Metabolic disorders associated with obstructive sleep apnea in adults

Advances in Cardiology

Volumn 46, Issue , 2011, Pages 67-137

[No Author Info available]

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; APELIN; ETANERCEPT; GLUCOSE; HEMOGLOBIN A1C; HEPCIDIN; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; LEPTIN; LIVER ENZYME; LOW DENSITY LIPOPROTEIN; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PLACEBO; RESISTIN; TUMOR NECROSIS FACTOR ALPHA; VASPIN;

ADIPOSE TISSUE; ARTICLE; ARTIFICIAL VENTILATION; ATHEROSCLEROSIS; AUTONOMIC NERVOUS SYSTEM; BLOOD PRESSURE; BODY MASS; BREATHING; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CHRONIC DISEASE; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; DYSLIPIDEMIA; ENDOCRINE GLAND; ENDOTHELIAL DYSFUNCTION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; HUMAN; HYPERCAPNIA; HYPERTENSION; HYPOXEMIA; HYPOXIA; INFLAMMATION; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LUNG VOLUME; METABOLIC DISORDER; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONALCOHOLIC FATTY LIVER; NONREM SLEEP; OBESITY; OBESITY HYPOVENTILATION SYNDROME; OXYGEN SATURATION; POSITIVE END EXPIRATORY PRESSURE; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SEX DIFFERENCE; SLEEP APNEA SYNDROME; UPPER AIRWAY RESISTANCE SYNDROME; UPPER RESPIRATORY TRACT; VISCERAL OBESITY; WAIST CIRCUMFERENCE; WEIGHT GAIN; WEIGHT REDUCTION;

ADIPOKINES; ADULT; ANIMALS; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CYTOKINES; DYSLIPIDEMIAS; FATTY LIVER; GLUCOSE; HUMANS; METABOLIC DISEASES; OBESITY; RISK FACTORS; SEX FACTORS; SLEEP APNEA, OBSTRUCTIVE;

EID: 82755195276     PISSN: 00652326     EISSN: 16622839     Source Type: Book Series    
DOI: 10.1159/000325106     Document Type: Article

References (357)

1. Pillar G, Shehadeh N: Abdominal fat and sleep apnea: the chicken or the egg? Diabetes Care 2008;31(suppl 2):S303-S309.
2. Vgontzas AN: Does obesity play a major role in the pathogenesis of sleep apnoea and its associated manifestations via inflammation, visceral adiposity, and insulin resistance? Arch Physiol Biochem 2008; 114:211-223.
3. Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL: Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proc Am Thorac Soc 2008;5:185-192. (Pubitemid 351237877)
4. Shah N, Roux F: The relationship of obesity and obstructive sleep apnea. Clin Chest Med 2009;30: 455- 465, vii.
5. Dempsey JA, Veasey SC, Morgan BJ, O'Donnell CP: Pathophysiology of sleep apnea. Physiol Rev 2010; 90:47-112.
6. Schwartz AR, Patil SP, Squier S, Schneider H, Kirkness JP, Smith PL: Obesity and upper airway control during sleep. J Appl Physiol 2010;108: 430-435.
7. World Health Organization: Global database on body mass index. 2010. http://apps.who.int/bmi/index.jsp.
8. McClean KM, Kee F, Young IS, Elborn JS: Obesity and the lung. 1. Epidemiology. Thorax 2008;63:649-654.
9. Ogden CL, Fryar CD, Carroll MD, Flegal KM: Mean body weight, height, and body mass index, United States 1960- 2002. Adv Data 2004;347:1-17.
10. Charles MA, Eschwege E, Basdevant A: Monitoring the obesity epidemic in France: the Obepi surveys 1997- 2006. Obesity (Silver Spring) 2008;16:2182-2186.
11. Ogden CL, Carroll MD, Curtin LR, McDowell MA, Tabak CJ, Flegal KM: Prevalence of overweight and obesity in the United States, 1999- 2004. JAMA 2006;295:1549-1555.
12. Flegal KM, Carroll MD, Ogden CL, Curtin LR: Prevalence and trends in obesity among US adults, 1999- 2008. JAMA 2010;303:235-241.
13. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S: The occurrence of sleep- disordered breathing among middle- aged adults. N Engl J Med 1993; 328:1230-1235. (Pubitemid 23115702)
14. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD, Pickering TG: Association of sleep- disordered breathing, sleep apnea, and hypertension in a large community- based study. Sleep Heart Health Study. JAMA 2000;283:1829-1836. (Pubitemid 30207619)
15. Peppard PE, Young T, Palta M, Dempsey J, Skatrud J: Longitudinal study of moderate weight change and sleep- disordered breathing. JAMA 2000;284: 3015-3021. (Pubitemid 32014738)
16. Newman AB, Nieto FJ, Guidry U, Lind BK, Redline S, Pickering TG, Quan SF: Relation of sleepdisordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study. Am J Epidemiol 2001;154:50-59. (Pubitemid 32565686)
17. Foster GD, Sanders MH, Millman R, Zammit G, Borradaile KE, Newman AB, Wadden TA, Kelley D, Wing RR, Sunyer FX, Darcey V, Kuna ST: Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care 2009;32:1017-1019.
