메뉴 건너뛰기




Volumn 15, Issue 2, 2014, Pages 326-338

Advances in metered dose inhaler technology: Hardware development

Author keywords

actuator; add on devices; canister; dose counters; metering valve

Indexed keywords

BECLOMETASONE DIPROPIONATE; CICLESONIDE; FLUTICASONE PROPIONATE PLUS SALMETEROL XINAFOATE; PROPELLANT;

EID: 84898024686     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-013-0062-y     Document Type: Review
Times cited : (90)

References (115)
  • 1
    • 79957454222 scopus 로고    scopus 로고
    • Retail sales of inhalation devices in European countries: So much for a global policy
    • 21489771
    • Lavorini F, Corrigan C, Barnes P, Dekhuijzen P, Levy M, Pedersen S, et al. Retail sales of inhalation devices in European countries: so much for a global policy. Respir Med. 2011;105(7):1099-103.
    • (2011) Respir Med , vol.105 , Issue.7 , pp. 1099-1103
    • Lavorini, F.1    Corrigan, C.2    Barnes, P.3    Dekhuijzen, P.4    Levy, M.5    Pedersen, S.6
  • 2
    • 79955499377 scopus 로고    scopus 로고
    • Cost-effectiveness of metered-dose inhalers for asthma exacerbations in the pediatric emergency department
    • 21464192
    • Doan Q, Shefrin A, Johnson D. Cost-effectiveness of metered-dose inhalers for asthma exacerbations in the pediatric emergency department. Pediatrics. 2011;127(5):e1105-11.
    • (2011) Pediatrics , vol.127 , Issue.5
    • Doan, Q.1    Shefrin, A.2    Johnson, D.3
  • 3
    • 0001504546 scopus 로고    scopus 로고
    • From Susie's question to CFC free: An inventor's perspective on forty years of MDI development and regulation
    • Thiel CG. From Susie's question to CFC free: an inventor's perspective on forty years of MDI development and regulation. Respir Drug Deliv. 1996;1:115-24.
    • (1996) Respir Drug Deliv , vol.1 , pp. 115-124
    • Thiel, C.G.1
  • 4
    • 84871385237 scopus 로고    scopus 로고
    • Inhaler competence in asthma: Common errors, barriers to use and recommended solutions
    • 23098685
    • Price D, Bosnic-Anticevich S, Briggs A, Chrystyn H, Rand C, Scheuch G, et al. Inhaler competence in asthma: common errors, barriers to use and recommended solutions. Respir Med. 2012;107(1):37-46.
    • (2012) Respir Med , vol.107 , Issue.1 , pp. 37-46
    • Price, D.1    Bosnic-Anticevich, S.2    Briggs, A.3    Chrystyn, H.4    Rand, C.5    Scheuch, G.6
  • 5
    • 0032827577 scopus 로고    scopus 로고
    • Advances in metered dose inhaler technology with the development of a chlorofluorocarbon-free drug delivery system
    • 10623331
    • Ross DL, Gabrio BJ. Advances in metered dose inhaler technology with the development of a chlorofluorocarbon-free drug delivery system. J Aerosol Med. 1999;12(3):151-60.
    • (1999) J Aerosol Med , vol.12 , Issue.3 , pp. 151-160
    • Ross, D.L.1    Gabrio, B.J.2
  • 6
    • 84898049499 scopus 로고    scopus 로고
    • Optimization of fluid flow in pMDI valves
    • Fradley G, Hodson D. Optimization of fluid flow in pMDI valves. Respir Drug Deliv. 2008;2:329-32.
    • (2008) Respir Drug Deliv , vol.2 , pp. 329-332
    • Fradley, G.1    Hodson, D.2
  • 7
    • 84898021154 scopus 로고    scopus 로고
    • Understanding the cause of increasing dose through life from a pressurised metered dose inhaler (pMDI)
    • Colombani AC, Chambers F, Lee K, Jansen R, Hodson D. Understanding the cause of increasing dose through life from a pressurised metered dose inhaler (pMDI). J Pharm Pharmacol. 2010;62(10):1314-5.
    • (2010) J Pharm Pharmacol , vol.62 , Issue.10 , pp. 1314-1315
    • Colombani, A.C.1    Chambers, F.2    Lee, K.3    Jansen, R.4    Hodson, D.5
  • 11
    • 84898034880 scopus 로고    scopus 로고
    • Bespak plc, assignee European patent EP 801,009. 2001 Nov 7
    • Howlett D, Conroy G, inventors; Bespak plc, assignee. Metering valve for dispensers. European patent EP 801,009. 2001 Nov 7.
    • Metering Valve for Dispensers
    • Howlett, D.1    Conroy2
  • 12
    • 84898022770 scopus 로고    scopus 로고
    • inventor; 3M Innovative Properties Company, assignee World Intellectual Property Organization patent WO 2004/022142. 2004 Feb 26
    • Hodson PD, inventor; 3M Innovative Properties Company, assignee. Metering valve for a metered dose inhaler providing consistent delivery. World Intellectual Property Organization patent WO 2004/022142. 2004 Feb 26.
    • Metering Valve for A Metered Dose Inhaler Providing Consistent Delivery
    • Hodson, P.D.1
  • 14
    • 84898025724 scopus 로고    scopus 로고
    • inventor; Minnesota Mining and Manufacturing Company, assignee United States patent US 5,593,069. 1997 Jan 14
    • Jinks PA, inventor; Minnesota Mining and Manufacturing Company, assignee. Aerosol valves with movable agitator. United States patent US 5,593,069. 1997 Jan 14.
