spray-freeze drying: influence of atomization on protein aggregation and biological activity. Eur J Pharm Sci 2006; 27: 9-18.
    • (2006) Eur J Pharm Sci , vol.27 , pp. 9-18
    • Yu, Z.1    Johnston, K.P.2    Williams, R.O.3
  • 78
    • 68949085125 scopus 로고    scopus 로고
    • Mechanisms of protein stabilization in the solid state
    • Chang LL, Pikal MJ. Mechanisms of protein stabilization in the solid state. J Pharm Sci 2009; 98: 2886-908.
    • (2009) J Pharm Sci , vol.98 , pp. 2886-2908
    • Chang, L.L.1    Pikal, M.J.2
  • 79
    • 0034730570 scopus 로고    scopus 로고
    • Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: The particle isolation hypothesis
    • Allison SD, Molina MC, Anchordoquy TJ. Stabilization of lipid/DNA complexes during the freezing step of the lyophilization process: the particle isolation hypothesis. Biochim Biophys Acta 2000; 1468: 127-38.
    • (2000) Biochim Biophys Acta , vol.1468 , pp. 127-138
    • Allison, S.D.1    Molina, M.C.2    Anchordoquy, T.J.3
  • 80
    • 23844447975 scopus 로고    scopus 로고
    • Mechanism of protein stabilization by sugars during freeze-drying and storage: Native structure preservation, specific interaction, and/or immobilization in a glassy matrix?
    • Chang L, Shepherd D, Sun J, et al. Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix? J Pharm Sci 2005; 94: 1427-44.
    • (2005) J Pharm Sci , vol.94 , pp. 1427-1444
    • Chang, L.1    Shepherd, D.2    Sun, J.3
  • 82
    • 77952670572 scopus 로고    scopus 로고
    • Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation
    • Mohri K, Okuda T, Mori A, Danjo K, Okamoto H. Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation. J Control Release 2010; 144: 221-6.
    • (2010) J Control Release , vol.144 , pp. 221-226
    • Mohri, K.1    Okuda, T.2    Mori, A.3    Danjo, K.4    Okamoto, H.5
  • 83
    • 84863539162 scopus 로고    scopus 로고
    • Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method
    • Tsukamoto M, Okuda T, Okamoto H, et al. Bovine serum albumin as a lyoprotectant for preparation of DNA dry powder formulations using the spray-freeze drying method. Biol Pharm Bull 2012; 35: 1178-81.
    • (2012) Biol Pharm Bull , vol.35 , pp. 1178-1181
    • Tsukamoto, M.1    Okuda, T.2    Okamoto, H.3
  • 85
    • 33750804217 scopus 로고    scopus 로고
    • Particle engineering techniques for inhaled biopharmaceuticals
    • Shoyele SA, Cawthorne S. Particle engineering techniques for inhaled biopharmaceuticals. Adv Drug Deliv Rev 2006; 58: 1009- 29.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 1009-1029
    • Shoyele, S.A.1    Cawthorne, S.2
  • 86
    • 49549099754 scopus 로고    scopus 로고
    • Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids
    • Cape SP, Villa JA, Huang ET, Yang TH, Carpenter JF, Sievers RE. Preparation of active proteins, vaccines and pharmaceuticals as fine powders using supercritical or near-critical fluids. Pharm Res 2008; 25: 1967-90.
    • (2008) Pharm Res , vol.25 , pp. 1967-1990
    • Cape, S.P.1    Villa, J.A.2    Huang, E.T.3    Yang, T.H.4    Carpenter, J.F.5    Sievers, R.E.6
  • 87
    • 36048983812 scopus 로고    scopus 로고
    • Stable sugar-based protein formulations by supercritical fluid drying
    • Jovanovic N, Bouchard A, Sutter M, et al. Stable sugar-based protein formulations by supercritical fluid drying. Int J Pharm 2008; 346: 102-8.
    • (2008) Int J Pharm , vol.346 , pp. 102-108
    • Jovanovic, N.1    Bouchard, A.2    Sutter, M.3
  • 88
    • 38949106175 scopus 로고    scopus 로고
    • Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation
    • Okamoto H, Danjo K. Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation. Adv Drug Deliv Rev 2008; 60: 433-46.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 433-446
    • Okamoto, H.1    Danjo, K.2
  • 89
    • 0001860822 scopus 로고    scopus 로고
    • Formation of small organic particles by RESS: Experimental and theoretical investigations
    • Türk M. Formation of small organic particles by RESS: experimental and theoretical investigations. J Supercrit Fluids 1999; 15: 79- 89.
