Protein spray-freeze drying. Effect of atomization conditions on particle size and stability

Pharmaceutical Research

Volumn 17, Issue 11, 2000, Pages 1374-1383

  Costantino, Henry R ^a   Firouzabadian, Laleh ^a   Hogeland, Ken ^a   Wu, Chichih ^a   Beganski, Chris ^a   Carrasquillo, Karen G ^b   Córdova, Melissa ^b   Griebenow, Kai ^b   Zale, Stephen E ^a   Tracy, Mark A ^a  

^a ALKERMES INC   (United States)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Particle size; PLG microspheres; Protein delivery; Spray freeze drying; Stability

Indexed keywords

BOVINE SERUM ALBUMIN; EXCIPIENT; MICROSPHERE; MONOMER; ORGANIC SOLVENT; POLYGLACTIN; ZINC;

ARTICLE; COMPLEX FORMATION; DRY POWDER; ENCAPSULATION; FOURIER ANALYSIS; FREEZE DRYING; GEL PERMEATION CHROMATOGRAPHY; IN VITRO STUDY; LASER DIFFRACTION; LIGHT SCATTERING; NEBULIZATION; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; ULTRASOUND;

BIOCOMPATIBLE MATERIALS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG STABILITY; FREEZE DRYING; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; POLYGLYCOLIC ACID; POLYMERS; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SERUM ALBUMIN, BOVINE;

EID: 0034495318     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007570030368     Document Type: Article

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