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Volumn 448, Issue 1, 2013, Pages 58-70

Treating mannitol in a saturated solution of mannitol: A novel approach to modify mannitol crystals for improved drug delivery to the lungs

Author keywords

Agglomeration; Aggregation; Dry powder inhaler; Mannitol; Surface roughness

Indexed keywords

MANNITOL; SALBUTAMOL SULFATE;

EID: 84875684659     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.03.005     Document Type: Article
Times cited : (22)

References (61)
  • 1
    • 84873705586 scopus 로고    scopus 로고
    • Effects of mechanical impaction on aerosol performance of particles with different surface roughness
    • S. Adi, H. Adi, H.K. Chan, Z. Tong, R. Yang, and A. Yu Effects of mechanical impaction on aerosol performance of particles with different surface roughness Powder Technol. 236 2013 164 170
    • (2013) Powder Technol. , vol.236 , pp. 164-170
    • Adi, S.1    Adi, H.2    Chan, H.K.3    Tong, Z.4    Yang, R.5    Yu, A.6
  • 2
    • 33644644745 scopus 로고    scopus 로고
    • Dry powder inhalers: An overview
    • P.J. Atkins Dry powder inhalers: an overview Respir. Care 50 2005 1304
    • (2005) Respir. Care , vol.50 , pp. 1304
    • Atkins, P.J.1
  • 3
    • 0036354543 scopus 로고    scopus 로고
    • Pull-off force measurements between rough surfaces by atomic force microscopy
    • DOI 10.1006/jcis.2001.8126
    • E. Beach, G. Tormoen, J. Drelich, and R. Han Pull-off force measurements between rough surfaces by atomic force microscopy J. Colloid. Interface Sci. 247 2002 84 99 (Pubitemid 34953468)
    • (2002) Journal of Colloid and Interface Science , vol.247 , Issue.1 , pp. 84-99
    • Beach, E.R.1    Tormoen, G.W.2    Drelich, J.3    Han, R.4
  • 4
    • 0027241416 scopus 로고
    • The lung deposition of salbutamol, directly labelled with technetium-99m, delivered by pressurised metered dose and dry powder inhalers
    • DOI 10.1016/0378-5173(93)90330-I
    • M.F. Biddiscombe, R. Melchor, V.H.F. Mak, R.J. Marriott, A.J. Taylor, M.D. Short, and S.G. Spiro The lung deposition of salbutamol, directly labelled with technetium-99 m, delivered by pressurised metered dose and dry powder inhalers Int. J. Pharm. 91 1993 111 121 (Pubitemid 23159814)
    • (1993) International Journal of Pharmaceutics , vol.91 , Issue.2-3 , pp. 111-121
    • Biddiscombe, M.F.1    Melchor, R.2    Mak, V.H.F.3    Marriott, R.J.4    Taylor, A.J.5    Short, M.D.6    Spiro, S.G.7
  • 5
    • 0036396163 scopus 로고    scopus 로고
    • Advanced control of crystallization processes
    • DOI 10.1016/S1367-5788(02)80016-5, PII S1367578802000111
    • R.D. Braatz Advanced control of crystallization processes Annu. Rev. Contr. 26 2002 87 99 (Pubitemid 35170482)
    • (2002) Annual Reviews in Control , vol.I26 , pp. 87-99
    • Braatz, R.D.1
  • 7
    • 61449124939 scopus 로고    scopus 로고
    • Effect of solvent on the crystal structure and habit of hydrocortisone
    • J.X. Chen, J.K. Wang, J. Ulrich, Q.X. Yin, and L.Z. Xue Effect of solvent on the crystal structure and habit of hydrocortisone Cryst. Growth Des. 8 2008 1490 1494
    • (2008) Cryst. Growth Des. , vol.8 , pp. 1490-1494
    • Chen, J.X.1    Wang, J.K.2    Ulrich, J.3    Yin, Q.X.4    Xue, L.Z.5
  • 8
    • 0034750024 scopus 로고    scopus 로고
    • Use of solid corrugated particles to enhance powder aerosol performance
    • DOI 10.1023/A:1013082531394