    • (1999) J Supercrit Fluids , vol.15 , pp. 79-89
    • Türk, M.1
  • 90
    • 27644576801 scopus 로고    scopus 로고
    • Formation of ultrafine aspirin particles through rapid expansion of supercritical solutions (RESS)
    • Huang Z, Sun G-B, Chiew YC, Kawi S. Formation of ultrafine aspirin particles through rapid expansion of supercritical solutions (RESS). Powder Technol 2005; 160: 127-34.
    • (2005) Powder Technol , vol.160 , pp. 127-134
    • Huang, Z.1    Sun, G.-B.2    Chiew, Y.C.3    Kawi, S.4
  • 92
    • 39149138682 scopus 로고    scopus 로고
    • Particle design of poorly water-soluble drug substances using supercritical fluid technologies
    • Yasuji T, Takeuchi H, Kawashima Y. Particle design of poorly water-soluble drug substances using supercritical fluid technologies. Adv Drug Deliv Rev 2008; 60: 388-98.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 388-398
    • Yasuji, T.1    Takeuchi, H.2    Kawashima, Y.3
  • 93
    • 12344298504 scopus 로고    scopus 로고
    • Stability of chitosanpDNA complex powder prepared by supercritical carbon dioxide process
    • Okamoto H, Sakakura Y, Shiraki K, et al. Stability of chitosanpDNA complex powder prepared by supercritical carbon dioxide process. Int J Pharm 2005; 290: 73-81.
    • (2005) Int J Pharm , vol.290 , pp. 73-81
    • Okamoto, H.1    Sakakura, Y.2    Shiraki, K.3
  • 94
    • 79952986481 scopus 로고    scopus 로고
    • Chitosan- interferon-beta gene complex powder for inhalation treatment of lung metastasis in mice
    • Okamoto H, Shiraki K, Yasuda R, Danjo K, Watanabe Y. Chitosan- interferon-beta gene complex powder for inhalation treatment of lung metastasis in mice. J Control Release 2011; 150: 187-95.
    • (2011) J Control Release , vol.150 , pp. 187-195
    • Okamoto, H.1    Shiraki, K.2    Yasuda, R.3    Danjo, K.4    Watanabe, Y.5
  • 95
    • 33846474236 scopus 로고    scopus 로고
    • Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity
    • Bouchard A, Jovanović N, Jiskoot W, et al. Lysozyme particle formation during supercritical fluid drying: Particle morphology and molecular integrity. J Supercrit Fluids 2007; 40: 293-307.
    • (2007) J Supercrit Fluids , vol.40 , pp. 293-307
    • Bouchard, A.1    Jovanović, N.2    Jiskoot, W.3
  • 96
    • 2142646383 scopus 로고    scopus 로고
    • Optimisation of powders for pulmonary delivery using supercritical fluid technology
    • Rehman M, Shekunov BY, York P, et al. Optimisation of powders for pulmonary delivery using supercritical fluid technology. Eur J Pharm Sci 2004; 22: 1-17.
    • (2004) Eur J Pharm Sci , vol.22 , pp. 1-17
    • Rehman, M.1    Shekunov, B.Y.2    York, P.3
  • 97
    • 0034875112 scopus 로고    scopus 로고
    • Current issues relating to antisolvent micronisation techniques and their extension to industrial scales
    • Thiering R, Dehghani F, Foster NR. Current issues relating to antisolvent micronisation techniques and their extension to industrial scales. J Supercrit Fluids 2001; 21: 159-77.
    • (2001) J Supercrit Fluids , vol.21 , pp. 159-177
    • Thiering, R.1    Dehghani, F.2    Foster, N.R.3
  • 98
    • 53949105869 scopus 로고    scopus 로고
    • Non-viral dried powders for respiratory gene delivery prepared by cationic and chitosan loaded liposomes
    • Colonna C, Conti B, Genta I, Alpar OH. Non-viral dried powders for respiratory gene delivery prepared by cationic and chitosan loaded liposomes. Int J Pharm 2008; 364: 108-18.
    • (2008) Int J Pharm , vol.364 , pp. 108-118
    • Colonna, C.1    Conti, B.2    Genta, I.3    Alpar, O.H.4
  • 99
    • 1542615793 scopus 로고    scopus 로고
    • Protein powders for encapsulation: A comparison of spray-freeze drying and spray drying of darbepoetin alfa
    • Nguyen XC, Herberger JD, Burke PA. Protein powders for encapsulation: a comparison of spray-freeze drying and spray drying of darbepoetin alfa. Pharm Res 2004; 21: 507-14.
