H2O2-activated mitochondrial phospholipase iPLA2γ prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic β-cells

Antioxidants and Redox Signaling

Volumn 23, Issue 12, 2015, Pages 958-972

  Ježek, Jan ^a   Dlasková, Andrea ^a   Zelenka, Jaroslav ^a   Jabůrek, Martin ^a   Ježek, Petr ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; G PROTEIN COUPLED RECEPTOR 40; GLUCOSE; HYDROGEN PEROXIDE; PALMITIC ACID; PHOSPHOLIPASE A2 GROUP I; PHOSPHOLIPASE A2 GROUP I GAMMA; SUPEROXIDE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; ANTIOXIDANT; G PROTEIN COUPLED RECEPTOR; G-PROTEIN-COUPLED RECEPTOR 40, RAT; INSULIN; ION CHANNEL; LIPID; MITOCHONDRIAL PROTEIN; PHOSPHOLIPASE A2 GROUP II; TERT BUTYL HYDROPEROXIDE; UCP2 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVATION; FEEDBACK SYSTEM; INSULIN RELEASE; LIPOTOXICITY; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; SECRETION (PROCESS); TUMOR CELL LINE;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; GROUP II PHOSPHOLIPASES A2; HYDROGEN PEROXIDE; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; LIPIDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SUPEROXIDES; TERT-BUTYLHYDROPEROXIDE; UNCOUPLING PROTEIN 2;

EID: 84945956960     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2014.6195     Document Type: Article

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