Complex transcriptional and translational regulation of iPLA 2γ resulting in multiple gene products containing dual competing sites for mitochondrial or peroxisomal localization

European Journal of Biochemistry

Volumn 271, Issue 23-24, 2004, Pages 4709-4724

  Mancuso, David J ^a   Jenkins, Christopher M ^a   Sims, Harold F ^a   Cohen, Joshua M ^a   Yang, Jingyue ^a   Gross, Richard W ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Mitochondria; Peroxisomes; Phospholipase; Transcription; Translation

Indexed keywords

FATTY ACID; GENE PRODUCT; MEMBRANE ASSOCIATED CALCIUM INDEPENDENT PHOSPHOLIPASE A 2GAMMA; METHIONINE; NUCLEAR PROTEIN; PHOSPHOLIPASE A2; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EXON; FLUORESCENCE; MESSENGER RNA SYNTHESIS; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; RAT; REGULATORY MECHANISM; THERMOGENESIS; TRANSCRIPTION REGULATION; TRANSLATION REGULATION;

ALTERNATIVE SPLICING; BASE SEQUENCE; BLOTTING, NORTHERN; DNA PRIMERS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; PEROXISOMES; PHOSPHOLIPASES A; POLYMERASE CHAIN REACTION; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

ANIMALIA;

EID: 11244266429     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1432-1033.2004.04435.x     Document Type: Article

References (67)

