Prognostic relevance of light chain 3 (LC3A) autophagy patterns in colorectal adenocarcinomas

Journal of Clinical Pathology

Volumn 63, Issue 10, 2010, Pages 867-872

  Giatromanolaki, Alexandra ^a   Koukourakis, Michael I ^a   Harris, Adrian L ^a,b,c   Polychronidis, Alexandros ^a   Gatter, Kevin C ^c   Sivridis, Efthimios ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTATE DEHYDROGENASE; MARKER; MICROTUBULE PROTEIN; SYNAPSIN I;

ADULT; AGED; ARTICLE; AUTOPHAGY; BIOACCUMULATION; BREAST CARCINOMA; CANCER STAGING; CELL STRUCTURE; CELL VACUOLE; COLON ADENOCARCINOMA; CONTROLLED STUDY; CYTOPLASM; DEATH; DISEASE ASSOCIATION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDEPENDENT VARIABLE; LIGHT CHAIN; LIGHT CHAIN 3; MAJOR CLINICAL STUDY; MALE; METASTASIS; MULTIVARIATE ANALYSIS; PREDICTOR VARIABLE; PRIORITY JOURNAL; PROGNOSIS; RECTUM CARCINOMA; STONE LIKE STRUCTURE; TUMOR CELL;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; AUTOPHAGY; COLORECTAL NEOPLASMS; CYTOPLASM; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; MALE; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; NEOPLASM STAGING; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 77957840133     PISSN: 00219746     EISSN: 14724146     Source Type: Journal    
DOI: 10.1136/jcp.2010.079525     Document Type: Article

References (19)

1. Giatromanolaki A, Sivridis E, Koukourakis MI. Tumour angiogenesis: vascular growth and survival. APMIS 2004;112:431-40. (Pubitemid 39626051)
2. Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
3. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004;306:990-5. (Pubitemid 39482894)
4. Sivridis E, Koukourakis M, Zois C, et al. LC3A-positive light microscopy-detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010;176:2477-89.
5. Kabeya Y, Mizushima N, Ueno T, et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000;19:5720-8.
6. He H, Dang Y, Dai F, et al. Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B. J Biol Chem 2003;278:29278-87. (Pubitemid 36935844)
7. Koukourakis MI, Giatromanolaki A, Sivridis E, et al; Tumour Angiogenesis Research Group. Lactate dehydrogenase 5 expression in operable colorectal cancer: strong association with survival and activated vascular endothelial growth factor pathway - a report of the Tumour Angiogenesis Research Group. J Clin Oncol 2006;24:4301-8. (Pubitemid 46630788)
8. Eisenberg-Lerner A, Kimchi A. The paradox of autophagy and its implication in cancer etiology and therapy. Apoptosis 2009;14:376-91.
9. Pirtoli L, Cevenini G, Tini P, et al. The prognostic role of Beclin 1 protein expression in high-grade gliomas. Autophagy 2009;5:930-6.
10. Li BX, Li CY, Peng RQ, et al. The expression of beclin 1 is associated with favorable prognosis in stage IIIB colon cancers. Autophagy 2009;5:303-6.
11. Ding ZB, Shi YH, Zhou J, et al. Association of autophagy defect with a malignant phenotype and poor prognosis of hepatocellular carcinoma. Cancer Res 2008;68:9167-75.
12. Fujii S, Mitsunaga S, Yamazaki M, et al. Autophagy is activated in pancreatic cancer cells and correlates with poor patient outcome. Cancer Sci 2008;99:1813-19.
13. Lomonaco SL, Finniss S, Xiang C, et al. The induction of autophagy by gamma-radiation contributes to the radioresistance of glioma stem cells. Int J Cancer 2009;125:717-22.
14. Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PloS One 2009;4:e6251.
15. Liang C, Lee JS, Inn KS, et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat Cell Biol 2008;10:776-87. (Pubitemid 351927707)
16. Novikoff AB, Shin WY. Endoplasmic reticulum and autophagy in rat hepatocytes. Proc Natl Acad Sci USA 1978;75:5039-42.
17. Miyata S, Takemura G, Kawase Y, et al. Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factor. Am J Pathol 2006;168:386-97. (Pubitemid 43271138)
18. Chen JL, Lin HH, Kim KJ, et al. Novel roles for protein kinase Cdelta-dependent ignalling pathways in acute hypoxic stress-induced autophagy. J Biol Chem 2008;283:34432-44.
19. Samokhvalov V, Scott BA, Crowder CM. Autophagy protects against hypoxic injury in C. elegans. Autophagy 2008;4:1034-41.