메뉴 건너뛰기




Volumn 21, Issue 4, 2007, Pages 1137-1144

Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers

Author keywords

Anion transporter; Artificial bilayer membranes; Mitochondria; Proton transport; Reactive oxygen species

Indexed keywords

ARACHIDONIC ACID; ICOSATRIENOIC ACID; LINOLEIC ACID; OLEIC ACID; PALMITIC ACID; POLYUNSATURATED FATTY ACID; PURINE NUCLEOTIDE; RETINOIC ACID; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

EID: 33947630244     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-7489com     Document Type: Article
Times cited : (100)

References (68)
  • 1
    • 2342605549 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins-facts and fantasies
    • Jezek, P., Zackova, M., Ruzicka, M., Skobisova, E., and Jaburek, M. (2004) Mitochondrial uncoupling proteins-facts and fantasies. Physiol. Res. 53 Suppl. 1, 199-211
    • (2004) Physiol. Res , vol.53 , Issue.SUPPL. 1 , pp. 199-211
    • Jezek, P.1    Zackova, M.2    Ruzicka, M.3    Skobisova, E.4    Jaburek, M.5
  • 3
    • 0025930608 scopus 로고
    • Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation
    • Skulachev, V. P. (1991) Fatty acid circuit as a physiological mechanism of uncoupling of oxidative phosphorylation. FEBS Lett. 294, 158-162
    • (1991) FEBS Lett , vol.294 , pp. 158-162
    • Skulachev, V.P.1
  • 4
    • 0030039607 scopus 로고    scopus 로고
    • On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein
    • Garlid, K. D., Orosz, D. E., Modriansky, M., Vassanelli, S., and Jezek, P. (1996) On the mechanism of fatty acid-induced proton transport by mitochondrial uncoupling protein. J. Biol. Chem. 271, 2615-2620
    • (1996) J. Biol. Chem , vol.271 , pp. 2615-2620
    • Garlid, K.D.1    Orosz, D.E.2    Modriansky, M.3    Vassanelli, S.4    Jezek, P.5
  • 5
    • 0042358650 scopus 로고    scopus 로고
    • Transport kinetics of uncoupling proteins: Analysis of UCP1 reconstituted in planar lipid bilayers
    • Urbankova, E., Voltchenko, A., Pohl, P., Jezek, P., and Pohl, E. E. (2003) Transport kinetics of uncoupling proteins: Analysis of UCP1 reconstituted in planar lipid bilayers. J. Biol. Chem. 278, 32497-32500
    • (2003) J. Biol. Chem , vol.278 , pp. 32497-32500
    • Urbankova, E.1    Voltchenko, A.2    Pohl, P.3    Jezek, P.4    Pohl, E.E.5
  • 6
    • 0032901360 scopus 로고    scopus 로고
    • Structure and function of the uncoupling protein from brown adipose tissue
    • Klingenberg, M., and Huang, S. G. (1999) Structure and function of the uncoupling protein from brown adipose tissue. Biochim. Biophys. Acta. 1415, 271-296
    • (1999) Biochim. Biophys. Acta , vol.1415 , pp. 271-296
    • Klingenberg, M.1    Huang, S.G.2
  • 7
    • 0027980820 scopus 로고
    • + transport activity of the reconstituted uncoupling protein
    • + transport activity of the reconstituted uncoupling protein. J. Biol. Chem. 269, 2508-2515
    • (1994) J. Biol. Chem , vol.269 , pp. 2508-2515
    • Winkler, E.1    Klingenberg, M.2
  • 12
    • 11144234168 scopus 로고    scopus 로고
    • Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2
    • Jaburek, M., Miyamoto, S., Di Mascio, P., Garlid, K. D., and Jezek, P. (2004) Hydroperoxy fatty acid cycling mediated by mitochondrial uncoupling protein UCP2. J. Biol. Chem. 279, 53097-53102
    • (2004) J. Biol. Chem , vol.279 , pp. 53097-53102
    • Jaburek, M.1    Miyamoto, S.2    Di Mascio, P.3    Garlid, K.D.4    Jezek, P.5
  • 13
    • 25144476923 scopus 로고    scopus 로고
    • Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
    • Brand, M. D., and Esteves, T. C. (2005) Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. Cell Metab. 2, 85-93
    • (2005) Cell Metab , vol.2 , pp. 85-93
    • Brand, M.D.1    Esteves, T.C.2
  • 14
  • 16
    • 0037253404 scopus 로고    scopus 로고
    • The 'novel' 'uncoupling' proteins UCP2 and UCP3: What do they really do? Pros and cons for suggested functions