    • Aerosol Valves with Movable Agitator
    • Jinks, P.A.1
  • 17
    • 84908230132 scopus 로고    scopus 로고
    • Alston W, Clark AR, Nektar Therapeutics, Schuler C, Walsh KR, assignees World Intellectual Property Organization patent WO 2004/041340. 2004 May 31
    • Alston W, Clark AR, Schuler C, Walsh KR, inventors; Alston W, Clark AR, Nektar Therapeutics, Schuler C, Walsh KR, assignees. Increased dosage metered dose inhaler. World Intellectual Property Organization patent WO 2004/041340. 2004 May 31.
    • Increased Dosage Metered Dose Inhaler
    • Alston, W.1    Clark, A.R.2    Schuler, C.3    Walsh, K.R.4
  • 18
    • 84898048969 scopus 로고    scopus 로고
    • Predicting HFA-MDI dose retention properties: Engineering the marriage between canisters, valves and formulations
    • Lewis DA, O'Shea H, Johnson R, Church T. Predicting HFA-MDI dose retention properties: engineering the marriage between canisters, valves and formulations. Respir Drug Deliv Eur. 2011;1:89-100.
    • (2011) Respir Drug Deliv Eur , vol.1 , pp. 89-100
    • Lewis, D.A.1    O'Shea, H.2    Johnson, R.3    Church, T.4
  • 19
    • 84898020824 scopus 로고    scopus 로고
    • inventor; Minnesota Mining and Manufacturing Company, assignee United States patent US 6,006,745. 1999 Dec 28
    • Marecki PE, inventor; Minnesota Mining and Manufacturing Company, assignee. Device for delivering an aerosol. United States patent US 6,006,745. 1999 Dec 28.
    • Device for Delivering An Aerosol
    • Marecki, P.E.1
  • 20
    • 0032790248 scopus 로고    scopus 로고
    • Drug-surfactant-propellant interactions in HFA-formulations
    • 10469920
    • Vervaet C, Byron PR. Drug-surfactant-propellant interactions in HFA-formulations. Int J Pharm. 1999;186(1):13-30.
    • (1999) Int J Pharm , vol.186 , Issue.1 , pp. 13-30
    • Vervaet, C.1    Byron, P.R.2
  • 22
    • 84898045142 scopus 로고    scopus 로고
    • The application of a new high performance dual-layer coating to pressurized metered dose inhaler hardware
    • Dohmeier DM, Heyworth D, Wilde T. The application of a new high performance dual-layer coating to pressurized metered dose inhaler hardware. Respir Drug Deliv Eur. 2009;2:209-12.
    • (2009) Respir Drug Deliv Eur , vol.2 , pp. 209-212
    • Dohmeier, D.M.1    Heyworth, D.2    Wilde, T.3
  • 24
    • 84875898396 scopus 로고    scopus 로고
    • Effects of direct spiking of silicone oil into a model pMDI formulation
    • 22630349
    • Fallon JK, Peyron ID, Hickey AJ. Effects of direct spiking of silicone oil into a model pMDI formulation. Drug Dev Ind Pharm. 2013;39(5):681-6.
    • (2013) Drug Dev Ind Pharm , vol.39 , Issue.5 , pp. 681-686
    • Fallon, J.K.1    Peyron, I.D.2    Hickey, A.J.3
  • 26
    • 1842507484 scopus 로고    scopus 로고
    • Influence of the valve lubricant on the aerodynamic particle size of a metered dose inhaler
    • 15109026
    • Berry J, Kline L, Naini V, Chaudhry S, Hart J, Sequeira J. Influence of the valve lubricant on the aerodynamic particle size of a metered dose inhaler. Drug Dev Ind Pharm. 2004;30(3):267-75.
    • (2004) Drug Dev Ind Pharm , vol.30 , Issue.3 , pp. 267-275
    • Berry, J.1    Kline, L.2    Naini, V.3    Chaudhry, S.4    Hart, J.5    Sequeira, J.6
  • 28
    • 84859744261 scopus 로고    scopus 로고
    • Forced degradation studies of corticosteroids with an alumina-steroid-ethanol model for predicting chemical stability and degradation products of pressurized metereddose inhaler formulations 22410760
    • Wu Z, Thatcher ML, Lundberg JK, Ogawa MK, Jacoby CB, Battiste JL, et al. Forced degradation studies of corticosteroids with an alumina-steroid-ethanol model for predicting chemical stability and degradation products of pressurized metered dose inhaler formulations. J Pharm Sci. 2012;101(6):2109-22.
    • (2012) J Pharm Sci , vol.101 , Issue.6 , pp. 2109-2122
    • Wu, Z.1    Thatcher, M.L.2    Lundberg, J.K.3    Ogawa, M.K.4    Jacoby, C.B.5    Battiste, J.L.6
  • 29
    • 84898028415 scopus 로고    scopus 로고
    • Glaxo Wellcome Inc, Glaxo Group Limited, assignees Metered dose inhaler for albuterol United States patent US 6,131,566. 2000 Oct 17
    • Ashurst IC, Herman CS, Li-Bovet L, Riehe MT, inventors; Glaxo Wellcome Inc, Glaxo Group Limited, assignees. Metered dose inhaler for albuterol. United States patent US 6,131,566. 2000 Oct 17.
