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Volumn 17, Issue 12, 2010, Pages 1515-1519

Reduced expression of LC3B-II and Beclin 1 in glioblastoma multiforme indicates a down-regulated autophagic capacity that relates to the progression of astrocytic tumors

Author keywords

Astrocytic tumors; Autophagy; Beclin 1; Glioblastoma multiforme; LC3; Survival

Indexed keywords

BECLIN 1; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3B; UNCLASSIFIED DRUG;

EID: 78049460392     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2010.03.051     Document Type: Article
Times cited : (134)

References (38)
  • 1
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • B. Levine, and D.J. Klionsky Development by self-digestion: molecular mechanisms and biological functions of autophagy Dev Cell 6 2004 463 477
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 2
    • 0037451783 scopus 로고    scopus 로고
    • Autophagy: A barrier or an adaptive response to cancer
    • E. Ogier-Denis, and P. Codogno Autophagy: a barrier or an adaptive response to cancer Biochim Biophys Acta 1603 2003 113 128
    • (2003) Biochim Biophys Acta , vol.1603 , pp. 113-128
    • Ogier-Denis, E.1    Codogno, P.2
  • 3
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • D. Gozuacik, and A. Kimchi Autophagy as a cell death and tumor suppressor mechanism Oncogene 23 2004 2891 2906
    • (2004) Oncogene , vol.23 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 4
    • 0346998038 scopus 로고    scopus 로고
    • Defective autophagy leads to cancer
    • A.L. Edinger, and C.B. Thompson Defective autophagy leads to cancer Cancer Cell 4 2003 422 424
    • (2003) Cancer Cell , vol.4 , pp. 422-424
    • Edinger, A.L.1    Thompson, C.B.2
  • 5
    • 25444440875 scopus 로고    scopus 로고
    • Role of autophagy in cancer development and response to therapy
    • Y. Kondo, T. Kanzawa, and R. Sawaya Role of autophagy in cancer development and response to therapy Nat Rev Cancer 5 2005 726 734
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3
  • 6
    • 33646271855 scopus 로고    scopus 로고
    • A matter of life or death (or both): Understanding autophagy in cancer
    • W.N. Hait, S. Jin, and J.M. Yang A matter of life or death (or both): understanding autophagy in cancer Clin Cancer Res 12 2006 1961 1965
    • (2006) Clin Cancer Res , vol.12 , pp. 1961-1965
    • Hait, W.N.1    Jin, S.2    Yang, J.M.3
  • 7
    • 43949106884 scopus 로고    scopus 로고
    • Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3
    • H. Aoki, Y. Kondo, and K. Aldape Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3 Autophagy 4 2008 467 475
    • (2008) Autophagy , vol.4 , pp. 467-475
    • Aoki, H.1    Kondo, Y.2    Aldape, K.3
  • 8
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • Y. Kabeya, N. Mizushima, and T. Ueno LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing EMBO J 19 2000 5720 5728
    • (2000) EMBO J , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3
  • 9
    • 0032563798 scopus 로고    scopus 로고
    • A protein conjugation system essential for autophagy
    • N. Mizushima, T. Noda, and T. Yoshimori A protein conjugation system essential for autophagy Nature 395 1998 395 398
    • (1998) Nature , vol.395 , pp. 395-398
    • Mizushima, N.1    Noda, T.2    Yoshimori, T.3
  • 10
    • 0042206454 scopus 로고    scopus 로고
    • Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B
    • H. He, Y. Dang, and F. Dai Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B J Biol Chem 278 2003 29278 29287
    • (2003) J Biol Chem , vol.278 , pp. 29278-29287
    • He, H.1    Dang, Y.2    Dai, F.3
  • 11
    • 0035911162 scopus 로고    scopus 로고
    • Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
    • N. Mizushima, A. Yamamoto, and M. Hatano Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells J Cell Biol 152 2001 657 668
    • (2001) J Cell Biol , vol.152 , pp. 657-668
    • Mizushima, N.1    Yamamoto, A.2    Hatano, M.3
  • 12
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • D.J. Klionsky, H. Abeliovich, and P. Agostinis Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes Autophagy 4 2008 151 175
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3
  • 13
    • 0000906170 scopus 로고    scopus 로고
    • Induction of autophagy and inhibition of tumorigenesis by beclin 1
    • X.H. Liang, S. Jackson, and M. Seaman Induction of autophagy and inhibition of tumorigenesis by beclin 1 Nature 402 1999 672 676