    • Nedergaard, J., and Cannon, B. (2003) The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions. Exp. Physiol. 88, 65-84
    • (2003) Exp. Physiol , vol.88 , pp. 65-84
    • Nedergaard, J.1    Cannon, B.2
  • 17
    • 0042415622 scopus 로고    scopus 로고
    • A function for novel uncoupling proteins: Antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet
    • Goglia, F., and Skulachev, V. P. (2003) A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet. FASEB J. 17, 1585-1591
    • (2003) FASEB J , vol.17 , pp. 1585-1591
    • Goglia, F.1    Skulachev, V.P.2
  • 18
    • 0032564864 scopus 로고    scopus 로고
    • Uncoupling: New approaches to an old problem of bioenergetics
    • Skulachev, V. P. (1998) Uncoupling: new approaches to an old problem of bioenergetics. Biochim. Biophys. Acta. 1363, 100-124
    • (1998) Biochim. Biophys. Acta , vol.1363 , pp. 100-124
    • Skulachev, V.P.1
  • 22
    • 1242336976 scopus 로고    scopus 로고
    • Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice
    • Horimoto, M., Fulop, P., Derdak, Z., Wands, J. R., and Baffy, G. (2004) Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice. Hepatology 39, 386-392
    • (2004) Hepatology , vol.39 , pp. 386-392
    • Horimoto, M.1    Fulop, P.2    Derdak, Z.3    Wands, J.R.4    Baffy, G.5
  • 23
    • 0035282920 scopus 로고    scopus 로고
    • Uncoupling proteins: The issues from a biochemist point of view
    • Klingenberg, M., and Echtay, K. S. (2001) Uncoupling proteins: the issues from a biochemist point of view. Biochim. Biophys. Acta. 1504, 128-143
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 128-143
    • Klingenberg, M.1    Echtay, K.S.2
  • 24
    • 0035282777 scopus 로고    scopus 로고
    • Mitochondrial proton leak: A role for uncoupling proteins 2 and 3?
    • Porter, R. K. (2001) Mitochondrial proton leak: a role for uncoupling proteins 2 and 3? Biochim. Biophys. Acta. 1504, 120-127
    • (2001) Biochim. Biophys. Acta , vol.1504 , pp. 120-127
    • Porter, R.K.1
  • 25
    • 33745594011 scopus 로고    scopus 로고
    • A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1
    • Beck, V., Jaburek, M., Breen, E. P., Porter, R. K., Jezek, P., and Pohl, E. E. (2006) A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1. Biochim. Biophys. Acta. 1757, 474-479
    • (2006) Biochim. Biophys. Acta , vol.1757 , pp. 474-479
    • Beck, V.1    Jaburek, M.2    Breen, E.P.3    Porter, R.K.4    Jezek, P.5    Pohl, E.E.6
  • 26
    • 0032582799 scopus 로고    scopus 로고
    • The mechanism of proton transport mediated by mitochondrial uncoupling proteins
    • Garlid, K. D., Jaburek, M., and Jezek, P. (1998) The mechanism of proton transport mediated by mitochondrial uncoupling proteins. FEBS Lett. 438, 10-14
    • (1998) FEBS Lett , vol.438 , pp. 10-14
    • Garlid, K.D.1    Jaburek, M.2    Jezek, P.3
  • 27
    • 0343900275 scopus 로고    scopus 로고
    • The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter
    • Gonzalez-Barroso, M. M., Fleury, C., Bouillaud, F., Nicholls, D. G., and Rial, E. (1998) The uncoupling protein UCP1 does not increase the proton conductance of the inner mitochondrial membrane by functioning as a fatty acid anion transporter. J. Biol. Chem. 273, 15528-15532
    • (1998) J. Biol. Chem , vol.273 , pp. 15528-15532
    • Gonzalez-Barroso, M.M.1    Fleury, C.2    Bouillaud, F.3    Nicholls, D.G.4    Rial, E.5
  • 28
    • 1042286448 scopus 로고    scopus 로고
    • Alkylsulfonates activate the uncoupling protein UCP1: Implications for the transport mechanism
    • Rial, E., Aguirregoitia, E., Jimenez-Jimenez, J., and Ledesma, A. (2004) Alkylsulfonates activate the uncoupling protein UCP1: implications for the transport mechanism. Biochim. Biophys. Acta. 1608, 122-130
    • (2004) Biochim. Biophys. Acta , vol.1608 , pp. 122-130
    • Rial, E.1    Aguirregoitia, E.2    Jimenez-Jimenez, J.3    Ledesma, A.4