18. Young T, Peppard PE, Taheri S: Excess weight and sleep- disordered breathing. J Appl Physiol 2005;99: 1592-1599. (Pubitemid 43014371)
19. Newman AB, Foster G, Givelber R, Nieto FJ, Redline S, Young T: Progression and regression of sleepdisordered breathing with changes in weight: the Sleep Heart Health Study. Arch Intern Med 2005; 165:2408-2413. (Pubitemid 41640854)
20. Young T, Peppard PE, Gottlieb DJ: Epidemiology of obstructive sleep apnea: a population health perspective. Am J Respir Crit Care Med 2002;165:1217-1239. (Pubitemid 34461732)
21. Grunstein RR, Stenlof K, Hedner JA, Peltonen M, Karason K, Sjostrom L: Two year reduction in sleep apnea symptoms and associated diabetes incidence after weight loss in severe obesity. Sleep 2007;30:703-710. (Pubitemid 46854757)
22. Lam B, Sam K, Mok WY, Cheung MT, Fong DY, Lam JC, Lam DC, Yam LY, Ip MS: Randomised study of three non- surgical treatments in mild to moderate obstructive sleep apnoea. Thorax 2007;62: 354-359. (Pubitemid 46580579)
23. Foster GD, Borradaile KE, Sanders MH, Millman R, Zammit G, Newman AB, Wadden TA, Kelley D, Wing RR, Pi- Sunyer FX, Reboussin D, Kuna ST: A randomized study on the effect of weight loss on obstructive sleep apnea among obese patients with type 2 diabetes: the Sleep AHEAD study. Arch Intern Med 2009;169:1619-1626.
24. Johansson K, Neovius M, Lagerros YT, Harlid R, Rossner S, Granath F, Hemmingsson E: Effect of a very low energy diet on moderate and severe obstructive sleep apnoea in obese men: a randomized controlled trial. BMJ 2009;339:b4609.
25. Tuomilehto HP, Seppa JM, Partinen MM, Peltonen M, Gylling H, Tuomilehto JO, Vanninen EJ, Kokkarinen J, Sahlman JK, Martikainen T, Soini EJ, Randell J, Tukiainen H, Uusitupa M: Lifestyle intervention with weight reduction: first- line treatment in mild obstructive sleep apnea. Am J Respir Crit Care Med 2009;179:320-327.
26. Tuomilehto H, Gylling H, Peltonen M, Martikainen T, Sahlman J, Kokkarinen J, Randell J, Tukiainen H, Vanninen E, Partinen M, Tuomilehto J, Uusitupa M, Seppa J: Sustained improvement in mild obstructive sleep apnea after a diet- and physical activity- based lifestyle intervention: postinterventional follow- up. Am J Clin Nutr 2010;92:688-696.
27. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K: Bariatric surgery: a systematic review and meta- analysis. JAMA 2004;292:1724-1737. (Pubitemid 39346675)
28. Greenburg DL, Lettieri CJ, Eliasson AH: Effects of surgical weight loss on measures of obstructive sleep apnea: a meta- analysis. Am J Med 2009;122: 535-542.
29. Mokhlesi B, Gozal D: Update in sleep medicine 2009. Am J Respir Crit Care Med 2010;181:545-549.
30. Jordan AS, McEvoy RD: Gender differences in sleep apnea: epidemiology, clinical presentation and pathogenic mechanisms. Sleep Med Rev 2003;7:377-389. (Pubitemid 37221982)
31. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela- Bueno A, Kales A: Prevalence of sleepdisordered breathing in women: effects of gender. Am J Respir Crit Care Med 2001;163:608-613. (Pubitemid 32230817)
32. Millman RP, Carlisle CC, McGarvey ST, Eveloff SE, Levinson PD: Body fat distribution and sleep apnea severity in women. Chest 1995;107:362-366.
33. Shinohara E, Kihara S, Yamashita S, Yamane M,Nishida M, Arai T, Kotani K, Nakamura T, Takemura K, Matsuzawa Y: Visceral fat accumulation as an important risk factor for obstructive sleep apnoea syndrome in obese subjects. J Intern Med 1997;241: 11-18. (Pubitemid 27051198)
34. Vgontzas AN, Papanicolaou DA, Bixler EO, Hopper K, Lotsikas A, Lin HM, Kales A, Chrousos GP: Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia. J Clin Endocrinol Metab 2000;85:1151-1158. (Pubitemid 32269364)
35. Schafer H, Pauleit D, Sudhop T, Gouni- Berthold I, Ewig S, Berthold HK: Body fat distribution, serum leptin, and cardiovascular risk factors in men with obstructive sleep apnea. Chest 2002;122:829-839.
36. Vgontzas AN, Zoumakis E, Bixler EO, Lin HM, Collins B, Basta M, Pejovic S, Chrousos GP: Selective effects of CPAP on sleep apnoea- associated manifestations. Eur J Clin Invest 2008;38:585-595. (Pubitemid 352019140)
37. Soriano- Co M, Vanhecke TE, Franklin BA, Sangal RB, Hakmeh B, McCullough PA: Increased central adiposity in morbidly obese patients with obstructive sleep apnea. Intern Med J 2011;41:560-566.
