Autophagy: A novel therapeutic target for hepatocarcinoma (Review)

Oncology Letters

Volumn 7, Issue 5, 2014, Pages 1345-1351

  Wang, Zhanggui ^a   Han, Weidong ^a   Sui, Xinbing ^a   Fang, Yong ^a   Pan, Hongming ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Anti hepatocarcinoma therapy; Autophagy; Hepatocarcinoma

Indexed keywords

2 AMINO N [4 [5 (2 PHENANTHRENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL] PHENYL] ACETAMIDE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BEVACIZUMAB; BORTEZOMIB; CISPLATIN; DOXORUBICIN; FLUOROURACIL; GAMMA INTERFERON; INTERLEUKIN 2; NILOTINIB; OXALIPLATIN; SORAFENIB; UNCLASSIFIED DRUG;

AUTOPHAGOSOME; AUTOPHAGY; CANCER CHEMOTHERAPY; CELL DEATH; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CHEMOEMBOLIZATION; COMPUTER ASSISTED RADIOTHERAPY; HUMAN; IMMUNOTHERAPY; LIVER CELL CARCINOMA; LIVER METASTASIS; LIVER TRANSPLANTATION; MOLECULARLY TARGETED THERAPY; NONHUMAN; PHASE 2 CLINICAL TRIAL (TOPIC); PHOTODYNAMIC THERAPY; REVIEW; STEREOTACTIC BODY RADIATION THERAPY; SURVIVAL TIME; SYSTEMATIC REVIEW; THERAPY RESISTANCE; TREATMENT PLANNING;

EID: 84896285400     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.1916     Document Type: Review

References (83)