    • N.Y.K. Chew, and H.K. Chan Use of solid corrugated particles to enhance powder aerosol performance Pharm. Res. 18 2001 1570 1577 (Pubitemid 33022413)
    • (2001) Pharmaceutical Research , vol.18 , Issue.11 , pp. 1570-1577
    • Chew, N.Y.K.1    Chan, H.-K.2
  • 9
    • 0001144994 scopus 로고
    • Structural and kinetic features of crystal growth inhibition: Adipic acid growing in the presence of n-alkanoic acids
    • R.J. Davey, S.N. Black, D. Logan, S.J. Maginn, J.E. Fairbrother, and D.J.W. Grant Structural and kinetic features of crystal growth inhibition: adipic acid growing in the presence of n-alkanoic acids J. Chem. Soc. Faraday Trans 88 1992 3461 3466
    • (1992) J. Chem. Soc. Faraday Trans , vol.88 , pp. 3461-3466
    • Davey, R.J.1    Black, S.N.2    Logan, D.3    Maginn, S.J.4    Fairbrother, J.E.5    Grant, D.J.W.6
  • 10
    • 58949098427 scopus 로고    scopus 로고
    • Particle engineering using sonocrystallization, Salbutamol sulphate for pulmonary delivery
    • R.S. Dhumal, S.V. Biradar, A.R. Paradkar, and P. York Particle engineering using sonocrystallization, Salbutamol sulphate for pulmonary delivery Int. J. Pharm. 368 2009 129 137
    • (2009) Int. J. Pharm. , vol.368 , pp. 129-137
    • Dhumal, R.S.1    Biradar, S.V.2    Paradkar, A.R.3    York, P.4
  • 11
    • 57149145085 scopus 로고    scopus 로고
    • Ultrasound assisted engineering of lactose crystals
    • R.S. Dhumal, S.V. Biradar, A.R. Paradkar, and P. York Ultrasound assisted engineering of lactose crystals Pharm. Res. 25 2008 2835 2844
    • (2008) Pharm. Res. , vol.25 , pp. 2835-2844
    • Dhumal, R.S.1    Biradar, S.V.2    Paradkar, A.R.3    York, P.4
  • 12
    • 0026107166 scopus 로고
    • Application of bravais-friedel-donnay-harker, attachment energy and ising models to predicting and understanding the morphology of molecular crystals
    • R. Docherty, G. Clydesdale, K. Roberts, and P. Bennema Application of bravais-friedel-donnay-harker, attachment energy and ising models to predicting and understanding the morphology of molecular crystals J. Phys. D 24 1991 89
    • (1991) J. Phys. D , vol.24 , pp. 89
    • Docherty, R.1    Clydesdale, G.2    Roberts, K.3    Bennema, P.4
  • 13
    • 78349311366 scopus 로고    scopus 로고
    • Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations
    • M.J. Donovan, and H.D.C. Smyth Influence of size and surface roughness of large lactose carrier particles in dry powder inhaler formulations Int. J. Pharm. 402 2010 1 9
    • (2010) Int. J. Pharm. , vol.402 , pp. 1-9
    • Donovan, M.J.1    Smyth, H.D.C.2
  • 14
    • 1842739246 scopus 로고    scopus 로고
    • The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers
    • M.P. Flament, P. Leterme, and A. Gayot The influence of carrier roughness on adhesion, content uniformity and the in vitro deposition of terbutaline sulphate from dry powder inhalers Int. J. Pharm. 275 2004 201
    • (2004) Int. J. Pharm. , vol.275 , pp. 201
    • Flament, M.P.1    Leterme, P.2    Gayot, A.3
  • 16
    • 69549118327 scopus 로고    scopus 로고
    • Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design
    • E. Guenette, A. Barrett, D. Kraus, R. Brody, L. Harding, and G. Magee Understanding the effect of lactose particle size on the properties of DPI formulations using experimental design Int. J. Pharm. 380 2009 80
    • (2009) Int. J. Pharm. , vol.380 , pp. 80
    • Guenette, E.1    Barrett, A.2    Kraus, D.3    Brody, R.4    Harding, L.5    Magee, G.6
  • 17
    • 0019092206 scopus 로고
