-
1
-
-
78049486018
-
Autophagy in liver diseases
-
[CrossRef] [PubMed]
-
Rautou, P.E.; Mansouri, A.; Lebrec, D.; Durand, F.; Valla, D.; Moreau, R. Autophagy in liver diseases. J. Hepatol. 2010, 53, 1123-1134. [CrossRef] [PubMed]
-
(2010)
J Hepatol
, vol.53
, pp. 1123-1134
-
-
Rautou, P.E.1
Mansouri, A.2
Lebrec, D.3
Durand, F.4
Valla, D.5
Moreau, R.6
-
2
-
-
79958167078
-
Functions of autophagy in hepatic and pancreatic physiology and disease
-
[CrossRef] [PubMed]
-
Czaja, M.J. Functions of autophagy in hepatic and pancreatic physiology and disease. Gastroenterology 2011, 140, 1895-1908. [CrossRef] [PubMed]
-
(2011)
Gastroenterology
, vol.140
, pp. 1895-1908
-
-
Czaja, M.J.1
-
3
-
-
78649338141
-
Autophagy and the integrated stress response
-
[CrossRef] [PubMed]
-
Kroemer, G.; Marino, G.; Levine, B. Autophagy and the integrated stress response. Mol. Cell 2010, 40, 280-293. [CrossRef] [PubMed]
-
(2010)
Mol Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Marino, G.2
Levine, B.3
-
4
-
-
81055144784
-
Autophagy: Renovation of cells and tissues
-
[CrossRef] [PubMed]
-
Mizushima, N.; Komatsu, M. Autophagy: Renovation of cells and tissues. Cell 2011, 147, 728-741. [CrossRef] [PubMed]
-
(2011)
Cell
, vol.147
, pp. 728-741
-
-
Mizushima, N.1
Komatsu, M.2
-
5
-
-
35448981935
-
Autophagy: From phenomenology to molecular understanding in less than a decade
-
[CrossRef] [PubMed]
-
Klionsky, D.J. Autophagy: From phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell Biol. 2007, 8, 931-937. [CrossRef] [PubMed]
-
(2007)
Nat. Rev. Mol Cell Biol
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
6
-
-
34548299555
-
Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability
-
[CrossRef] [PubMed]
-
Ding, W.X.; Ni, H.M.; Gao, W.; Yoshimori, T.; Stolz, D.B.; Ron, D.; Yin, X.M. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am. J. Pathol. 2007, 171, 513-524. [CrossRef] [PubMed]
-
(2007)
Am. J Pathol
, vol.171
, pp. 513-524
-
-
Ding, W.X.1
Ni, H.M.2
Gao, W.3
Yoshimori, T.4
Stolz, D.B.5
Ron, D.6
Yin, X.M.7
-
7
-
-
79955631150
-
Autophagy in the cellular energetic balance
-
[CrossRef] [PubMed]
-
Singh, R.; Cuervo, A.M. Autophagy in the cellular energetic balance. Cell Metab. 2011, 13, 495-504. [CrossRef] [PubMed]
-
(2011)
Cell Metab
, vol.13
, pp. 495-504
-
-
Singh, R.1
Cuervo, A.M.2
-
8
-
-
84882254367
-
The role of autophagy in neurodegenerative disease
-
[CrossRef] [PubMed]
-
Nixon, R.A. The role of autophagy in neurodegenerative disease. Nat. Med. 2013, 19, 983-997. [CrossRef] [PubMed]
-
(2013)
Nat Med
, vol.19
, pp. 983-997
-
-
Nixon, R.A.1
-
9
-
-
78751672975
-
Autophagy in immunity and inflammation
-
[CrossRef] [PubMed]
-
Levine, B.; Mizushima, N.; Virgin, H.W. Autophagy in immunity and inflammation. Nature 2011, 469, 323-335. [CrossRef] [PubMed]
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
10
-
-
84877628647
-
Autophagy in human health and disease
-
[CrossRef] [PubMed]
-
Choi, A.M.; Ryter, S.W.; Levine, B. Autophagy in human health and disease. N. Engl. J. Med. 2013, 368, 651-662. [CrossRef] [PubMed]
-
(2013)
N. Engl. J Med
, vol.368
, pp. 651-662
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
11
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
[CrossRef] [PubMed]
-
White, E. Deconvoluting the context-dependent role for autophagy in cancer. Nat. Rev. Cancer 2012, 12, 401-410. [CrossRef] [PubMed]
-
(2012)
Nat. Rev Cancer
, vol.12
, pp. 401-410
-
-
White, E.1
-
12
-
-
84902655291
-
Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue
-
[CrossRef] [PubMed]
-
Kwanten, W.J.; Martinet, W.; Michielsen, P.P.; Francque, S.M. Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue. World J. Gastroenterol. 2014, 20, 7325-7338. [CrossRef] [PubMed]
-
(2014)
World J Gastroenterol
, vol.20
, pp. 7325-7338
-
-
Kwanten, W.J.1
Martinet, W.2
Michielsen, P.P.3
Francque, S.M.4
-
13
-
-
84861972253
-
Autophagy and cancer cell metabolism
-
[CrossRef] [PubMed]
-
Lozy, F.; Karantza, V. Autophagy and cancer cell metabolism. Semin. Cell Dev. Biol. 2012, 23, 395-401. [CrossRef] [PubMed]
-
(2012)
Semin. Cell Dev Biol
, vol.23
, pp. 395-401
-
-
Lozy, F.1
Karantza, V.2
-
14
-
-
84875251503
-
The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets
-
[CrossRef] [PubMed]
-
Cui, J.; Gong, Z.; Shen, H.M. The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets. Biochim. Biophys. Acta 2013, 1836, 15-26. [CrossRef] [PubMed]
-
(2013)
Biochim. Biophys Acta
, vol.1836
, pp. 15-26
-
-
Cui, J.1
Gong, Z.2
Shen, H.M.3
-
15
-
-
79952231921
-
Management of hepatocellular carcinoma: An update
-
[CrossRef] [PubMed]
-
Bruix, J.; Sherman, M. Management of hepatocellular carcinoma: An update. Hepatology 2011, 53, 1020-1022. [CrossRef] [PubMed]
-
(2011)
Hepatology
, vol.53
, pp. 1020-1022
-
-
Bruix, J.1
Sherman, M.2
-
16
-
-
84859212951
-
Hepatocellular carcinoma
-
[CrossRef]
-
Forner, A.; Llovet, J.M.; Bruix, J. Hepatocellular carcinoma. Lancet 2012, 379, 1245-1255. [CrossRef]
-
(2012)
Lancet
, vol.379
, pp. 1245-1255
-
-
Forner, A.1
Llovet, J.M.2
Bruix, J.3
-
17
-
-
84920924216
-
Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells
-
[CrossRef] [PubMed]
-
Yan, J.; Zhou, Y.; Chen, D.; Li, L.; Yang, X.; You, Y.; Ling, X. Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells. J. Cancer 2015, 6, 151-159. [CrossRef] [PubMed]
-
(2015)
J Cancer
, vol.6
, pp. 151-159
-
-
Yan, J.1
Zhou, Y.2
Chen, D.3
Li, L.4
Yang, X.5
You, Y.6
Ling, X.7
-
18
-
-
84872788552
-
Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma
-
[PubMed]
-
Huo, X.; Zhang, Q.; Liu, A.M.; Tang, C.; Gong, Y.; Bian, J.; Luk, J.M.; Xu, Z.; Chen, J. Overexpression of Yes-associated protein confers doxorubicin resistance in hepatocellullar carcinoma. Oncol. Rep. 2013, 29, 840-846. [PubMed]
-
(2013)
Oncol Rep
, vol.29
, pp. 840-846
-
-
Huo, X.1
Zhang, Q.2
Liu, A.M.3
Tang, C.4
Gong, Y.5
Bian, J.6
Luk, J.M.7
Xu, Z.8
Chen, J.9
-
19
-
-
84896691995
-
The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Lee, Y.J.; Hah, Y.J.; Kang, Y.N.; Kang, K.J.; Hwang, J.S.; Chung, W.J.; Cho, K.B.; Park, K.S.; Kim, E.S.; Seo, H.Y.; et al. The autophagy-related marker LC3 can predict prognosis in human hepatocellular carcinoma. PLoS ONE 2013, 8, e81540. [CrossRef] [PubMed]
-
(2013)
PLoS ONE
, vol.8
-
-
Lee, Y.J.1
Hah, Y.J.2
Kang, Y.N.3
Kang, K.J.4
Hwang, J.S.5
Chung, W.J.6
Cho, K.B.7
Park, K.S.8
Kim, E.S.9
Seo, H.Y.10
-
20
-
-
84900318897
-
The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance
-
[CrossRef] [PubMed]
-
Qiu, D.M.; Wang, G.L.; Chen, L.; Xu, Y.Y.; He, S.; Cao, X.L.; Qin, J.; Zhou, J.M.; Zhang, Y.X.; Qun, E. The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance. BMC Cancer 2014, 14. [CrossRef] [PubMed]
-
(2014)
BMC Cancer
, pp. 14
-
-
Qiu, D.M.1
Wang, G.L.2
Chen, L.3
Xu, Y.Y.4
He, S.5
Cao, X.L.6
Qin, J.7
Zhou, J.M.8
Zhang, Y.X.9
Qun, E.10
-
21
-
-
84946844556
-
Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib
