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Volumn 14, Issue 1, 2014, Pages

The expression of beclin-1, an autophagic gene, in hepatocellular carcinoma associated with clinical pathological and prognostic significance

Author keywords

Autophagy; Beclin 1; HCC; Microvessels; Prognosis proliferation, Apoptosis

Indexed keywords

BECLIN 1; CD34 ANTIGEN; CYCLINE; NORADRENALIN TRANSPORTER; PROTEIN BAX; PROTEIN BCL 2; SURVIVIN; TUMOR MARKER; APOPTOSIS REGULATORY PROTEIN; BAX PROTEIN, HUMAN; BECN1 PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; INHIBITOR OF APOPTOSIS PROTEIN; MEMBRANE PROTEIN; NET1 PROTEIN, HUMAN; ONCOPROTEIN;

EID: 84900318897     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-14-327     Document Type: Article
Times cited : (105)

References (37)
  • 2
    • 0032833628 scopus 로고    scopus 로고
    • Epidemiology of primary liver cancer
    • 10.1055/s-2007-1007117, 10518307
    • Bosch FX, Ribes J, Borràs J. Epidemiology of primary liver cancer. Semin Liver Dis 1999, 19:271-285. 10.1055/s-2007-1007117, 10518307.
    • (1999) Semin Liver Dis , vol.19 , pp. 271-285
    • Bosch, F.X.1    Ribes, J.2    Borràs, J.3
  • 3
    • 0033809358 scopus 로고    scopus 로고
    • Survival and recurrence after hepatic resection of 386 consecutive patients with hepatocellular carcinoma
    • 10.1016/S1072-7515(00)00700-6, 11030243
    • Hanazaki K, Kajikawa S, Shimozawa N, Mihara M, Shimada K, Hiraguri M, Koide N, Adachi W, Amano J. Survival and recurrence after hepatic resection of 386 consecutive patients with hepatocellular carcinoma. J Am Coll Surg 2000, 191:381-388. 10.1016/S1072-7515(00)00700-6, 11030243.
    • (2000) J Am Coll Surg , vol.191 , pp. 381-388
    • Hanazaki, K.1    Kajikawa, S.2    Shimozawa, N.3    Mihara, M.4    Shimada, K.5    Hiraguri, M.6    Koide, N.7    Adachi, W.8    Amano, J.9
  • 4
    • 33644513055 scopus 로고    scopus 로고
    • Local injection therapy for hepatocellular carcinoma
    • Lin XD, Lin LW. Local injection therapy for hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int 2006, 5:16-21.
    • (2006) Hepatobiliary Pancreat Dis Int , vol.5 , pp. 16-21
    • Lin, X.D.1    Lin, L.W.2
  • 5
    • 7044272630 scopus 로고    scopus 로고
    • Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    • Fattovich G, Stroffolini T, Zagni I, Donato F. Hepatocellular carcinoma in cirrhosis: incidence and risk factors. Gastroenterology 2004, 127(5 Suppl 1):S35-S50.
    • (2004) Gastroenterology , vol.127 , Issue.5 SUPPL 1
    • Fattovich, G.1    Stroffolini, T.2    Zagni, I.3    Donato, F.4
  • 6
    • 79959445345 scopus 로고    scopus 로고
    • Zinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis
    • 10.1186/1471-2407-11-271, 3145616, 21702992
    • Wang Q, Tan YX, Ren YB, Dong LW, Xie ZF, Tang L, Cao D, Zhang WP, Hu HP, Wang HY. Zinc finger protein ZBTB20 expression is increased in hepatocellular carcinoma and associated with poor prognosis. BMC Cancer 2011, 11:271. 10.1186/1471-2407-11-271, 3145616, 21702992.
    • (2011) BMC Cancer , vol.11 , pp. 271
    • Wang, Q.1    Tan, Y.X.2    Ren, Y.B.3    Dong, L.W.4    Xie, Z.F.5    Tang, L.6    Cao, D.7    Zhang, W.P.8    Hu, H.P.9    Wang, H.Y.10
  • 7
    • 80053172942 scopus 로고    scopus 로고
    • Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma
    • 10.1186/1479-5876-9-166, 3192685, 21955323