    • Ashurst, I.C.1    Herman, C.S.2    Li-Bovet, L.3    Riehe, M.T.4
  • 31
    • 84898026552 scopus 로고    scopus 로고
    • Chiesi Farmaceutici S.P.A., assignee World Intellectual Property Organization patent WO 2000/030608. 2000 Jun 2
    • Lewis D, Ganderton D, Meakin B, Ventura P, Brambilla G, Garzia R, inventors; Chiesi Farmaceutici S.P.A., assignee. Pressurized metered dose inhalers (MDI). World Intellectual Property Organization patent WO 2000/030608. 2000 Jun 2.
    • Pressurized Metered Dose Inhalers (MDI)
  • 34
    • 84898046787 scopus 로고    scopus 로고
    • Chiesi Farmaceutici S.p.A., assignee HFA propellant, and co-solvent and comprising a container with a specific internal surface composition and/or lining. United States patent US 8,142,763. 2012 Mar 27
    • Lewis D, Ganderton D, Meakin B, Ventura P, Brambilla G, Garzia R, inventors; Chiesi Farmaceutici S.p.A., assignee. Pressurized metered dose inhalers (MDI) containing a solution comprising ipratropium bromide, HFA propellant, and co-solvent and comprising a container with a specific internal surface composition and/or lining. United States patent US 8,142,763. 2012 Mar 27.
    • Pressurized Metered Dose Inhalers (MDI) Containing A Solution Comprising Ipratropium Bromide
  • 37
    • 84898044793 scopus 로고    scopus 로고
    • 3M Innovative Properties Company, assignee World Intellectual Property Organization patent WO 2002/056949. 2002 Jul 25
    • Clayton CD, Scott JS, inventors; 3M Innovative Properties Company, assignee. Medicinal aerosols. World Intellectual Property Organization patent WO 2002/056949. 2002 Jul 25.
    • Medicinal Aerosols
    • Clayton, C.D.1    Scott, J.S.2
  • 38
    • 84898048664 scopus 로고    scopus 로고
    • Container closure system solutions for delivering low numbers of doses from a pressurised metered dose inhaler
    • Moore JM, Bradley L, Charnock P, Brown S. Container closure system solutions for delivering low numbers of doses from a pressurised metered dose inhaler. Respir Drug Deliv. 2004;2:333-6.
    • (2004) Respir Drug Deliv , vol.2 , pp. 333-336
    • Moore, J.M.1    Bradley, L.2    Charnock, P.3    Brown, S.4
  • 39
    • 84894420024 scopus 로고    scopus 로고
    • Dihydroergotamine inhalation aerosol for the treatment of migraine: Insights from pharmaceutical and clinical development
    • Kellerman DJ, Armer TA, Borland SW, Nelson TS. Dihydroergotamine inhalation aerosol for the treatment of migraine: insights from pharmaceutical and clinical development. Respir Drug Deliv Eur. 2013;1:35-46.
    • (2013) Respir Drug Deliv Eur , vol.1 , pp. 35-46
    • Kellerman, D.J.1    Armer, T.A.2    Borland, S.W.3    Nelson, T.S.4
  • 41
    • 0031437330 scopus 로고    scopus 로고
    • An experimental investigation of the spray issued from a pMDI using laser diagnostic techniques
    • 10175964
    • Dunbar C, Watkins A, Miller J. An experimental investigation of the spray issued from a pMDI using laser diagnostic techniques. J Aerosol Med. 1997;10(4):351-68.
    • (1997) J Aerosol Med , vol.10 , Issue.4 , pp. 351-368
    • Dunbar, C.1    Watkins, A.2    Miller, J.3
  • 42
    • 0007948246 scopus 로고    scopus 로고
    • Theoretical investigation of the spray from a pressurized metered-dose inhaler
    • Dunbar C, Miller J. Theoretical investigation of the spray from a pressurized metered-dose inhaler. Atomization Sprays. 1997;7(4):417-36.
    • (1997) Atomization Sprays , vol.7 , Issue.4 , pp. 417-436
    • Dunbar, C.1    Miller, J.2
  • 43
    • 0032764740 scopus 로고    scopus 로고
    • A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers
    • 10469919
    • Gabrio BJ, Stein SW, Velasquez DJ. A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers. Int J Pharm. 1999;186(1):3-12.
    • (1999) Int J Pharm , vol.186 , Issue.1 , pp. 3-12
    • Gabrio, B.J.1    Stein, S.W.2    Velasquez, D.J.3
  • 44
    • 0010128315 scopus 로고    scopus 로고
    • PMDI optimization using an actuator flow model
    • Dunbar CA, Hickey AJ. pMDI optimization using an actuator flow model. Respir Drug Deliv. 1998;1:319-22.
    • (1998) Respir Drug Deliv , vol.1 , pp. 319-322
    • Dunbar, C.A.1    Hickey, A.J.2
  • 45
    • 84898031274 scopus 로고    scopus 로고
    • The relationship between MDI droplet lifetime and drug delivery efficiency
    • Stein SW, Myrdal PB. The relationship between MDI droplet lifetime and drug delivery efficiency. Respir Drug Deliv. 2006;2:351-6.