-
[CrossRef] [PubMed]
-
Pan, H.; Wang, Z.; Jiang, L.; Sui, X.; You, L.; Shou, J.; Jing, Z.; Xie, J.; Ge, W.; Cai, X.; et al. Autophagy inhibition sensitizes hepatocellular carcinoma to the multikinase inhibitor linifanib. Sci. Rep. 2014, 4. [CrossRef] [PubMed]
-
(2014)
Sci. Rep
, pp. 4
-
-
Pan, H.1
Wang, Z.2
Jiang, L.3
Sui, X.4
You, L.5
Shou, J.6
Jing, Z.7
Xie, J.8
Ge, W.9
Cai, X.10
-
22
-
-
80053554108
-
Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation
-
[CrossRef] [PubMed]
-
Ding, Z.B.; Hui, B.; Shi, Y.H.; Zhou, J.; Peng, Y.F.; Gu, C.Y.; Yang, H.; Shi, G.M.; Ke, A.W.; Wang, X.Y.; et al. Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation. Clin. Cancer Res. 2011, 17, 6229-6238. [CrossRef] [PubMed]
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6229-6238
-
-
Ding, Z.B.1
Hui, B.2
Shi, Y.H.3
Zhou, J.4
Peng, Y.F.5
Gu, C.Y.6
Yang, H.7
Shi, G.M.8
Ke, A.W.9
Wang, X.Y.10
-
23
-
-
74949090299
-
An overview of the molecular mechanism of autophagy
-
[PubMed]
-
Yang, Z.; Klionsky, D.J. An overview of the molecular mechanism of autophagy. Curr. Top. Microbiol. Immunol. 2009, 335, 1-32. [PubMed]
-
(2009)
Curr. Top. Microbiol Immunol
, vol.335
, pp. 1-32
-
-
Yang, Z.1
Klionsky, D.J.2
-
24
-
-
79959952405
-
Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
-
[CrossRef] [PubMed]
-
Ezaki, J.; Matsumoto, N.; Takeda-Ezaki, M.; Komatsu, M.; Takahashi, K.; Hiraoka, Y.; Taka, H.; Fujimura, T.; Takehana, K.; Yoshida, M.; et al. Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy 2011, 7, 727-736. [CrossRef] [PubMed]
-
(2011)
Autophagy
, vol.7
, pp. 727-736
-
-
Ezaki, J.1
Matsumoto, N.2
Takeda-Ezaki, M.3
Komatsu, M.4
Takahashi, K.5
Hiraoka, Y.6
Taka, H.7
Fujimura, T.8
Takehana, K.9
Yoshida, M.10
-
25
-
-
65949095803
-
Autophagy regulates lipid metabolism
-
[CrossRef] [PubMed]
-
Singh, R.; Kaushik, S.; Wang, Y.; Xiang, Y.; Novak, I.; Komatsu, M.; Tanaka, K.; Cuervo, A.M.; Czaja, M.J. Autophagy regulates lipid metabolism. Nature 2009, 458, 1131-1135. [CrossRef] [PubMed]
-
(2009)
Nature
, vol.458
, pp. 1131-1135
-
-
Singh, R.1
Kaushik, S.2
Wang, Y.3
Xiang, Y.4
Novak, I.5
Komatsu, M.6
Tanaka, K.7
Cuervo, A.M.8
Czaja, M.J.9
-
26
-
-
21044455137
-
Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice
-
[CrossRef] [PubMed]
-
Komatsu, M.; Waguri, S.; Ueno, T.; Iwata, J.; Murata, S.; Tanida, I.; Ezaki, J.; Mizushima, N.; Ohsumi, Y.; Uchiyama, Y.; et al. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 2005, 169, 425-434. [CrossRef] [PubMed]
-
(2005)
J Cell Biol
, vol.169
, pp. 425-434
-
-
Komatsu, M.1
Waguri, S.2
Ueno, T.3
Iwata, J.4
Murata, S.5
Tanida, I.6
Ezaki, J.7
Mizushima, N.8
Ohsumi, Y.9
Uchiyama, Y.10
-
27
-
-
79955492012
-
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
-
[CrossRef] [PubMed]
-
Inami, Y.; Waguri, S.; Sakamoto, A.; Kouno, T.; Nakada, K.; Hino, O.; Watanabe, S.; Ando, J.; Iwadate, M.; Yamamoto, M.; et al. Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells. J. Cell Biol. 2011, 193, 275-284. [CrossRef] [PubMed]
-
(2011)
J Cell Biol
, vol.193
, pp. 275-284
-
-
Inami, Y.1
Waguri, S.2
Sakamoto, A.3
Kouno, T.4
Nakada, K.5
Hino, O.6
Watanabe, S.7
Ando, J.8
Iwadate, M.9
Yamamoto, M.10
-
28
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
[CrossRef] [PubMed]
-
Takamura, A.; Komatsu, M.; Hara, T.; Sakamoto, A.; Kishi, C.; Waguri, S.; Eishi, Y.; Hino, O.; Tanaka, K.; Mizushima, N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011, 25, 795-800. [CrossRef] [PubMed]
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
Eishi, Y.7
Hino, O.8
Tanaka, K.9
Mizushima, N.10
-
29
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
[CrossRef] [PubMed]
-
Kim, J.; Kundu, M.; Viollet, B.; Guan, K.L. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat. Cell Biol. 2011, 13, 132-141. [CrossRef] [PubMed]
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
30
-
-
79251587803
-
Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
-
[CrossRef] [PubMed]
-
Egan, D.F.; Shackelford, D.B.; Mihaylova, M.M.; Gelino, S.; Kohnz, R.A.; Mair, W.; Vasquez, D.S.; Joshi, A.; Gwinn, D.M.; Taylor, R.; et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science 2011, 331, 456-461. [CrossRef] [PubMed]
-
(2011)
Science
, vol.331
, pp. 456-461
-
-
Egan, D.F.1
Shackelford, D.B.2
Mihaylova, M.M.3
Gelino, S.4
Kohnz, R.A.5
Mair, W.6
Vasquez, D.S.7
Joshi, A.8
Gwinn, D.M.9
Taylor, R.10
-
31
-
-
0034707036
-
A ubiquitin-like system mediates protein lipidation
-
[PubMed]
-
Ichimura, Y.; Kirisako, T.; Takao, T.; Satomi, Y.; Shimonishi, Y.; Ishihara, N.; Mizushima, N.; Tanida, I.; Kominami, E.; Ohsumi, M.; et al. A ubiquitin-like system mediates protein lipidation. Nature 2000, 408, 488-492. [PubMed]
-
(2000)
Nature
, vol.408
, pp. 488-492
-
-
Ichimura, Y.1
Kirisako, T.2
Takao, T.3
Satomi, Y.4
Shimonishi, Y.5
Ishihara, N.6
Mizushima, N.7
Tanida, I.8
Kominami, E.9
Ohsumi, M.10
-
32
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
[CrossRef] [PubMed]
-
Kabeya, Y.; Mizushima, N.; Ueno, T.; Yamamoto, A.; Kirisako, T.; Noda, T.; Kominami, E.; Ohsumi, Y.; Yoshimori, T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 2000, 19, 5720-5728. [CrossRef] [PubMed]
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
33
-
-
77954237882
-
Network organization of the human autophagy system
-
[CrossRef] [PubMed]
-
Behrends, C.; Sowa, M.E.; Gygi, S.P.; Harper, J.W. Network organization of the human autophagy system. Nature 2010, 466, 68-76. [CrossRef] [PubMed]
-
(2010)
Nature
, vol.466
, pp. 68-76
-
-
Behrends, C.1
Sowa, M.E.2
Gygi, S.P.3
Harper, J.W.4
-
34
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
[CrossRef] [PubMed]
-
Ogata, M.; Hino, S.; Saito, A.; Morikawa, K.; Kondo, S.; Kanemoto, S.; Murakami, T.; Taniguchi, M.; Tanii, I.; Yoshinaga, K.; et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol. Cell. Biol. 2006, 26, 9220-9231. [CrossRef] [PubMed]
-
(2006)
Mol. Cell Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
-
35
-
-
84895930872
-
Liver autophagy: Much more than just taking out the trash
-
[CrossRef] [PubMed]
-
Schneider, J.L.; Cuervo, A.M. Liver autophagy: Much more than just taking out the trash. Nat. Rev. Gastroenterol. Hepatol. 2014, 11, 187-200. [CrossRef] [PubMed]
-
(2014)
Nat. Rev. Gastroenterol Hepatol
, vol.11
, pp. 187-200
-
-
Schneider, J.L.1
Cuervo, A.M.2
-
36
-
-
36249025723
-
Autophagy: Process and function
-
[CrossRef] [PubMed]
-
Mizushima, N. Autophagy: Process and function. Genes Dev. 2007, 21, 2861-2873. [CrossRef] [PubMed]
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
37
-
-
43949123866
-
Autophagy in the liver
-
[CrossRef] [PubMed]
-
Yin, X.M.; Ding, W.X.; Gao, W. Autophagy in the liver. Hepatology 2008, 47, 1773-1785. [CrossRef] [PubMed]
-
(2008)
Hepatology
, vol.47
, pp. 1773-1785
-
-
Yin, X.M.1
Ding, W.X.2
Gao, W.3
-
38
-
-
34249934085
-
Selective degradation of mitochondria by mitophagy
