Formulation of pH responsive peptides as inhalable dry powders for pulmonary delivery of nucleic acids

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 86, Issue 1, 2014, Pages 64-73

  Liang, Wanling ^a   Kwok, Philip C L ^a,b   Chow, Michael Y T ^a   Tang, Patricia ^b   Mason, A James ^c   Chan, Hak Kim ^b   Lam, Jenny K W ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b UNIVERSITY OF SYDNEY   (Australia)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Gene delivery; Non viral vector; Peptides; pH responsive; Pulmonary delivery; Spray drying; Spray freeze drying

Indexed keywords

2,3 DIAMINOPROPIONIC ACID; DNA FRAGMENT; HISTIDINE; LAH 4 L1 PEPTIDE; LIPOFECTAMINE; LUNG SURFACTANT; MANNITOL; NUCLEIC ACID; PEPTIDE; PLASMID DNA; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DISPERSION; DNA PURIFICATION; DNA TRANSFECTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRY POWDER; DRY POWDER INHALER; EPITHELIUM CELL; FREEZE DRYING; GEL ELECTROPHORESIS; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; LUNG LAVAGE; MOLECULAR WEIGHT; PARTICLE SIZE; PH; PULMONARY DELIVERY; SCANNING ELECTRON MICROSCOPY; SPRAY DRYING;

GENE DELIVERY; NON-VIRAL VECTOR; PEPTIDES; PH RESPONSIVE; PULMONARY DELIVERY; SPRAY DRYING; SPRAY FREEZE DRYING;

AMINO ACID SEQUENCE; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DNA; DRUG CARRIERS; DRUG COMPOUNDING; DRY POWDER INHALERS; EPITHELIAL CELLS; EQUIPMENT DESIGN; FREEZE DRYING; HUMANS; HYDROGEN-ION CONCENTRATION; LUNG; MOLECULAR SEQUENCE DATA; PARTICLE SIZE; PEPTIDES; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; SURFACE PROPERTIES; TRANSFECTION;

EID: 84896691375     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.05.006     Document Type: Article

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