    • (2006) Respir Drug Deliv , vol.2 , pp. 351-356
    • Stein, S.W.1    Myrdal, P.B.2
  • 46
    • 0141680642 scopus 로고    scopus 로고
    • Influence of the metering chamber volume and actuator design on the aerodynamic particle size of a metered dose inhaler
    • 14570307
    • Berry J, Heimbecher S, Hart JL, Sequeira J. Influence of the metering chamber volume and actuator design on the aerodynamic particle size of a metered dose inhaler. Drug Dev Ind Pharm. 2003;29(8):865-76.
    • (2003) Drug Dev Ind Pharm , vol.29 , Issue.8 , pp. 865-876
    • Berry, J.1    Heimbecher, S.2    Hart, J.L.3    Sequeira, J.4
  • 47
    • 3843075402 scopus 로고    scopus 로고
    • A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions
    • 15236462
    • Stein SW, Myrdal PB. A theoretical and experimental analysis of formulation and device parameters affecting solution MDI size distributions. J Pharm Sci. 2004;93(8):2158-75.
    • (2004) J Pharm Sci , vol.93 , Issue.8 , pp. 2158-2175
    • Stein, S.W.1    Myrdal, P.B.2
  • 48
    • 34248669337 scopus 로고    scopus 로고
    • New actuators versus old: Reasons and results for actuator modifications for HFA solution MDIs
    • Lewis DA, Meakin BJ, Brambilla G. New actuators versus old: reasons and results for actuator modifications for HFA solution MDIs. Respir Drug Deliv. 2006;1:101-10.
    • (2006) Respir Drug Deliv , vol.1 , pp. 101-110
    • Lewis, D.A.1    Meakin, B.J.2    Brambilla, G.3
  • 50
    • 0002906168 scopus 로고    scopus 로고
    • Formulation of metered dose inhalers
    • T.S. Purewal D.J.W. Grant (eds) 1 Interpharm Illinois
    • Purewal TS. Formulation of metered dose inhalers. In: Purewal TS, Grant DJW, editors. Metered dose inhaler technology. 1st ed. Illinois: Interpharm; 1998. p. 6-68.
    • (1998) Metered Dose Inhaler Technology , pp. 6-68
    • Purewal, T.S.1
  • 52
    • 34248655965 scopus 로고    scopus 로고
    • Fundamentals and resilience of the original MDI actuator design
    • Versteeg HK, Hargrave GK. Fundamentals and resilience of the original MDI actuator design. Respir Drug Deliv. 2006;1:91-100.
    • (2006) Respir Drug Deliv , vol.1 , pp. 91-100
    • Versteeg, H.K.1    Hargrave, G.K.2
  • 56
    • 84898023662 scopus 로고    scopus 로고
    • Nozzle design characterization of metered dose inhalers (MDI) using quality by design (QbD) tools
    • Fachinger J, Hoelz H, Spallek MW, Ziegler J. Nozzle design characterization of metered dose inhalers (MDI) using quality by design (QbD) tools. Respir Drug Deliv Eur. 2009;2:261-4.
    • (2009) Respir Drug Deliv Eur , vol.2 , pp. 261-264
    • Fachinger, J.1    Hoelz, H.2    Spallek, M.W.3    Ziegler, J.4
  • 57
    • 84898036974 scopus 로고    scopus 로고
    • The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition
    • Chen Y, Traini D, Fletcher D, Chan H, Lewis D, Church T, et al. The effect of pressurized metered dose inhaler (pMDI) actuator nozzle design on triboelectrification and aerosol deposition. Respir Drug Deliv Eur 2013;2:439-44.
    • (2013) Respir Drug Deliv Eur , vol.2 , pp. 439-444
    • Chen, Y.1    Traini, D.2    Fletcher, D.3    Chan, H.4    Lewis, D.5    Church, T.6
  • 58
    • 34548567783 scopus 로고    scopus 로고
    • The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency
    • Stein SW, Myrdal PB. The relative influence of atomization and evaporation on metered dose inhaler drug delivery efficiency. Aerosol Sci Tech. 2006;40(5):335-47.
    • (2006) Aerosol Sci Tech , vol.40 , Issue.5 , pp. 335-347
    • Stein, S.W.1    Myrdal, P.B.2
  • 59
    • 84861583062 scopus 로고    scopus 로고
    • Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part I. Numerical predictions and dual laser measurements
    • 22575753
    • Ju D, Shrimpton J, Bowdrey M, Hearn A. Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part I. Numerical predictions and dual laser measurements. Int J Pharm. 2012;432(1):23-31.
    • (2012) Int J Pharm , vol.432 , Issue.1 , pp. 23-31
    • Ju, D.1    Shrimpton, J.2    Bowdrey, M.3    Hearn, A.4
  • 60
    • 84861586158 scopus 로고    scopus 로고
    • Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part II: High speed imaging measurements
    • 22579579
    • Ju D, Shrimpton J, Bowdrey M, Hearn A. Effect of expansion chamber geometry on atomization and spray dispersion characters of a flashing mixture containing inerts. Part II: high speed imaging measurements. Int J Pharm. 2012;432(1):32-41.
    • (2012) Int J Pharm , vol.432 , Issue.1 , pp. 32-41
    • Ju, D.1    Shrimpton, J.2    Bowdrey, M.3    Hearn, A.4
  • 61
    • 0031389982 scopus 로고    scopus 로고
    • Atomization mechanisms of the pressurized metered dose inhaler
    • Dunbar C. Atomization mechanisms of the pressurized metered dose inhaler. Part Sci Technol. 1997;15(3):195-216.
