UCP2 regulates the glucagon response to fasting and starvation

Diabetes

Volumn 62, Issue 5, 2013, Pages 1623-1633

  Allister, Emma M ^a   Robson Doucette, Christine A ^a   Prentice, Kacey J ^a   Hardy, Alexandre B ^a   Sultan, Sobia ^a   Gaisano, Herbert Y ^a   Kong, Dong ^b   Gilon, Patrick ^c   Herrera, Pedro L ^d   Lowell, Bradford B ^b   Wheeler, Michael B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

^c UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^d UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; BLOOD SAMPLING; CONTROLLED STUDY; CROSS COUPLING REACTION; DIET RESTRICTION; FOOD DEPRIVATION; GENE DELETION; GENE EXPRESSION; GLUCAGON RELEASE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOGLYCEMIA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET; PANCREAS ISLET ALPHA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STARVATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM SIGNALING; CALORIC RESTRICTION; FASTING; GLUCAGON; GLUCAGON-SECRETING CELLS; HUMANS; HYPOGLYCEMIA; ION CHANNELS; ISLETS OF LANGERHANS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, 129 STRAIN; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RNA, MESSENGER; TISSUE CULTURE TECHNIQUES; UNCOUPLING AGENTS; UP-REGULATION;

EID: 84876566528     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0981     Document Type: Article

References (46)