38. Stauffer JL, Buick MK, Bixler EO, Sharkey FE, Abt AB, Manders EK, Kales A, Cadieux RJ, Barry JD, Zwillich CW: Morphology of the uvula in obstructive sleep apnea. Am Rev Respir Dis 1989;140:724-728. (Pubitemid 19234320)
39. Schwab RJ: Upper airway imaging. Clin Chest Med 1998;19:33-54. (Pubitemid 28164529)
40. Shelton KE, Gay SB, Hollowell DE, Woodson H, Suratt PM: Mandible enclosure of upper airway and weight in obstructive sleep apnea. Am Rev Respir Dis 1993;148:195-200. (Pubitemid 23187241)
41. Schwab RJ, Gupta KB, Gefter WB, Metzger LJ, Hoffman EA, Pack AI: Upper airway and soft tissue anatomy in normal subjects and patients with sleepdisordered breathing: significance of the lateral pharyngeal walls. Am J Respir Crit Care Med 1995;152:1673-1689.
42. Mortimore IL, Marshall I, Wraith PK, Sellar RJ, Douglas NJ: Neck and total body fat deposition in nonobese and obese patients with sleep apnea compared with that in control subjects. Am J Respir Crit Care Med 1998;157:280-283. (Pubitemid 28071293)
43. Schwab RJ, Kuna ST, Remmers JE: Anatomy and physiology of upper airway obstruction; in Kryger MH, Roth T, Dement WC (eds): Principles and Practice of Sleep Medicine, ed 4 online. Philadelphia, Saunders, 2005, pp 983- 1000.
44. Schwab RJ, Gefter WB, Hoffman EA, Gupta KB, Pack AI: Dynamic upper airway imaging during awake respiration in normal subjects and patients with sleep disordered breathing. Am Rev Respir Dis 1993;148:1385-1400. (Pubitemid 23326043)
45. Whittle AT, Marshall I, Mortimore IL, Wraith PK, Sellar RJ, Douglas NJ: Neck soft tissue and fat distribution: comparison between normal men and women by magnetic resonance imaging. Thorax 1999;54:323-328. (Pubitemid 29150160)
46. Schwab RJ, Pasirstein M, Pierson R, Mackley A, Hachadoorian R, Arens R, Maislin G, Pack AI: Identification of upper airway anatomic risk factors for obstructive sleep apnea with volumetric magnetic resonance imaging. Am J Respir Crit Care Med 2003;168:522-530. (Pubitemid 37088593)
47. Schwab RJ: Genetic determinants of upper airway structures that predispose to obstructive sleep apnea. Respir Physiol Neurobiol 2005;147:289-298. (Pubitemid 41112746)
48. Gold AR, Schwartz AR: The pharyngeal critical pressure: the whys and hows of using nasal continuous positive airway pressure diagnostically. Chest 1996;110:1077-1088. (Pubitemid 26347629)
49. Boudewyns A, Punjabi N, Van de Heyning PH, De Backer WA, O'Donnell CP, Schneider H, Smith PL, Schwartz AR: Abbreviated method for assessing upper airway function in obstructive sleep apnea. Chest 2000;118:1031-1041.
50. Isono S, Remmers JE, Tanaka A, Sho Y, Sato J, Nishino T: Anatomy of pharynx in patients with obstructive sleep apnea and in normal subjects. J Appl Physiol 1997;82:1319-1326. (Pubitemid 27172336)
51. Eastwood PR, Szollosi I, Platt PR, Hillman DR: Comparison of upper airway collapse during general anaesthesia and sleep. Lancet 2002;359:1207-1209. (Pubitemid 34304263)
52. Eastwood PR, Szollosi I, Platt PR, Hillman DR: Collapsibility of the upper airway during anesthesia with isoflurane. Anesthesiology 2002;97:786-793.
53. Oliven A, Aspandiarov E, Gankin I, Gaitini L, Tov N: Collapsibility of the relaxed pharynx and risk of sleep apnoea. Eur Respir J 2008;32:1309-1315.
54. Patil SP, Schneider H, Marx JJ, Gladmon E, Schwartz AR, Smith PL: Neuromechanical control of upper airway patency during sleep. J Appl Physiol 2007; 102:547-556. (Pubitemid 46220882)
55. Schwartz AR, Gold AR, Schubert N, Stryzak A, Wise RA, Permutt S, Smith PL: Effect of weight loss on upper airway collapsibility in obstructive sleep apnea. Am Rev Respir Dis 1991;144:494-498.
56. Simpson L, Mukherjee S, Cooper MN, Ward KL, Lee JD, Fedson AC, Potter J, Hillman DR, Eastwood P, Palmer LJ, Kirkness J: Sex differences in the association of regional fat distribution with the severity of obstructive sleep apnea. Sleep 2010;33:467-474.
57. Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea. J Appl Physiol 2005;99: 2020-2027. (Pubitemid 41547205)
58. Kirkness JP, Schwartz AR, Schneider H, Punjabi NM, Maly JJ, Laffan AM, McGinley BM, Magnuson T, Schweitzer M, Smith PL, Patil SP: Contribution of male sex, age, and obesity to mechanical instability of the upper airway during sleep. J Appl Physiol 2008;104:1618-1624.
59. Sharp JT, Henry JP, Sweany SK, Meadows WR, Pietras RJ: Effects of mass loading the respiratory system in man. J Appl Physiol 1964;19:959-966.
60. Van de Graaff WB: Thoracic influence on upper airway patency. J Appl Physiol 1988;65:2124-2131.
61. Van de Graaff WB: Thoracic traction on the trachea: mechanisms and magnitude. J Appl Physiol 1991;70: 1328-1336.
62. Thut DC, Schwartz AR, Roach D, Wise RA, Permutt S, Smith PL: Tracheal and neck position influence upper airway airflow dynamics by altering airway length. J Appl Physiol 1993;75:2084-2090. (Pubitemid 23352380)
63. Kairaitis K, Byth K, Parikh R, Stavrinou R, Wheatley JR, Amis TC: Tracheal traction effects on upper airway patency in rabbits: the role of tissue pressure. Sleep 2007;30:179-186.
64. Rowley JA, Permutt S, Willey S, Smith PL, Schwartz AR: Effect of tracheal and tongue displacement on upper airway airflow dynamics. J Appl Physiol 1996; 80:2171-2178. (Pubitemid 26243799)
65. Schwartz AR, Rowley JA, Thut DC, Permutt S, Smith PL: Structural basis for alterations in upper airway collapsibility. Sleep 1996;19:S184-S188. (Pubitemid 27138524)
66. Begle RL, Badr S, Skatrud JB, Dempsey JA: Effect of lung inflation on pulmonary resistance during NREM sleep. Am Rev Respir Dis 1990;141:854-860. (Pubitemid 20157709)
67. Series F, Cormier Y, Desmeules M: Influence of passive changes of lung volume on upper airways. J Appl Physiol 1990;68:2159-2164. (Pubitemid 20183110)
68. Series F, Marc I: Influence of lung volume dependence of upper airway resistance during continuous negative airway pressure. J Appl Physiol 1994;77: 840-844. (Pubitemid 24258320)
69. Stanchina ML, Malhotra A, Fogel RB, Trinder J, Edwards JK, Schory K, White DP: The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep. Sleep 2003;26:851-856. (Pubitemid 39610631)
70. Tagaito Y, Isono S, Remmers JE, Tanaka A, Nishino T: Lung volume and collapsibility of the passive pharynx in patients with sleep- disordered breathing. J Appl Physiol 2007;103:1379-1385. (Pubitemid 47605977)
71. Owens RL, Malhotra A, Eckert DJ, White DP, Jordan AS: The influence of end- expiratory lung volume on measurements of pharyngeal collapsibility. J Appl Physiol 2010;108:445-451.
72. Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP: Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea. Am J Respir Crit Care Med 2005;172:114-117. (Pubitemid 40923322)
73. Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP: Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea. Thorax 2006;61:435-439. (Pubitemid 43723329)
74. Squier SB, Patil SP, Schneider H, Kirkness JP, Smith PL, Schwartz AR: Effect of end- expiratory lung volume on upper airway collapsibility in sleeping men and women. J Appl Physiol 2010;109:977-985.
75. Ye J, Gao Z, Yin J, He Q: Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007;293:E1118-E1128. (Pubitemid 47535846)
76. Trayhurn P, Wang B, Wood IS: Hypoxia in adipose tissue: a basis for the dysregulation of tissue function in obesity? Br J Nutr 2008;100:227-235.
77. Fried SK, Bunkin DA, Greenberg AS: Omental and subcutaneous adipose tissues of obese subjects release interleukin- 6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 1998;83:847-850. (Pubitemid 28496456)
78. Hotamisligil GS: Mechanisms of TNF- alphainduced insulin resistance. Exp Clin Endocrinol Diabetes 1999;107:119-125. (Pubitemid 29179278)
79. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr: Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003;112:1796-1808. (Pubitemid 38063703)
80. Hopkins TA, Ouchi N, Shibata R, Walsh K: Adiponectin actions in the cardiovascular system. Cardiovasc Res 2007;74:11-18. (Pubitemid 46366942)
81. Schwartz AR, Patil SP, Schneider H, Smith PL: Modelling pathogenic mechanisms of upper airway dysfunction in the molecular age. Eur Respir J 2008;32:255-258.
82. Jequier E: Leptin signaling, adiposity, and energy balance. Ann NY Acad Sci 2002;967:379-388. (Pubitemid 34721923)
83. Paracchini V, Pedotti P, Taioli E: Genetics of leptin and obesity: a HuGE review. Am J Epidemiol 2005; 162:101-114. (Pubitemid 41373535)
84. Steiner AA, Romanovsky AA: Leptin: at the crossroads of energy balance and systemic inflammation. Prog Lipid Res 2007;46:89-107. (Pubitemid 46654230)
85. Anubhuti, Arora S: Leptin and its metabolic interactions: an update. Diabetes Obes Metab 2008;10: 973-993.
86. Lago R, Gomez R, Lago F, Gomez- Reino J, Gualillo O: Leptin beyond body weight regulation - current concepts concerning its role in immune function and inflammation. Cell Immunol 2008;252:139-145.
