Drying of a plasmid containing formulation: Chitosan as a protecting agent

DARU, Journal of Pharmaceutical Sciences

Volumn 20, Issue 1, 2012, Pages

  Mohajel, Nasir ^a,b   Najafabadi, Abdolhossein R ^a   Azadmanesh, Kayhan ^b   Amini, Mohsen ^c   Vatanara, Alireza ^a   Moazeni, Esmail ^a   Rahimi, Amirabbas ^a   Gilani, Kambiz ^a  

^a TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Freeze drying; Gene therapy; Nanocomplex; Polymeric gene delivery; Spray drying

Indexed keywords

CHITOSAN; LACTOSE; LEUCINE; PLASMID DNA; PROTECTIVE AGENT;

ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DEPOLYMERIZATION; DNA DEGRADATION; DNA STRUCTURE; DNA SUPERCOILING; FREEZE DRYING; GEL ELECTROPHORESIS; GEL PERMEATION CHROMATOGRAPHY; GENETIC TRANSFECTION; IN VITRO GENE TRANSFER; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; SPRAY DRYING; TEMPERATURE STRESS; ZETA POTENTIAL;

EID: 84903755570     PISSN: 15608115     EISSN: 20082231     Source Type: Journal    
DOI: 10.1186/2008-2231-20-22     Document Type: Article

References (26)

1. Glover DJ, Lipps HJ, Jans DA: Towards safe, non-viral therapeutic gene expression in humans. Nat Rev Genet 2005, 6:299-310. (Pubitemid 40469049)
2. Anderson DG, Lynn DM, Langer R: Semi-Automated synthesis and screening of a large library of degradable cationic polymers for gene delivery. Angew Chem Int Ed Engl 2003, 42:3153-3158. (Pubitemid 36898737)
3. Nabel GJ, Nabel EG, Yang ZY, Fox BA, Plautz GE, Gao X, Huang L, Shu S, Gordon D, Chang AE: Direct gene transfer with DNA-liposome complexes in melanoma: expression, biologic activity, and lack of toxicity in humans. Proc Natl Acad Sci U S A 1993, 90:11307-11311. (Pubitemid 23354418)
4. Anchordoquy TJ, Girouard LG, Carpenter JF, Kroll DJ: Stability of lipid/DNA complexes during agitation and freeze-Thawing. J Pharm Sci 1998, 87:1046-1051. (Pubitemid 28452102)
5. Zheng-Rong L: Stability of Proteins and Nucleic Acids. in Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids. Edited by Mahato RI. Boca Raton: CRC Press; 2004.
6. Davies LA, McLachlan G, Sumner-Jones SG, Ferguson D, Baker A, Tennant P, Gordon C, Vrettou C, Baker E, Zhu J, Alton EWFW, Collie DDS, Porteous DJ, Hyde SC, Gill DR: Enhanced lung gene expression after aerosol delivery of concentrated pDNA/PEI complexes. Mol Ther 2008, 16:1283-1290. (Pubitemid 351866060)
7. MdC M, Anchordoquy TJ. Metal contaminants promote degradation of lipid/DNA complexes during lyophilization. Biochimica et Biophysica Acta - Biomembranes 2007, 1768:669-677. (Pubitemid 46275603)
8. Anchordoquy TJ, Koe GS: Physical stability of nonviral plasmid-based therapeutics. J Pharm Sci 2000, 89:289-296. (Pubitemid 30152430)
9. Grenha A, Seijo B, Remunan-Lopez C: Microencapsulated chitosan nanoparticles for lung protein delivery. Eur J Pharm Sci 2005, 25:427-437. (Pubitemid 40853870)
10. Wong YL, Sampson S, Germishuizen WA, Goonesekera S, Caponetti G, Sadoff J, Bloom BR, Edwards D: Drying a tuberculosis vaccine without freezing. Proc Natl Acad Sci U S A 2007, 104:2591-2595. (Pubitemid 46327924)
11. Seville PC, Kellaway IW, Birchall JC: Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spray-drying. J Gene Med 2002, 4:428-437. (Pubitemid 40277180)
12. Li HY, Seville PC, Williamson IJ, Birchall JC: The use of amino acids to enhance the aerosolisation of spray-dried powders for pulmonary gene therapy. J Gene Med 2005, 7:343-353. (Pubitemid 40443763)
13. Li HY, Seville PC, Williamson IJ, Birchall JC: The use of absorption enhancers to enhance the despersibility of spray-dried powders for pulmonary gene therapy. J Gene Med 2005, 7:1035-1043. (Pubitemid 41195065)
14. Okamoto H, Nishida S, Todo H, Sakakura Y, Iida K, Danjo K: Pulmonary gene delivery by chitosan-pDNA complex powder prepared by a supercritical carbon dioxide process. J Pharm Sci 2003, 92:371-380. (Pubitemid 36169309)
15. Mao S, Sun W, Kissel T: Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 2009, 62:12-27.
16. Koping-Hoggard M, Tubulekas I, Guan H, Edwards K, Nilsson M, Varum KM, Artursson P: Chitosan as a nonviral gene delivery system. Structureproperty relationships and characteristics compared withpolyethylenimine in vitro and after lung administration in vivo. Gene Ther 2001, 8:1108-1121. (Pubitemid 32962708)
17. Koping-Hoggard M, Varum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, Artursson P: Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther 2004, 11:1441-1452. (Pubitemid 39359435)
18. Mao S, Shuai X, Unger F, Simon M, Bi D, Kissel T: The depolymerization of chitosan: effects on physicochemical and biological properties. Int J Pharm 2004, 281:45-54. (Pubitemid 39024262)
19. Strand SP, Lelu S, Reitan NK, de Lange Davies, C, Artursson P, Varum KM. Molecular design of chitosan gene delivery systems with an optimized balance between polyplex stability and polyplex unpacking. Biomaterials 2009, 31:975-987.
20. Abdelwahed W, Degobert G, Stainmesse S, Fessi H: Freeze-drying of nanoparticles: formulation, process and storage considerations. Adv Drug Del Rev 2006, 58:1688-1713. (Pubitemid 44827432)
21. Kuo JH, Hwang R: Preparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: effect of protective agents (polyethyleneimine and sugars) on the stability of DNA. J Pharm Pharmacol 2004, 56:27-33. (Pubitemid 38195325)
22. Mohri K, Okuda T, Mori A, Danjo K, Okamoto H: Optimized pulmonary gene transfection in mice by spray-freeze dried powder inhalation. J Control Release 2010, 144:221-226.
23. Lystsov VN, Moshkovskii I: Crylolytic degradation of DNA. I. Cryolysis and the regimes of freezing and melting of solutions. Biofizika 1969, 14:219-227.
24. Lystsov VN, Kopankina EA, Malysheva LF, Moshkovskii I: DNA cryolysis. Biofizika 1966, 11:726-728.
25. Talsma H, Cherng JY, Lehrmann H, Kursa M, Ogris M, Hennink WE, Cotten M, Wagner E: Stabilization of gene delivery systems by freeze-drying. Int J Pharm 1997, 157:233-238. (Pubitemid 27471175)
26. Li HY, Neill H, Innocent R, Seville P, Williamson I, Birchall JC: Enhanced dispersibility and deposition of spray-dried powders for pulmonary gene therapy. J Drug Target 2003, 11:425-432. (Pubitemid 38455828)