1. Burcelin R, Knauf C, Cani PD. Pancreatic alpha-cell dysfunction in diabetes. Diabetes Metab 2008;34(Suppl. 2):S49-S55
2. Kawamori D, Welters HJ, Kulkarni RN. Molecular pathways underlying the pathogenesis of pancreatic alpha-cell dysfunction. Adv Exp Med Biol 2010;654:421-445
3. Cryer PE. Hypoglycaemia: the limiting factor in the glycaemic management of Type I and Type II diabetes. Diabetologia 2002;45:937-948 (Pubitemid 34762188)
4. Rorsman P, Berggren PO, Bokvist K, et al. Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels. Nature 1989;341:233-236 (Pubitemid 19231723)
5. Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB. Islet betacell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 2003;5:330-335 (Pubitemid 36432297)
6. Gyulkhandanyan AV, Lu H, Lee SC, et al. Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells. J Biol Chem 2008;283:10184-10197
7. Diao J, Asghar Z, Chan CB, Wheeler MB. Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cells. J Biol Chem 2005;280:33487-33496 (Pubitemid 41397148)
8. Le Marchand SJ, Piston DW. Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets. J Biol Chem 2010;285:14389-14398
9. Kawamori D, Kurpad AJ, Hu J, et al. Insulin signaling in alpha cells modulates glucagon secretion in vivo. Cell Metab 2009;9:350-361
10. Hardy AB, Serino AS, Wijesekara N, Chimienti F, Wheeler MB. Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model. Diabetes Obes Metab 2011;13(Suppl. 1):112-117
11. Diao J, Allister EM, Koshkin V, et al. UCP2 is highly expressed in pancreatic alpha-cells and influences secretion and survival. Proc Natl Acad Sci USA 2008;105:12057-12062
12. Millet L, Vidal H, Andreelli F, et al. Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest 1997;100:2665-2670 (Pubitemid 28007533)
13. Affourtit C, Jastroch M, Brand MD. Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species. Free Radic Biol Med 2011;50:609-616
14. Couplan E, del Mar Gonzalez-Barroso M, Alves-Guerra MC, Ricquier D, Goubern M, Bouillaud F. No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria. J Biol Chem 2002;277:26268-26275 (Pubitemid 34967116)
15. Bouillaud F. UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing. Biochim Biophys Acta 2009;1787:377-383
16. Arsenijevic D, Onuma H, Pecqueur C, et al. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 2000;26:435-439
17. Pi J, Bai Y, Daniel KW, et al. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology 2009;150:3040-3048
18. Robson-Doucette CA, Sultan S, Allister EM, et al. Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion. Diabetes 2011;60:2710-2719
19. Echtay KS, Roussel D, St-Pierre J, et al. Superoxide activates mitochondrial uncoupling proteins. Nature 2002;415:96-99 (Pubitemid 34062457)
20. Pi J, Bai Y, Zhang Q, et al. Reactive oxygen species as a signal in glucosestimulated insulin secretion. Diabetes 2007;56:1783-1791 (Pubitemid 47025446)
21. Rorsman P, Salehi SA, Abdulkader F, Braun M, MacDonald PE. K(ATP)-channels and glucose-regulated glucagon secretion. Trends Endocrinol Metab 2008;19:277-284
22. Gromada J, Ma X, Høy M, et al. ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wildtype and SUR1-/- mouse alpha-cells. Diabetes 2004;53(Suppl. 3):S181-S189 (Pubitemid 39564542)
23. Braun M, Rorsman P. The glucagon-producing alpha cell: an electrophysiologically exceptional cell. Diabetologia 2010;53:1827-1830
24. MacDonald PE, De Marinis YZ, Ramracheya R, et al. A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans. PLoS Biol 2007;5:e143
25. Kong D, Vong L, Parton LE, et al. Glucose stimulation of hypothalamic MCH neurons involves K(ATP) channels, is modulated by UCP2, and regulates peripheral glucose homeostasis. Cell Metab 2010;12:545-552
26. Herrera PL. Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages. Development 2000;127:2317-2322 (Pubitemid 30386571)
27. Quoix N, Cheng-Xue R, Guiot Y, Herrera PL, Henquin JC, Gilon P. The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. FEBS Lett 2007;581:4235-4240 (Pubitemid 47301858)
28. Shapiro AM, Lakey JR, Ryan EA, et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000;343:230-238 (Pubitemid 30490390)
29. Kin T, O'Gorman D, Schroeder A, et al. Human islet distribution program for basic research at a single center. Transplant Proc 2011;43:3195-3197
30. Suzuki Y, Lanner C, Kim JH, et al. Insulin control of glycogen metabolism in knockout mice lacking the muscle-specific protein phosphatase PP1G/RGL. Mol Cell Biol 2001;21:2683-2694 (Pubitemid 32244913)
31. Li LO, Hu YF, Wang L, Mitchell M, Berger A, Coleman RA. Early hepatic insulin resistance in mice: a metabolomics analysis. Mol Endocrinol 2010;24:657-666
32. Hardy AB, Fox JE, Giglou PR, et al. Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human islets. J Biol Chem 2009;284:30441-30452
33. Basford CL, Prentice KJ, Hardy AB, et al. The functional and molecular characterisation of human embryonic stem cell-derived insulin-positive cells compared with adult pancreatic beta cells. Diabetologia 2012;55:358-371
34. Braun M, Ramracheya R, Bengtsson M, et al. Gamma-aminobutyric acid (GABA) is an autocrine excitatory transmitter in human pancreatic beta-cells. Diabetes 2010;59:1694-1701
35. Lee SC, Robson-Doucette CA, Wheeler MB. Uncoupling protein 2 regulates reactive oxygen species formation in islets and in fluences susceptibility to diabetogenic action of streptozotocin. J Endocrinol 2009;203:33-43
36. Conarello SL, Jiang G, Mu J, et al. Glucagon receptor knockout mice are resistant to diet-induced obesity and streptozotocin-mediated beta cell loss and hyperglycaemia. Diabetologia 2007;50:142-150 (Pubitemid 46035862)
37. Zhang CY, Parton LE, Ye CP, et al. Genipin inhibits UCP2-mediated proton leak and acutely reverses obesity- and high glucose-induced beta cell dysfunction in isolated pancreatic islets. Cell Metab 2006;3:417-427 (Pubitemid 43811776)
38. Leloup C, Tourrel-Cuzin C, Magnan C, et al. Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion. Diabetes 2009;58:673-681
39. González-Vélez V, Dupont G, Gil A, González A, Quesada I. Model for glucagon secretion by pancreatic a-cells. PLoS ONE 2012;7:e32282
40. Yabaluri N, Bashyam MD. Hormonal regulation of gluconeogenic gene transcription in the liver. J Biosci 2010;35:473-484
41. St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 2002;132:329-332 (Pubitemid 34208728)
42. Yang J, MacDougall ML, McDowell MT, et al. Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC Genomics 2011;12:281
43. Thorel F, Damond N, Chera S, et al. Normal glucagon signaling and β-cell function after near-total α-cell ablation in adult mice. Diabetes 2011;60:2872-2882
44. Quoix N, Cheng-Xue R, Mattart L, et al. Glucose and pharmacological modulators of ATP-sensitive K+ channels control [Ca2+]c by different mechanisms in isolated mouse alpha-cells. Diabetes 2009;58:412-421
45. Walker JN, Ramracheya R, Zhang Q, Johnson PR, Braun M, Rorsman P. Regulation of glucagon secretion by glucose: paracrine, intrinsic or both? Diabetes Obes Metab 2011;13(Suppl. 1):95-105
46. Martens GA, Cai Y, Hinke S, Stangé G, Van de Casteele M, Pipeleers D. Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells. J Biol Chem 2005;280:20389-20396 (Pubitemid 40776738)