87. Yildiz BO, Haznedaroglu IC: Rethinking leptin and insulin action: therapeutic opportunities for diabetes. Int J Biochem Cell Biol 2006;38:820-830. (Pubitemid 43363414)
88. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL, et al: Serum immunoreactive- leptin concentrations in normalweight and obese humans. N Engl J Med 1996;334: 292-295. (Pubitemid 26033933)
89. Bravo PE, Morse S, Borne DM, Aguilar EA, Reisin E: Leptin and hypertension in obesity. Vasc Health Risk Manag 2006;2:163- 169. (Pubitemid 43853431)
90. Shimizu H, Oh IS, Okada S, Mori M: Leptin resistance and obesity. Endocr J 2007;54:17-26. (Pubitemid 46481666)
91. Lam QL, Lu L: Role of leptin in immunity. Cell Mol Immunol 2007;4:1-13.
92. Bouloumie A, Marumo T, Lafontan M, Busse R: Leptin induces oxidative stress in human endothelial cells. Faseb J 1999;13:1231-1238. (Pubitemid 29300368)
93. Shin HJ, Oh J, Kang SM, Lee JH, Shin MJ, Hwang KC, Jang Y, Chung JH: Leptin induces hypertrophy via p38 mitogen- activated protein kinase in rat vascular smooth muscle cells. Biochem Biophys Res Commun 2005;329:18-24. (Pubitemid 40255414)
94. Wolk R, Deb A, Caplice NM, Somers VK: Leptin receptor and functional effects of leptin in human endothelial progenitor cells. Atherosclerosis 2005; 183:131-139. (Pubitemid 41416831)
95. Fantuzzi G, Mazzone T: Adipose tissue and atherosclerosis: exploring the connection. Arterioscler Thromb Vasc Biol 2007;27:996-1003. (Pubitemid 46641984)
96. Ip MS, Lam KS, Ho C, Tsang KW, Lam W: Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 2000;118:580-586.
97. Berg AH, Scherer PE: Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005;96:939-949. (Pubitemid 40712793)
98. Wannamethee SG, Tchernova J, Whincup P, Lowe GD, Kelly A, Rumley A, Wallace AM, Sattar N: Plasma leptin: associations with metabolic, inflammatory and haemostatic risk factors for cardiovascular disease. Atherosclerosis 2007;191:418-426. (Pubitemid 46400705)
99. Reis JP, Macera CA, Wingard DL, Araneta MR, Lindsay SP, Marshall SJ: The relation of leptin and insulin with obesity- related cardiovascular risk factors in US adults. Atherosclerosis 2008;200:150-160.
100. O'Donnell CP, Schaub CD, Haines AS, Berkowitz DE, Tankersley CG, Schwartz AR, Smith PL: Leptin prevents respiratory depression in obesity. Am J Respir Crit Care Med 1999;159:1477-1484. (Pubitemid 29227857)
101. Tankersley CG, O'Donnell C, Daood MJ, Watchko JF, Mitzner W, Schwartz A, Smith P: Leptin attenuates respiratory complications associated with the obese phenotype. J Appl Physiol 1998;85:2261-2269. (Pubitemid 28558084)
102. O'Donnell CP, Tankersley CG, Polotsky VP, Schwartz AR, Smith PL: Leptin, obesity, and respiratory function. Respir Physiol 2000;119:163-170.
103. Polotsky VY, Wilson JA, Smaldone MC, Haines AS, Hurn PD, Tankersley CG, Smith PL, Schwartz AR, O'Donnell CP: Female gender exacerbates respiratory depression in leptin- deficient obesity. Am J Respir Crit Care Med 2001;164:1470-1475. (Pubitemid 33124029)
104. Ambrosini G, Nath AK, Sierra- Honigmann MR, Flores- Riveros J: Transcriptional activation of the human leptin gene in response to hypoxia: involvement of hypoxia- inducible factor 1. J Biol Chem 2002;277:34601-34609.
105. Grosfeld A, Andre J, Hauguel- De Mouzon S, Berra E, Pouyssegur J, Guerre- Millo M: Hypoxia- inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 2002;277:42953-42957. (Pubitemid 35285673)
106. Phipps PR, Starritt E, Caterson I, Grunstein RR: Association of serum leptin with hypoventilation in human obesity. Thorax 2002;57:75-76. (Pubitemid 34081548)
107. Shimura R, Tatsumi K, Nakamura A, Kasahara Y, Tanabe N, Takiguchi Y, Kuriyama T: Fat accumulation, leptin, and hypercapnia in obstructive sleep apnea- hypopnea syndrome. Chest 2005;127:543-549. (Pubitemid 40229315)
108. Yee BJ, Cheung J, Phipps P, Banerjee D, Piper AJ, Grunstein RR: Treatment of obesity hypoventilation syndrome and serum leptin. Respiration 2006;73: 209-212.