    • Qiu J, Huang P, Liu Q, Hong J, Li B, Lu C, Wang L, Wang J, Yuan Y. Identification of MACC1 as a novel prognostic marker in hepatocellular carcinoma. J Transl Med 2011, 9:166. 10.1186/1479-5876-9-166, 3192685, 21955323.
    • (2011) J Transl Med , vol.9 , pp. 166
    • Qiu, J.1    Huang, P.2    Liu, Q.3    Hong, J.4    Li, B.5    Lu, C.6    Wang, L.7    Wang, J.8    Yuan, Y.9
  • 8
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • 2732363, 11099404
    • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000, 290:1717-1721. 2732363, 11099404.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 9
    • 41749114288 scopus 로고    scopus 로고
    • Autophagy: basic principles and relevance to disease
    • 10.1146/annurev.pathmechdis.2.010506.091842, 18039129
    • Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol 2008, 3:427-455. 10.1146/annurev.pathmechdis.2.010506.091842, 18039129.
    • (2008) Annu Rev Pathol , vol.3 , pp. 427-455
    • Kundu, M.1    Thompson, C.B.2
  • 10
    • 34347404887 scopus 로고    scopus 로고
    • Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis
    • 10.1101/gad.1565707, 1899472, 17606641
    • Karantza-Wadsworth V, Patel S, Kravchuk O, Chen G, Mathew R, Jin S, White E. Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev 2007, 21:1621-1635. 10.1101/gad.1565707, 1899472, 17606641.
    • (2007) Genes Dev , vol.21 , pp. 1621-1635
    • Karantza-Wadsworth, V.1    Patel, S.2    Kravchuk, O.3    Chen, G.4    Mathew, R.5    Jin, S.6    White, E.7
  • 11
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • 10.1038/nrc1692, 16148885
    • Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005, 5:726-734. 10.1038/nrc1692, 16148885.
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 12
    • 70349969648 scopus 로고    scopus 로고
    • Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?
    • 10.1111/j.1742-4658.2009.07332.x, 19788415
    • Corcelle EA, Puustinen P, Jäättelä M. Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'?. FEBS J 2009, 276:6084-6096. 10.1111/j.1742-4658.2009.07332.x, 19788415.
    • (2009) FEBS J , vol.276 , pp. 6084-6096
    • Corcelle, E.A.1    Puustinen, P.2    Jäättelä, M.3
  • 14
    • 77951247552 scopus 로고    scopus 로고
    • Targeting cancer cells through autophagy for anticancer therapy
    • 10.1016/j.ceb.2009.12.007, 4012537, 20056398
    • Turcotte S, Giaccia AJ. Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol 2010, 22:246-251. 10.1016/j.ceb.2009.12.007, 4012537, 20056398.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 246-251
    • Turcotte, S.1    Giaccia, A.J.2
  • 15
    • 61949387423 scopus 로고    scopus 로고
    • Biochemical methods to monitor autophagy-related processes in yeast
    • Cheong H, Klionsky DJ. Biochemical methods to monitor autophagy-related processes in yeast. Methods Enzymol 2008, 451:1-26.
    • (2008) Methods Enzymol , vol.451 , pp. 1-26
    • Cheong, H.1    Klionsky, D.J.2
  • 16
    • 62949091373 scopus 로고    scopus 로고
    • Autophagy: a lysosomal degradation pathway with a central role in health and disease
    • 10.1016/j.bbamcr.2008.07.014, 18706940
    • Eskelinen EL, Saftig P. Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 2009, 1793:664-673. 10.1016/j.bbamcr.2008.07.014, 18706940.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 664-673
    • Eskelinen, E.L.1    Saftig, P.2
  • 17
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • 10.1093/embo-reports/kve061, 1083858, 11306555
    • Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001, 2:330-335. 10.1093/embo-reports/kve061, 1083858, 11306555.
    • (2001) EMBO Rep , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3    Yoshimori, T.4
  • 18
    • 67650305520 scopus 로고    scopus 로고
    • Regulation of Beclin 1 in autophagy
    • 10.4161/auto.5.5.8524, 2789700, 19372752
    • Sun Q, Fan W, Zhong Q. Regulation of Beclin 1 in autophagy. Autophagy 2009, 5:713-716. 10.4161/auto.5.5.8524, 2789700, 19372752.
    • (2009) Autophagy , vol.5 , pp. 713-716
    • Sun, Q.1    Fan, W.2    Zhong, Q.3
  • 19
    • 53549132786 scopus 로고    scopus 로고
    • Beclin 1 bridges autophagy, apoptosis and differentiation
    • Wang J. Beclin 1 bridges autophagy, apoptosis and differentiation. Autophagy 2008, 4:947-948.
    • (2008) Autophagy , vol.4 , pp. 947-948
    • Wang, J.1
  • 20
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • 10.1073/pnas.2436255100, 299911, 14657337
    • Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003, 100:15077-15082. 10.1073/pnas.2436255100, 299911, 14657337.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3    Levine, A.J.4    Heintz, N.5
  • 22
    • 65249180744 scopus 로고    scopus 로고
    • The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers
    • 10.4161/auto.5.3.7491, 19066461
    • Li BX, Li CY, Peng RQ, Wu XJ, Wang HY, Wan DS, Zhu XF, Zhang XS. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009, 5:303-306. 10.4161/auto.5.3.7491, 19066461.
    • (2009) Autophagy , vol.5 , pp. 303-306
    • Li, B.X.1    Li, C.Y.2    Peng, R.Q.3    Wu, X.J.4    Wang, H.Y.5    Wan, D.S.6    Zhu, X.F.7    Zhang, X.S.8
  • 23
    • 58149084586 scopus 로고    scopus 로고
    • Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer
    • Shen Y, Li DD, Wang LL, Deng R, Zhu XF. Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer. Autophagy 2008, 4:1067-1068.
    • (2008) Autophagy , vol.4 , pp. 1067-1068
    • Shen, Y.1    Li, D.D.2    Wang, L.L.3    Deng, R.4    Zhu, X.F.5
  • 25
    • 67650095390 scopus 로고    scopus 로고
    • The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells
    • 10.1002/ijc.24402, 19431142
    • Lomonaco SL, Finniss S, Xiang C, Decarvalho A, Umansky F, Kalkanis SN, Mikkelsen T, Brodie C. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009, 125:717-722. 10.1002/ijc.24402, 19431142.
    • (2009) Int J Cancer , vol.125 , pp. 717-722
    • Lomonaco, S.L.1    Finniss, S.2    Xiang, C.3    Decarvalho, A.4    Umansky, F.5    Kalkanis, S.N.6    Mikkelsen, T.7    Brodie, C.8
  • 26
    • 84884536033 scopus 로고    scopus 로고
    • MicroRNA-mediated autophagic signaling networks and cancer chemoresistance
    • 10.1089/cbr.2012.1460, 23841710
    • Pan B, Yi J, Song H. MicroRNA-mediated autophagic signaling networks and cancer chemoresistance. Cancer Biother Radiopharm 2013, 28:573-578. 10.1089/cbr.2012.1460, 23841710.
    • (2013) Cancer Biother Radiopharm , vol.28 , pp. 573-578
    • Pan, B.1    Yi, J.2    Song, H.3
  • 27
    • 0346998038 scopus 로고    scopus 로고
    • Defective autophagy leads to cancer
    • 10.1016/S1535-6108(03)00306-4, 14706333
    • Edinger AL, Thompson CB. Defective autophagy leads to cancer. Cancer Cell 2003, 4:422-424. 10.1016/S1535-6108(03)00306-4, 14706333.
    • (2003) Cancer Cell , vol.4 , pp. 422-424
    • Edinger, A.L.1    Thompson, C.B.2
  • 28
    • 84861574345 scopus 로고    scopus 로고
    • Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling
    • 10.1016/j.cellsig.2012.04.009, 22560876
    • Zou M, Lu N, Hu C, Liu W, Sun Y, Wang X, You Q, Gu C, Xi T, Guo Q. Beclin 1-mediated autophagy in hepatocellular carcinoma cells: implication in anticancer efficiency of oroxylin A via inhibition of mTOR signaling. Cell Signal 2012, 24:1722-1732. 10.1016/j.cellsig.2012.04.009, 22560876.
    • (2012) Cell Signal , vol.24 , pp. 1722-1732
    • Zou, M.1    Lu, N.2    Hu, C.3    Liu, W.4    Sun, Y.5    Wang, X.6    You, Q.7    Gu, C.8    Xi, T.9    Guo, Q.10
  • 29
    • 36448943299 scopus 로고    scopus 로고
    • Role of autophagy in cancer
    • 10.1038/nrc2254, 2866167, 17972889
    • Mathew R, Karantza-Wadsworth V, White E. Role of autophagy in cancer. Nat Rev Cancer 2007, 7:961-967. 10.1038/nrc2254, 2866167, 17972889.
    • (2007) Nat Rev Cancer , vol.7 , pp. 961-967
    • Mathew, R.1    Karantza-Wadsworth, V.2    White, E.3
  • 30
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • 10.1038/45257, 10604474
    • Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999, 402:672-676. 10.1038/45257, 10604474.
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3    Brown, K.4    Kempkes, B.5    Hibshoosh, H.6    Levine, B.7
  • 31
    • 35848947032 scopus 로고    scopus 로고
    • Role of autophagy in breast cancer
    • 2859167, 17786023
    • Karantza-Wadsworth V, White E. Role of autophagy in breast cancer. Autophagy 2007, 3:610-613. 2859167, 17786023.
    • (2007) Autophagy , vol.3 , pp. 610-613
    • Karantza-Wadsworth, V.1    White, E.2
  • 32
    • 34147193472 scopus 로고    scopus 로고
    • Cell biology: autophagy and cancer
    • 10.1038/446745a, 17429391
    • Levine B. Cell biology: autophagy and cancer. Nature 2007, 446:745-747. 10.1038/446745a, 17429391.
    • (2007) Nature , vol.446 , pp. 745-747
    • Levine, B.1
  • 34
    • 37549063395 scopus 로고    scopus 로고
    • Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers
    • 10.1111/j.1600-0463.2007.00858.x, 18184403
    • Ahn CH, Jeong EG, Lee JW, Kim MS, Kim SH, Kim SS, Yoo NJ, Lee SH. Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers. APMIS 2007, 115:1344-1349. 10.1111/j.1600-0463.2007.00858.x, 18184403.
    • (2007) APMIS , vol.115 , pp. 1344-1349
    • Ahn, C.H.1    Jeong, E.G.2    Lee, J.W.3    Kim, M.S.4    Kim, S.H.5    Kim, S.S.6    Yoo, N.J.7    Lee, S.H.8
  • 36
    • 77954242444 scopus 로고    scopus 로고
    • Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas
    • 10.1038/modpathol.2010.80, 20473282
    • Nicotra G, Mercalli F, Peracchio C, Castino R, Follo C, Valente G, Isidoro C. Autophagy-active beclin-1 correlates with favourable clinical outcome in non-Hodgkin lymphomas. Mod Pathol 2010, 23:937-950. 10.1038/modpathol.2010.80, 20473282.
    • (2010) Mod Pathol , vol.23 , pp. 937-950
    • Nicotra, G.1    Mercalli, F.2    Peracchio, C.3    Castino, R.4    Follo, C.5    Valente, G.6    Isidoro, C.7
  • 37
    • 70349641918 scopus 로고    scopus 로고
    • Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression
    • 10.1007/s12253-008-9143-8, 2791489, 19130303
    • Chen Y, Lu Y, Lu C, Zhang L. Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res 2009, 15:487-493. 10.1007/s12253-008-9143-8, 2791489, 19130303.
    • (2009) Pathol Oncol Res , vol.15 , pp. 487-493
    • Chen, Y.1    Lu, Y.2    Lu, C.3    Zhang, L.4


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