Fatty acids do not activate UCP2 in pancreatic beta cells: Comparison with UCP1

Pflugers Archiv European Journal of Physiology

Volumn 457, Issue 4, 2009, Pages 931-940

  Galetti, Sandrine ^a   Sarre, Alexandre ^a   Perreten, Hélène ^a   Produit Zengaffinen, Nathalie ^a   Muzzin, Patrick ^a   Assimacopoulos Jeannet, Françoise ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Fatty acid induced uncoupling; INS 1 cells; Mitochondria; UCP1; UCP2

Indexed keywords

FATTY ACID; GLUCOSE; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CELL METABOLISM; CONTROLLED STUDY; GENE OVEREXPRESSION; HALF LIFE TIME; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; CELL LINE; FATTY ACIDS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXYGEN CONSUMPTION; RATS; UNCOUPLING AGENTS;

EID: 58649106881     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0548-8     Document Type: Article

References (52)

1. N Lameloise P Muzzin M Prentki F Assimacopoulos-Jeannet 2001 Uncoupling protein 2: a possible link between fatty acid excess and impaired glucose-induced insulin secretion Diabetes 50 803 809
2. E Ito S Ozawa K Takahashi T Tanaka H Katsuta S Yamaguchi M Maruyama M Takizawa H Katahira K Yoshimoto S Nagamatsu H Ishida 2004 PPAR-gamma overexpression selectively suppresses insulin secretory capacity in isolated pancreatic islets through induction of UCP-2 protein Biochem Biophys Res Commun 324 810 814
3. G Patane M Anello S Piro R Vigneri F Purrello AM Rabuazzo 2002 Role of ATP production and uncoupling protein-2 in the insulin secretory defect induced by chronic exposure to high glucose or free fatty acids and effects of peroxisome proliferator-activated receptor-gamma inhibition Diabetes 51 2749 2756
4. K Tordjman KN Standley C Bernal-Mizrachi TC Leone T Coleman DP Kelly CF Semenkovich 2002 PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells J Lipid Res 43 936 943
5. K Ravnskjaer M Boergesen B Rubi JK Larsen T Nielsen J Fridriksson P Maechler S Mandrup 2005 Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells Endocrinology 146 3266 3276
6. CY Zhang G Baffy P Perret S Krauss O Peroni D Grujic T Hagen AJ Vidal-Puig O Boss YB Kim XX Zheng MB Wheeler GI Shulman CB Chan BB Lowell 2001 Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes Cell 105 745 755
7. CB Chan D De Leo JW Joseph TS McQuaid XF Ha F Xu RG Tsushima PS Pennefather AM Salapatek MB Wheeler 2001 Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: mechanism of action Diabetes 50 1302 1310
8. Y Hong BD Fink JS Dillon WI Sivitz 2001 Effects of adenoviral overexpression of uncoupling protein-2 and -3 on mitochondrial respiration in insulinoma cells Endocrinology 142 249 256
9. L Bordone MC Motta F Picard A Robinson US Jhala J Apfeld T McDonagh M Lemieux M McBurney A Szilvasi EJ Easlon SJ Lin L Guarente 2006 Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells PLoS Biol 4 e31
10. MZ Vatamaniuk RK Gupta KA Lantz NM Doliba FM Matschinsky KH Kaestner 2006 Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation Diabetes 55 2730 2736
11. M Anello R Lupi D Spampinato S Piro M Masini U Boggi S Del Prato AM Rabuazzo F Purrello P Marchetti 2005 Functional and morphological alterations of mitochondria in pancreatic beta cells from type 2 diabetic patients Diabetologia 48 282 289
12. N Produit-Zengaffinen N Davis-Lameloise H Perreten D Becard A Gjinovci PA Keller CB Wollheim P Herrera P Muzzin F Assimacopoulos-Jeannet 2007 Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species Diabetologia 50 84 93