109. Redolfi S, Corda L, La Piana G, Spandrio S, Prometti P, Tantucci C: Long- term non- invasive ventilation increases chemosensitivity and leptin in obesityhypoventilation syndrome. Respir Med 2007;101:1191-1195. (Pubitemid 46679500)
110. Campo A, Fruhbeck G, Zulueta JJ, Iriarte J, Seijo LM, Alcaide AB, Galdiz JB, Salvador J: Hyperleptinaemia, respiratory drive and hypercapnic response in obese patients. Eur Respir J 2007; 30:223-231. (Pubitemid 47194174)
111. Phillips BG, Kato M, Narkiewicz K, Choe I, Somers VK: Increases in leptin levels, sympathetic drive, and weight gain in obstructive sleep apnea. Am J Physiol Heart Circ Physiol 2000;279:H234-H237. (Pubitemid 30616665)
112. McArdle N, Hillman D, Beilin L, Watts G: Metabolic risk factors for vascular disease in obstructive sleep apnea: a matched controlled study. Am J Respir Crit Care Med 2007;175:190-195. (Pubitemid 46115091)
113. Drummond M, Winck JC, Guimaraes JT, Santos AC, Almeida J, Marques JA: Autoadjusting- CPAP effect on serum leptin concentrations in obstructive sleep apnoea patients. BMC Pulm Med 2008;8:21.
114. Barcelo A, Barbe F, Llompart E, de la Pena M, Duran- Cantolla J, Ladaria A, Bosch M, Guerra L, Agusti AG: Neuropeptide Y and leptin in patients with obstructive sleep apnea syndrome: role of obesity. Am J Respir Crit Care Med 2005;171:183-187. (Pubitemid 40105419)
115. Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K: Association of sleep apnea severity and obesity with insulin resistance, C- reactive protein, and leptin levels in male patients with obstructive sleep apnea. Lung 2008;186:209-217.
116. Yamamoto Y, Fujiuchi S, Hiramatsu M, Nishigaki Y, Takeda A, Fujita Y, Yamazaki Y: Resistin is closely related to systemic inflammation in obstructive sleep apnea. Respiration 2008;76:377-385.
117. Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S: Relationship between obstructive sleep apnea and diurnal leptin rhythms. Sleep 2004;27:235-239. (Pubitemid 44138831)
118. Tatsumi K, Kasahara Y, Kurosu K, Tanabe N, Takiguchi Y, Kuriyama T: Sleep oxygen desaturation and circulating leptin in obstructive sleep apneahypopnea syndrome. Chest 2005;127:716-721. (Pubitemid 40775497)
119. Chin K, Shimizu K, Nakamura T, Narai N, Masuzaki H, Ogawa Y, Mishima M, Nakamura T, Nakao K, Ohi M: Changes in intra- abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 1999;100: 706-712. (Pubitemid 29383639)
120. Sanner BM, Kollhosser P, Buechner N, Zidek W, Tepel M: Influence of treatment on leptin levels in patients with obstructive sleep apnoea. Eur Respir J 2004;23:601-604. (Pubitemid 38456004)
121. Cuhadaroglu C, Utkusavas A, Ozturk L, Salman S, Ece T: Effects of nasal CPAP treatment on insulin resistance, lipid profile, and plasma leptin in sleep apnea. Lung 2009;187:75-81.
122. Harsch IA, Konturek PC, Koebnick C, Kuehnlein PP, Fuchs FS, Pour Schahin S, Wiest GH, Hahn EG, Lohmann T, Ficker JH: Leptin and ghrelin levels in patients with obstructive sleep apnoea: effect of CPAP treatment. Eur Respir J 2003;22:251-257. (Pubitemid 36986993)
123. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y: Paradoxical decrease of an adipose- specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 1999;257:79-83. (Pubitemid 29299050)
124. Chiarugi P, Fiaschi T: Adiponectin in health and diseases: from metabolic syndrome to tissue regeneration. Expert Opin Ther Targets 2010;14:193-206.
125. Kawano J, Arora R. The role of adiponectin in obesity, diabetes, and cardiovascular disease. J Cardiometab Syndr 2009;4:44-49.
126. Goldstein BJ, Scalia RG, Ma XL: Protective vascular and myocardial effects of adiponectin. Nat Clin Pract Cardiovasc Med 2009;6:27-35.
127. Pischon T: Use of obesity biomarkers in cardiovascular epidemiology. Dis Markers 2009;26:247-263.
128. Pischon T, Girman CJ, Hotamisligil GS, Rifai N, Hu FB, Rimm EB: Plasma adiponectin levels and risk of myocardial infarction in men. JAMA 2004;291:1730-1737. (Pubitemid 38489895)
129. Wolk R, Svatikova A, Nelson CA, Gami AS, Govender K, Winnicki M, Somers VK: Plasma levels of adiponectin, a novel adipocyte- derived hormone, in sleep apnea. Obes Res 2005;13:186-190.
130. Masserini B, Morpurgo PS, Donadio F, Baldessari C, Bossi R, Beck- Peccoz P, Orsi E: Reduced levels of adiponectin in sleep apnea syndrome. J Endocrinol Invest 2006;29:700-705. (Pubitemid 44756174)
131. Buxton OM, Pavlova M, Reid EW, Wang W, Simonson DC, Adler GK: Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes 2010;59:2126-2133.