-
[CrossRef] [PubMed]
-
Kim, I.; Rodriguez-Enriquez, S.; Lemasters, J.J. Selective degradation of mitochondria by mitophagy. Arch. Biochem. Biophys. 2007, 462, 245-253. [CrossRef] [PubMed]
-
(2007)
Arch. Biochem Biophys
, vol.462
, pp. 245-253
-
-
Kim, I.1
Rodriguez-Enriquez, S.2
Lemasters, J.J.3
-
39
-
-
33644606491
-
Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes
-
[CrossRef] [PubMed]
-
Rodriguez-Enriquez, S.; Kim, I.; Currin, R.T.; Lemasters, J.J. Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2006, 2, 39-46. [CrossRef] [PubMed]
-
(2006)
Autophagy
, vol.2
, pp. 39-46
-
-
Rodriguez-Enriquez, S.1
Kim, I.2
Currin, R.T.3
Lemasters, J.J.4
-
40
-
-
79958847617
-
Role of autophagy in liver physiology and pathophysiology
-
[CrossRef] [PubMed]
-
Ding, W.X. Role of autophagy in liver physiology and pathophysiology. World J. Biol. Chem. 2010, 1, 3-12. [CrossRef] [PubMed]
-
(2010)
World J. Biol Chem
, vol.1
, pp. 3-12
-
-
Ding, W.X.1
-
41
-
-
84896285400
-
Autophagy: A novel therapeutic target for hepatocarcinoma (Review)
-
[CrossRef] [PubMed]
-
Wang, Z.; Han, W.; Sui, X.; Fang, Y.; Pan, H. Autophagy: A novel therapeutic target for hepatocarcinoma (Review). Oncol. Lett. 2014, 7, 1345-1351. [CrossRef] [PubMed]
-
(2014)
Oncol Lett
, vol.7
, pp. 1345-1351
-
-
Wang, Z.1
Han, W.2
Sui, X.3
Fang, Y.4
Pan, H.5
-
42
-
-
33747830764
-
Hepatocellular carcinoma pathogenesis: From genes to environment
-
[CrossRef] [PubMed]
-
Farazi, P.A.; DePinho, R.A. Hepatocellular carcinoma pathogenesis: From genes to environment. Nat. Rev. Cancer 2006, 6, 674-687. [CrossRef] [PubMed]
-
(2006)
Nat. Rev Cancer
, vol.6
, pp. 674-687
-
-
Farazi, P.A.1
DePinho, R.A.2
-
43
-
-
77956400005
-
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
-
[CrossRef] [PubMed]
-
Yang, L.; Li, P.; Fu, S.; Calay, E.S.; Hotamisligil, G.S. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010, 11, 467-478. [CrossRef] [PubMed]
-
(2010)
Cell Metab
, vol.11
, pp. 467-478
-
-
Yang, L.1
Li, P.2
Fu, S.3
Calay, E.S.4
Hotamisligil, G.S.5
-
44
-
-
84883017889
-
Functions of autophagy in normal and diseased liver
-
[CrossRef] [PubMed]
-
Czaja, M.J.; Ding, W.X.; Donohue, T.M., Jr.; Friedman, S.L.; Kim, J.S.; Komatsu, M.; Lemasters, J.J.; Lemoine, A.; Lin, J.D.; Ou, J.H.; et al. Functions of autophagy in normal and diseased liver. Autophagy 2013, 9, 1131-1158. [CrossRef] [PubMed]
-
(2013)
Autophagy
, vol.9
, pp. 1131-1158
-
-
Czaja, M.J.1
Ding, W.X.2
Donohue, T.M.3
Friedman, S.L.4
Kim, J.S.5
Komatsu, M.6
Lemasters, J.J.7
Lemoine, A.8
Lin, J.D.9
Ou, J.H.10
-
45
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
[CrossRef] [PubMed]
-
Yang, S.; Wang, X.; Contino, G.; Liesa, M.; Sahin, E.; Ying, H.; Bause, A.; Li, Y.; Stommel, J.M.; Dell'antonio, G.; et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011, 25, 717-729. [CrossRef] [PubMed]
-
(2011)
Genes Dev
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'antonio, G.10
-
46
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
[CrossRef] [PubMed]
-
Yue, Z.; Jin, S.; Yang, C.; Levine, A.J.; Heintz, N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc. Natl. Acad. Sci. USA 2003, 100, 15077-15082. [CrossRef] [PubMed]
-
(2003)
Proc. Natl. Acad. Sci USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
47
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
[CrossRef] [PubMed]
-
Qu, X.; Yu, J.; Bhagat, G.; Furuya, N.; Hibshoosh, H.; Troxel, A.; Rosen, J.; Eskelinen, E.L.; Mizushima, N.; Ohsumi, Y.; et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J. Clin. Investig. 2003, 112, 1809-1820. [CrossRef] [PubMed]
-
(2003)
J. Clin Investig
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.L.8
Mizushima, N.9
Ohsumi, Y.10
-
48
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
[CrossRef] [PubMed]
-
Kuma, A.; Hatano, M.; Matsui, M.; Yamamoto, A.; Nakaya, H.; Yoshimori, T.; Ohsumi, Y.; Tokuhisa, T.; Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432, 1032-1036. [CrossRef] [PubMed]
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
49
-
-
78651282673
-
p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding
-
[CrossRef] [PubMed]
-
Itakura, E.; Mizushima, N. p62 Targeting to the autophagosome formation site requires self-oligomerization but not LC3 binding. J. Cell Biol. 2011, 192, 17-27. [CrossRef] [PubMed]
-
(2011)
J Cell Biol
, vol.192
, pp. 17-27
-
-
Itakura, E.1
Mizushima, N.2
-
50
-
-
79952355107
-
Selective autophagy mediated by autophagic adapter proteins
-
[CrossRef] [PubMed]
-
Johansen, T.; Lamark, T. Selective autophagy mediated by autophagic adapter proteins. Autophagy 2011, 7, 279-296. [CrossRef] [PubMed]
-
(2011)
Autophagy
, vol.7
, pp. 279-296
-
-
Johansen, T.1
Lamark, T.2
-
51
-
-
77956912877
-
Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth
-
[CrossRef] [PubMed]
-
Gan, N.; Sun, X.; Song, L. Activation of Nrf2 by microcystin-LR provides advantages for liver cancer cell growth. Chem. Res. Toxicol. 2010, 23, 1477-1484. [CrossRef] [PubMed]
-
(2010)
Chem. Res Toxicol
, vol.23
, pp. 1477-1484
-
-
Gan, N.1
Sun, X.2
Song, L.3
-
52
-
-
66449099090
-
Autophagy suppresses tumorigenesis through elimination of p62
-
[CrossRef] [PubMed]
-
Mathew, R.; Karp, C.M.; Beaudoin, B.; Vuong, N.; Chen, G.; Chen, H.Y.; Bray, K.; Reddy, A.; Bhanot, G.; Gelinas, C.; et al. Autophagy suppresses tumorigenesis through elimination of p62. Cell 2009, 137, 1062-1075. [CrossRef] [PubMed]
-
(2009)
Cell
, vol.137
, pp. 1062-1075
-
-
Mathew, R.1
Karp, C.M.2
Beaudoin, B.3
Vuong, N.4
Chen, G.5
Chen, H.Y.6
Bray, K.7
Reddy, A.8
Bhanot, G.9
Gelinas, C.10
-
53
-
-
78649464206
-
Autophagy is a therapeutic target in anticancer drug resistance
-
[CrossRef] [PubMed]
-
Chen, S.; Rehman, S.K.; Zhang, W.; Wen, A.; Yao, L.; Zhang, J. Autophagy is a therapeutic target in anticancer drug resistance. Biochim. Biophys. Acta 2010, 1806, 220-229. [CrossRef] [PubMed]
-
(2010)
Biochim. Biophys Acta
, vol.1806
, pp. 220-229
-
-
Chen, S.1
Rehman, S.K.2
Zhang, W.3
Wen, A.4
Yao, L.5
Zhang, J.6
-
54
-
-
80051668850
-
The dual role of autophagy in cancer
-
[CrossRef] [PubMed]
-
Eskelinen, E.L. The dual role of autophagy in cancer. Curr. Opin. Pharmacol. 2011, 11, 294-300. [CrossRef] [PubMed]
-
(2011)
Curr. Opin Pharmacol
, vol.11
, pp. 294-300
-
-
Eskelinen, E.L.1
-
55
-
-
69349087479
-
Anti-and pro-tumor functions of autophagy
-
[CrossRef] [PubMed]
-
Morselli, E.; Galluzzi, L.; Kepp, O.; Vicencio, J.M.; Criollo, A.; Maiuri, M.C.; Kroemer, G. Anti-and pro-tumor functions of autophagy. Biochim. Biophys. Acta 2009, 1793, 1524-1532. [CrossRef] [PubMed]
-
(2009)
Biochim. Biophys Acta
, vol.1793
, pp. 1524-1532
-
-
Morselli, E.1
Galluzzi, L.2
Kepp, O.3
Vicencio, J.M.4
Criollo, A.5
Maiuri, M.C.6
Kroemer, G.7
-
56
-
-
84863022322
-
Genes associated with recurrence of hepatocellular carcinoma: Integrated analysis by gene expression and methylation profiling