    • The attachment energy as a habit controlling factor: I. Theoretical considerations
    • P. Hartman, and P.J. Bennema The attachment energy as a habit controlling factor: I. Theoretical considerations Cryst. Growth 49 1980 145 156
    • (1980) Cryst. Growth , vol.49 , pp. 145-156
    • Hartman, P.1    Bennema, P.J.2
  • 18
    • 79957987387 scopus 로고    scopus 로고
    • Inhalation performance of pollen-shape carrier in dry powder formulation: Effect of size and surface morphology
    • M.S. Hassan, and R. Lau Inhalation performance of pollen-shape carrier in dry powder formulation: effect of size and surface morphology Int. J. Pharm. 413 2011 93 102
    • (2011) Int. J. Pharm. , vol.413 , pp. 93-102
    • Hassan, M.S.1    Lau, R.2
  • 19
    • 0342803734 scopus 로고    scopus 로고
    • Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate
    • P.W.S. Heng, L.W. Chan, and L.T. Lim Quantification of the surface morphologies of lactose carriers and their effect on the in vitro deposition of salbutamol sulphate Chem. Pharm. Bull. 48 2000 393 398 (Pubitemid 30187256)
    • (2000) Chemical and Pharmaceutical Bulletin , vol.48 , Issue.3 , pp. 393-398
    • Heng, P.W.S.1    Chan, L.W.2    Lim, L.T.3
  • 20
    • 72949110914 scopus 로고    scopus 로고
    • Crystal habits and the variation in surface energy heterogeneity
    • R. Ho, D.A. Wilson, and J.Y.Y. Heng Crystal habits and the variation in surface energy heterogeneity Cryst. Growth Des. 9 2009 4907 4911
    • (2009) Cryst. Growth Des. , vol.9 , pp. 4907-4911
    • Ho, R.1    Wilson, D.A.2    Heng, J.Y.Y.3
  • 21
    • 84859735921 scopus 로고    scopus 로고
    • Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery - A review for multidisciplinary researchers
    • N. Islam, and M.J. Cleary Developing an efficient and reliable dry powder inhaler for pulmonary drug delivery - a review for multidisciplinary researchers Med. Eng. Phys. 34 2012 409 427
    • (2012) Med. Eng. Phys. , vol.34 , pp. 409-427
    • Islam, N.1    Cleary, M.J.2
  • 22
    • 23844553097 scopus 로고    scopus 로고
    • Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy
    • DOI 10.1002/jps.20381
    • N. Islam, P. Stewart, I. Larson, and P. Hartley Surface roughness contribution to the adhesion force distribution of salmeterol xinafoate on lactose carriers by atomic force microscopy J. Pharm. Sci. 94 2005 1500 1511 (Pubitemid 41168680)
    • (2005) Journal of Pharmaceutical Sciences , vol.94 , Issue.7 , pp. 1500-1511
    • Islam, N.1    Stewart, P.2    Larson, I.3    Hartley, P.4
  • 23
    • 1842429885 scopus 로고    scopus 로고
    • Effect of Carrier Size on the Dispersion of Salmeterol Xinafoate from Interactive Mixtures
    • DOI 10.1002/jps.10583
    • N. Islam, P. Stewart, I. Larson, and P. Hartley Effect of carrier size on the dispersion of salmeterol xinafoate from interactive mixtures J. Pharm. Sci. 93 2004 1030 1038 (Pubitemid 38420412)
    • (2004) Journal of Pharmaceutical Sciences , vol.93 , Issue.4 , pp. 1030-1038
    • Islam, N.1    Stewart, P.2    Larson, I.3    Hartley, P.4
  • 24
    • 84856517911 scopus 로고    scopus 로고
    • Dry powder inhalers: Mechanistic evaluation of lactose formulations containing salbutamol sulphate
    • W. Kaialy, M.D. Ticehurst, and A. Nokhodchi Dry powder inhalers: mechanistic evaluation of lactose formulations containing salbutamol sulphate Int. J. Pharm. 423 2012 184 194
    • (2012) Int. J. Pharm. , vol.423 , pp. 184-194
    • Kaialy, W.1    Ticehurst, M.D.2    Nokhodchi, A.3