132. Tasali E, Leproult R, Ehrmann DA, Van Cauter E: Slow- wave sleep and the risk of type 2 diabetes in humans. Proc Natl Acad Sci USA 2008;105:1044-1049. (Pubitemid 351282078)
133. Zhang XL, Yin KS, Wang H, Su S: Serum adiponectin levels in adult male patients with obstructive sleep apnea hypopnea syndrome. Respiration 2006;73:73-77.
134. Lam JC, Xu A, Tam S, Khong PI, Yao TJ, Lam DC, Lai AY, Lam B, Lam KS, Mary SM: Hypoadiponectinemia is related to sympathetic activation and severity of obstructive sleep apnea. Sleep 2008;31:1721-1727.
135. Kanbay A, Kokturk O, Ciftci TU, Tavil Y, Bukan N: Comparison of serum adiponectin and tumor necrosis factor- alpha levels between patients with and without obstructive sleep apnea syndrome. Respiration 2008;76:324-330.
136. Nakagawa Y, Kishida K, Kihara S, Sonoda M, Hirata A, Yasui A, Nishizawa H, Nakamura T, Yoshida R, Shimomura I, Funahashi T: Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apneahypopnea syndrome. Am J Physiol Endocrinol Metab 2008;294:E778-E784. (Pubitemid 351483603)
137. Takahashi K, Chin K, Nakamura H, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Fukuhara S, Yodoi J, Mishima M: Plasma thioredoxin, a novel oxidative stress marker, in patients with obstructive sleep apnea before and after nasal continuous positive airway pressure. Antioxid Redox Signal 2008;10:715-726. (Pubitemid 351225903)
138. Makino S, Handa H, Suzukawa K, Fujiwara M, Nakamura M, Muraoka S, Takasago I, Tanaka Y, Hashimoto K, Sugimoto T: Obstructive sleep apnoea syndrome, plasma adiponectin levels, and insulin resistance. Clin Endocrinol (Oxf) 2006;64:12-19.
139. Sharma SK, Kumpawat S, Goel A, Banga A, Ramakrishnan L, Chaturvedi P: Obesity, and not obstructive sleep apnea, is responsible for metabolic abnormalities in a cohort with sleep- disordered breathing. Sleep Med 2007;8:12-17. (Pubitemid 46044133)
140. Tokuda F, Sando Y, Matsui H, Koike H, Yokoyama T: Serum levels of adipocytokines, adiponectin and leptin, in patients with obstructive sleep apnea syndrome. Intern Med 2008;47:1843-1849.
141. De Lima AM, Franco CM, de Castro CM, Bezerra Ade A, Ataide L Jr, Halpern A: Effects of nasal continuous positive airway pressure treatment on oxidative stress and adiponectin levels in obese patients with obstructive sleep apnea. Respiration 2010;79: 370-376.
142. Carneiro G, Togeiro SM, Ribeiro- Filho FF, Truksinas E, Ribeiro AB, Zanella MT, Tufik S: Continuous positive airway pressure therapy improves hypoadiponectinemia in severe obese men with obstructive sleep apnea without changes in insulin resistance. Metab Syndr Relat Disord 2009;7:537-542.
143. Zhang XL, Yin KS, Li C, Jia EZ, Li YQ, Gao ZF: Effect of continuous positive airway pressure treatment on serum adiponectin level and mean arterial pressure in male patients with obstructive sleep apnea syndrome. Chin Med J (Engl) 2007;120:1477-1481. (Pubitemid 47496581)
144. Harsch IA, Wallaschofski H, Koebnick C, Pour Schahin S, Hahn EG, Ficker JH, Lohmann T. Adiponectin in patients with obstructive sleep apnea syndrome: course and physiological relevance. Respiration 2004;71:580-586. (Pubitemid 40091430)
145. West SD, Nicoll DJ, Wallace TM, Matthews DR, Stradling JR: Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 2007;62:969-974. (Pubitemid 350084496)
146. Kohler M, Ayers L, Pepperell JC, Packwood KL, Ferry B, Crosthwaite N, Craig S, Siccoli MM, Davies RJ, Stradling JR: Effects of continuous positive airway pressure on systemic inflammation in patients with moderate to severe obstructive sleep apnoea: a randomised controlled trial. Thorax 2009;64:67-73.
147. Arnardottir ES, Mackiewicz M, Gislason T, Teff KL, Pack AI: Molecular signatures of obstructive sleep apnea in adults: a review and perspective. Sleep 2009;32:447-470.
148. Lavie L, Lavie P. Molecular mechanisms of cardiovascular disease in OSAHS: the oxidative stress link. Eur Respir J 2009;33:1467-84.
149. Spiegel K, Tasali E, Leproult R, Van Cauter E: Effects of poor and short sleep on glucose metabolism and obesity risk. Nat Rev Endocrinol 2009;5:253-261.
150. Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 2009;33:54-66.