-
[CrossRef] [PubMed]
-
Yang, J.D.; Seol, S.Y.; Leem, S.H.; Kim, Y.H.; Sun, Z.; Lee, J.S.; Thorgeirsson, S.S.; Chu, I.S.; Roberts, L.R.; Kang, K.J. Genes associated with recurrence of hepatocellular carcinoma: Integrated analysis by gene expression and methylation profiling. J. Korean Med. Sci. 2011, 26, 1428-1438. [CrossRef] [PubMed]
-
(2011)
J. Korean Med Sci
, vol.26
, pp. 1428-1438
-
-
Yang, J.D.1
Seol, S.Y.2
Leem, S.H.3
Kim, Y.H.4
Sun, Z.5
Lee, J.S.6
Thorgeirsson, S.S.7
Chu, I.S.8
Roberts, L.R.9
Kang, K.J.10
-
57
-
-
80053428657
-
Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency
-
[CrossRef] [PubMed]
-
Kim, J.H.; Kim, H.Y.; Lee, Y.K.; Yoon, Y.S.; Xu, W.G.; Yoon, J.K.; Choi, S.E.; Ko, Y.G.; Kim, M.J.; Lee, S.J.; et al. Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency. Autophagy 2011, 7, 1187-1198. [CrossRef] [PubMed]
-
(2011)
Autophagy
, vol.7
, pp. 1187-1198
-
-
Kim, J.H.1
Kim, H.Y.2
Lee, Y.K.3
Yoon, Y.S.4
Xu, W.G.5
Yoon, J.K.6
Choi, S.E.7
Ko, Y.G.8
Kim, M.J.9
Lee, S.J.10
-
58
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
[CrossRef] [PubMed]
-
Lum, J.J.; Bauer, D.E.; Kong, M.; Harris, M.H.; Li, C.; Lindsten, T.; Thompson, C.B. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005, 120, 237-248. [CrossRef] [PubMed]
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
Lindsten, T.6
Thompson, C.B.7
-
59
-
-
33745713171
-
Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
-
[CrossRef] [PubMed]
-
Degenhardt, K.; Mathew, R.; Beaudoin, B.; Bray, K.; Anderson, D.; Chen, G.; Mukherjee, C.; Shi, Y.; Gelinas, C.; Fan, Y.; et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10, 51-64. [CrossRef] [PubMed]
-
(2006)
Cancer Cell
, vol.10
, pp. 51-64
-
-
Degenhardt, K.1
Mathew, R.2
Beaudoin, B.3
Bray, K.4
Anderson, D.5
Chen, G.6
Mukherjee, C.7
Shi, Y.8
Gelinas, C.9
Fan, Y.10
-
60
-
-
84871986560
-
Medical therapies for hepatocellular carcinoma: A critical view of the evidence
-
[CrossRef] [PubMed]
-
Villanueva, A.; Hernandez-Gea, V.; Llovet, J.M. Medical therapies for hepatocellular carcinoma: A critical view of the evidence. Nat. Rev. Gastroenterol. Hepatol. 2013, 10, 34-42. [CrossRef] [PubMed]
-
(2013)
Nat. Rev. Gastroenterol Hepatol
, vol.10
, pp. 34-42
-
-
Villanueva, A.1
Hernandez-Gea, V.2
Llovet, J.M.3
-
61
-
-
80052321906
-
Autophagy and endocrine resistance in breast cancer
-
[CrossRef] [PubMed]
-
Cook, K.L.; Shajahan, A.N.; Clarke, R. Autophagy and endocrine resistance in breast cancer. Expert Rev. Anticancer Ther. 2011, 11, 1283-1294. [CrossRef] [PubMed]
-
(2011)
Expert Rev Anticancer Ther
, vol.11
, pp. 1283-1294
-
-
Cook, K.L.1
Shajahan, A.N.2
Clarke, R.3
-
62
-
-
83455197015
-
Autophagy in brain tumors: A new target for therapeutic intervention
-
[CrossRef] [PubMed]
-
Kaza, N.; Kohli, L.; Roth, K.A. Autophagy in brain tumors: A new target for therapeutic intervention. Brain Pathol. 2012, 22, 89-98. [CrossRef] [PubMed]
-
(2012)
Brain Pathol
, vol.22
, pp. 89-98
-
-
Kaza, N.1
Kohli, L.2
Roth, K.A.3
-
63
-
-
84874003850
-
Autophagy in cervical cancer: An emerging therapeutic target
-
[CrossRef] [PubMed]
-
Pandey, S.; Chandravati. Autophagy in cervical cancer: An emerging therapeutic target. Asian Pac. J. Cancer Prev. APJCP 2012, 13, 4867-4871. [CrossRef] [PubMed]
-
(2012)
Asian Pac. J. Cancer Prev APJCP
, vol.13
, pp. 4867-4871
-
-
Pandey, S.1
Chandravati2
-
64
-
-
84938999272
-
Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Osman, N.A.; Abd El-Rehim, D.M.; Kamal, I.M. Defective Beclin-1 and elevated hypoxia-inducible factor (HIF)-1α expression are closely linked to tumorigenesis, differentiation, and progression of hepatocellular carcinoma. Tumour Biol. 2015. [CrossRef] [PubMed]
-
(2015)
Tumour Biol
-
-
Osman, N.A.1
Abd El-Rehim, D.M.2
Kamal, I.M.3
-
65
-
-
56449107131
-
Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Ding, Z.B.; Shi, Y.H.; Zhou, J.; Qiu, S.J.; Xu, Y.; Dai, Z.; Shi, G.M.; Wang, X.Y.; Ke, A.W.; Wu, B.; et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res. 2008, 68, 9167-9175. [CrossRef] [PubMed]
-
(2008)
Cancer Res
, vol.68
, pp. 9167-9175
-
-
Ding, Z.B.1
Shi, Y.H.2
Zhou, J.3
Qiu, S.J.4
Xu, Y.5
Dai, Z.6
Shi, G.M.7
Wang, X.Y.8
Ke, A.W.9
Wu, B.10
-
66
-
-
84865323320
-
Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Kotsafti, A.; Farinati, F.; Cardin, R.; Cillo, U.; Nitti, D.; Bortolami, M. Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC Gastroenterol. 2012, 12, 118. [CrossRef] [PubMed]
-
(2012)
BMC Gastroenterol
, vol.12
, pp. 118
-
-
Kotsafti, A.1
Farinati, F.2
Cardin, R.3
Cillo, U.4
Nitti, D.5
Bortolami, M.6
-
67
-
-
84903802616
-
Clinical significance of autophagic protein LC3 levels and its correlation with XIAP expression in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Wu, W.Y.; Kim, H.; Zhang, C.L.; Meng, X.L.; Wu, Z.S. Clinical significance of autophagic protein LC3 levels and its correlation with XIAP expression in hepatocellular carcinoma. Med. Oncol. 2014, 31, 108. [CrossRef] [PubMed]
-
(2014)
Med Oncol
, vol.31
, pp. 108
-
-
Wu, W.Y.1
Kim, H.2
Zhang, C.L.3
Meng, X.L.4
Wu, Z.S.5
-
68
-
-
84875241014
-
The "stone-like" pattern of LC3A expression and its clinicopathologic significance in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Xi, S.Y.; Lu, J.B.; Chen, J.W.; Cao, Y.; Luo, R.Z.; Wu, Q.L.; Cai, M.Y. The "stone-like" pattern of LC3A expression and its clinicopathologic significance in hepatocellular carcinoma. Biochem. Biophys. Res. Commun. 2013, 431, 760-766. [CrossRef] [PubMed]
-
(2013)
Biochem. Biophys. Res Commun
, vol.431
, pp. 760-766
-
-
Xi, S.Y.1
Lu, J.B.2
Chen, J.W.3
Cao, Y.4
Luo, R.Z.5
Wu, Q.L.6
Cai, M.Y.7
-
69
-
-
84901405852
-
Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial β-oxidation
-
[CrossRef] [PubMed]
-
Toshima, T.; Shirabe, K.; Matsumoto, Y.; Yoshiya, S.; Ikegami, T.; Yoshizumi, T.; Soejima, Y.; Ikeda, T.; Maehara, Y. Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial β-oxidation. J. Gastroenterol. 2014, 49, 907-916. [CrossRef] [PubMed]
-
(2014)
J Gastroenterol
, vol.49
, pp. 907-916
-
-
Toshima, T.1
Shirabe, K.2
Matsumoto, Y.3
Yoshiya, S.4
Ikegami, T.5
Yoshizumi, T.6
Soejima, Y.7
Ikeda, T.8
Maehara, Y.9
-
70
-
-
84925285679
-
Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Wu, D.H.; Jia, C.C.; Chen, J.; Lin, Z.X.; Ruan, D.Y.; Li, X.; Lin, Q.; Min, D.; Ma, X.K.; Wan, X.B.; et al. Autophagic LC3B overexpression correlates with malignant progression and predicts a poor prognosis in hepatocellular carcinoma. Tumour Biol. 2014, 35, 12225-12233. [CrossRef] [PubMed]
-
(2014)
Tumour Biol
, vol.35
, pp. 12225-12233
-
-
Wu, D.H.1
Jia, C.C.2
Chen, J.3
Lin, Z.X.4
Ruan, D.Y.5
Li, X.6
Lin, Q.7
Min, D.8
Ma, X.K.9
Wan, X.B.10
-
71
-
-
84921605764
-
SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
-
[CrossRef] [PubMed]
-
Huang, G.M.; Jiang, Q.H.; Cai, C.; Qu, M.; Shen, W. SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. Cancer Lett. 2015, 358, 180-190. [CrossRef] [PubMed]