1. 2. J. Biol. Chem. 272, 16709-16712.
2. 2. J. Biol. Chem. 272, 16069-16072.
3. 2 and its role in brain tissue. J. Neurochem. 69, 889-901.
4. 2 by depletion of internal calcium stores. Biochem. Soc. Trans. 26, 345-349.
5. 2. Prog. Nucleic Acids Res. Mol. Biol. 67, 1-33.
6. 2 in canine myocardium. J. Biol. Chem. 260, 7295-7303.
7. 2 from transplant recipients suffering from end stage ischemic heart disease. Circ. Res. 70, 486-495.
8. 2 isoform: fast atom bombardment mass spectroscopic and reverse phase HPLC identification of choline and ethanolamine glycerophospholipid substrates. J. Clin. Invest. 91, 2513-2522.
9. 2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate. J. Biol. Chem. 266, 5629-5633.
10. 2 during myocardial ischemia. J. Clin. Invest. 88, 331-335.
11. Gross, R.W. (1985) Identification of plasmalogen as the major phospholipid constituent of cardiac sarcoplasmic reticulum. Biochemistry 24, 1662-1668.
12. 2. J. Biol. Chem. 266, 7227-7232.
13. 2. J. Med. Chem. 36, 95-100.
14. 2s. J. Biol. Chem. 277, 32807-32814.
15. 2+- independent degradation of mitochondrial phospholipids. Biochemistry 41, 7771-7780.
16. Urbánková, E., Voltchenko, A., Pohl, P., Jezek, P. & Pohl, E.E. (2003) Transport kinetics of uncoupling proteins. Analysis of UCP1 reconstituted in planar lipid bilayers. J. Biol. Chem. 278, 32497-32500.
17. Fink, K.L. & Gross, R.W. (1984) Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds. Circ. Res. 55, 585-594.
18. + channel, Kv1.1. J. Biol. Chem. 271, 32519-32522.
19. 2. J. Biol. Chem. 270, 2885-2888.
20. Smani, T., Zakharov, S.I., Csutora, P., Leno, E., Trepakova, E.S. & Bolotina, V.M. (2004) A novel mechanism for the store-operated calcium influx pathway. Nat. Cell Biol. 6, 113-120.
21. 2: a calcium independent phospholipase with absolute sn-2 regio specificity for diradyl glycerophospholipids. J. Biol. Chem. 265, 10622-10630.
22. 2 gene. Multiple enzymes with distinct properties from a single gene. Eur. J. Biochem. 262, 575-585.
23. 2. J. Biol. Chem. 271, 30879-30895.
24. 2 contains eight ankyrin motifs. J. Biol. Chem. 272, 8567-8575.
25. Stewart, A., Ghosh, M., Spencer, D.M. & Leslie, C.C. (2002) Enzymatic properties of human cytosolic phospholipase A(2) gamma. J. Biol. Chem. 277, 29526-29536.
26. Mancuso, D.J., Jenkins, C.M. & Gross, R.W. (2000) The genomic organization, complete mRNA sequence, cloning, and expression of a novel human intracellular membrane-associated calcium-independent phospholipase A(2). J. Biol. Chem. 275, 9937-9945.
27. Yang, J., Han, X. & Gross, R.W. (2003) Identification of hepatic peroxisomal phospholipase A(2) and characterization of arachidonic acid-containing choline glycerophospholipids in hepatic peroxisomes. FEBS Lett. 546, 247-250.
28. Andrews, D.L., Bemes, B., Summers, M.D. & Park, W.D. (1988) Characterization of the lipid acyl hydrolase activity of the major potato (Solanum tuberosum) tuber protein, patatin, by cloning and abundant expression in a baculovirus vector. Biochem. J. 252, 199-206.
29. 2. Implications for cardiac cycle-dependent alterations in phospholipolysis. J. Biol. Chem. 271, 20989-20992.
30. 2beta. implications for structure and function. J. Biol. Chem. 276, 7129-7135.
31. 2 augments spontaneous fatty acid release. J. Biol. Chem. 275, 18248-18258.
32. 2, which undergoes proteolytic inactivation. J. Biol. Chem. 273, 13870-13877.
33. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
34. Kozak, M. (1996) Interpreting cDNA sequences: some insights from studies on translation. Mamm. Genome 7, 563-574.
35. Kozak, M. (1987) An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125-8148.
36. Chin, M.T., Maemura, K., Fukumoto, S., Jain, M.K., Layne, M.D., Watanabe, M., Hsieh, C.-M. & Lee, M.-E. (2000) Cardiovascular basic helix loop helix factor 1, a novel transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. J. Biol. Chem. 275, 6381-6387.
37. Claros, M.G. & Vincens, P. (1996) Computational method to predict mitochondrially imported proteins and their targeting sequences. Eur. J. Biochem. 241, 779-786.
38. Luckow, V.A. & Summers, M.D. (1988) Signals important for high-level expression of foreign genes in Autographa californica nuclear polyhedrosis virus expression vectors. Virology 167, 56-71.
39. Luckow, V.A. & Summers, M.D. (1989) High level expression of nonfused foreign genes with Autographa californica nuclear polyhedrosis virus expression vectors. Virology 170, 31-39.
