Preparation of DNA dry powder for non-viral gene delivery by spray-freeze drying: Effect of protective agents (polyethyleneimine and sugars) on the stability of DNA

Journal of Pharmacy and Pharmacology

Volumn 56, Issue 1, 2004, Pages 27-33

  Kuo, Jung Hua Steven ^a   Hwang, Robin ^b  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGAROSE; DNA; MANNITOL; POLYETHYLENEIMINE; POLYMER; PROTECTIVE AGENT; SUCROSE; SUGAR; TREHALOSE;

ANIMAL CELL; ARTICLE; ASSAY; CELL CULTURE; CONTROLLED STUDY; DNA DEGRADATION; DNA STRUCTURE; DNA TRANSFECTION; DRY POWDER; ELECTROSTATIC PRECIPITATION; FEASIBILITY STUDY; FREEZE DRYING; GEL ELECTROPHORESIS; GENE TARGETING; MOUSE; NONHUMAN; PARTICLE SIZE; REHYDRATION; SPRAY DRYING; STATISTICAL ANALYSIS; STRESS; ZETA POTENTIAL;

ANIMALS; BETA-GALACTOSIDASE; CARBOHYDRATES; CELLS, CULTURED; DNA; DRUG DELIVERY SYSTEMS; DRUG STABILITY; ELECTROPHORESIS, AGAR GEL; ELECTROSTATICS; FREEZE DRYING; GENE TRANSFER TECHNIQUES; MICE; NIH 3T3 CELLS; PARTICLE SIZE; POLYETHYLENEIMINE; POWDERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 1042292677     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357022494     Document Type: Article

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