-
(2015)
Cancer Lett
, vol.358
, pp. 180-190
-
-
Huang, G.M.1
Jiang, Q.H.2
Cai, C.3
Qu, M.4
Shen, W.5
-
72
-
-
84923292207
-
CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Lu, G.D.; Ang, Y.H.; Zhou, J.; Tamilarasi, J.; Yan, B.; Lim, Y.C.; Srivastava, S.; Salto-Tellez, M.; Hui, K.M.; Shen, H.M.; et al. CCAAT/enhancer binding protein α predicts poorer prognosis and prevents energy starvation-induced cell death in hepatocellular carcinoma. Hepatology 2015, 61, 965-978. [CrossRef] [PubMed]
-
(2015)
Hepatology
, vol.61
, pp. 965-978
-
-
Lu, G.D.1
Ang, Y.H.2
Zhou, J.3
Tamilarasi, J.4
Yan, B.5
Lim, Y.C.6
Srivastava, S.7
Salto-Tellez, M.8
Hui, K.M.9
Shen, H.M.10
-
73
-
-
84898605742
-
Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Liu, C.; Xia, Y.; Jiang, W.; Liu, Y.; Yu, L. Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma. Oncol. Rep. 2014, 31, 2043-2048. [CrossRef] [PubMed]
-
(2014)
Oncol Rep
, vol.31
, pp. 2043-2048
-
-
Liu, C.1
Xia, Y.2
Jiang, W.3
Liu, Y.4
Yu, L.5
-
74
-
-
84883015957
-
UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma
-
[PubMed]
-
Xu, H.; Yu, H.; Zhang, X.; Shen, X.; Zhang, K.; Sheng, H.; Dai, S.; Gao, H. UNC51-like kinase 1 as a potential prognostic biomarker for hepatocellular carcinoma. Int. J. Clin. Exp. Pathol. 2013, 6, 711-717. [PubMed]
-
(2013)
Int. J. Clin. Exp Pathol
, vol.6
, pp. 711-717
-
-
Xu, H.1
Yu, H.2
Zhang, X.3
Shen, X.4
Zhang, K.5
Sheng, H.6
Dai, S.7
Gao, H.8
-
75
-
-
84946892633
-
PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression
-
[CrossRef] [PubMed]
-
Luo, T.; Fu, J.; Xu, A.; Su, B.; Ren, Y.; Li, N.; Zhu, J.; Zhao, X.; Dai, R.; Cao, J.; et al. PSMD10/Gankyrin Induces Autophagy to Promote Tumor Progression through Cytoplasmic Interaction with ATG7 and Nuclear Transactivation of ATG7 Expression. Autophagy 2015. [CrossRef] [PubMed]
-
(2015)
Autophagy
-
-
Luo, T.1
Fu, J.2
Xu, A.3
Su, B.4
Ren, Y.5
Li, N.6
Zhu, J.7
Zhao, X.8
Dai, R.9
Cao, J.10
-
76
-
-
35348886043
-
Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein
-
[CrossRef] [PubMed]
-
Cao, Y.; Klionsky, D.J. Physiological functions of Atg6/Beclin 1: A unique autophagy-related protein. Cell Res. 2007, 17, 839-849. [CrossRef] [PubMed]
-
(2007)
Cell Res
, vol.17
, pp. 839-849
-
-
Cao, Y.1
Klionsky, D.J.2
-
77
-
-
67650305520
-
Regulation of Beclin 1 in autophagy
-
[CrossRef] [PubMed]
-
Sun, Q.; Fan, W.; Zhong, Q. Regulation of Beclin 1 in autophagy. Autophagy 2009, 5, 713-716. [CrossRef] [PubMed]
-
(2009)
Autophagy
, vol.5
, pp. 713-716
-
-
Sun, Q.1
Fan, W.2
Zhong, Q.3
-
78
-
-
66349103167
-
Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes
-
[CrossRef] [PubMed]
-
Itakura, E.; Mizushima, N. Atg14 and UVRAG: Mutually exclusive subunits of mammalian Beclin 1-PI3K complexes. Autophagy 2009, 5, 534-536. [CrossRef] [PubMed]
-
(2009)
Autophagy
, vol.5
, pp. 534-536
-
-
Itakura, E.1
Mizushima, N.2
-
79
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
[CrossRef] [PubMed]
-
Itakura, E.; Kishi, C.; Inoue, K.; Mizushima, N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 2008, 19, 5360-5372. [CrossRef] [PubMed]
-
(2008)
Mol. Biol Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
80
-
-
34848899280
-
Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
-
[CrossRef] [PubMed]
-
Takahashi, Y.; Coppola, D.; Matsushita, N.; Cualing, H.D.; Sun, M.; Sato, Y.; Liang, C.; Jung, J.U.; Cheng, J.Q.; Mule, J.J.; et al. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat. Cell Biol. 2007, 9, 1142-1151. [CrossRef] [PubMed]
-
(2007)
Nat Cell Biol
, vol.9
, pp. 1142-1151
-
-
Takahashi, Y.1
Coppola, D.2
Matsushita, N.3
Cualing, H.D.4
Sun, M.5
Sato, Y.6
Liang, C.7
Jung, J.U.8
Cheng, J.Q.9
Mule, J.J.10
-
81
-
-
64049086758
-
Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages
-
[CrossRef] [PubMed]
-
Matsunaga, K.; Saitoh, T.; Tabata, K.; Omori, H.; Satoh, T.; Kurotori, N.; Maejima, I.; Shirahama-Noda, K.; Ichimura, T.; Isobe, T.; et al. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 2009, 11, 385-396. [CrossRef] [PubMed]
-
(2009)
Nat Cell Biol
, vol.11
, pp. 385-396
-
-
Matsunaga, K.1
Saitoh, T.2
Tabata, K.3
Omori, H.4
Satoh, T.5
Kurotori, N.6
Maejima, I.7
Shirahama-Noda, K.8
Ichimura, T.9
Isobe, T.10
-
82
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
[CrossRef] [PubMed]
-
Pattingre, S.; Tassa, A.; Qu, X.; Garuti, R.; Liang, X.H.; Mizushima, N.; Packer, M.; Schneider, M.D.; Levine, B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005, 122, 927-939. [CrossRef] [PubMed]
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
83
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
[PubMed]
-
Liang, X.H.; Jackson, S.; Seaman, M.; Brown, K.; Kempkes, B.; Hibshoosh, H.; Levine, B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402, 672-676. [PubMed]
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
84
-
-
77953708091
-
Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma
-
[CrossRef] [PubMed]
-
Wan, X.B.; Fan, X.J.; Chen, M.Y.; Xiang, J.; Huang, P.Y.; Guo, L.; Wu, X.Y.; Xu, J.; Long, Z.J.; Zhao, Y.; et al. Elevated Beclin 1 expression is correlated with HIF-1α in predicting poor prognosis of nasopharyngeal carcinoma. Autophagy 2010, 6, 395-404. [CrossRef] [PubMed]
-
(2010)
Autophagy
, vol.6
, pp. 395-404
-
-
Wan, X.B.1
Fan, X.J.2
Chen, M.Y.3
Xiang, J.4
Huang, P.Y.5
Guo, L.6
Wu, X.Y.7
Xu, J.8
Long, Z.J.9
Zhao, Y.10
-
85
-
-
84877144192
-
Beclin 1 expression is an independent prognostic factor for gastric carcinomas
-
[CrossRef] [PubMed]
-
Yu, M.; Gou, W.F.; Zhao, S.; Xiao, L.J.; Mao, X.Y.; Xing, Y.N.; Takahashi, H.; Takano, Y.; Zheng, H.C. Beclin 1 expression is an independent prognostic factor for gastric carcinomas. Tumour Biol. 2013, 34, 1071-1083. [CrossRef] [PubMed]
-
(2013)
Tumour Biol
, vol.34
, pp. 1071-1083
-
-
Yu, M.1
Gou, W.F.2
Zhao, S.3
Xiao, L.J.4
Mao, X.Y.5
Xing, Y.N.6
Takahashi, H.7
Takano, Y.8
Zheng, H.C.9
-
86
-
-
80052606545
-
High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas
-
[CrossRef] [PubMed]
-
Giatromanolaki, A.; Koukourakis, M.I.; Koutsopoulos, A.; Chloropoulou, P.; Liberis, V.; Sivridis, E. High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas. Gynecol. Oncol. 2011, 123, 147-151. [CrossRef] [PubMed]
-
(2011)
Gynecol Oncol
, vol.123
, pp. 147-151
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Koutsopoulos, A.3
Chloropoulou, P.4
Liberis, V.5
Sivridis, E.6
-
87
-
-
0035910423
-
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3
-
[CrossRef] [PubMed]
-
Tanida, I.; Tanida-Miyake, E.; Ueno, T.; Kominami, E. The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. J. Biol. Chem. 2001, 276, 1701-1706. [CrossRef] [PubMed]
-
(2001)
J. Biol Chem
, vol.276
, pp. 1701-1706
-
-
Tanida, I.1
Tanida-Miyake, E.2
Ueno, T.3
Kominami, E.4
-
88
-
-
77957840133
-
Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas
-
[CrossRef] [PubMed]
-
Giatromanolaki, A.; Koukourakis, M.I.; Harris, A.L.; Polychronidis, A.; Gatter, K.C.; Sivridis, E. Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas. J. Clin. Pathol. 2010, 63, 867-872. [CrossRef] [PubMed]
-
(2010)
J. Clin Pathol
, vol.63
, pp. 867-872
-
-
Giatromanolaki, A.1
Koukourakis, M.I.2
Harris, A.L.3
Polychronidis, A.4
Gatter, K.C.5
Sivridis, E.6
-
89
-
-
50149095124
-
Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome
-
[CrossRef] [PubMed]
-
Fujii, S.; Mitsunaga, S.; Yamazaki, M.; Hasebe, T.; Ishii, G.; Kojima, M.; Kinoshita, T.; Ueno, T.; Esumi, H.; Ochiai, A. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci. 2008, 99, 1813-1819. [CrossRef] [PubMed]
-
(2008)
Cancer Sci
, vol.99
, pp. 1813-1819
-
-
Fujii, S.1
Mitsunaga, S.2
Yamazaki, M.3
Hasebe, T.4
Ishii, G.5
Kojima, M.6
Kinoshita, T.7
Ueno, T.8
Esumi, H.9
Ochiai, A.10
-
90
-
-
84868137413
-
Expression of Beclin 1 and LC3 in FIGO stage I-II cervical squamous cell carcinoma and relationship to survival
-
[CrossRef] [PubMed]
-
Zhu, W.; Pan, X.; Li, F.; Zhang, Y.; Lu, X. Expression of Beclin 1 and LC3 in FIGO stage I-II cervical squamous cell carcinoma and relationship to survival. Tumor Biol. 2012, 33, 1653-1659. [CrossRef] [PubMed]
-
(2012)
Tumor Biol
, vol.33
, pp. 1653-1659
-
-
Zhu, W.1
Pan, X.2
Li, F.3
Zhang, Y.4
Lu, X.5
-
91
-
-
78049460392
-
Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors
-
[CrossRef] [PubMed]
-
Huang, X.; Bai, H.M.; Chen, L.; Li, B.; Lu, Y.C. Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors. J. Clin. Neurosci. 2010, 17, 1515-1519. [CrossRef] [PubMed]
-
(2010)
J. Clin Neurosci
, vol.17
, pp. 1515-1519
-
-
Huang, X.1
Bai, H.M.2
Chen, L.3
Li, B.4
Lu, Y.C.5
-
92
-
-
79960420656
-
Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma
-
[CrossRef] [PubMed]
-
Jiang, S.; Li, Y.; Zhu, Y.H.;Wu, X.Q.; Tang, J.; Li, Z.; Feng, G.K.; Deng, R.; Li, D.D.; Luo, R.Z.; et al. Intensive expression of UNC-51-like kinase 1 is a novel biomarker of poor prognosis in patients with esophageal squamous cell carcinoma. Cancer Sci. 2011, 102, 1568-1575. [CrossRef] [PubMed]
-
(2011)
Cancer Sci
, vol.102
, pp. 1568-1575
-
-
Jiang, S.1
Li, Y.2
Zhu, Y.H.3
Wu, X.Q.4
Tang, J.5
Li, Z.6
Feng, G.K.7
Deng, R.8
Li, D.D.9
Luo, R.Z.10
-
93
-
-
84868195837
-
Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients
-
[CrossRef] [PubMed]
-
Tang, J.; Deng, R.; Luo, R.Z.; Shen, G.P.; Cai, M.Y.; Du, Z.M.; Jiang, S.; Yang, M.T.; Fu, J.H.; Zhu, X.F. Low expression of ULK1 is associated with operable breast cancer progression and is an adverse prognostic marker of survival for patients. Breast Cancer Res. Treat. 2012, 134, 549-560. [CrossRef] [PubMed]
-
(2012)
Breast Cancer Res Treat
, vol.134
, pp. 549-560
-
-
Tang, J.1
Deng, R.2
Luo, R.Z.3
Shen, G.P.4
Cai, M.Y.5
Du, Z.M.6
Jiang, S.7
Yang, M.T.8
Fu, J.H.9
Zhu, X.F.10
-
94
-
-
80053430056
-
GABARAPL1 (GEC1): Original or copycat?
-
[PubMed]
-
Le Grand, J.N.; Chakrama, F.Z.; Seguin-Py, S.; Fraichard, A.; Delage-Mourroux, R.; Jouvenot, M.; Boyer-Guittaut, M. GABARAPL1 (GEC1): Original or copycat? Autophagy 2011, 7, 1098-1107. [PubMed]
-
(2011)
Autophagy
, vol.7
, pp. 1098-1107
-
-
Le Grand, J.N.1
Chakrama, F.Z.2
Seguin-Py, S.3
Fraichard, A.4
Delage-Mourroux, R.5
Jouvenot, M.6
Boyer-Guittaut, M.7
-
95
-
-
77953728406
-
GABARAPL1 (GEC1) associates with autophagic vesicles
-
[CrossRef] [PubMed]
-
Chakrama, F.Z.; Seguin-Py, S.; Le Grand, J.N.; Fraichard, A.; Delage-Mourroux, R.; Despouy, G.; Perez, V.; Jouvenot, M.; Boyer-Guittaut, M. GABARAPL1 (GEC1) associates with autophagic vesicles. Autophagy 2010, 6, 495-505. [CrossRef] [PubMed]
-
(2010)
Autophagy
, vol.6
, pp. 495-505
-
-
Chakrama, F.Z.1
Seguin-Py, S.2
Le Grand, J.N.3
Fraichard, A.4
Delage-Mourroux, R.5
Despouy, G.6
Perez, V.7
Jouvenot, M.8
Boyer-Guittaut, M.9
-
96
-
-
77949541314
-
High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer
-
[CrossRef] [PubMed]
-
Berthier, A.; Seguin, S.; Sasco, A.J.; Bobin, J.Y.; de Laroche, G.; Datchary, J.; Saez, S.; Rodriguez-Lafrasse, C.; Tolle, F.; Fraichard, A.; et al. High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer. Br. J. Cancer 2010, 102, 1024-1031. [CrossRef] [PubMed]
-
(2010)
Br. J Cancer
, vol.102
, pp. 1024-1031
-
-
Berthier, A.1
Seguin, S.2
Sasco, A.J.3
Bobin, J.Y.4
de Laroche, G.5
Datchary, J.6
Saez, S.7
Rodriguez-Lafrasse, C.8
Tolle, F.9
Fraichard, A.10
-
97
-
-
0037832581
-
Recent insights into stearoyl-CoA desaturase-1
-
[CrossRef] [PubMed]
-
Ntambi, J.M.; Miyazaki, M. Recent insights into stearoyl-CoA desaturase-1. Curr. Opin. Lipidol. 2003, 14, 255-261. [CrossRef] [PubMed]
-
(2003)
Curr. Opin Lipidol
, vol.14
, pp. 255-261
-
-
Ntambi, J.M.1
Miyazaki, M.2
-
98
-
-
84894468653
-
Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway
-
[CrossRef] [PubMed]
-
Tan, S.H.; Shui, G.; Zhou, J.; Shi, Y.; Huang, J.; Xia, D.; Wenk, M.R.; Shen, H.M. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway. Autophagy 2014, 10, 226-242. [CrossRef] [PubMed]
-
(2014)
Autophagy
, vol.10
, pp. 226-242
-
-
Tan, S.H.1
Shui, G.2
Zhou, J.3
Shi, Y.4
Huang, J.5
Xia, D.6
Wenk, M.R.7
Shen, H.M.8
-
99
-
-
33746861562
-
C/EBPα: A tumour suppressor in multiple tissues? Biochim
-
[CrossRef] [PubMed]
-
Schuster, M.B.; Porse, B.T. C/EBPα: A tumour suppressor in multiple tissues? Biochim. Biophys. Acta 2006, 1766, 88-103. [CrossRef] [PubMed]
-
(2006)
Biophys Acta
, vol.1766
, pp. 88-103
-
-
Schuster, M.B.1
Porse, B.T.2
-
100
-
-
8344273515
-
Hepatic CCAAT/enhancer binding protein α mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice
-
[CrossRef] [PubMed]
-
Matsusue, K.; Gavrilova, O.; Lambert, G.; Brewer, H.B., Jr.;Ward, J.M.; Inoue, Y.; LeRoith, D.; Gonzalez, F.J. Hepatic CCAAT/enhancer binding protein α mediates induction of lipogenesis and regulation of glucose homeostasis in leptin-deficient mice. Mol. Endocrinol. 2004, 18, 2751-2764. [CrossRef] [PubMed]
-
(2004)
Mol Endocrinol
, vol.18
, pp. 2751-2764
-
-
Matsusue, K.1
Gavrilova, O.2
Lambert, G.3
Brewer, H.B.4
Ward, J.M.5
Inoue, Y.6
LeRoith, D.7
Gonzalez, F.J.8
-
101
-
-
77955507119
-
C/EBPα is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation
-
[CrossRef] [PubMed]
-
Lu, G.D.; Leung, C.H.; Yan, B.; Tan, C.M.; Low, S.Y.; Aung, M.O.; Salto-Tellez, M.; Lim, S.G.; Hooi, S.C. C/EBPα is up-regulated in a subset of hepatocellular carcinomas and plays a role in cell growth and proliferation. Gastroenterology 2010, 139, 632-643. [CrossRef] [PubMed]
-
(2010)
Gastroenterology
, vol.139
, pp. 632-643
-
-
Lu, G.D.1
Leung, C.H.2
Yan, B.3
Tan, C.M.4
Low, S.Y.5
Aung, M.O.6
Salto-Tellez, M.7
Lim, S.G.8
Hooi, S.C.9
-
102
-
-
33751264911
-
Gankyrin, the 26 S proteasome, the cell cycle and cancer
-
[CrossRef] [PubMed]
-
Mayer, R.J.; Fujita, J. Gankyrin, the 26 S proteasome, the cell cycle and cancer. Biochem. Soc. Trans. 2006, 34, 746-748. [CrossRef] [PubMed]