    • (2004) Pharm Res , vol.21 , pp. 507-514
    • Nguyen, X.C.1    Herberger, J.D.2    Burke, P.A.3
  • 100
    • 80052475487 scopus 로고    scopus 로고
    • A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions
    • Dontireddy R, Crean AM. A comparative study of spray-dried and freeze-dried hydrocortisone/polyvinyl pyrrolidone solid dispersions. Drug Dev Ind Pharm 2011; 37: 1141-9.
    • (2011) Drug Dev Ind Pharm , vol.37 , pp. 1141-1149
    • Dontireddy, R.1    Crean, A.M.2
  • 101
    • 67650806122 scopus 로고    scopus 로고
    • Particle characterization of poorly water-soluble drugs using a spray freeze drying technique
    • Kondo M, Niwa T, Okamoto H, Danjo K. Particle characterization of poorly water-soluble drugs using a spray freeze drying technique. Chem Pharm Bull (Tokyo) 2009; 57: 657-62.
    • (2009) Chem Pharm Bull (Tokyo) , vol.57 , pp. 657-662
    • Kondo, M.1    Niwa, T.2    Okamoto, H.3    Danjo, K.4
  • 104
    • 0034605693 scopus 로고    scopus 로고
    • Human lung deposition data: The bridge between in vitro and clinical evaluations for inhaled drug products?
    • Newman SP, Wilding IR, Hirst PH. Human lung deposition data: the bridge between in vitro and clinical evaluations for inhaled drug products? Int J Pharm 2000; 208: 49-60.
    • (2000) Int J Pharm , vol.208 , pp. 49-60
    • Newman, S.P.1    Wilding, I.R.2    Hirst, P.H.3
  • 105
    • 84908279497 scopus 로고    scopus 로고
    • Pulmonary drug delivery by powder aerosols
    • Yang MY, Chan JG, Chan HK. Pulmonary drug delivery by powder aerosols. J Control Release 2014; 193C: 228-40.
    • (2014) J Control Release , vol.193 C , pp. 228-240
    • Yang, M.Y.1    Chan, J.G.2    Chan, H.K.3
  • 106
    • 78650545991 scopus 로고    scopus 로고
    • In vitro and in vivo testing methods for respiratory drug delivery
    • Agu RU, Ugwoke MI. In vitro and in vivo testing methods for respiratory drug delivery. Expert Opin Drug Deliv 2011; 8: 57-69.
    • (2011) Expert Opin Drug Deliv , vol.8 , pp. 57-69
    • Agu, R.U.1    Ugwoke, M.I.2
  • 107
    • 1642515071 scopus 로고    scopus 로고
    • Cascade impactors for the size characterization of aerosols from medical inhalers: Their uses and limitations
    • Mitchell JP, Nagel MW. Cascade impactors for the size characterization of aerosols from medical inhalers: their uses and limitations. J Aerosol Med 2003; 16: 341-77.
    • (2003) J Aerosol Med , vol.16 , pp. 341-377
    • Mitchell, J.P.1    Nagel, M.W.2
  • 108
    • 38049138950 scopus 로고    scopus 로고
    • In vitro and in vivo aspects of cascade impactor tests and inhaler performance: A review
    • Mitchell J, Newman S, Chan HK. In vitro and in vivo aspects of cascade impactor tests and inhaler performance: a review. AAPS PharmSciTech 2007; 8: E110.
    • (2007) AAPS PharmSciTech , vol.8
    • Mitchell, J.1    Newman, S.2    Chan, H.K.3
  • 109
    • 79957692320 scopus 로고    scopus 로고
    • Formation, characterization, and fate of inhaled drug nanoparticles
    • Zhang J, Wu L, Chan HK, Watanabe W. Formation, characterization, and fate of inhaled drug nanoparticles. Adv Drug Deliv Rev 2011; 63: 441-55.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 441-455
    • Zhang, J.1    Wu, L.2    Chan, H.K.3    Watanabe, W.4
  • 110
    • 34249300511 scopus 로고    scopus 로고
    • Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics
    • Hickey AJ, Mansour HM, Telko MJ, et al. Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics. J Pharm Sci 2007; 96: 1282-301.
