In vitro and in vivo evaluation of a dry powder endotracheal insufflator device for use in dose-dependent preclinical studies in mice

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 81, Issue 3, 2012, Pages 627-634

  Duret, Christophe ^a   Wauthoz, Nathalie ^a   Merlos, Romain ^a   Goole, Jonathan ^a   Maris, Calliope ^b   Roland, Isabelle ^b   Sebti, Thami ^c   Vanderbist, Francis ^c   Amighi, Karim ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b ERASME HOSPITAL   (Belgium)

^c SMB SA   (Belgium)

Author keywords

Dry powder; Endotracheal; Fluorescent microspheres; Insufflation; Mice; Pulmonary delivery

Indexed keywords

DRUG CARRIER; ITRACONAZOLE; MANNITOL; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PHOSPHOLIPON 90H; UNCLASSIFIED DRUG;

AEROSOL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DISTRIBUTION VOLUME; DOSE RESPONSE; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG PENETRATION; DRY POWDER ENDOTRACHEAL INSUFFLATOR DEVICE; EVALUATION; FLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; LASER; LUNG ALVEOLUS; LUNG PARENCHYMA; MALE; MASS; MOUSE; NONHUMAN; PARTICLE SIZE; POWDER INHALER; REPRODUCIBILITY; SPRAY DRYING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRY POWDER INHALERS; EXCIPIENTS; ITRACONAZOLE; LASERS; LUNG; MALE; MANNITOL; MICE; MICE, INBRED ICR; MICROSCOPY, FLUORESCENCE; PARTICLE SIZE; PHOSPHOLIPIDS; REPRODUCIBILITY OF RESULTS; SCATTERING, RADIATION; TISSUE DISTRIBUTION;

EID: 84863780069     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.04.004     Document Type: Article

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