  • 25
    • 84862623650 scopus 로고    scopus 로고
    • Influence of lactose carrier particle size on the aerosol performance of budesonide from a dry powder inhaler
    • W. Kaialy, A. Alhalaweh, S.P. Velaga, and A. Nokhodchi Influence of lactose carrier particle size on the aerosol performance of budesonide from a dry powder inhaler Powder Technol. 227 2012 74 85
    • (2012) Powder Technol. , vol.227 , pp. 74-85
    • Kaialy, W.1    Alhalaweh, A.2    Velaga, S.P.3    Nokhodchi, A.4
  • 26
    • 84864490841 scopus 로고    scopus 로고
    • The effect of engineered mannitol-lactose mixture on dry powder inhaler performance
    • W. Kaialy, H. Larhrib, G.P. Martin, and A. Nokhodchi The effect of engineered mannitol-lactose mixture on dry powder inhaler performance Pharm. Res. 29 2012 2139 2156
    • (2012) Pharm. Res. , vol.29 , pp. 2139-2156
    • Kaialy, W.1    Larhrib, H.2    Martin, G.P.3    Nokhodchi, A.4
  • 27
    • 84861871907 scopus 로고    scopus 로고
    • Influence of batch cooling crystallization on mannitol physical properties and drug dispersion from dry powder inhalers
    • W. Kaialy, H. Larhrib, M.D. Ticehurst, and A. Nokhodchi Influence of batch cooling crystallization on mannitol physical properties and drug dispersion from dry powder inhalers Cryst. Growth Des. 12 2012 3006 3017
    • (2012) Cryst. Growth Des. , vol.12 , pp. 3006-3017
    • Kaialy, W.1    Larhrib, H.2    Ticehurst, M.D.3    Nokhodchi, A.4
  • 28
    • 79951988746 scopus 로고    scopus 로고
    • Characterisation and deposition studies of recrystallised lactose from binary mixtures of ethanol/butanol for improved drug delivery from dry powder inhalers
    • W. Kaialy, G.P. Martin, M.D. Ticehurst, P. Royall, M.A. Mohammad, J. Murphy, and A. Nokhodchi Characterisation and deposition studies of recrystallised lactose from binary mixtures of ethanol/butanol for improved drug delivery from dry powder inhalers AAPS J. 13 2011 30 43
    • (2011) AAPS J. , vol.13 , pp. 30-43
    • Kaialy, W.1    Martin, G.P.2    Ticehurst, M.D.3    Royall, P.4    Mohammad, M.A.5    Murphy, J.6    Nokhodchi, A.7
  • 29
    • 79955613972 scopus 로고    scopus 로고
    • Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone
    • W. Kaialy, M.D. Ticehurst, J. Murphy, and A. Nokhodchi Improved aerosolization performance of salbutamol sulfate formulated with lactose crystallized from binary mixtures of ethanol-acetone J. Pharm. Sci. 100 2011 2665 2684
    • (2011) J. Pharm. Sci. , vol.100 , pp. 2665-2684
    • Kaialy, W.1    Ticehurst, M.D.2    Murphy, J.3    Nokhodchi, A.4
  • 30
    • 81155122980 scopus 로고    scopus 로고
    • Effect of carrier particle shape on dry powder inhaler performance
    • W. Kaialy, A. Alhalaweh, S.P. Velaga, and A. Nokhodchi Effect of carrier particle shape on dry powder inhaler performance Int. J. Pharm. 421 2011 12 23
    • (2011) Int. J. Pharm. , vol.421 , pp. 12-23
    • Kaialy, W.1    Alhalaweh, A.2    Velaga, S.P.3    Nokhodchi, A.4
  • 31
    • 77953915537 scopus 로고    scopus 로고
    • Engineered mannitol as an alternative carrier to enhance deep lung penetration of salbutamol sulphate from dry powder inhaler
    • W. Kaialy, M.N. Momin, M.D. Ticehurst, J. Murphy, and A. Nokhodchi Engineered mannitol as an alternative carrier to enhance deep lung penetration of salbutamol sulphate from dry powder inhaler Colloid. Surface B. 79 2010 345 356
    • (2010) Colloid. Surface B. , vol.79 , pp. 345-356