    • (2007) J Pharm Sci , vol.96 , pp. 1282-1301
    • Hickey, A.J.1    Mansour, H.M.2    Telko, M.J.3
  • 111
    • 84875684659 scopus 로고    scopus 로고
    • Treating mannitol in a saturated solution of mannitol: A novel approach to modify mannitol crystals for improved drug delivery to the lungs
    • Kaialy W, Nokhodchi A. Treating mannitol in a saturated solution of mannitol: a novel approach to modify mannitol crystals for improved drug delivery to the lungs. Int J Pharm 2013; 448: 58-70.
    • (2013) Int J Pharm , vol.448 , pp. 58-70
    • Kaialy, W.1    Nokhodchi, A.2
  • 112
    • 20044363723 scopus 로고    scopus 로고
    • The cohesiveadhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy
    • Begat P, Morton DA, Staniforth JN, Price R. The cohesiveadhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy. Pharm Res 2004; 21: 1591-7.
    • (2004) Pharm Res , vol.21 , pp. 1591-1597
    • Begat, P.1    Morton, D.A.2    Staniforth, J.N.3    Price, R.4
  • 113
    • 33747177115 scopus 로고    scopus 로고
    • Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids
    • Shah B, Kakumanu VK, Bansal AK. Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids. J Pharm Sci 2006; 95: 1641-65.
    • (2006) J Pharm Sci , vol.95 , pp. 1641-1665
    • Shah, B.1    Kakumanu, V.K.2    Bansal, A.K.3
  • 114
    • 0043170800 scopus 로고    scopus 로고
    • Characterisation and deposition studies of engineered lactose crystals with potential for use as a carrier for aerosolised salbutamol sulfate from dry powder inhalers
    • Larhrib H, Martin GP, Prime D, Marriott C. Characterisation and deposition studies of engineered lactose crystals with potential for use as a carrier for aerosolised salbutamol sulfate from dry powder inhalers. Eur J Pharm Sci 2003; 19: 211-21.
    • (2003) Eur J Pharm Sci , vol.19 , pp. 211-221
    • Larhrib, H.1    Martin, G.P.2    Prime, D.3    Marriott, C.4
  • 115
    • 79961107858 scopus 로고    scopus 로고
    • Optimization and characterization of dry powder of fanhuncaoin for inhalation based on selection of excipients
    • Yang XB, Wang XB, Pan WS, et al. Optimization and characterization of dry powder of fanhuncaoin for inhalation based on selection of excipients. Chem Pharm Bull (Tokyo) 2011; 59: 929-37.
    • (2011) Chem Pharm Bull (Tokyo) , vol.59 , pp. 929-937
    • Yang, X.B.1    Wang, X.B.2    Pan, W.S.3
  • 116
    • 70350608409 scopus 로고    scopus 로고
    • The characterization and comparison of spray-dried mannitol samples
    • Hulse WL, Forbes RT, Bonner MC, Getrost M. The characterization and comparison of spray-dried mannitol samples. Drug Dev Ind Pharm 2009; 35: 712-8.
    • (2009) Drug Dev Ind Pharm , vol.35 , pp. 712-718
    • Hulse, W.L.1    Forbes, R.T.2    Bonner, M.C.3    Getrost, M.4
  • 117
    • 79960921592 scopus 로고    scopus 로고
    • Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung
    • Pfeifer C, Hasenpusch G, Uezguen S, et al. Dry powder aerosols of polyethylenimine (PEI)-based gene vectors mediate efficient gene delivery to the lung. J Control Release 2011; 154: 69-76.
    • (2011) J Control Release , vol.154 , pp. 69-76
    • Pfeifer, C.1    Hasenpusch, G.2    Uezguen, S.3
  • 118
    • 21044450964 scopus 로고    scopus 로고
    • Comparison of postemulsification freeze drying or spray drying processes for the microencapsulation of plasmid DNA
    • Lane ME, Brennan FS, Corrigan OI. Comparison of postemulsification freeze drying or spray drying processes for the microencapsulation of plasmid DNA. J Pharm Pharmacol 2005; 57: 831-8.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 831-838
    • Lane, M.E.1    Brennan, F.S.2    Corrigan, O.I.3
  • 119
    • 0033959120 scopus 로고    scopus 로고
    • Human airway epithelial cell lines for in vitro drug transport and metabolism studies
    • Forbes II. Human airway epithelial cell lines for in vitro drug transport and metabolism studies. Pharm Sci Technolo Today 2000; 3: 18-27.
