Low expression of GABARAPL1 is associated with a poor outcome for patients with hepatocellular carcinoma

Oncology Reports

Volumn 31, Issue 5, 2014, Pages 2043-2048

  Liu, Chao ^a   Xia, Yan ^a   Jiang, Wei ^a   Liu, Yinkun ^a,b   Yu, Long ^a  

^a FUDAN UNIVERSITY   (China)

^b ZHONGSHAN HOSPITAL OF FUDAN UNIVERSITY   (China)

Author keywords

Autophagy; GABARAPL1; Hepatocellular carcinoma; Prognosis

Indexed keywords

MESSENGER RNA; SMALL INTERFERING RNA; GABARAPL1 PROTEIN, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TUMOR MARKER;

ADULT; ANIMAL CELL; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CANCER PROGNOSIS; CANCER TISSUE; CELL DIFFERENTIATION; CONTROLLED STUDY; FEMALE; GABARAPL1 GENE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; HUMAN; HUMAN TISSUE; LIVER; LIVER CELL CARCINOMA; MALE; NONHUMAN; ONCOGENE; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; AUTOPHAGY; BIOSYNTHESIS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GENETICS; HEPG2 CELL LINE; KAPLAN MEIER METHOD; LIVER NEOPLASMS; MIDDLE AGED; MORTALITY; PATHOLOGY; RNA INTERFERENCE; TREATMENT OUTCOME; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; KAPLAN-MEIER ESTIMATE; LIVER; LIVER NEOPLASMS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84898605742     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2014.3096     Document Type: Article

References (37)

1. Yang JD and Roberts LR: Hepatocellular carcinoma: A global view. Nat Rev Gastroenterol Hepatol 7: 448-458, 2010
2. Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 55: 74-108, 2005
3. Klionsky DJ and Emr SD: Autophagy as a regulated pathway of cellular degradation. Science 290: 1717-1721, 2000
4. Yang Z and Klionsky DJ: Eaten alive: A history of macroautophagy. Nat Cell Biol 12: 814-822, 2010
5. Shintani T and Klionsky DJ: Autophagy in health and disease: A double-edged sword. Science 306: 990-995, 2004
6. Li Y, Zhang J, Chen X, et al: Molecular machinery of autophagy and its implication in cancer. Am J Med Sci 343: 155-161, 2011
7. Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D and Moreau R: Autophagy in liver diseases. J Hepatol 53: 1123-1134, 2010
8. Pandey S and Chandravati: Autophagy in cervical cancer: An emerging therapeutic target. Asian Pac J Cancer Prev 13: 4867-4871, 2012
9. Kaza N, Kohli L and Roth KA: Autophagy in brain tumors: A new target for therapeutic intervention. Brain Pathol 22: 89-98, 2012
10. Cook KL, Shajahan AN and Clarke R: Autophagy and endocrine resistance in breast cancer. Expert Rev Anticancer Ther 11: 1283-1294, 2011
11. Yue Z, Jin S, Yang C, Levine AJ and Heintz N: Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 100: 15077-15082, 2003
12. Liang XH, Jackson S, Seaman M, et al: Induction of autophagy and inhibition of tumorigenesis by beclinn
13. Nature 402: 672-676, 1999
14. Qu X, Yu J, Bhagat G, et al: Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 112: 1809-1820, 2003
15. Takahashi Y, Coppola D, Matsushita N, et al: Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol 9: 1142-1151, 2007
16. Ding ZB, Shi YH, Zhou J, et al: Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 68: 9167-9175, 2008
17. Pellerin I, Vuillermoz C, Jouvenot M, Ordener C, Royez M and Adessi GL: Identification and characterization of an early estrogen-regulated RNA in cultured guinea-pig endometrial cells. Mol Cell Endocrinol 90: R17-R21, 1993
18. Jouvenot M, Pellerin I, Alkhalaf M, Marechal G, Royez M and Adessi GL: Effects of 17 beta-estradiol and growth factors on c-fos gene expression in endometrial epithelial cells in primary culture. Mol Cell Endocrinol 72: 149-157, 1990
19. Chakrama FZ, Seguin-Py S, Le Grand JN, et al: GABARAPL1 (GEC1) associates with autophagic vesicles. Autophagy 6: 495-505, 2010
20. Pankiv S, Clausen TH, Lamark T, et al: P62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282: 24131-24145, 2007
21. Berthier A, Seguin S, Sasco AJ, et al: High expression of gabarapl1 is associated with a better outcome for patients with lymph node-positive breast cancer. Br J Cancer 102: 1024-1031, 2010
22. Wittekind C: Pitfalls in the classification of liver tumors. Pathologe 27: 289-293, 2006 (In German)
23. Rhodes DR, Yu J, Shanker K, et al: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia 6: 1-6, 2004
24. Chen X, Cheung ST, So S, et al: Gene expression patterns in human liver cancers. Mol Biol Cell 13: 1929-1939, 2002
25. Roessler S, Jia HL, Budhu A, et al: A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients. Cancer Res 70: 10202-10212, 2010
26. Wurmbach E, Chen YB, Khitrov G, et al: Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma. Hepatology 45: 938-947, 2007
27. Mas VR, Maluf DG, Archer KJ, et al: Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma. Mol Med 15: 85-94, 2009
28. Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408, 2001
29. Wu Y, Zuo J, Ji G, et al: Proapoptotic function of integrin ?3 in human hepatocellular carcinoma cells. Clin Cancer Res 15: 60-69, 2009
30. Rhodes DR, Kalyana-Sundaram S, Mahavisno V, et al: Oncomine 3.0: Genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia 9: 166-180, 2007
31. Inoue D, Suzuki T, Mitsuishi Y, et al: Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma. Cancer Sci 103: 760-766, 2012
32. Klebig C, Seitz S, Arnold W, et al: Characterization of ?-aminobutyric acid type A receptor-associated protein, a novel tumor suppressor, showing reduced expression in breast cancer. Cancer Res 65: 394-400, 2005
33. Liu GH, Zhong Q, Ye YL, et al: Expression of beclin 1 in bladder cancer and its clinical significance. Int J Biol Markers 28: 56-62, 2013
34. Alemu EA, Lamark T, Torgersen KM, et al: ATG8 family proteins act as scaffolds for assembly of the ULK complex: Sequence requirements for LC3-interacting region (LIR) motifs. J Biol Chem 287: 39275-39290, 2012
35. Weidberg H, Shvets E, Shpilka T, Shimron F, Shinder V and Elazar Z: LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis. EMBO J 29: 1792-1802, 2010
36. Roberts SS, Mori M, Pattee P, et al: GABAergic system gene expression predicts clinical outcome in patients with neuroblastoma. J Clin Oncol 22: 4127-4134, 2004
37. Zhang Y, Wang F, Han L, et al: GABARAPL1 negatively regulates Wnt/?-catenin signaling by mediating Dvl2 degradation through the autophagy pathway. Cell Physiol Biochem 27: 503-512, 2011