Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells

Journal of Cancer

Volumn 6, Issue 2, 2015, Pages 151-159

  Yan, Jing ^a   Zhou, Yuan ^a   Chen, DaiXing ^a   Li, LiLi ^a   Yang, Xin ^a   You, Yang ^a   Ling, Xianlong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Hepatocellular carcinoma; Mitochondria; Multidrug resistance; Telomerase

Indexed keywords

ANTINEOPLASTIC AGENT; MITOCHONDRIAL DNA; SHORT HAIRPIN RNA; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CELL CULTURE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG RESISTANCE; GENETIC TRANSFECTION; HEPATOCELLULAR CARCINOMA CELL LINE; HEPG2 CELL LINE; IMMUNOFLUORESCENCE; LIVER CELL CARCINOMA; MITOCHONDRIAL TRANSLOCATION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY CHAIN; WESTERN BLOTTING;

EID: 84920924216     PISSN: None     EISSN: 18379664     Source Type: Journal    
DOI: 10.7150/jca.10419     Document Type: Article

References (25)

1. Smith LL, Coller HA, Roberts JM. Telomerase modulates expression of growth-controlling genes and enhances cell proliferation. Nat Cell Biol. 2003;5:474-9.
2. Geserick C, Tejera A, Gonzalez-Suarez E, et al. Expression of mTert in primary murine cells links the growth-promoting effects of telomerase to transforming growth factor-beta signaling. Oncogene. 2006; 25:4310-9.
3. Masutomi K, Possemato R, Wong JMY, et al. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. P Natl Acad Sci USA. 2005;102:8222-7.
4. Gu BW, Bessler M, Mason PJ. A pathogenic dyskerin mutation impairs proliferation and activates a DNA damage response independent of telomere length in mice. P Natl Acad Sci USA. 2008;105:10173-8.
5. Mondello C, Bottone MG, Noriki S, et al. Oxidative stress response in telomerase-immortalized fibroblasts from a centenarian. Ann NY Acad Sci. 2006;1091:94-101.
6. Lee J, Sung YH, Cheong C, et al. TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene. 2008;27:3754-60.
7. Santos JH, Meyer JN, Skorvaga M, et al. Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. Aging Cell. 2004;3:399-411.
8. Haendeler J, Hoffmann J, Brandes RP, et al. Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707. Molecular cellular biology. 2003;23:4598-610.
9. Jakob S, Schroeder P, Lukosz M, et al. Nuclear Protein Tyrosine Phosphatase Shp-2 Is One Important Negative Regulator of Nuclear Export of Telomerase Reverse Transcriptase. J Biol Chem. 2008;283:33155-61.
10. Sharma NK, Reyes A, Green P, et al. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 2012;40:712-25.
11. Maida Y, Yasukawa M, Furuuchi M, et al. An RNA-dependent RNA polymerase formed by TERT and the RMRP RNA. Nature. 2009;461:230-U104.
12. Maida Y,Masutomi K. RNA-dependent RNA polymerases in RNA silencing. Biol Chem. 2011;392:299-304.
13. Santos JH, Meyer JN,Van Houten B. Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis. Hum Mol Genet. 2006;15:1757-68.
14. Indran IR, Hande MP, Pervaiz S. hTERT Overexpression Alleviates Intracelluar ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells. Cancer Res. 2011;71:266-76.
15. Haendeler J, Drose S, Buchner N, et al. Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage. Arterioscl Throm Vas. 2009; 29:929-U400.
16. Singhapol C, Pal D, Czapiewski R, et al. Mitochondrial Telomerase Protects Cancer Cells from Nuclear DNA Damage and Apoptosis. Plos One 2013; 8:e52989.
17. Ling X, Wen L, Zhou Y. Role of mitochondrial translocation of telomerase in hepatocelluar carcinoma cells with mutidrug resistance. Int J Med Sci. 2012;9:545-54.
18. Santos JH, Meyer JN, Mandavilli BS. Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. Methods Mol Biol.2006; 3: 183-99.
19. Liu FS. Mechanisms of chemotherapeutic drug resistance in cancer therapy--a quick review. Taiwanese obstetrics & gynecology.2009;48:239-44.
20. Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer. 2008; 8:167-79.
21. Ruden M, Puri N. Novel anticancer therapeutics targeting telomerase. Cancer Treat Rev 2013;39:444-56.
22. Wang L, Li PF, Geng M, et al. Correlation between chemosensitivity to anticancer drugs and telomerase reverse transcriptase mRNA expression in gastric cancer. Diagnostic pathology.2013;8:33-7.
23. Ahmed S, Passos JF, Birket MJ, et al. Telomerase does not counteract telomere shortening but protects mitochondrial function under oxidative stress. J Cell Sci.2008;121:1046-53.
24. Kovalenko OA, Kaplunov J, Herbig U, et al. Expression of (NES-)hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress. Plos One, 2010;5(5):e10812.
25. Kovalenko OA, Caron MJ, Ulema P, et al. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell. 2010;9:203-19.