Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species

Diabetologia

Volumn 50, Issue 1, 2007, Pages 84-93

  Produit Zengaffinen, N ^a   Davis Lameloise, N ^a   Perreten, H ^a   Becard D ^a   Gjinovci, A ^a   Keller, P A ^a   Wollheim, C B ^a   Herrera, P ^b   Muzzin, P ^a   Assimacopoulos Jeannet, F ^a  

^a Center Médical Universitaire   (Switzerland)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

ATP ADP ratio; Insulin secretion; Mitochondrial membrane potential; Oxygen consumption; Pancreatic beta cells; Reactive oxygen species; Transgenic mice; Uncoupling protein 2

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; GLUCOSE; INSULIN; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; MALE; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; CELL RESPIRATION; DOXYCYCLINE; FEMALE; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; MITOCHONDRIAL PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 33845949078     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0499-6     Document Type: Article

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