Uncoupling protein-2 attenuates glucose-stimulated insulin secretion in INS-1E insulinoma cells by lowering mitochondrial reactive oxygen species

Free Radical Biology and Medicine

Volumn 50, Issue 5, 2011, Pages 609-616

  Affourtit, Charles ^a,b   Jastroch, Martin ^b   Brand, Martin D ^a,b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

Author keywords

Coupling efficiency of oxidative phosphorylation; Free radicals; Glucose stimulated insulin secretion; Metabolic syndrome; Mitochondrial respiration; Pancreatic cells; Reactive oxygen species; Type 2 diabetes; Uncoupling protein 2

Indexed keywords

GLUCOSE; INSULIN; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOENERGY; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; INSULIN RELEASE; INSULINOMA; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOUSE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; ENERGY METABOLISM; GENE KNOCKDOWN TECHNIQUES; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; METALLOPORPHYRINS; MICE; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; RATS; REACTIVE OXYGEN SPECIES;

EID: 79551479549     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.12.020     Document Type: Article

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