    • (1999) Nature , vol.402 , pp. 672-676
    • Liang, X.H.1    Jackson, S.2    Seaman, M.3
  • 14
    • 0345166111 scopus 로고    scopus 로고
    • Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
    • Z. Yue, S. Jin, and C. Yang Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor Proc Natl Acad Sci USA 100 2003 15077 15082
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 15077-15082
    • Yue, Z.1    Jin, S.2    Yang, C.3
  • 15
    • 32244442749 scopus 로고    scopus 로고
    • Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking
    • X. Zeng, J.H. Overmeyer, and W.A. Maltese Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking J Cell Sci 119 2006 259 270
    • (2006) J Cell Sci , vol.119 , pp. 259-270
    • Zeng, X.1    Overmeyer, J.H.2    Maltese, W.A.3
  • 16
    • 9144240441 scopus 로고    scopus 로고
    • Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
    • X. Qu, J. Yu, and G. Bhagat Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene J Clin Invest 112 2003 1809 1820
    • (2003) J Clin Invest , vol.112 , pp. 1809-1820
    • Qu, X.1    Yu, J.2    Bhagat, G.3
  • 17
    • 0035032723 scopus 로고    scopus 로고
    • Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network
    • A. Kihara, Y. Kabeya, and Y. Ohsumi Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network EMBO Rep 2 2001 330 335
    • (2001) EMBO Rep , vol.2 , pp. 330-335
    • Kihara, A.1    Kabeya, Y.2    Ohsumi, Y.3
  • 18
    • 4344624322 scopus 로고    scopus 로고
    • LC3 conjugation system in mammalian autophagy
    • I. Tanida, T. Ueno, and E. Kominami LC3 conjugation system in mammalian autophagy Int J Biochem Cell Biol 36 2004 2503 2518
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 2503-2518
    • Tanida, I.1    Ueno, T.2    Kominami, E.3
  • 19
    • 0344142468 scopus 로고    scopus 로고
    • Cloning and genomic organization of Beclin 1, a candidate tumor suppressor gene on chromosome 17q21
    • V.M. Aita, X.H. Liang, and V.V. Murty Cloning and genomic organization of Beclin 1, a candidate tumor suppressor gene on chromosome 17q21 Genomics 59 1999 59 65
    • (1999) Genomics , vol.59 , pp. 59-65
    • Aita, V.M.1    Liang, X.H.2    Murty, V.V.3
  • 20
    • 19544373434 scopus 로고    scopus 로고
    • Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity
    • D. Furuya, N. Tsuji, and A. Yagihashi Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity Exp Cell Res 307 2005 26 40
    • (2005) Exp Cell Res , vol.307 , pp. 26-40
    • Furuya, D.1    Tsuji, N.2    Yagihashi, A.3
  • 21
    • 0035863399 scopus 로고    scopus 로고
    • A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles
    • S. Paglin, T. Hollister, and T. Delohery A novel response of cancer cells to radiation involves autophagy and formation of acidic vesicles Cancer Res 61 2001 439 444
    • (2001) Cancer Res , vol.61 , pp. 439-444
    • Paglin, S.1    Hollister, T.2    Delohery, T.3
  • 22
    • 34047271129 scopus 로고    scopus 로고
    • Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours
    • C. Miracco, E. Cosci, and G. Oliveri Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours Int J Oncol 30 2007 429 436
    • (2007) Int J Oncol , vol.30 , pp. 429-436
    • Miracco, C.1    Cosci, E.2    Oliveri, G.3
  • 23
    • 37549063395 scopus 로고    scopus 로고
    • Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers
    • C.H. Ahn, E.G. Jeong, and J.W. Lee Expression of beclin-1, an autophagy-related protein, in gastric and colorectal cancers APMIS 115 2007 1344 1349
    • (2007) APMIS , vol.115 , pp. 1344-1349
    • Ahn, C.H.1    Jeong, E.G.2    Lee, J.W.3
  • 24
    • 69349094578 scopus 로고    scopus 로고
    • Role and regulation of autophagy in cancer
    • N. Chen, and V. Karantza-Wadsworth Role and regulation of autophagy in cancer Biochim Biophys Acta 1793 2009 1516 1523
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1516-1523
    • Chen, N.1    Karantza-Wadsworth, V.2
  • 26
    • 55149094116 scopus 로고    scopus 로고
    • Long-term prognostic assessment of 185 newly diagnosed gliomas: Grade III glioma showed prognosis comparable to that of grade II glioma
    • C. Shinohara, Y. Muragaki, and T. Maruyama Long-term prognostic assessment of 185 newly diagnosed gliomas: grade III glioma showed prognosis comparable to that of grade II glioma Jpn J Clin Oncol 38 2008 730 733