    • (1997) Part Sci Technol , vol.15 , Issue.3 , pp. 195-216
    • Dunbar, C.1
  • 62
    • 1242349621 scopus 로고    scopus 로고
    • Understanding throat deposition during cascade impactor testing
    • Stein SW, Gabrio BJ. Understanding throat deposition during cascade impactor testing. Respir Drug Deliv. 2000;2:287-90.
    • (2000) Respir Drug Deliv , vol.2 , pp. 287-290
    • Stein, S.W.1    Gabrio, B.J.2
  • 63
    • 0034862979 scopus 로고    scopus 로고
    • Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways
    • 11693845
    • Lin T, Breysse PN, Laube BL, Swift DL. Mouthpiece diameter affects deposition efficiency in cast models of the human oral airways. J Aerosol Med. 2001;14(3):335-41.
    • (2001) J Aerosol Med , vol.14 , Issue.3 , pp. 335-341
    • Lin, T.1    Breysse, P.N.2    Laube, B.L.3    Swift, D.L.4
  • 65
    • 84898051281 scopus 로고    scopus 로고
    • 3M Innovative Properties Company, assignee United States patent US 6,615,826. 2003 Sep 9
    • Gabrio BJ, Velasquez DJ, inventors; 3M Innovative Properties Company, assignee. Slow spray metered dose inhaler. United States patent US 6,615,826. 2003 Sep 9.
    • Slow Spray Metered Dose Inhaler
    • Gabrio, B.J.1    Velasquez, D.J.2
  • 66
    • 0027262967 scopus 로고
    • Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler
    • 8486025
    • Newman S, Clarke S. Bronchodilator delivery from Gentlehaler, a new low-velocity pressurized aerosol inhaler. Chest. 1993;103(5):1442-6.
    • (1993) Chest , vol.103 , Issue.5 , pp. 1442-1446
    • Newman, S.1    Clarke, S.2
  • 67
    • 84898047232 scopus 로고    scopus 로고
    • inventor; Bespak plc, assignee United States patent US 6,062,214. 2000 May 16
    • Howlett D, inventor; Bespak plc, assignee. Inhaler for medicament. United States patent US 6,062,214. 2000 May 16.
    • Inhaler for Medicament
  • 68
    • 42649131701 scopus 로고    scopus 로고
    • Breath-synchronized plume-control inhaler for pulmonary delivery of fluticasone propionate
    • 18289809
    • Shrewsbury SB, Armer TA, Newman SP, Pitcairn G. Breath-synchronized plume-control inhaler for pulmonary delivery of fluticasone propionate. Int J Pharm. 2008;356(1):137-43.
    • (2008) Int J Pharm , vol.356 , Issue.1 , pp. 137-143
    • Shrewsbury, S.B.1    Armer, T.A.2    Newman, S.P.3    Pitcairn, G.4
  • 69
    • 0141712206 scopus 로고    scopus 로고
    • PMDI aerosol momentum manipulation and biotargeted delivery
    • Mohsen NM. pMDI aerosol momentum manipulation and biotargeted delivery. Respir Drug Deliv. 2002;2:593-8.
    • (2002) Respir Drug Deliv , vol.2 , pp. 593-598
    • Mohsen, N.M.1
  • 70
    • 0020322578 scopus 로고
    • Problems patients have using pressurized aerosol inhalers
    • 6954081
    • Crompton GK. Problems patients have using pressurized aerosol inhalers. Eur J Respir Dis Suppl. 1982;119:101-4.
    • (1982) Eur J Respir Dis Suppl , vol.119 , pp. 101-104
    • Crompton, G.K.1
  • 71
    • 0028239963 scopus 로고
    • Evaluation of conventional press-and-breathe metered-dose inhaler technique in 501 patients
    • 8195061
    • Larsen JS, Hahn M, Ekholm B, Wick KA. Evaluation of conventional press-and-breathe metered-dose inhaler technique in 501 patients. J Asthma. 1994;31(3):193-9.
    • (1994) J Asthma , vol.31 , Issue.3 , pp. 193-199
    • Larsen, J.S.1    Hahn, M.2    Ekholm, B.3    Wick, K.A.4
  • 72
    • 0025951893 scopus 로고
    • Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique
    • 463388 1750017
    • Newman SP, Weisz A, Talaee N, Clarke S. Improvement of drug delivery with a breath actuated pressurised aerosol for patients with poor inhaler technique. Thorax. 1991;46(10):712-6.
    • (1991) Thorax , vol.46 , Issue.10 , pp. 712-716
    • Newman, S.P.1    Weisz, A.2    Talaee, N.3    Clarke, S.4
  • 73
    • 29844448453 scopus 로고    scopus 로고
    • Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler
    • 16379614
    • Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ. Influence of particle size and patient dosing technique on lung deposition of HFA-beclomethasone from a metered dose inhaler. J Aerosol Med. 2005;18(4):379-85.
    • (2005) J Aerosol Med , vol.18 , Issue.4 , pp. 379-385
    • Leach, C.L.1    Davidson, P.J.2    Hasselquist, B.E.3    Boudreau, R.J.4
  • 74
    • 0032970171 scopus 로고    scopus 로고
    • Handling and acceptability of the Easi-Breathe device compared with a conventional metered dose inhaler by patients and practice nurses
    • 10344063
    • Price DB, Pearce L, Powell SR, Shirley J, Sayers MK. Handling and acceptability of the Easi-Breathe device compared with a conventional metered dose inhaler by patients and practice nurses. Int J Clin Pract. 1999;53(1):31-6.