40. 2beta, precipitating ventricular tachyarrhythmias in transgenic mice: rescue of the lethal electrophysiologic phenotype by mechanism-based inhibition. J. Biol. Chem. 278, 22231-22236.
41. Zeng, Y., Han, X., Schlesinger, P. & Gross, R.W. (1998) Nonesterified fatty acids induce transmembrane monovalent cation flux: host-guest interactions as determinants of fatty acid-induced ion transport. Biochemistry 37, 9497-9508.
42. 2 gene multiple enzymes with distinct properties from a single gene. Eur. J. Biochem. 262, 575-585.
43. 2 gene on chromosome 22q13.1. J. Biol. Chem. 274, 9607-9616.
44. 2 and their effect on enzyme activity. J. Biol. Chem. 273, 207-214.
45. Tanaka, H., Takeya, R. & Sumimoto, H. (2000) A novel intracellular membrane-bound calcium-independent phospholipase A(2). Biochem. Biophys. Res. Commun. 272, 320-326.
46. Verrijzer, C.P., Chen, J.-L., Yokomori, K. & Tjian, R. (1995) Binding of TAFs to core elements directs promoter selectivity by RNA polymerase II. Cell 81, 1115-1125.
47. Arnold, H.H. & Winter, B. (1998) Muscle differentiation: more complexity to the network of myogenic regulators. Curr. Opin. Genet. Dev. 8, 539-544.
48. Mckinsey, T.A., Zhang, C.L. & Olson, E.N. (2001) Control of muscle development by dueling HATs and HDACs. Curr. Opin. Genet. Dev. 11, 497-504.
49. Puri, P.L. & Sartorelli, V. (2000) Regulation of muscle regulatory factors by DNA-binding, interacting proteins, and post-transcriptional modifications. J. Cell Physiol. 185, 155-173.
50. 2. J. Biol. Chem. 268, 20713-20716.
51. Ramanadham, S., Gross, R.W., Han, X. & Turk, J. (1993) Inhibition of arachidonate release by secretagogue-stimulated pancreatic islets suppresses both insulin secretion and the rise in beta-cell cytosolic calcium ion concentration. Biochemistry 32, 337-346.
52. 2 (iPLA2beta) indicate a signaling rather than a housekeeping role for iPLA2beta. J. Biol. Chem. 276, 13198-13208.
53. Seegers, H.C., Gross, R.W. & Boyle, W.A. (2002) Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine. Exp. Therap. 302, 918-923.
54. Ogboume, S. & Antalis, T.M. (1998) Transcriptional control and the role of silencers in transcriptional regulation in eukaryotes. Biochem. J. 331, 1-14.
55. Morel, N. & Massoulié, J. (2000) Comparative expression of homologous proteins. A novel mode of transcriptional regulation by the coding sequence folding compatibility of chimeras. J. Biol. Chem. 275, 7304-7312.
56. Pasté, M., Huez, G. & Kruys, V. (2003) Deadenylation of interferon-beta mRNA is mediated by both the AU-rich element in the 3′-untranslated region and an instability sequence in the coding region. Eur. J. Biochem. 270, 1590-1597.
57. Fallaux, F.J., Hoeben, R.C., Cramer, S.J., van den Wollenberg, D.J., Briet, E., van Ormondt, H. & van der Eb, A.J. (1996) The human clotting factor VIII cDNA contains an autonomously replicating sequence consensus- and matrix attachment region-like sequence that binds a nuclear factor, represses heterologous gene expression, and mediates the transcriptional effects of sodium butyrate. Mol. Cell. Biol. 16, 4264-4272.
58. Xiang, S., Parsons, H.K. & Murray, M. (1998) Identification of a novel transcriptional silencer in the protein-coding region of the human CYP2C9 gene. Gene. 209, 123-129.
59. Willis, A.E. (1999) Translational control of growth factor and proto-oncogene expression. Int. J. Biochem. Cell. Biol. 31, 73-86.
60. Leff, S.E. & Rosenfeld, M.G. (1986) Complex transcriptional units: diversity in gene expression by alternative RNA processing. Annu. Rev. Biochem. 55, 1091-1117.
61. Breitbart, R.E., Andreadis, A. & Nadal-Ginard, B. (1987) Alternative splicing: a ubiquitous mechanism for the generation of multiple protein isoforms from single genes. Annu. Rev. Biochem. 56, 467-495.
62. Proudfoot, N.J., Furger, A. & Dye, M.J. (2002) Integrating mRNA processing with transcription. Cell 108, 501-512.
63. Maniatis, T. & Tasic, B. (2002) Alternative pre-mRNA splicing and proteome expansion in metazoans. Nature 418, 236-243.
64. Latruffe, N. & Vamecq, J. (2000) Evolutionary aspects of peroxisomes as cell organelles, and of genes encoding peroxisomal proteins. Biol. Cell 92, 389-395.
65. van der Klei, I.J. & Veenhuis, M. (1997) Yeast peroxisomes: function and biogenesis of a versatile cell organelle. Trends Microbiol. 5, 502-509.
66. Mannaerts, G.P. & van Veldhoven, P.P. (1996) Functions and organization of peroxisomal beta-oxidation. Ann. NY Acad. Sci. 804, 99-115.
67. 2 or inhibits the hormone-induced differentiation of 3T3-L1 preadipocytes. J. Biol. Chem. 279, 21740-21748.