1. Degenhardt K, Mathew R, Beaudoin B, et al: Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 10: 51-64, 2006.
2. Kroemer G, Marino G and Levine B: Autophagy and the integrated stress response. Mol Cell 40: 280-293, 2010.
3. Rosenfeldt MT and Ryan KM: The multiple roles of autophagy in cancer. Carcinogenesis 32: 955-963, 2011.
4. Mizushima N: Autophagy: process and function. Genes Dev 21: 2861-2873, 2007.
5. Yue Z: Regulation of neuronal autophagy in axon: implication of autophagy in axonal function and dysfunction/degeneration. Autophagy 3: 139-141, 2007.
6. Scharl M and Rogler G: Inflammatory bowel disease: dysfunction of autophagy? Dig Dis 30 (Suppl 3): 12-19, 2012.
7. Yamaguchi O and Otsu K: Role of autophagy in aging. J Cardiovasc Pharmacol 60: 242-247, 2012.
8. Eskelinen EL: The dual role of autophagy in cancer. Curr Opin Pharmacol 11: 294-300, 2011.
9. Liang C and Jung JU: Autophagy genes as tumor suppressors. Curr Opin Cell Biol 22: 226-233, 2010.
10. Yang JD and Roberts LR: Hepatocellular carcinoma: a global view. Nat Rev Gastroenterol Hepatol 7: 448-458, 2010.
11. Fares N and Peron JM: Epidemiology, natural history, and risk factors of hepatocellular carcinoma. Rev Prat 63: 216-217, 2013(In French).
12. Guerrieri F, Belloni L, Pediconi N, et al: Molecular mechanisms of HBV-associated hepatocarcinogenesis. Semin Liver Dis 33: 147-156, 2013.
13. Yamazaki K, Masugi Y and Sakamoto M: Molecular pathogenesis of hepatocellular carcinoma: altering transforming growth factor-beta signaling in hepatocarcinogenesis. Dig Dis 29: 284-288, 2011.
14. Maillard E: Epidemiology, natural history and pathogenesis of hepatocellular carcinoma. Cancer Radiother 15: 3-6, 2011(In French).
15. Ni HM, Williams JA, Yang H, et al: Targeting autophagy for the treatment of liver diseases. Pharmacol Res 66: 463-474, 2012.
16. Cui J, Gong Z and Shen HM: The role of autophagy in liver cancer: molecular mechanisms and potential therapeutic targets. Biochim Biophys Acta 1836: 15-26, 2013.
17. Rautou PE, Mansouri A, Lebrec D, et al: Autophagy in liver diseases. J Hepatol 53: 1123-1134, 2010.
18. Cabibbo G, Maida M, Genco C, et al: Natural history of untreatable hepatocellular carcinoma: a retrospective cohort study. World J Hepatol 4: 256-261, 2012.
19. Singh R, Kaushik S, Wang Y, et al: Autophagy regulates lipid metabolism. Nature 458: 1131-1135, 2009.
20. Dolganiuc A, Thomes PG, Ding WX, et al: Autophagy in alcohol-induced liver diseases. Alcohol Clin Exp Res 36: 1301-1308, 2012.
21. Ding WX, Li M and Yin XM: Selective taste of ethanol-induced autophagy for mitochondria and lipid droplets. Autophagy 7: 248-249, 2011.
22. Lavanchy D: Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 11: 97-107, 2004.
23. Beasley RP: Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61: 1942-1956, 1988.
24. Sir D, Tian Y, Chen WL, et al: The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication. Proc Natl Acad Sci USA 107: 4383-4388, 2010.
25. Tian Y, Sir D, Kuo CF, et al: Autophagy required for hepatitis B virus replication in transgenic mice. J Virol 85: 13453-13456, 2011.
26. Tang H, Da L, Mao Y, et al: Hepatitis B virus X protein sensitizes cells to starvation-induced autophagy via up-regulation of beclin 1 expression. Hepatology 49: 60-71, 2009.
27. Shinohara Y, Imajo K, Yoneda M, et al: Unfolded protein response pathways regulate Hepatitis C virus replication via modulation of autophagy. Biochem Biophys Res Commun 432: 326-332, 2013.
28. Sir D, Kuo CF, Tian Y, et al: Replication of hepatitis C virus RNA on autophagosomal membranes. J Biol Chem 287: 18036-18043, 2012.
29. Shrivastava S, Bhanja Chowdhury J, Steele R, et al: Hepatitis C virus upregulates Beclin1 for induction of autophagy and activates mTOR signaling. J Virol 86: 8705-8712, 2012.
30. Dreux M, Gastaminza P, Wieland SF and Chisari FV: The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci USA 106: 14046-14051, 2009.
31. Thoen LF, Guimaraes EL, Dolle L, et al: A role for autophagy during hepatic stellate cell activation. J Hepatol 55: 1353-1360, 2011.
32. Fang H, Liu A, Dahmen U and Dirsch O: Dual role of chloroquine in liver ischemia reperfusion injury: reduction of liver damage in early phase, but aggravation in late phase. Cell Death Dis 4: e694, 2013.