    • (1999) Int J Clin Pract , vol.53 , Issue.1 , pp. 31-36
    • Price, D.B.1    Pearce, L.2    Powell, S.R.3    Shirley, J.4    Sayers, M.K.5
  • 75
    • 0027978050 scopus 로고
    • Reduction in patient timing errors using a breath-activated metered dose inhaler
    • 7774321
    • Hampson NB, Mueller MP. Reduction in patient timing errors using a breath-activated metered dose inhaler. Chest. 1994;106(2):462-5.
    • (1994) Chest , vol.106 , Issue.2 , pp. 462-465
    • Hampson, N.B.1    Mueller, M.P.2
  • 76
    • 79952763932 scopus 로고    scopus 로고
    • Aerosol drug delivery: Developments in device design and clinical use
    • 21036392
    • Dolovich MB, Dhand R. Aerosol drug delivery: developments in device design and clinical use. Lancet. 2011;377(9770):1032-45.
    • (2011) Lancet , vol.377 , Issue.9770 , pp. 1032-1045
    • Dolovich, M.B.1    Dhand, R.2
  • 77
    • 0034129205 scopus 로고    scopus 로고
    • Inappropriate inhaler use: Assessment of use and patient preference of seven inhalation devices
    • 10868714
    • Lenney J, Innes J, Crompton G. Inappropriate inhaler use: assessment of use and patient preference of seven inhalation devices. Respir Med. 2000;94(5):496-500.
    • (2000) Respir Med , vol.94 , Issue.5 , pp. 496-500
    • Lenney, J.1    Innes, J.2    Crompton, G.3
  • 78
    • 84898037283 scopus 로고    scopus 로고
    • PA Knowledge Limited, assignee United States patent US 6,405,727. 2002 Jun 18
    • MacMichael DBA, Hearne DJ, inventors; PA Knowledge Limited, assignee. Inhaler mechanism. United States patent US 6,405,727. 2002 Jun 18.
    • Inhaler Mechanism
    • Dba, M.1    Hearne, D.J.2
  • 79
    • 84898035616 scopus 로고    scopus 로고
    • Cambridge Consultants Limited, assignee World Intellectual Property Organization patent WO 2004/041339. 2004 Jun 2
    • Burge S, Isaacs WP, Smith SJ, Tuckwell JD, inventors; Cambridge Consultants Limited, assignee. Pressurized inhalers. World Intellectual Property Organization patent WO 2004/041339. 2004 Jun 2.
    • Pressurized Inhalers
    • Burge, S.1    Isaacs, W.P.2    Smith, S.J.3    Tuckwell, J.D.4
  • 80
    • 84888205767 scopus 로고    scopus 로고
    • IEP Pharmaceutical Devices Inc., assignee United States patent US 6,328,035. 2001 Dec 11
    • Wakefield K Genova PA, inventors; IEP Pharmaceutical Devices Inc., assignee. Pneumatic breath actuated inhaler. United States patent US 6,328,035. 2001 Dec 11.
    • Pneumatic Breath Actuated Inhaler
    • Wakefield, K.1    Genova, P.A.2
  • 81
    • 84898048571 scopus 로고    scopus 로고
    • inventor; KOS Pharmaceuticals Inc., assignee United States patent US 6,155,251. 2000 Dec 5
    • Hauser SG, inventor; KOS Pharmaceuticals Inc., assignee. Breath coordinated inhaler. United States patent US 6,155,251. 2000 Dec 5.
    • Breath Coordinated Inhaler
    • Hauser, S.G.1
  • 83
    • 0036202243 scopus 로고    scopus 로고
    • Accuracy of three electronic monitors for metered-dose inhalers
    • 11888975
    • Julius SM, Sherman JM, Hendeles L. Accuracy of three electronic monitors for metered-dose inhalers. Chest. 2002;121(3):871-6.
    • (2002) Chest , vol.121 , Issue.3 , pp. 871-876
    • Julius, S.M.1    Sherman, J.M.2    Hendeles, L.3
  • 84
    • 0030816678 scopus 로고    scopus 로고
    • A new millennium for inhaler technology
    • Hickey AJ, Dunbar CA. A new millennium for inhaler technology. Pharm Technol. 1997;21(6):116-25.
    • (1997) Pharm Technol , vol.21 , Issue.6 , pp. 116-125
    • Hickey, A.J.1    Dunbar, C.A.2
  • 85
    • 84898048205 scopus 로고    scopus 로고
    • Inhaling cannabinoids [abstract]. New Horizons in Inhaled Drug Del., Mgmt Forum. London, UK
    • Dave R. Inhaling cannabinoids [abstract]. New Horizons in Inhaled Drug Del., Mgmt Forum. London, UK, 2002.
    • (2002)
    • Dave, R.1
  • 87
    • 78650026416 scopus 로고    scopus 로고
    • Additional technology for pressurized metered dose inhalers
    • S. Newman (eds) Respiratory Drug Delivery Online Richmond
    • Newman SP. Additional technology for pressurized metered dose inhalers. In: Newman SP, editor. Respiratory drug delivery: essential theory & practice. Richmond: Respiratory Drug Delivery Online; 2009. p. 217-56.
    • (2009) Respiratory Drug Delivery: Essential Theory & Practice , pp. 217-256
    • Newman, S.P.1
  • 88
    • 0025114502 scopus 로고
    • Do large volume spacer devices reduce the systemic effects of high dose inhaled corticosteroids?