    • (2000) Pharm Sci Technolo Today , vol.3 , pp. 18-27
    • Forbes, I.I.1
  • 120
    • 84908253462 scopus 로고    scopus 로고
    • Carrier interactions with the biological barriers of the lung: Advanced in vitro models and challenges for pulmonary drug delivery
    • de Souza Carvalho C, Daum N, Lehr CM. Carrier interactions with the biological barriers of the lung: advanced in vitro models and challenges for pulmonary drug delivery. Adv Drug Deliv Rev 2014; 75: 129-40.
    • (2014) Adv Drug Deliv Rev , vol.75 , pp. 129-140
    • de Souza Carvalho, C.1    Daum, N.2    Lehr, C.M.3
  • 121
    • 0036632415 scopus 로고    scopus 로고
    • Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spraydrying
    • Seville PC, Kellaway IW, Birchall JC. Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spraydrying. J Gene Med 2002; 4: 428-37.
    • (2002) J Gene Med , vol.4 , pp. 428-437
    • Seville, P.C.1    Kellaway, I.W.2    Birchall, J.C.3
  • 122
    • 78650653743 scopus 로고    scopus 로고
    • The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia
    • Pezzulo AA, Starner TD, Scheetz TE, et al. The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia. Am J Physiol Lung Cell Mol Physiol 2011; 300: L25-31.
    • (2011) Am J Physiol Lung Cell Mol Physiol , vol.300 , pp. L25-L31
    • Pezzulo, A.A.1    Starner, T.D.2    Scheetz, T.E.3
  • 123
    • 84866317436 scopus 로고    scopus 로고
    • Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research
    • Stewart CE, Torr EE, Mohd Jamili NH, Bosquillon C, Sayers I. Evaluation of differentiated human bronchial epithelial cell culture systems for asthma research. J Allergy (Cairo) 2012; 2012: 943982.
    • (2012) J Allergy (Cairo) , vol.2012
    • Stewart, C.E.1    Torr, E.E.2    Mohd Jamili, N.H.3    Bosquillon, C.4    Sayers, I.5
  • 124
    • 84864496479 scopus 로고    scopus 로고
    • Evaluation of layers of the rat airway epithelial cell line RL- 65 for permeability screening of inhaled drug candidates
    • Hutter V, Hilgendorf C, Cooper A, Zann V, Pritchard DI, Bosquillon C. Evaluation of layers of the rat airway epithelial cell line RL- 65 for permeability screening of inhaled drug candidates. Eur J Pharm Sci 2012; 47: 481-9.
    • (2012) Eur J Pharm Sci , vol.47 , pp. 481-489
    • Hutter, V.1    Hilgendorf, C.2    Cooper, A.3    Zann, V.4    Pritchard, D.I.5    Bosquillon, C.6
  • 125
    • 59849094684 scopus 로고    scopus 로고
    • The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa
    • Grainger CI, Greenwell LL, Martin GP, Forbes B. The permeability of large molecular weight solutes following particle delivery to air-interfaced cells that model the respiratory mucosa. Eur J Pharm Biopharm 2009; 71: 318-24.
    • (2009) Eur J Pharm Biopharm , vol.71 , pp. 318-324
    • Grainger, C.I.1    Greenwell, L.L.2    Martin, G.P.3    Forbes, B.4
  • 126
    • 5644221318 scopus 로고    scopus 로고
    • Insights into the pathogenesis of asthma utilizing murine models
    • Taube C, Dakhama A, Gelfand EW. Insights into the pathogenesis of asthma utilizing murine models. Int Arch Allergy Immunol 2004; 135: 173-86.
    • (2004) Int Arch Allergy Immunol , vol.135 , pp. 173-186
    • Taube, C.1    Dakhama, A.2    Gelfand, E.W.3
  • 127
    • 0036644808 scopus 로고    scopus 로고
    • Pro: Mice are a good model of human airway disease
    • Gelfand EW. Pro: mice are a good model of human airway disease. Am J Respir Crit Care Med 2002; 166: 5-6.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 5-6
    • Gelfand, E.W.1
  • 128
    • 0026724473 scopus 로고
    • Techniques for drug delivery to the airways, and the assessment of lung function in animal models
    • Raeburn D, Underwood SL, Villamil ME. Techniques for drug delivery to the airways, and the assessment of lung function in animal models. J Pharmacol Toxicol Methods 1992; 27: 143-59.
    • (1992) J Pharmacol Toxicol Methods , vol.27 , pp. 143-159
    • Raeburn, D.1    Underwood, S.L.2    Villamil, M.E.3
  • 129
    • 0242432561 scopus 로고    scopus 로고
    • Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs
    • Nadithe V, Rahamatalla M, Finlay WH, Mercer JR, Samuel J. Evaluation of nose-only aerosol inhalation chamber and comparison of experimental results with mathematical simulation of aerosol deposition in mouse lungs. J Pharm Sci 2003; 92: 1066-76.