13. C Kjorholt MC Akerfeldt TJ Biden DR Laybutt 2005 Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes Diabetes 54 2755 2763
14. MZ Khaldi Y Guiot P Gilon JC Henquin JC Jonas 2004 Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose Am J Physiol Endocrinol Metab 287 E207 E217
15. E Couplan M del Mar Gonzalez-Barroso MC Alves-Guerra D Ricquier M Goubern F Bouillaud 2002 No evidence for a basal, retinoic, or superoxide-induced uncoupling activity of the uncoupling protein 2 present in spleen or lung mitochondria J Biol Chem 277 26268 26275
16. JA Stuart JA Harper KM Brindle MB Jekabsons MD Brand 2001 Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria J Biol Chem 276 18633 18639
17. J Nedergaard B Cannon 2003 The 'novel' 'uncoupling' proteins UCP2 and UCP3: what do they really do? Pros and cons for suggested functions Exp Physiol 88 65 84
18. B Cannon IG Shabalina TV Kramarova N Petrovic J Nedergaard 2006 Uncoupling proteins: a role in protection against reactive oxygen species-or not Biochim Biophys Acta 1757 449 458
19. V Bezaire EL Seifert ME Harper 2007 Uncoupling protein-3: clues in an ongoing mitochondrial mystery FASEB J 21 312 324
20. RM Locke E Rial ID Scott DG Nicholls 1982 Fatty acids as acute regulators of the proton conductance of hamster brown-fat mitochondria Eur J Biochem 129 373 380
21. O Boss S Samec A Paoloni-Giacobino C Rossier A Dulloo J Seydoux P Muzzin JP Giacobino 1997 Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression FEBS Lett 408 39 42
22. H Wang PB Iynedjian 1997 Modulation of glucose responsiveness of insulinoma beta-cells by graded overexpression of glucokinase Proc Natl Acad Sci U S A 94 4372 4377
23. V Herbert KS Lau CW Gottlieb SJ Bleicher 1965 Coated charcoal immunoassay of insulin J Clin Endocrinol Metab 25 1375 1384
24. C Labarca K Paigen 1980 A simple, rapid, and sensitive DNA assay procedure Anal Biochem 102 344 352
25. V Schultz I Sussman K Bokvist K Tornheim 1993 Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP Anal Biochem 215 302 304
26. A Merglen S Theander B Rubi G Chaffard CB Wollheim P Maechler 2004 Glucose sensitivity and metabolism-secretion coupling studied during two-year continuous culture in INS-1E insulinoma cells Endocrinology 145 667 678
27. S Rousset J Mozo G Dujardin Y Emre S Masscheleyn D Ricquier AM Cassard-Doulcier 2007 UCP2 is a mitochondrial transporter with an unusual very short half-life FEBS Lett 581 479 482
28. F Ranta D Avram S Berchtold M Dufer G Drews F Lang S Ullrich 2006 Dexamethasone induces cell death in insulin-secreting cells, an effect reversed by exendin-4 Diabetes 55 1380 1390
29. A Matthias KB Ohlson JM Fredriksson A Jacobsson J Nedergaard B Cannon 2000 Thermogenic responses in brown fat cells are fully UCP1-dependent. UCP2 or UCP3 do not substitute for UCP1 in adrenergically or fatty acid-induced thermogenesis J Biol Chem 275 25073 25081
30. E Larrarte J Margareto FJ Novo A Marti J Alfredo Martinez 2002 UCP1 muscle gene transfer and mitochondrial proton leak mediated thermogenesis Arch Biochem Biophys 404 166 171
31. L Casteilla O Blondel S Klaus S Raimbault P Diolez F Moreau F Bouillaud D Ricquier 1990 Stable expression of functional mitochondrial uncoupling protein in Chinese hamster ovary cells Proc Natl Acad Sci U S A 87 5124 5128
32. D Guerini E Prati U Desai HP Nick R Flammer S Gruninger F Cumin M Kaleko S Connelly M Chiesi 2002 Uncoupling of protein-3 induces an uncontrolled uncoupling of mitochondria after expression in muscle derived L6 cells Eur J Biochem 269 1373 1381
33. BD Fink YS Hong MM Mathahs TD Scholz JS Dillon WI Sivitz 2002 UCP2-dependent proton leak in isolated mammalian mitochondria J Biol Chem 277 3918 3925