    • 462716 2247863
    • Brown PH, Blundell G, Greening AP, Crompton G. Do large volume spacer devices reduce the systemic effects of high dose inhaled corticosteroids? Thorax. 1990;45(10):736-9.
    • (1990) Thorax , vol.45 , Issue.10 , pp. 736-739
    • Brown, P.H.1    Blundell, G.2    Greening, A.P.3    Crompton, G.4
  • 89
    • 0025107529 scopus 로고
    • Morning serum cortisol concentrations after 2 mg inhaled beclomethasone dipropionate in normal subjects: Effect of a 750 ml spacing device
    • 462717 2247864
    • Farrer M, Francis A, Pearce S. Morning serum cortisol concentrations after 2 mg inhaled beclomethasone dipropionate in normal subjects: effect of a 750 ml spacing device. Thorax. 1990;45(10):740-2.
    • (1990) Thorax , vol.45 , Issue.10 , pp. 740-742
    • Farrer, M.1    Francis, A.2    Pearce, S.3
  • 90
    • 0029070370 scopus 로고
    • The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler
    • 1365031 8527272
    • Barry P, O'Callaghan C. The effect of delay, multiple actuations and spacer static charge on the in vitro delivery of budesonide from the Nebuhaler. Br J Clin Pharmacol. 1995;40(1):76-8.
    • (1995) Br J Clin Pharmacol , vol.40 , Issue.1 , pp. 76-78
    • Barry, P.1    O'Callaghan, C.2
  • 92
    • 84964219078 scopus 로고    scopus 로고
    • Spacer devices
    • H. Bisgaard C. O'Callaghan G.C. Smaldone (eds) Marcel Dekker New York
    • Bisgaard H, Anhøj J, Wildhaber JH. Spacer devices. In: Bisgaard H, O'Callaghan C, Smaldone GC, editors. Drug delivery to the lung. New York: Marcel Dekker; 2002. p. 389-420.
    • (2002) Drug Delivery to the Lung , pp. 389-420
    • Bisgaard, H.1    Anhøj, J.2    Wildhaber, J.H.3
  • 93
    • 0029595260 scopus 로고
    • How patients determine when to replace their metered-dose inhalers
    • 8603277
    • Ogren R, Baldwin J, Simon R. How patients determine when to replace their metered-dose inhalers. Ann Allergy Asthma Immunol. 1995;75(6):485-9.
    • (1995) Ann Allergy Asthma Immunol , vol.75 , Issue.6 , pp. 485-489
    • Ogren, R.1    Baldwin, J.2    Simon, R.3
  • 94
    • 84874342044 scopus 로고    scopus 로고
    • Prospective, open-label assessment of albuterol sulfate hydrofluoroalkane metered-dose inhaler with new integrated dose counter
    • 23265285
    • Given J, Taveras H, Iverson H, Lepore M. Prospective, open-label assessment of albuterol sulfate hydrofluoroalkane metered-dose inhaler with new integrated dose counter. Allergy Asthma Proc. 2013;34:42-51.
    • (2013) Allergy Asthma Proc , vol.34 , pp. 42-51
    • Given, J.1    Taveras, H.2    Iverson, H.3    Lepore, M.4
  • 97
    • 84898030665 scopus 로고    scopus 로고
    • Minnesota Mining and Manufacturing Company, assignee World Intellectual Property Organization patent WO 1996/009229. 1996 Mar 28
    • Hodson PD, Smith DK, inventors; Minnesota Mining and Manufacturing Company, assignee. Aerosol dispenser comprising contents indicator. World Intellectual Property Organization patent WO 1996/009229. 1996 Mar 28.
    • Aerosol Dispenser Comprising Contents Indicator
    • Hodson, P.D.1    Smith, D.K.2
  • 100
    • 34248649106 scopus 로고    scopus 로고
    • Developing dose counters: An appraisal based on regulator, pharma, and user needs
    • Bradshaw DR. Developing dose counters: an appraisal based on regulator, pharma, and user needs. Respir Drug Deliv. 2006;1:121-32.
    • (2006) Respir Drug Deliv , vol.1 , pp. 121-132
    • Bradshaw, D.R.1
  • 102
    • 33748579871 scopus 로고    scopus 로고
    • Fluticasone propionate/salmeterol hydrofluoroalkane via metereddose inhaler with integrated dose counter: Performance and patient satisfaction
    • 16981966
    • Sheth K, Wasserman R, Lincourt W, Locantore N, Carranza-Rosenzweig J, Crim C. Fluticasone propionate/salmeterol hydrofluoroalkane via metered dose inhaler with integrated dose counter: performance and patient satisfaction. Int J Clin Pract. 2006;60(10):1218-24.
    • (2006) Int J Clin Pract , vol.60 , Issue.10 , pp. 1218-1224
    • Sheth, K.1    Wasserman, R.2    Lincourt, W.3    Locantore, N.4    Carranza-Rosenzweig, J.5    Crim, C.6
  • 103
    • 79960483231 scopus 로고    scopus 로고
    • Patient satisfaction with a pressurized metered-dose inhaler with an integrated dose counter containing a fixed-dose mometasone furoate/formoterol combination
    • 21726121
    • LaForce C, Weinstein C, Nathan RA, Weinstein SF, Staudinger H, Meltzer EO. Patient satisfaction with a pressurized metered-dose inhaler with an integrated dose counter containing a fixed-dose mometasone furoate/formoterol combination. J Asthma. 2011;48(6):625-31.