33. Yang JD, Seol SY, Leem SH, et al: Genes associated with recurrence of hepatocellular carcinoma: integrated analysis by gene expression and methylation profiling. J Korean Med Sci 26: 1428-1438, 2011.
34. Kim JH, Kim HY, Lee YK, et al: Involvement of mitophagy in oncogenic K-Ras-induced transformation: overcoming a cellular energy deficit from glucose deficiency. Autophagy 7: 1187-1198, 2011.
35. Rosenfeldt MT and Ryan KM: The role of autophagy in tumour development and cancer therapy. Expert Rev Mol Med 11: e36, 2009.
36. Qu X, Yu J, Bhagat G, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820, 2003.
37. Kotsafti A, Farinati F, Cardin R, et al: Autophagy and apoptosis-related genes in chronic liver disease and hepatocellular carcinoma. BMC Gastroenterol 12: 118, 2012.
38. Takamura A, Komatsu M, Hara T, et al: Autophagy-deficient mice develop multiple liver tumors. Genes Dev 25: 795-800, 2011.
39. Guo XL, Li D, Hu F, et al: Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett 320: 171-179, 2012.
40. Uhm JE, Park JO, Lee J, et al: A phase II study of oxaliplatin in combination with doxorubicin as first-line systemic chemotherapy in patients with inoperable hepatocellular carcinoma. Cancer Chemother Pharmacol 63: 929-935, 2009.
41. Ding ZB, Hui B, Shi YH, et al: Autophagy activation in hepatocellular carcinoma contributes to the tolerance of oxaliplatin via reactive oxygen species modulation. Clin Cancer Res 17: 6229-6238, 2011.
42. Manov I, Pollak Y, Broneshter R and Iancu TC: Inhibition of doxorubicin-induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib - the role of extracellular signal-regulated kinase counteraction. FEBS J 278: 3494-3507, 2011.
43. Huynh H, Nguyen TT, Chow KH, et al: Over-expression of the mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK in hepatocellular carcinoma: its role in tumor progression and apoptosis. BMC Gastroenterol 3: 19, 2003.
44. Wilhelm S, Carter C, Lynch M, et al: Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov 5: 835-844, 2006.
45. Zhang X, Yang XR, Huang XW, et al: Sorafenib in treatment of patients with advanced hepatocellular carcinoma: a systematic review. Hepatobiliary Pancreat Dis Int 11: 458-466, 2012.
46. Xie B, Wang DH and Spechler SJ: Sorafenib for treatment of hepatocellular carcinoma: a systematic review. Dig Dis Sci 57: 1122-1129, 2012.
47. Shimizu S, Takehara T, Hikita H, et al: Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma. Int J Cancer 131: 548-557, 2012.
48. Shi YH, Ding ZB, Zhou J, et al: Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis. Autophagy 7: 1159-1172, 2011.
49. Hayashi-Nishino M, Fujita N, Noda T, et al: A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation. Nat Cell Biol 11: 1433-1437, 2009.
50. Hui B, Shi YH, Ding ZB, et al: Proteasome inhibitor interacts synergistically with autophagy inhibitor to suppress proliferation and induce apoptosis in hepatocellular carcinoma. Cancer 118: 5560-5571, 2012.
51. Yu HC, Hou DR, Liu CY, et al: Cancerous inhibitor of protein phosphatase 2A mediates bortezomib-induced autophagy in hepatocellular carcinoma independent of proteasome. PLoS One 8: e55705, 2013.
52. Guo XL, Li D, Sun K, et al: Inhibition of autophagy enhances anticancer effects of bevacizumab in hepatocarcinoma. J Mol Med (Berl) 91: 473-483, 2013.
53. Tai WT, Shiau CW, Chen HL, et al: Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis 4: e485, 2013.
54. Gao M, Yeh PY, Lu YS, et al: OSU-03012, a novel celecoxib derivative, induces reactive oxygen species-related autophagy in hepatocellular carcinoma. Cancer Res 68: 9348-9357, 2008.
55. Yu HC, Lin CS, Tai WT, et al: Nilotinib induces autophagy in hepatocellular carcinoma through AMPK activation. J Biol Chem 288: 18249-18259, 2013.
56. Soliman H, Ringash J, Jiang H, et al: Phase II trial of palliative radiotherapy for hepatocellular carcinoma and liver metastases. J Clin Oncol 31: 3980-3986, 2013.
57. Anbalagan S, Pires IM, Blick C, et al: Radiosensitization of renal cell carcinoma in vitro through the induction of autophagy. Radiother Oncol 103: 388-393, 2012.