    • Kaialy, W.1    Momin, M.N.2    Ticehurst, M.D.3    Murphy, J.4    Nokhodchi, A.5
  • 32
    • 77952742519 scopus 로고    scopus 로고
    • The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient
    • W. Kaialy, G.P. Martin, M.D. Ticehurst, M.N. Momin, and A. Nokhodchi The enhanced aerosol performance of salbutamol from dry powders containing engineered mannitol as excipient Int. J. Pharm. 392 2010 178 188
    • (2010) Int. J. Pharm. , vol.392 , pp. 178-188
    • Kaialy, W.1    Martin, G.P.2    Ticehurst, M.D.3    Momin, M.N.4    Nokhodchi, A.5
  • 33
    • 84866737402 scopus 로고    scopus 로고
    • The use of engineered lactose for improved pulmonary drug delivery
    • TEFARCO Innova, BioPharma Net Parma, Italy
    • W. Kaialy, and A. Nokhodchi The use of engineered lactose for improved pulmonary drug delivery Lactose as a Carrier for Inhalation Products 2010 TEFARCO Innova, BioPharma Net Parma, Italy
    • (2010) Lactose As A Carrier for Inhalation Products
    • Kaialy, W.1    Nokhodchi, A.2
  • 34
    • 0025688947 scopus 로고
    • The influence of carrier surface on the characteristics of inspirable powder aerosols
    • N.M. Kassem, and D. Ganderton The influence of carrier surface on the characteristics of inspirable powder aerosols J. Pharm. Pharmacol. 42 1990 11
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 11
    • Kassem, N.M.1    Ganderton, D.2
  • 35
    • 0032531782 scopus 로고    scopus 로고
    • Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate
    • DOI 10.1016/S0378-5173(98)00202-6, PII S0378517398002026
    • Y. Kawashima, T. Serigano, T. Hino, H. Yamamoto, and H. Takeuchi Effect of surface morphology of carrier lactose on dry powder inhalation property of pranlukast hydrate Int. J. Pharm. 172 1998 179 188 (Pubitemid 28430255)
    • (1998) International Journal of Pharmaceutics , vol.172 , Issue.1-2 , pp. 179-188
    • Kawashima, Y.1    Serigano, T.2    Hino, T.3    Yamamoto, H.4    Takeuchi, H.5
  • 36
    • 0344513087 scopus 로고    scopus 로고
    • Pulmonary drug delivery. Part I: Physiological factors affecting therapeutic effectiveness of aerosolized medications
    • N.R. Labiris, and M.B. Dolovich Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications Br. J. Clin. Pharmacol. 56 2003 588
    • (2003) Br. J. Clin. Pharmacol. , vol.56 , pp. 588
    • Labiris, N.R.1    Dolovich, M.B.2
  • 37
    • 0037433847 scopus 로고    scopus 로고
    • The influence of carrier and drug morphology on drug delivery from dry powder formulations
    • DOI 10.1016/S0378-5173(03)00156-X
    • H. Larhrib, G.P. Martin, C. Marriott, and D. Prime The influence of carrier and drug morphology on drug delivery from dry powder formulations Int. J. Pharm. 257 2003 283 296 (Pubitemid 36507054)
    • (2003) International Journal of Pharmaceutics , vol.257 , Issue.1-2 , pp. 283-296
    • Larhrib, H.1    Martin, G.P.2    Marriott, C.3    Prime, D.4
  • 38
    • 84862854529 scopus 로고    scopus 로고
    • Dry powder inhalers: Study of the parameters influencing adhesion and dispersion of fluticasone propionate
    • V.N.P. Le, T.H.H. Thi, E. Robins, and M. Flament Dry powder inhalers: study of the parameters influencing adhesion and dispersion of fluticasone propionate AAPS Pharm. Sci. Tech. 13 2012 477 484
    • (2012) AAPS Pharm. Sci. Tech. , vol.13 , pp. 477-484
    • Le, V.N.P.1    Thi, T.H.H.2    Robins, E.3    Flament, M.4
  • 39
    • 84655169980 scopus 로고    scopus 로고
    • Influence of the lactose grade within dry powder formulations of fluticasone propionate and terbutaline sulphate