    • (2011) J Asthma , vol.48 , Issue.6 , pp. 625-631
    • Laforce, C.1    Weinstein, C.2    Nathan, R.A.3    Weinstein, S.F.4    Staudinger, H.5    Meltzer, E.O.6
  • 104
    • 79957528899 scopus 로고    scopus 로고
    • Dose counter performance of mometasone furoate/formoterol inhalers in subjects with asthma or COPD
    • 21398104
    • Weinstein C, Staudinger H, Scott I, Amar NJ, LaForce C. Dose counter performance of mometasone furoate/formoterol inhalers in subjects with asthma or COPD. Respir Med. 2011;105(7):979-88.
    • (2011) Respir Med , vol.105 , Issue.7 , pp. 979-988
    • Weinstein, C.1    Staudinger, H.2    Scott, I.3    Amar, N.J.4    Laforce, C.5
  • 106
    • 84898039584 scopus 로고    scopus 로고
    • inventors. Minnesota Mining and Manufacturing Company, assignee United States patent US 5,349,945. 1994 Sep 27
    • Wass ACL, Law BR, inventors. Minnesota Mining and Manufacturing Company, assignee. Aerosol dispenser comprising an indicator assembly. United States patent US 5,349,945. 1994 Sep 27.
    • Aerosol Dispenser Comprising An Indicator Assembly
    • Acl, W.1    Law, B.R.2
  • 107
  • 108
    • 84898034124 scopus 로고    scopus 로고
    • Glaxo Group Limited, assignee World Intellectual Property Organization patent WO 1998/056444. 1998 Dec 17
    • Rand PK, Brand PJ, Godfrey JW, Bonney SG, inventors; Glaxo Group Limited, assignee. Dispenser with doses' counter. World Intellectual Property Organization patent WO 1998/056444. 1998 Dec 17.
    • Dispenser with Doses' Counter
    • Rand, P.K.1    Brand, P.J.2    Godfrey, J.W.3    Bonney, S.G.4
  • 109
    • 84898040785 scopus 로고    scopus 로고
    • IEP Group Inc., assignee United States patent US 5,622,163. 1997 Apr 22
    • Jewett W, Ebeling FA, inventors; IEP Group Inc., assignee. Counter for fluid dispensers. United States patent US 5,622,163. 1997 Apr 22.
    • Counter for Fluid Dispensers
    • Jewett, W.1    Ebeling, F.A.2
  • 110
    • 84898035095 scopus 로고    scopus 로고
    • IEP Group Inc., assignee United States patent US 5,544,647. 1996 Aug 13
    • Jewett W, Ebeling FA, inventors; IEP Group Inc., assignee. Metered dose inhalator. United States patent US 5,544,647. 1996 Aug 13.
    • Metered Dose Inhalator
    • Jewett, W.1    Ebeling, F.A.2
  • 111
    • 84870291047 scopus 로고    scopus 로고
    • Six-month in vitro validation of a metered-dose inhaler electronic monitoring device: Implications for asthma clinical trial use
    • 22920492
    • Patel M, Pilcher J, Chan A, Perrin K, Black P, Beasley R. Six-month in vitro validation of a metered-dose inhaler electronic monitoring device: implications for asthma clinical trial use. J Allergy Clin Immunol. 2012;130:1420-2.
    • (2012) J Allergy Clin Immunol , vol.130 , pp. 1420-1422
    • Patel, M.1    Pilcher, J.2    Chan, A.3    Perrin, K.4    Black, P.5    Beasley, R.6
  • 112
    • 84909426080 scopus 로고
    • United Nations Environment Program. The Montreal Protocol on Substances that Deplete the Ozone Layer
    • Ozone Secretariat, United Nations Environment Program. The Montreal Protocol on Substances that Deplete the Ozone Layer. 1987.
    • (1987) Ozone Secretariat
  • 113
    • 0032745765 scopus 로고    scopus 로고
    • Adverse effects of benzalkonium chloride on the nasal mucosa: Allergic rhinitis and rhinitis medicamentosa
    • 10566570
    • Graf P. Adverse effects of benzalkonium chloride on the nasal mucosa: allergic rhinitis and rhinitis medicamentosa. Clin Ther. 1999;21(10):1749-55.
    • (1999) Clin Ther , vol.21 , Issue.10 , pp. 1749-1755
    • Graf, P.1
  • 114
    • 42449161954 scopus 로고    scopus 로고
    • In vitro effects of preservatives in nasal sprays on human nasal epithelial cells
    • 18416966
    • Ho C, Wu M, Lan M, Tan C, Yang A. In vitro effects of preservatives in nasal sprays on human nasal epithelial cells. Am J Rhinol. 2008;22(2):125-9.
    • (2008) Am J Rhinol , vol.22 , Issue.2 , pp. 125-129
    • Ho, C.1    Wu, M.2    Lan, M.3    Tan, C.4    Yang, A.5
  • 115
    • 34248653215 scopus 로고    scopus 로고
    • Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: Single versus multiple exposure
    • 17324538
    • Mallants R, Jorissen M, Augustijns P. Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: single versus multiple exposure. Int J Pharm. 2007;338:64-9.
    • (2007) Int J Pharm , vol.338 , pp. 64-69
    • Mallants, R.1    Jorissen, M.2    Augustijns, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.