58. Cerniglia GJ, Karar J, Tyagi S, et al: Inhibition of autophagy as a strategy to augment radiosensitization by the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235. Mol Pharmacol 82: 1230-1240, 2012.
59. Bristol ML, Di X, Beckman MJ, et al: Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D 3. Autophagy 8: 739-753, 2012.
60. Wilson EN, Bristol ML, Di X, et al: A switch between cytoprotective and cytotoxic autophagy in the radiosensitization of breast tumor cells by chloroquine and vitamin D. Horm Cancer 2: 272-285, 2011.
61. Altmeyer A, Jung AC, Ignat M, et al: Pharmacological enhancement of autophagy induced in a hepatocellular carcinoma cell line by high-LET radiation. Anticancer Res 30: 303-310, 2010.
62. Altmeyer A, Ignat M, Denis JM, et al: Cell death after high-LET irradiation in orthotopic human hepatocellular carcinoma in vivo. In Vivo 25: 1-9, 2011.
63. Gao L, Song JR, Zhang JW, et al: Chloroquine promotes the anticancer effect of TACE in a rabbit VX2 liver tumor model. Int J Biol Sci 9: 322-330, 2013.
64. Ochsner M: Photophysical and photobiological processes in the photodynamic therapy of tumours. J Photochem Photobiol B 39: 1-18, 1997.
65. Andrzejak M, Price M and Kessel DH: Apoptotic and autophagic responses to photodynamic therapy in 1c1c7 murine hepatoma cells. Autophagy 7: 979-984, 2011
66. Arum CJ, Anderssen E, Viset T, et al: Cancer immunoediting from immunosurveillance to tumor escape in microvillus-formed niche: a study of syngeneic orthotopic rat bladder cancer model in comparison with human bladder cancer. Neoplasia 12: 434-442, 2010.
67. Liang X, De Vera ME, Buchser WJ, et al: Inhibiting systemic autophagy during interleukin 2 immunotherapy promotes long-term tumor regression. Cancer Res 72: 2791-2801, 2012.
68. Li P, Du Q, Cao Z, et al: Interferon-gamma induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1). Cancer Lett 314: 213-222, 2012.
69. Su S, Zhou H, Xue M, et al: Anti-tumor efficacy of a hepatocellular carcinoma vaccine based on dendritic cells combined with tumor-derived autophagosomes in murine models. Asian Pac J Cancer Prev 14: 3109-3116, 2013.
70. Leithead JA, Armstrong MJ, Corbett C, et al: Hepatic ischemia reperfusion injury is associated with acute kidney injury following donation after brain death liver transplantation. Transpl Int 26: 1116-1125, 2013.
71. Yasuda H, Leelahavanichkul A, Tsunoda S, et al: Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury. Am J Physiol Renal Physiol 294: F1050-F1058, 2008.
72. Hoshino A, Matoba S, Iwai-Kanai E, et al: p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia. J Mol Cell Cardiol 52: 175-184, 2012.
73. Gotoh K, Lu Z, Morita M, et al: Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation. Autophagy 5: 351-360, 2009.
74. Degli Esposti D, Sebagh M, Pham P, et al: Ischemic preconditioning induces autophagy and limits necrosis in human recipients of fatty liver grafts, decreasing the incidence of rejection episodes. Cell Death Dis 2: e111, 2011.
75. Toso C, Merani S, Bigam DL, et al: Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma. Hepatology 51: 1237-1243, 2010.
76. Yang ZJ, Chee CE, Huang S and Sinicrope FA: The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther 10: 1533-1541, 2011.
77. Toshima T, Shirabe K, Matsumoto Y, et al: Autophagy enhances hepatocellular carcinoma progression by activation of mitochondrial beta-oxidation. J Gastroenterol: May 24, 2013 (Epub ahead of print).
78. Gozuacik D and Kimchi A: Autophagy as a cell death and tumor suppressor mechanism. Oncogene 23: 2891-2906, 2004.
79. Kanzawa T, Kondo Y, Ito H, et al: Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 63: 2103-2108, 2003.
80. Kim EH, Sohn S, Kwon HJ, et al: Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 67: 6314-6324, 2007.
81. Dupere-Richer D, Kinal M, Menasche V, et al: Vorinostat-induced autophagy switches from a death-promoting to a cytoprotective signal to drive acquired resistance. Cell Death Dis 4: e486, 2013.
82. Takahashi A, Kimura T, Takabatake Y, et al: Autophagy guards against cisplatin-induced acute kidney injury. Am J Pathol 180: 517-525, 2012.
83. Ching JK and Weihl CC: Rapamycin-induced autophagy aggravates pathology and weakness in a mouse model of VCP-associated myopathy. Autophagy 9: 799-800, 2013.