Uncoupling protein-2 contributes significantly to high mitochondrial proton leak in INS-1E insulinoma cells and attenuates glucose-stimulated insulin secretion

Biochemical Journal

Volumn 409, Issue 1, 2008, Pages 199-204

  Affourtit, Charles ^a   Brand, Martin D ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Glucose stimulated insulin secretion; Mitochondrial uncoupling; Oxidative phosphorylation; Pancreatic cell; Type 2 diabetes; Uncoupling protein 2 (UCP2)

Indexed keywords

CELLS; PHOSPHORYLATION; PROTON CONDUCTIVITY; RNA;

GLUCOSE-STIMULATED INSULIN SECRETION; MITOCHONDRIAL UNCOUPLING; TYPE 2 DIABETES; UNCOUPLING PROTEIN-2 (UCP2);

PROTEINS;

GLUCOSE; INSULIN; MYXOTHIAZOL; OLIGOMYCIN; OLIGONUCLEOTIDE; PROTON; SMALL INTERFERING RNA; UNCOUPLING PROTEIN 2; ION CHANNEL; METHACRYLIC ACID DERIVATIVE; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; OXYGEN; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; INSULIN RELEASE; INSULINOMA; MITOCHONDRION; MUSCLE CELL; MYOBLAST; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTON TRANSPORT; RNA INTERFERENCE; ANIMAL; CELL MEMBRANE POTENTIAL; CYTOPLASM; METABOLISM; OXYGEN CONSUMPTION; PHOSPHORYLATION; PHYSIOLOGY; RAT; SECRETION;

RATTUS;

ANIMALS; CYTOPLASM; GLUCOSE; INSULIN; INSULIN-SECRETING CELLS; ION CHANNELS; MEMBRANE POTENTIALS; METHACRYLATES; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OLIGOMYCINS; OXYGEN; OXYGEN CONSUMPTION; PHOSPHORYLATION; RATS; RNA INTERFERENCE; THIAZOLES;

EID: 38149130672     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070954     Document Type: Article

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