Molecular and metabolic evidence for mitochondrial defects associated with β-cell dysfunction in a mouse model of type 2 diabetes

Diabetes

Volumn 59, Issue 2, 2010, Pages 448-459

  Lu, Hongfang ^a   Koshkin, Vasilij ^a   Allister, Emma M ^a   Gyulkhandanyan, Armen V ^a   Wheeler, Michael B ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CYTOCHROME C OXIDASE; GLUCOSE; INSULIN; MITOCHONDRIAL PROTEIN; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; CALCIUM; MITOCHONDRIAL DNA; PROTEIN; RIBOSOME RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM SIGNALING; CALCIUM TRANSPORT; CONTROLLED STUDY; HYPERGLYCEMIA; INSULIN RELEASE; INSULIN RESISTANCE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY CHAIN; TRANSGENIC MOUSE; ANIMAL; CELL MEMBRANE POTENTIAL; DISEASE MODEL; GENETICS; GLUCOSE BLOOD LEVEL; HUMAN; ISOLATION AND PURIFICATION; METABOLISM; MITOCHONDRION; MOUSE STRAIN; OXIDATIVE PHOSPHORYLATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETION;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; BLOOD GLUCOSE; CALCIUM; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DNA, MITOCHONDRIAL; HUMANS; HYPERGLYCEMIA; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MEMBRANE POTENTIALS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MITOCHONDRIA; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL;

EID: 77449154126     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-0129     Document Type: Article

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