  • 29
    • 4644295401 scopus 로고    scopus 로고
    • Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids
    • Shabalina, I. G., Jacobsson, A., Cannon, B., and Nedergaard, J. (2004) Native UCP1 displays simple competitive kinetics between the regulators purine nucleotides and fatty acids. J. Biol. Chem. 279, 38236-38248
    • (2004) J. Biol. Chem , vol.279 , pp. 38236-38248
    • Shabalina, I.G.1    Jacobsson, A.2    Cannon, B.3    Nedergaard, J.4
  • 30
    • 23244454768 scopus 로고    scopus 로고
    • The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3
    • Esteves, T. C., and Brand, M. D. (2005) The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3. Biochim. Biophys. Acta. 1709, 35-44
    • (2005) Biochim. Biophys. Acta , vol.1709 , pp. 35-44
    • Esteves, T.C.1    Brand, M.D.2
  • 31
    • 0036487271 scopus 로고    scopus 로고
    • Reconstitution of novel mitochondrial uncoupling proteins UCP2 and UCP3
    • Zackova, M., and Jezek, P. (2002) Reconstitution of novel mitochondrial uncoupling proteins UCP2 and UCP3. Biosci. Rep. 22, 33-46
    • (2002) Biosci. Rep , vol.22 , pp. 33-46
    • Zackova, M.1    Jezek, P.2
  • 32
    • 0038419546 scopus 로고    scopus 로고
    • Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3
    • Zackova, M., Skobisova, E., Urbankova, E., and Jezek, P. (2003) Activating omega-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3. J. Biol. Chem. 278, 20761-20769
    • (2003) J. Biol. Chem , vol.278 , pp. 20761-20769
    • Zackova, M.1    Skobisova, E.2    Urbankova, E.3    Jezek, P.4
  • 33
    • 0032488633 scopus 로고    scopus 로고
    • + transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3
    • + transport by uncoupling protein (UCP-1) is dependent on a histidine pair, absent in UCP-2 and UCP-3. Biochemistry 37, 3-8
    • (1998) Biochemistry , vol.37 , pp. 3-8
    • Bienengraeber, M.1    Echtay, K.S.2    Klingenberg, M.3
  • 35
    • 0035947694 scopus 로고    scopus 로고
    • Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria
    • Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B., and Brand, M. D. (2001) Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. J. Biol. Chem. 276, 18633-18639
    • (2001) J. Biol. Chem , vol.276 , pp. 18633-18639
    • Stuart, J.A.1    Harper, J.A.2    Brindle, K.M.3    Jekabsons, M.B.4    Brand, M.D.5
  • 37
    • 0033379826 scopus 로고    scopus 로고
    • UCP1: The original uncoupling protein- and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice
    • Nedergaard, J., Matthias, A., Golozoubova, V., Jacobsson, A., and Cannon, B. (1999) UCP1: the original uncoupling protein- and perhaps the only one? New perspectives on UCP1, UCP2, and UCP3 in the light of the bioenergetics of the UCP1-ablated mice. J. Bioenerg. Biomembr. 31, 475-491
    • (1999) J. Bioenerg. Biomembr , vol.31 , pp. 475-491
    • Nedergaard, J.1    Matthias, A.2    Golozoubova, V.3    Jacobsson, A.4    Cannon, B.5
  • 38
    • 0034682795 scopus 로고    scopus 로고
    • Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis
    • Matthias, A., Ohlson, K. B., Fredriksson, J. M., Jacobsson, A., Nedergaard, J., and Cannon, B. (2000) Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis. J. Biol. Chem. 275, 25073-25081
    • (2000) J. Biol. Chem , vol.275 , pp. 25073-25081
    • Matthias, A.1    Ohlson, K.B.2    Fredriksson, J.M.3    Jacobsson, A.4    Nedergaard, J.5    Cannon, B.6
  • 40
    • 0344182443 scopus 로고    scopus 로고
    • Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells
    • Hinz, W., Gruninger, S., De Pover, A., and Chiesi, M. (1999) Properties of the human long and short isoforms of the uncoupling protein-3 expressed in yeast cells. FEBS Lett. 462, 411-415
    • (1999) FEBS Lett , vol.462 , pp. 411-415
    • Hinz, W.1    Gruninger, S.2    De Pover, A.3    Chiesi, M.4
  • 41
    • 0032907853 scopus 로고    scopus 로고
    • Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system
    • Zhang, C. Y., Hagen, T., Mootha, V. K., Slieker, L. J., and Lowell, B. B. (1999) Assessment of uncoupling activity of uncoupling protein 3 using a yeast heterologous expression system. FEBS Lett. 449, 129-134
    • (1999) FEBS Lett , vol.449 , pp. 129-134
    • Zhang, C.Y.1    Hagen, T.2    Mootha, V.K.3    Slieker, L.J.4    Lowell, B.B.5
  • 42
    • 0036212333 scopus 로고    scopus 로고
    • Mitochondrial uncoupling proteins in human physiology and disease
    • Hagen, T., and Vidal-Puig, A. (2002) Mitochondrial uncoupling proteins in human physiology and disease. Minerva. Med. 93, 41-57
    • (2002) Minerva. Med , vol.93 , pp. 41-57
    • Hagen, T.1    Vidal-Puig, A.2
  • 44
    • 0038168520 scopus 로고    scopus 로고
    • Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10
    • Jaburek, M., and Garlid, K. D. (2003) Reconstitution of recombinant uncoupling proteins: UCP1, -2, and -3 have similar affinities for ATP and are unaffected by coenzyme Q10. J. Biol. Chem. 278, 25825-25831
    • (2003) J. Biol. Chem , vol.278 , pp. 25825-25831
    • Jaburek, M.1    Garlid, K.D.2
  • 46
    • 0037992992 scopus 로고    scopus 로고
    • Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling
    • Jaburek, M., Varecha, M., Jezek, P., and Garlid, K. D. (2001) Alkylsulfonates as probes of uncoupling protein transport mechanism. Ion pair transport demonstrates that direct H(+) translocation by UCP1 is not necessary for uncoupling. J. Biol. Chem. 276, 31897-31905
    • (2001) J. Biol. Chem , vol.276 , pp. 31897-31905
    • Jaburek, M.1    Varecha, M.2    Jezek, P.3    Garlid, K.D.4
  • 48
    • 0034700981 scopus 로고    scopus 로고
    • Changes of intrinsic membrane potentials induced by flip-flop of longchain fatty acids
    • Pohl, E. E., Peterson, U., Sun, J., and Pohl, P. (2000) Changes of intrinsic membrane potentials induced by flip-flop of longchain fatty acids. Biochemistry 39, 1834-1839
    • (2000) Biochemistry , vol.39 , pp. 1834-1839
    • Pohl, E.E.1    Peterson, U.2    Sun, J.3    Pohl, P.4
  • 49
    • 0023428319 scopus 로고
    • Proton conductance through phospholipid bilayers: Water wires or weak acids
    • Gutknecht, J. (1987) Proton conductance through phospholipid bilayers: water wires or weak acids. J. Bioenerg. Biomembr. 19, 427-442
    • (1987) J. Bioenerg. Biomembr , vol.19 , pp. 427-442
    • Gutknecht, J.1
  • 50
    • 0028211624 scopus 로고
    • Permeability and electrical properties of planar lipid membranes from thylakoid lipids
    • Fuks, B., and Homble, F. (1994) Permeability and electrical properties of planar lipid membranes from thylakoid lipids. Biophys. J. 66, 1404-1414
    • (1994) Biophys. J , vol.66 , pp. 1404-1414
    • Fuks, B.1    Homble, F.2
  • 52
    • 0032742372 scopus 로고    scopus 로고
    • UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged
    • Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., and Brand, M. D. (1999) UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged. FEBS Lett. 462, 257-260
    • (1999) FEBS Lett , vol.462 , pp. 257-260
    • Cadenas, S.1    Buckingham, J.A.2    Samec, S.3    Seydoux, J.4    Din, N.5    Dulloo, A.G.6    Brand, M.D.7
  • 53
    • 0035195527 scopus 로고    scopus 로고
    • Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice
    • Bezaire, V., Hofmann, W., Kramer, J. K., Kozak, L. P., and Harper, M. E. (2001) Effects of fasting on muscle mitochondrial energetics and fatty acid metabolism in Ucp3(-/-) and wild-type mice. Am. J. Physiol. Endocrinol. Metab. 281, E975-E982
    • (2001) Am. J. Physiol. Endocrinol. Metab , vol.281
    • Bezaire, V.1    Hofmann, W.2    Kramer, J.K.3    Kozak, L.P.4    Harper, M.E.5
  • 54
    • 0023790651 scopus 로고
    • Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes
    • Gutknecht, J. (1988) Proton conductance caused by long-chain fatty acids in phospholipid bilayer membranes. J. Membr. Biol. 106, 83-93
    • (1988) J. Membr. Biol , vol.106 , pp. 83-93
    • Gutknecht, J.1
  • 55
    • 13944284082 scopus 로고    scopus 로고
    • Fatty acid flip-flop and proton transport determined by short-circuit current in planar bilayers
    • Brunaldi, K., Miranda, M. A., Abdulkader, F., Curi, R., and Procopio, J. (2005) Fatty acid flip-flop and proton transport determined by short-circuit current in planar bilayers. J. Lipid Res. 46, 245-251
    • (2005) J. Lipid Res , vol.46 , pp. 245-251
    • Brunaldi, K.1    Miranda, M.A.2    Abdulkader, F.3    Curi, R.4    Procopio, J.5
  • 56
    • 0037116518 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids in lipid bilayers: Intrinsic and environmental contributions to their unique physical properties
    • Feller, S. E., Gawrisch, K., and MacKerell, A. D., Jr. (2002) Polyunsaturated fatty acids in lipid bilayers: intrinsic and environmental contributions to their unique physical properties. J. Am. Chem. Soc. 124, 318-326
    • (2002) J. Am. Chem. Soc , vol.124 , pp. 318-326
    • Feller, S.E.1    Gawrisch, K.2    MacKerell Jr., A.D.3
  • 57
    • 0029997915 scopus 로고    scopus 로고
    • Effect of unsaturation on the chain order of phosphatidylcholines in a dioleoylphosphatidylethanolamine matrix
    • Separovic, F., and Gawrisch, K. (1996) Effect of unsaturation on the chain order of phosphatidylcholines in a dioleoylphosphatidylethanolamine matrix. Biophys. J. 71, 274-282
    • (1996) Biophys. J , vol.71 , pp. 274-282
    • Separovic, F.1    Gawrisch, K.2
  • 58
    • 0030720253 scopus 로고    scopus 로고
    • Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting
    • Kleinfeld, A. M., Chu, P., and Romero, C. (1997) Transport of long-chain native fatty acids across lipid bilayer membranes indicates that transbilayer flip-flop is rate limiting. Biochemistry 36, 14146-14158
    • (1997) Biochemistry , vol.36 , pp. 14146-14158
    • Kleinfeld, A.M.1    Chu, P.2    Romero, C.3
  • 60
    • 0034069724 scopus 로고    scopus 로고
    • Transport of heptafluorostearate across model membranes. Membrane transport of long-chain fatty acid anions I
    • Schmider, W., Fahr, A., Blum, H. E., and Kurz, G. (2000) Transport of heptafluorostearate across model membranes. Membrane transport of long-chain fatty acid anions I. J. Lipid Res. 41, 775-787
    • (2000) J. Lipid Res , vol.41 , pp. 775-787
    • Schmider, W.1    Fahr, A.2    Blum, H.E.3    Kurz, G.4
  • 62
    • 0036683694 scopus 로고    scopus 로고
    • Brain mitochondrial uncoupling protein 2 (UCP2): A protective stress signal in neuronal injury
    • Bechmann, I., Diano, S., Warden, C. H., Bartfai, T., Nitsch, R., and Horvath, T. L. (2002) Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem. Pharmacol. 64, 363-367
    • (2002) Biochem. Pharmacol , vol.64 , pp. 363-367
    • Bechmann, I.1    Diano, S.2    Warden, C.H.3    Bartfai, T.4    Nitsch, R.5    Horvath, T.L.6
  • 66
    • 0017174790 scopus 로고
    • The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient
    • Heaton, G. M., and Nicholls, D. G. (1976) The calcium conductance of the inner membrane of rat liver mitochondria and the determination of the calcium electrochemical gradient. Biochem. J. 156, 635-646
    • (1976) Biochem. J , vol.156 , pp. 635-646
    • Heaton, G.M.1    Nicholls, D.G.2
  • 68
    • 0035059393 scopus 로고    scopus 로고
    • Structure-function relationships in UCP1, UCP2 and chimeras: EPR analysis and retinoic acid activation of UCP2
    • Chomiki, N., Voss, J. C., and Warden, C. H. (2001) Structure-function relationships in UCP1, UCP2 and chimeras: EPR analysis and retinoic acid activation of UCP2. Eur. J. Biochem. 268, 903-913
    • (2001) Eur. J. Biochem , vol.268 , pp. 903-913
    • Chomiki, N.1    Voss, J.C.2    Warden, C.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.