    • V. Le, H. Bierend, E. Robins, H. Steckel, and M. Flament Influence of the lactose grade within dry powder formulations of fluticasone propionate and terbutaline sulphate Int. J. Pharm. 422 2012 75 82
    • (2012) Int. J. Pharm. , vol.422 , pp. 75-82
    • Le, V.1    Bierend, H.2    Robins, E.3    Steckel, H.4    Flament, M.5
  • 40
    • 31044438214 scopus 로고    scopus 로고
    • London-van der Waals adhesiveness of rough particles
    • DOI 10.1016/j.powtec.2005.10.012, PII S0032591005005413
    • Q. Li, V. Rudolph, and W. Peukert London-van der waals adhesiveness of rough particles Powder Technol. 161 2006 248 255 (Pubitemid 43120480)
    • (2006) Powder Technology , vol.161 , Issue.3 , pp. 248-255
    • Li, Q.1    Rudolph, V.2    Peukert, W.3
  • 41
    • 3242711466 scopus 로고    scopus 로고
    • Aerosol dispersion of respirable particles in narrow size distributions using drug-alone and lactose-blend formulations
    • DOI 10.1023/B:PHAM.0000032991.74736.3e
    • M.D. Louey, M. Van Oort, and A.J. Hickey Aerosol dispersion of respirable particles in narrow size distributions using drug-alone and lactose-blend formulations Pharm. Res. 21 2004 1207 1213 (Pubitemid 38954205)
    • (2004) Pharmaceutical Research , vol.21 , Issue.7 , pp. 1207-1213
    • Louey, M.D.1    Van Oort, M.2    Hickey, A.J.3
  • 42
    • 84866733553 scopus 로고    scopus 로고
    • The influence of using carriers with increasing elongation ratios on uniformity, adhesion and in vitro aerosolozation performance of salbutamol sulphate from dry powder inhalers
    • 30 July-03 August, Maryland, USA
    • A. Nokhodchi, W. Kaialy, and M.D. Ticehurst The influence of using carriers with increasing elongation ratios on uniformity, adhesion and in vitro aerosolozation performance of salbutamol sulphate from dry powder inhalers CRS Annual Meeting 30 July-03 August, Maryland, USA 2011
    • (2011) CRS Annual Meeting
    • Nokhodchi, A.1    Kaialy, W.2    Ticehurst, M.D.3
  • 43
    • 84858624234 scopus 로고    scopus 로고
    • Lactose characteristics and the generation of the aerosol
    • G. Pilcer, N. Wauthoz, and K. Amighi Lactose characteristics and the generation of the aerosol Adv. Drug Deliv. Rev. 64 2012 233 256
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 233-256
    • Pilcer, G.1    Wauthoz, N.2    Amighi, K.3
  • 44
    • 0033286452 scopus 로고    scopus 로고
    • The influence of particle size distribution and surface roughness of carrier particles on the in vitro properties of dry powder inhalations
    • DOI 10.1080/027868299304174
    • F. Podczeck The influence of particle size distribution and surface roughness of carrier particles on the in vitro properties of dry powder inhalations Aerosol Sci. Technol. 31 1999 301 321 (Pubitemid 32001438)
    • (1999) Aerosol Science and Technology , vol.31 , Issue.4 , pp. 301-321
    • Podczeck, F.1
  • 45
    • 0032509827 scopus 로고    scopus 로고
    • The relationship between physical properties of lactose monohydrate and the aerodynamic behaviour of adhered drug particles
    • DOI 10.1016/S0378-5173(97)00313-X, PII S037851739700313X
    • F. Podczeck The relationship between physical properties of lactose monohydrate and the aerodynamic behaviour of adhered drug particles Int. J. Pharm. 160 1998 119 130 (Pubitemid 28059936)
    • (1998) International Journal of Pharmaceutics , vol.160 , Issue.1 , pp. 119-130
    • Podczeck, F.1