    • (2003) J Pharm Sci , vol.92 , pp. 1066-1076
    • Nadithe, V.1    Rahamatalla, M.2    Finlay, W.H.3    Mercer, J.R.4    Samuel, J.5
  • 130
    • 12844263484 scopus 로고    scopus 로고
    • Design and evaluation of a restraint-free small animal inhalation dosing chamber
    • McConville JT, Williams RO 3rd, Carvalho TC, et al. Design and evaluation of a restraint-free small animal inhalation dosing chamber. Drug Dev Ind Pharm 2005; 31: 35-42.
    • (2005) Drug Dev Ind Pharm , vol.31 , pp. 35-42
    • McConville, J.T.1    Williams, R.O.2    Carvalho, T.C.3
  • 131
    • 84255182796 scopus 로고    scopus 로고
    • Development of an inhalation chamber and a dry powder inhaler device for administration of pulmonary medication in animal model
    • Sinha B, Mukherjee B. Development of an inhalation chamber and a dry powder inhaler device for administration of pulmonary medication in animal model. Drug Dev Ind Pharm 2012; 38: 171-9.
    • (2012) Drug Dev Ind Pharm , vol.38 , pp. 171-179
    • Sinha, B.1    Mukherjee, B.2
  • 133
    • 0032794416 scopus 로고    scopus 로고
    • A method of endotracheal intubation and pulmonary functional assessment for repeated studies in mice
    • Brown RH, Walters DM, Greenberg RS, Mitzner W. A method of endotracheal intubation and pulmonary functional assessment for repeated studies in mice. J Appl Physiol (1985) 1999; 87: 2362-5.
    • (1999) J Appl Physiol (1985) , vol.87 , pp. 2362-2365
    • Brown, R.H.1    Walters, D.M.2    Greenberg, R.S.3    Mitzner, W.4
  • 134
    • 0034952738 scopus 로고    scopus 로고
    • Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery
    • Lizio R, Westhof A, Lehr CM, Klenner T. Oral endotracheal intubation of rats for intratracheal instillation and aerosol drug delivery. Lab Anim 2001; 35: 257-60.
    • (2001) Lab Anim , vol.35 , pp. 257-260
    • Lizio, R.1    Westhof, A.2    Lehr, C.M.3    Klenner, T.4
  • 135
    • 44649149557 scopus 로고    scopus 로고
    • Microscopic wire guide-based orotracheal mouse intubation: Description, evaluation and comparison with transillumination
    • Hamacher J, Arras M, Bootz F, Weiss M, Schramm R, Moehrlen U. Microscopic wire guide-based orotracheal mouse intubation: description, evaluation and comparison with transillumination. Lab Anim 2008; 42: 222-30.
    • (2008) Lab Anim , vol.42 , pp. 222-230
    • Hamacher, J.1    Arras, M.2    Bootz, F.3    Weiss, M.4    Schramm, R.5    Moehrlen, U.6
  • 136
    • 33846597625 scopus 로고    scopus 로고
    • A novel and simple method for endotracheal intubation of mice
    • Spoelstra EN, Ince C, Koeman A, et al. A novel and simple method for endotracheal intubation of mice. Lab Anim 2007; 41: 128-35.
    • (2007) Lab Anim , vol.41 , pp. 128-135
    • Spoelstra, E.N.1    Ince, C.2    Koeman, A.3
  • 137
    • 84863780069 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of a dry powder endotracheal insufflator device for use in dose-dependent preclinical studies in mice
    • Duret C, Wauthoz N, Merlos R, et al. In vitro and in vivo evaluation of a dry powder endotracheal insufflator device for use in dose-dependent preclinical studies in mice. Eur J Pharm Biopharm 2012; 81: 627-34.
    • (2012) Eur J Pharm Biopharm , vol.81 , pp. 627-634
    • Duret, C.1    Wauthoz, N.2    Merlos, R.3
  • 138
    • 70350565410 scopus 로고    scopus 로고
    • Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies
    • Morello M, Krone CL, Dickerson S, et al. Dry-powder pulmonary insufflation in the mouse for application to vaccine or drug studies. Tuberculosis (Edinb) 2009; 89: 371-7.
    • (2009) Tuberculosis (Edinb) , vol.89 , pp. 371-377
    • Morello, M.1    Krone, C.L.2    Dickerson, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.