    • (2008) Jpn J Clin Oncol , vol.38 , pp. 730-733
    • Shinohara, C.1    Muragaki, Y.2    Maruyama, T.3
  • 27
    • 58149231552 scopus 로고    scopus 로고
    • Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival
    • J. Li, H.Y. Guan, and L.Y. Gong Clinical significance of sphingosine kinase-1 expression in human astrocytomas progression and overall patient survival Clin Cancer Res 14 2008 6996 7003
    • (2008) Clin Cancer Res , vol.14 , pp. 6996-7003
    • Li, J.1    Guan, H.Y.2    Gong, L.Y.3
  • 28
    • 64649085325 scopus 로고    scopus 로고
    • Autophagy and cancer: Dynamism of the metabolism of tumor cells and tissues
    • K. Tsuchihara, S. Fujii, and H. Esumi Autophagy and cancer: dynamism of the metabolism of tumor cells and tissues Cancer Lett 278 2009 130 138
    • (2009) Cancer Lett , vol.278 , pp. 130-138
    • Tsuchihara, K.1    Fujii, S.2    Esumi, H.3
  • 29
    • 70349649219 scopus 로고    scopus 로고
    • The prognostic role of beclin 1 protein expression in high-grade gliomas
    • L. Pirtoli, G. Cevenini, and P. Tini The prognostic role of beclin 1 protein expression in high-grade gliomas Autophagy 5 2009 930 936
    • (2009) Autophagy , vol.5 , pp. 930-936
    • Pirtoli, L.1    Cevenini, G.2    Tini, P.3
  • 30
    • 17144427728 scopus 로고    scopus 로고
    • Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
    • H. Takeuchi, Y. Kondo, and K. Fujiwara Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors Cancer Res 65 2005 3336 3346
    • (2005) Cancer Res , vol.65 , pp. 3336-3346
    • Takeuchi, H.1    Kondo, Y.2    Fujiwara, K.3
  • 31
    • 0029741890 scopus 로고    scopus 로고
    • Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: The role of autophagy
    • W. Bursch, A. Ellinger, and H. Kienzl Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy Carcinogenesis 17 1996 1595 1607
    • (1996) Carcinogenesis , vol.17 , pp. 1595-1607
    • Bursch, W.1    Ellinger, A.2    Kienzl, H.3
  • 32
    • 0038743077 scopus 로고    scopus 로고
    • Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    • T. Kanzawa, Y. Kondo, and H. Ito Induction of autophagic cell death in malignant glioma cells by arsenic trioxide Cancer Res 63 2003 2103 2108
    • (2003) Cancer Res , vol.63 , pp. 2103-2108
    • Kanzawa, T.1    Kondo, Y.2    Ito, H.3
  • 33
    • 0037306785 scopus 로고    scopus 로고
    • Molecular response of human glioblastoma multiforme cells to ionizing radiation: Cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
    • K.C. Yao, T. Komata, and Y. Kondo Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy J Neurosurg 98 2003 378 384
    • (2003) J Neurosurg , vol.98 , pp. 378-384
    • Yao, K.C.1    Komata, T.2    Kondo, Y.3
  • 34
    • 33646523798 scopus 로고    scopus 로고
    • A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death
    • S. Reef, E. Zalckvar, and O. Shifman A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death Mol Cell 22 2006 463 475
    • (2006) Mol Cell , vol.22 , pp. 463-475
    • Reef, S.1    Zalckvar, E.2    Shifman, O.3
  • 35
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • D. Crighton, S. Wilkinson, and J. O'Prey DRAM, a p53-induced modulator of autophagy, is critical for apoptosis Cell 126 2006 121 134
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3
  • 36
    • 27644466759 scopus 로고    scopus 로고
    • Autophagy and signaling: Their role in cell survival and cell death
    • P. Codogno, and A.J. Meijer Autophagy and signaling: their role in cell survival and cell death Cell Death Differ 12 Suppl. 2 2005 1509 1518
    • (2005) Cell Death Differ , vol.12 , Issue.SUPPL. 2 , pp. 1509-1518
    • Codogno, P.1    Meijer, A.J.2
  • 37
    • 58149084586 scopus 로고    scopus 로고
    • Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer
    • Y. Shen, D.D. Li, and L.L. Wang Decreased expression of autophagy-related proteins in malignant epithelial ovarian cancer Autophagy 4 2008 1067 1068
    • (2008) Autophagy , vol.4 , pp. 1067-1068
    • Shen, Y.1    Li, D.D.2    Wang, L.L.3
  • 38
    • 70349641918 scopus 로고    scopus 로고
    • Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1α expression
    • Y. Chen, Y. Lu, and C. Lu Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1α expression Pathol Oncol Res 15 2009 487 493
    • (2009) Pathol Oncol Res , vol.15 , pp. 487-493
    • Chen, Y.1    Lu, Y.2    Lu, C.3


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