  • 46
    • 3543128402 scopus 로고    scopus 로고
    • Evaluation of SCF-engineered particle-based lactose blends in passive dry powder inhalers
    • DOI 10.1016/j.ijpharm.2004.05.029, PII S037851730400328X
    • H. Schiavone, S. Palakodaty, A. Clark, P. York, and S.T. Tzannis Evaluation of SCF-engineered particle-based lactose blends in passive dry powder inhalers Int. J. Pharm. 281 2004 55 66 (Pubitemid 39024263)
    • (2004) International Journal of Pharmaceutics , vol.281 , Issue.1-2 , pp. 55-66
    • Schiavone, H.1    Palakodaty, S.2    Clark, A.3    York, P.4    Tzannis, S.T.5
  • 47
    • 1442285251 scopus 로고    scopus 로고
    • Aerosolisation behaviour of micronised and supercritically-processed powders
    • DOI 10.1016/S0021-8502(03)00022-3, PII S0021850203000223
    • B.Y. Shekunov, J.C. Feeley, A.H.L. Chow, H.H.Y. Tong, and P. York Aerosolisation behaviour of micronised and supercritically-processed powders J. Aerosol Sci. 34 2003 553 568 (Pubitemid 38352543)
    • (2003) Journal of Aerosol Science , vol.34 , Issue.5 , pp. 553-568
    • Shekunov, B.Y.1    Feeley, J.C.2    Chow, A.H.L.3    Tong, H.H.Y.4    York, P.5
  • 49
    • 22544457534 scopus 로고    scopus 로고
    • Carriers in drug powder delivery: Implications for inhalation system design
    • DOI 10.2165/00137696-200503020-00004
    • H.D.C. Smyth, and A.J. Hickey Carriers in drug powder delivery: implications for inhalation system design Am. J. Drug Deliv. 3 2005 117 132 (Pubitemid 41018283)
    • (2005) American Journal of Drug Delivery , vol.3 , Issue.2 , pp. 117-132
    • Smyth, H.D.C.1    Hickey, A.J.2
  • 50
    • 0342437435 scopus 로고    scopus 로고
    • In vitro evaluation of dry powder inhalers II: Influence of carrier particle size and concentration on in vitro deposition
    • DOI 10.1016/S0378-5173(97)00115-4, PII S0378517397001154
    • H. Steckel, and B.W. Müller In vitro evaluation of dry powder inhalers II: influence of carrier particle size and concentration on in vitro deposition Int. J. Pharm. 154 1997 31 37 (Pubitemid 27326817)
    • (1997) International Journal of Pharmaceutics , vol.154 , Issue.1 , pp. 31-37
    • Steckel, H.1    Muller, B.W.2
  • 51
    • 9644255612 scopus 로고    scopus 로고
    • Prediction of aerodynamic diameter of particles with rough surfaces
    • DOI 10.1016/j.powtec.2004.09.036, PII S0032591004003894
    • P. Tang, H.K. Chan, and J.A. Raper Prediction of aerodynamic diameter of particles with rough surfaces Powder Technol. 147 2004 64 78 (Pubitemid 39575132)
    • (2004) Powder Technology , vol.147 , Issue.1-3 , pp. 64-78
    • Tang, P.1    Chan, H.-K.2    Raper, J.A.3
  • 52
    • 0035806263 scopus 로고    scopus 로고
    • Effect of additives on insulin absorption from intratracheally administered dry powders in rats
    • DOI 10.1016/S0378-5173(01)00662-7, PII S0378517301006627
    • H. Todo, H. Okamoto, K. Iida, and K. Danjo Effect of additives on insulin absorption from intratracheally administered dry powders in rats Int. J. Pharm. 220 2001 101 110 (Pubitemid 32476846)
    • (2001) International Journal of Pharmaceutics , vol.220 , Issue.1-2 , pp. 101-110
    • Todo, H.1    Okamoto, H.2    Iida, K.3    Danjo, K.4
  • 53
    • 52149086340 scopus 로고    scopus 로고
    • The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations
    • D. Traini, P.M. Young, F. Thielmann, and M. Acharya The influence of lactose pseudopolymorphic form on salbutamol sulfate-lactose interactions in DPI formulations Drug Dev. Ind. Pharm. 34 2008 992 1001