-
(2006)
Biochem. Soc Trans
, vol.34
, pp. 746-748
-
-
Mayer, R.J.1
Fujita, J.2
-
103
-
-
0033978257
-
Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas
-
[PubMed]
-
Higashitsuji, H.; Itoh, K.; Nagao, T.; Dawson, S.; Nonoguchi, K.; Kido, T.; Mayer, R.J.; Arii, S.; Fujita, J. Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nat. Med. 2000, 6, 96-99. [PubMed]
-
(2000)
Nat Med
, vol.6
, pp. 96-99
-
-
Higashitsuji, H.1
Itoh, K.2
Nagao, T.3
Dawson, S.4
Nonoguchi, K.5
Kido, T.6
Mayer, R.J.7
Arii, S.8
Fujita, J.9
-
104
-
-
78751544628
-
p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways
-
[CrossRef] [PubMed]
-
Fu, J.; Chen, Y.; Cao, J.; Luo, T.; Qian, Y.W.; Yang, W.; Ren, Y.B.; Su, B.; Cao, G.W.; Yang, Y.; et al. p28GANK overexpression accelerates hepatocellular carcinoma invasiveness and metastasis via phosphoinositol 3-kinase/AKT/hypoxia-inducible factor-1α pathways. Hepatology 2011, 53, 181-192. [CrossRef] [PubMed]
-
(2011)
Hepatology
, vol.53
, pp. 181-192
-
-
Fu, J.1
Chen, Y.2
Cao, J.3
Luo, T.4
Qian, Y.W.5
Yang, W.6
Ren, Y.B.7
Su, B.8
Cao, G.W.9
Yang, Y.10
-
105
-
-
84869498677
-
Targeting autophagy for the treatment of liver diseases
-
[CrossRef] [PubMed]
-
Ni, H.M.; Williams, J.A.; Yang, H.; Shi, Y.H.; Fan, J.; Ding, W.X. Targeting autophagy for the treatment of liver diseases. Pharmacol. Res. 2012, 66, 463-474. [CrossRef] [PubMed]
-
(2012)
Pharmacol Res
, vol.66
, pp. 463-474
-
-
Ni, H.M.1
Williams, J.A.2
Yang, H.3
Shi, Y.H.4
Fan, J.5
Ding, W.X.6
-
106
-
-
84922378824
-
Autophagy in cancer
-
[CrossRef] [PubMed]
-
Zhi, X.; Zhong, Q. Autophagy in cancer. F1000prime Rep. 2015, 7, 18. [CrossRef] [PubMed]
-
(2015)
F1000prime Rep
, vol.7
, pp. 18
-
-
Zhi, X.1
Zhong, Q.2
-
107
-
-
84859609587
-
Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells
-
[CrossRef] [PubMed]
-
Guo, X.L.; Li, D.; Hu, F.; Song, J.R.; Zhang, S.S.; Deng, W.J.; Sun, K.; Zhao, Q.D.; Xie, X.Q.; Song, Y.J.; et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett. 2012, 320, 171-179. [CrossRef] [PubMed]
-
(2012)
Cancer Lett
, vol.320
, pp. 171-179
-
-
Guo, X.L.1
Li, D.2
Hu, F.3
Song, J.R.4
Zhang, S.S.5
Deng, W.J.6
Sun, K.7
Zhao, Q.D.8
Xie, X.Q.9
Song, Y.J.10
-
108
-
-
84857698541
-
Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Shimizu, S.; Takehara, T.; Hikita, H.; Kodama, T.; Tsunematsu, H.; Miyagi, T.; Hosui, A.; Ishida, H.; Tatsumi, T.; Kanto, T.; et al. Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int. J. Cancer 2012, 131, 548-557. [CrossRef] [PubMed]
-
(2012)
Int. J Cancer
, vol.131
, pp. 548-557
-
-
Shimizu, S.1
Takehara, T.2
Hikita, H.3
Kodama, T.4
Tsunematsu, H.5
Miyagi, T.6
Hosui, A.7
Ishida, H.8
Tatsumi, T.9
Kanto, T.10
-
109
-
-
80053420059
-
Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis
-
[CrossRef] [PubMed]
-
Shi, Y.H.; Ding, Z.B.; Zhou, J.; Hui, B.; Shi, G.M.; Ke, A.W.; Wang, X.Y.; Dai, Z.; Peng, Y.F.; Gu, C.Y.; et al. Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 2011, 7, 1159-1172. [CrossRef] [PubMed]
-
(2011)
Autophagy
, vol.7
, pp. 1159-1172
-
-
Shi, Y.H.1
Ding, Z.B.2
Zhou, J.3
Hui, B.4
Shi, G.M.5
Ke, A.W.6
Wang, X.Y.7
Dai, Z.8
Peng, Y.F.9
Gu, C.Y.10
-
110
-
-
66449136951
-
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
-
[CrossRef] [PubMed]
-
Kota, J.; Chivukula, R.R.; O'Donnell, K.A.; Wentzel, E.A.; Montgomery, C.L.; Hwang, H.W.; Chang, T.C.; Vivekanandan, P.; Torbenson, M.; Clark, K.R.; et al. Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 2009, 137, 1005-1017. [CrossRef] [PubMed]
-
(2009)
Cell
, vol.137
, pp. 1005-1017
-
-
Kota, J.1
Chivukula, R.R.2
O'Donnell, K.A.3
Wentzel, E.A.4
Montgomery, C.L.5
Hwang, H.W.6
Chang, T.C.7
Vivekanandan, P.8
Torbenson, M.9
Clark, K.R.10
-
111
-
-
84876450968
-
Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma
-
[PubMed]
-
Gailhouste, L.; Ochiya, T. Cancer-related microRNAs and their role as tumor suppressors and oncogenes in hepatocellular carcinoma. Histol. Histopathol. 2013, 28, 437-451. [PubMed]
-
(2013)
Histol Histopathol
, vol.28
, pp. 437-451
-
-
Gailhouste, L.1
Ochiya, T.2
-
112
-
-
84862750365
-
miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions
-
[CrossRef] [PubMed]
-
Chang, Y.; Yan, W.; He, X.; Zhang, L.; Li, C.; Huang, H.; Nace, G.; Geller, D.A.; Lin, J.; Tsung, A. miR-375 inhibits autophagy and reduces viability of hepatocellular carcinoma cells under hypoxic conditions. Gastroenterology 2012, 143, 177-187. [CrossRef] [PubMed]
-
(2012)
Gastroenterology
, vol.143
, pp. 177-187
-
-
Chang, Y.1
Yan, W.2
He, X.3
Zhang, L.4
Li, C.5
Huang, H.6
Nace, G.7
Geller, D.A.8
Lin, J.9
Tsung, A.10
-
113
-
-
84863568271
-
The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth
-
[CrossRef] [PubMed]
-
Luo, Z.; Yu, G.; Lee, H.W.; Li, L.; Wang, L.; Yang, D.; Pan, Y.; Ding, C.; Qian, J.; Wu, L.; et al. The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. Cancer Res. 2012, 72, 3360-3371. [CrossRef] [PubMed]
-
(2012)
Cancer Res
, vol.72
, pp. 3360-3371
-
-
Luo, Z.1
Yu, G.2
Lee, H.W.3
Li, L.4
Wang, L.5
Yang, D.6
Pan, Y.7
Ding, C.8
Qian, J.9
Wu, L.10
-
114
-
-
79551473364
-
Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway
-
[CrossRef] [PubMed]
-
Chen, L.H.; Loong, C.C.; Su, T.L.; Lee, Y.J.; Chu, P.M.; Tsai, M.L.; Tsai, P.H.; Tu, P.H.; Chi, C.W.; Lee, H.C.; et al. Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway. Biochem. Pharmacol. 2011, 81, 594-605. [CrossRef] [PubMed]
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 594-605
-
-
Chen, L.H.1
Loong, C.C.2
Su, T.L.3
Lee, Y.J.4
Chu, P.M.5
Tsai, M.L.6
Tsai, P.H.7
Tu, P.H.8
Chi, C.W.9
Lee, H.C.10
-
115
-
-
84861574345
-
Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling
-
[CrossRef] [PubMed]
-
Zou, M.; Lu, N.; Hu, C.; Liu, W.; Sun, Y.; Wang, X.; You, Q.; Gu, C.; Xi, T.; Guo, Q. Beclin 1-mediated autophagy in hepatocellular carcinoma cells: Implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. Cell Signal. 2012, 24, 1722-1732. [CrossRef] [PubMed]
-
(2012)
Cell Signal
, vol.24
, pp. 1722-1732
-
-
Zou, M.1
Lu, N.2
Hu, C.3
Liu, W.4
Sun, Y.5
Wang, X.6
You, Q.7
Gu, C.8
Xi, T.9
Guo, Q.10
-
116
-
-
0038743077
-
Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
-
[PubMed]
-
Kanzawa, T.; Kondo, Y.; Ito, H.; Kondo, S.; Germano, I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res. 2003, 63, 2103-2108. [PubMed]
-
(2003)
Cancer Res
, vol.63
, pp. 2103-2108
-
-
Kanzawa, T.1
Kondo, Y.2
Ito, H.3
Kondo, S.4
Germano, I.5
-
117
-
-
34447132925
-
Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
-
[CrossRef] [PubMed]
-
Kim, E.H.; Sohn, S.; Kwon, H.J.; Kim, S.U.; Kim, M.J.; Lee, S.J.; Choi, K.S. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res. 2007, 67, 6314-6324. [CrossRef] [PubMed]
-
(2007)
Cancer Res
, vol.67
, pp. 6314-6324
-
-
Kim, E.H.1
Sohn, S.2
Kwon, H.J.3
Kim, S.U.4
Kim, M.J.5
Lee, S.J.6
Choi, K.S.7
-
118
-
-
84876008743
-
Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance
-
[CrossRef] [PubMed]
-
Dupere-Richer, D.; Kinal, M.; Menasche, V.; Nielsen, T.H.; Del Rincon, S.; Pettersson, F.; Miller, W.H., Jr. Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance. Cell Death Dis. 2013, 4, e486. [CrossRef] [PubMed]
-
(2013)
Cell Death Dis
, vol.4
-
-
Dupere-Richer, D.1
Kinal, M.2
Menasche, V.3
Nielsen, T.H.4
Del Rincon, S.5
Pettersson, F.6
Miller, W.H.7
-
119
-
-
51449095342
-
Targeting the PI3K-AKT-mTOR pathway: Progress, pitfalls, and promises
-
[CrossRef] [PubMed]
-
Yap, T.A.; Garrett, M.D.; Walton, M.I.; Raynaud, F.; de Bono, J.S.; Workman, P. Targeting the PI3K-AKT-mTOR pathway: Progress, pitfalls, and promises. Curr. Opin. Pharmacol. 2008, 8, 393-412. [CrossRef] [PubMed]
-
(2008)
Curr. Opin Pharmacol
, vol.8
, pp. 393-412
-
-
Yap, T.A.1
Garrett, M.D.2
Walton, M.I.3
Raynaud, F.4
de Bono, J.S.5
Workman, P.6
-
120
-
-
33947501692
-
Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation
-
[CrossRef] [PubMed]
-
Sieghart, W.; Fuereder, T.; Schmid, K.; Cejka, D.; Werzowa, J.; Wrba, F.; Wang, X.; Gruber, D.; Rasoul-Rockenschaub, S.; Peck-Radosavljevic, M.; et al. Mammalian target of rapamycin pathway activity in hepatocellular carcinomas of patients undergoing liver transplantation. Transplantation 2007, 83, 425-432. [CrossRef] [PubMed]
-
(2007)
Transplantation
, vol.83
, pp. 425-432
-
-
Sieghart, W.1
Fuereder, T.2
Schmid, K.3
Cejka, D.4
Werzowa, J.5
Wrba, F.6
Wang, X.7
Gruber, D.8
Rasoul-Rockenschaub, S.9
Peck-Radosavljevic, M.10
-
121
-
-
57349087153
-
Pivotal role of mTOR signaling in hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Villanueva, A.; Chiang, D.Y.; Newell, P.; Peix, J.; Thung, S.; Alsinet, C.; Tovar, V.; Roayaie, S.; Minguez, B.; Sole, M.; et al. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology 2008, 135, 1972-1983. [CrossRef] [PubMed]
-
(2008)
Gastroenterology
, vol.135
, pp. 1972-1983
-
-
Villanueva, A.1
Chiang, D.Y.2
Newell, P.3
Peix, J.4
Thung, S.5
Alsinet, C.6
Tovar, V.7
Roayaie, S.8
Minguez, B.9
Sole, M.10
-
122
-
-
84861344950
-
Phase II study of sirolimus in treatment-naive patients with advanced hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Decaens, T.; Luciani, A.; Itti, E.; Hulin, A.; Roudot-Thoraval, F.; Laurent, A.; Zafrani, E.S.; Mallat, A.; Duvoux, C. Phase II study of sirolimus in treatment-naive patients with advanced hepatocellular carcinoma. Dig. Liver Dis. 2012, 44, 610-616. [CrossRef] [PubMed]
-
(2012)
Dig Liver Dis
, vol.44
, pp. 610-616
-
-
Decaens, T.1
Luciani, A.2
Itti, E.3
Hulin, A.4
Roudot-Thoraval, F.5
Laurent, A.6
Zafrani, E.S.7
Mallat, A.8
Duvoux, C.9
-
123
-
-
77950624678
-
Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Toso, C.; Merani, S.; Bigam, D.L.; Shapiro, A.M.; Kneteman, N.M. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology 2010, 51, 1237-1243. [CrossRef] [PubMed]
-
(2010)
Hepatology
, vol.51
, pp. 1237-1243
-
-
Toso, C.1
Merani, S.2
Bigam, D.L.3
Shapiro, A.M.4
Kneteman, N.M.5
-
124
-
-
67651142420
-
RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma
-
[CrossRef] [PubMed]
-
Huynh, H.; Chow, K.H.; Soo, K.C.; Toh, H.C.; Choo, S.P.; Foo, K.F.; Poon, D.; Ngo, V.C.; Tran, E. RAD001 (everolimus) inhibits tumour growth in xenograft models of human hepatocellular carcinoma. J. Cell. Mol. Med. 2009, 13, 1371-1380. [CrossRef] [PubMed]
-
(2009)
J. Cell. Mol Med
, vol.13
, pp. 1371-1380
-
-
Huynh, H.1
Chow, K.H.2
Soo, K.C.3
Toh, H.C.4
Choo, S.P.5
Foo, K.F.6
Poon, D.7
Ngo, V.C.8
Tran, E.9
-
125
-
-
84903593280
-
Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: The EVOLVE-1 randomized clinical trial
-
[CrossRef] [PubMed]
-
Zhu, A.X.; Kudo, M.; Assenat, E.; Cattan, S.; Kang, Y.K.; Lim, H.Y.; Poon, R.T.; Blanc, J.F.; Vogel, A.; Chen, C.L.; et al. Effect of everolimus on survival in advanced hepatocellular carcinoma after failure of sorafenib: The EVOLVE-1 randomized clinical trial. JAMA 2014, 312, 57-67. [CrossRef] [PubMed]
-
(2014)
JAMA
, vol.312
, pp. 57-67
-
-
Zhu, A.X.1
Kudo, M.2
Assenat, E.3
Cattan, S.4
Kang, Y.K.5
Lim, H.Y.6
Poon, R.T.7
Blanc, J.F.8
Vogel, A.9
Chen, C.L.10
-
126
-
-
84862895179
-
mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma
-
[CrossRef]
-
Thomas, H.E.; Mercer, C.A.; Carnevalli, L.S.; Park, J.; Andersen, J.B.; Conner, E.A.; Tanaka, K.; Matsutani, T.; Iwanami, A.; Aronow, B.J.; et al. mTOR inhibitors synergize on regression, reversal of gene expression, and autophagy in hepatocellular carcinoma. Sci. Transl. Med. 2012, 4, 139ra184. [CrossRef]
-
(2012)
Sci. Transl Med
, vol.4
-
-
Thomas, H.E.1
Mercer, C.A.2
Carnevalli, L.S.3
Park, J.4
Andersen, J.B.5
Conner, E.A.6
Tanaka, K.7
Matsutani, T.8
Iwanami, A.9
Aronow, B.J.10
-
127
-
-
84937523899
-
Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates
-
[PubMed]
-
Egan, D.F.; Chun, M.G.; Vamos, M.; Zou, H.; Rong, J.; Miller, C.J.; Lou, H.J.; Raveendra-Panickar, D.; Yang, C.C.; Sheffler, D.J.; et al. Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates. Mol. Cell 2015, 59, 285-297. [PubMed]
-
(2015)
Mol Cell
, vol.59
, pp. 285-297
-
-
Egan, D.F.1
Chun, M.G.2
Vamos, M.3
Zou, H.4
Rong, J.5
Miller, C.J.6
Lou, H.J.7
Raveendra-Panickar, D.8
Yang, C.C.9
Sheffler, D.J.10
-
128
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
[PubMed]
-
Llovet, J.M.; Ricci, S.; Mazzaferro, V.; Hilgard, P.; Gane, E.; Blanc, J.F.; de Oliveira, A.C.; Santoro, A.; Raoul, J.L.; Forner, A.; et al. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 2008, 359, 378-390. [PubMed]
-
(2008)
N. Engl. J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
de Oliveira, A.C.7
Santoro, A.8
Raoul, J.L.9
Forner, A.10
-
129
-
-
57749189578
-
Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
-
[CrossRef]
-
Cheng, A.L.; Kang, Y.K.; Chen, Z.; Tsao, C.J.; Qin, S.; Kim, J.S.; Luo, R.; Feng, J.; Ye, S.; Yang, T.S.; et al. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009, 10, 25-34. [CrossRef]
-
(2009)
Lancet Oncol
, vol.10
, pp. 25-34
-
-
Cheng, A.L.1
Kang, Y.K.2
Chen, Z.3
Tsao, C.J.4
Qin, S.5
Kim, J.S.6
Luo, R.7
Feng, J.8
Ye, S.9
Yang, T.S.10
-
130
-
-
84873949249
-
Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update
-
[CrossRef] [PubMed]
-
Gauthier, A.; Ho, M. Role of sorafenib in the treatment of advanced hepatocellular carcinoma: An update. Hepatol. Res. 2013, 43, 147-154. [CrossRef] [PubMed]
-
(2013)
Hepatol Res
, vol.43
, pp. 147-154
-
-
Gauthier, A.1
Ho, M.2
-
131
-
-
80052511885
-
Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib-The role of extracellular signal-regulated kinase counteraction
-
[CrossRef] [PubMed]
-
Manov, I.; Pollak, Y.; Broneshter, R.; Iancu, T.C. Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib-The role of extracellular signal-regulated kinase counteraction. FEBS J. 2011, 278, 3494-3507. [CrossRef] [PubMed]
-
(2011)
FEBS J
, vol.278
, pp. 3494-3507
-
-
Manov, I.1
Pollak, Y.2
Broneshter, R.3
Iancu, T.C.4
|