34. C Affourtit MD Brand 2008 Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion Biochem J 409 199 204
35. P Puigserver D Herron M Gianotti A Palou B Cannon J Nedergaard 1992 Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool Biochem J 284 Pt 2 393 398
36. J Rafael HJ Ludolph HJ Hohorst 1969 Mitochondria from brown adipose tissue: uncoupling of respiratory chain phosphorylation by long fatty acids and recoupling by guanosine triphosphate Hoppe Seylers Z Physiol Chem 350 1121 1131
37. KS Echtay D Roussel J St-Pierre MB Jekabsons S Cadenas JA Stuart JA Harper SJ Roebuck A Morrison S Pickering JC Clapham MD Brand 2002 Superoxide activates mitochondrial uncoupling proteins Nature 415 96 99
38. M Di Paola M Lorusso 2006 Interaction of free fatty acids with mitochondria: coupling, uncoupling and permeability transition Biochim Biophys Acta 1757 1330 1337
39. J Jimenez-Jimenez A Ledesma P Zaragoza MM Gonzalez-Barroso E Rial 2006 Fatty acid activation of the uncoupling proteins requires the presence of the central matrix loop from UCP1 Biochim Biophys Acta 1757 1292 1296
40. V Beck M Jaburek T Demina A Rupprecht RK Porter P Jezek EE Pohl 2007 Polyunsaturated fatty acids activate human uncoupling proteins 1 and 2 in planar lipid bilayers FASEB J 21 1137 1144
41. J Mozo G Ferry A Studeny C Pecqueur M Rodriguez JA Boutin F Bouillaud 2006 Expression of UCP3 in CHO cells does not cause uncoupling, but controls mitochondrial activity in the presence of glucose Biochem J 393 431 439
42. A Negre-Salvayre C Hirtz G Carrera R Cazenave M Troly R Salvayre L Penicaud L Casteilla 1997 A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation FASEB J 11 809 815
43. G Mattiasson M Shamloo G Gido K Mathi G Tomasevic S Yi CH Warden RF Castilho T Melcher M Gonzalez-Zulueta K Nikolich T Wieloch 2003 Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma Nat Med 9 1062 1068
44. ZB Andrews S Diano TL Horvath 2005 Mitochondrial uncoupling proteins in the CNS: in support of function and survival Nat Rev Neurosci 6 829 840
45. 2+ uniport Nat Cell Biol 9 445 452
46. F Criscuolo J Mozo C Hurtaud T Nubel F Bouillaud 2006 UCP2, UCP3, avUCP, what do they do when proton transport is not stimulated? Possible relevance to pyruvate and glutamine metabolism Biochim Biophys Acta 1757 1284 1291
47. N Zengaffinen H Perreten N Lameloise P Keller P Muzzin F Assimacopoulos-Jeannet 2005 Uncoupling protein 2 overexpression prevents cytokine-induced reactive oxygen species production and apoptosis in pancreatic beta cells Diabetologia 48 A38 abstract
48. Y Bai H Onuma X Bai AV Medvedev M Misukonis JB Weinberg W Cao J Robidoux LM Floering KW Daniel S Collins 2005 Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production J Biol Chem 280 19062 19069
49. Y Emre C Hurtaud T Nubel F Criscuolo D Ricquier AM Cassard-Doulcier 2007 Mitochondria contribute to LPS-induced MAPK activation via uncoupling protein UCP2 in macrophages Biochem J 402 271 278
50. T Kizaki K Suzuki Y Hitomi N Taniguchi D Saitoh K Watanabe K Onoe NK Day RA Good H Ohno 2002 Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages Proc Natl Acad Sci U S A 99 9392 9397
51. C Hurtaud C Gelly Z Chen C Levi-Meyrueis F Bouillaud 2007 Glutamine stimulates translation of uncoupling protein 2mRNA Cell Mol Life Sci 64 1853 1860
52. C Pecqueur MC Alves-Guerra C Gelly C Levi-Meyrueis E Couplan S Collins D Ricquier F Bouillaud B Miroux 2001 Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation J Biol Chem 276 8705 8712