    • (2008) Drug Dev. Ind. Pharm. , vol.34 , pp. 992-1001
    • Traini, D.1    Young, P.M.2    Thielmann, F.3    Acharya, M.4
  • 54
    • 0032440596 scopus 로고    scopus 로고
    • Preparation of polymorphic crystalline phases of D-mannitol: Influence of keggin heteropolyanions
    • DOI 10.1016/S0008-6215(98)00152-9, PII S0008621598001529
    • M.C.N. Trovão, A. Cavaleiro, and J.D. Pedrosa de Jesus Preparation of polymorphic crystalline phases of d-mannitol: influence of keggin heteropolyanions Carbohydr. Res. 309 1998 363 366 (Pubitemid 29034650)
    • (1998) Carbohydrate Research , vol.309 , Issue.4 , pp. 363-366
    • Trovao, M.C.N.1    Cavaleiro, A.M.V.2    Pedrosa De Jesus, J.D.3
  • 55
    • 84866732102 scopus 로고    scopus 로고
    • Studies on the effect of the size of polycaprolactone microspheres for the dispersion of salbutamol sulfate from dry powder inhaler formulations
    • R.A. Tuli, G.A. George, T.R. Dargaville, and N. Islam Studies on the effect of the size of polycaprolactone microspheres for the dispersion of salbutamol sulfate from dry powder inhaler formulations Pharm. Res. 29 2012 2445 2455
    • (2012) Pharm. Res. , vol.29 , pp. 2445-2455
    • Tuli, R.A.1    George, G.A.2    Dargaville, T.R.3    Islam, N.4
  • 56
    • 0025370395 scopus 로고
    • In vivo evaluation of the new multiple dose powder inhaler and the Rotahaler using the gamma scintigraphy
    • M. Vidgren, P. Paronen, P. Vidgren, P. Vainio, and J. Nuutinen In vivo evaluation of the new multiple dose powder inhaler and the rotahaler using the gamma scintigraphy Acta Pharm. Nord. 2 1990 3 10 (Pubitemid 20168637)
    • (1990) Acta Pharmaceutica Nordica , vol.2 , Issue.1 , pp. 3-10
    • Vidgren, M.1    Paronen, P.2    Vidgren, P.3    Vainio, P.4    Nuutinen, J.5
  • 57
    • 34249281670 scopus 로고    scopus 로고
    • The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance
    • DOI 10.1002/jps.20933
    • P.M. Young, H. Chan, H. Chiou, S. Edge, T.H.S. Tee, and D. Traini The influence of mechanical processing of dry powder inhaler carriers on drug aerosolization performance J. Pharm. Sci. 96 2007 1331 1341 (Pubitemid 46804584)
    • (2007) Journal of Pharmaceutical Sciences , vol.96 , Issue.5 , pp. 1331-1341
    • Young, P.M.1    Chan, H.-K.2    Chiou, H.3    Edge, S.4    Tee, T.H.S.5    Traini, D.6
  • 59
    • 0342657112 scopus 로고    scopus 로고
    • The influence of carrier morphology on drug delivery by dry powder inhalers
    • DOI 10.1016/S0378-5173(00)00347-1, PII S0378517300003471
    • X.M. Zeng, G.P. Martin, C. Marriott, and J. Pritchard The influence of carrier morphology on drug delivery by dry powder inhalers Int. J. Pharm. 200 2000 93 106 (Pubitemid 30177254)
    • (2000) International Journal of Pharmaceutics , vol.200 , Issue.1 , pp. 93-106
    • Zeng, X.M.1    Martin, G.P.2    Marriott, C.3    Pritchard, J.4
  • 61
    • 84858618162 scopus 로고    scopus 로고
    • Drug-lactose binding aspects in adhesive mixtures: Controlling performance in dry powder inhaler formulations by altering lactose carrier surfaces
    • Q.T. Zhou, and D.A.V. Morton Drug-lactose binding aspects in adhesive mixtures: controlling performance in dry powder inhaler formulations by altering lactose carrier surfaces Adv. Drug Deliv. Rev. 64 2012 275 284
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 275-284
    • Zhou, Q.T.1    Morton, D.A.V.2


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