151. Krueger JM, Rector DM, Churchill L. Sleep and Cytokines. Sleep Med Clin 2007;2:161-169.
152. Vgontzas AN, Zoumakis E, Lin HM, Bixler EO, Trakada G, Chrousos GP: Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor- alpha antagonist. J Clin Endocrinol Metab 2004;89:4409-4413. (Pubitemid 39244447)
153. Wysocka E, Cofta S, Dziegielewska S, Gozdzik J, Torlinski L, Batura- Gabryel H: Adipocytokines in sleep apnea syndrome. Eur J Med Res 2009;14(suppl 4):255-258.
154. Knutson KL, Spiegel K, Penev P, Van Cauter E: The metabolic consequences of sleep deprivation. Sleep Med Rev 2007;11:163-178. (Pubitemid 46778995)
155. Tasali E, Leproult R, Spiegel K: Reduced sleep duration or quality: relationships with insulin resistance and type 2 diabetes. Prog Cardiovasc Dis 2009;51: 381-391.
156. Gale SM, Castracane VD, Mantzoros CS: Energy homeostasis, obesity and eating disorders: recent advances in endocrinology. J Nutr 2004;134:295-298. (Pubitemid 38141808)
157. Knutson KL: Impact of sleep and sleep loss on glucose homeostasis and appetite regulation. Sleep Med Clin 2007;2:187-197.
158. Yildiz BO, Suchard MA, Wong ML, McCann SM,Licinio J: Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity. Proc Natl Acad Sci USA 2004;101:10434-10439. (Pubitemid 38924943)
159. Spiegel K, Tasali E, Penev P, Van Cauter E: Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med 2004;141:846-850. (Pubitemid 39601178)
160. Ukkola O: Ghrelin and metabolic disorders. Curr Protein Pept Sci 2009;10:2-7.
161. Granata R, Baragli A, Settanni F, Scarlatti F, Ghigo E: Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 2010; 45:107-118.
162. Takahashi K, Chin K, Akamizu T, Morita S, Sumi K, Oga T, Matsumoto H, Niimi A, Tsuboi T, Fukuhara S, Kangawa K, Mishima M: Acylated ghrelin level in patients with OSA before and after nasal CPAP treatment. Respirology 2008;13:810-816.
163. Ulukavak Ciftci T, Kokturk O, Bukan N, Bilgihan A: Leptin and ghrelin levels in patients with obstructive sleep apnea syndrome. Respiration 2005;72:395-401. (Pubitemid 41160173)
164. Sakurai T: Roles of orexins and orexin receptors in central regulation of feeding behavior and energy homeostasis. CNS Neurol Disord Drug Targets 2006;5:313-325. (Pubitemid 43884171)
165. Snow A, Gozal E, Malhotra A, Tiosano D, Perlman R, Vega C, Shahar E, Gozal D, Hochberg Z, Pillar G: Severe hypersomnolence after pituitary/ hypothalamic surgery in adolescents: clinical characteristics and potential mechanisms. Pediatrics 2002;110:e74.
166. Igarashi N, Tatsumi K, Nakamura A, Sakao S, Takiguchi Y, Nishikawa T, Kuriyama T: Plasma orexin- A levels in obstructive sleep apnea- hypopnea syndrome. Chest 2003;124:1381-1385. (Pubitemid 37290048)
167. Nishijima T, Sakurai S, Arihara Z, Takahashi K: Plasma orexin- A- like immunoreactivity in patients with sleep apnea hypopnea syndrome. Peptides 2003;24:407-411. (Pubitemid 36561212)
168. Busquets X, Barbe F, Barcelo A, de la Pena M, Sigritz N, Mayoralas LR, Ladaria A, Agusti A: Decreased plasma levels of orexin- A in sleep apnea. Respiration 2004;71:575-579. (Pubitemid 40091429)
169. Sakurai S, Nishijima T, Takahashi S, Yamauchi K, Arihara Z, Takahashi K: Low plasma orexin- A levels were improved by continuous positive airway pressure treatment in patients with severe obstructive sleep apnea- hypopnea syndrome. Chest 2005;127: 731-737. (Pubitemid 40775499)
170. Rizzi CF, Cintra F, Risso T, Pulz C, Tufik S, de Paola A, Poyares D: Exercise capacity and obstructive sleep apnea in lean subjects. Chest 2010;137:109-114.
171. Aguillard RN, Riedel BW, Lichstein KL, Grieve FG, Johnson CT, Noe SL: Daytime functioning in obstructive sleep apnea patients: exercise tolerance, subjective fatigue, and sleepiness. Appl Psychophysiol Biofeedback 1998;23:207-217. (Pubitemid 29352971)
172. Grote L, Hedner J, Peter JH: The heart rate response to exercise is blunted in patients with sleep- related breathing disorder. Cardiology 2004;102:93-99. (Pubitemid 39077803)
173. Basta M, Lin HM, Pejovic S, Sarrigiannidis A, Bixler E, Vgontzas AN: Lack of regular exercise, depression, and degree of apnea are predictors of excessive daytime sleepiness in patients with sleep apnea: sex differences. J Clin Sleep Med 2008;4:19-25. (Pubitemid 352038666)
174. Vasquez MM, Goodwin JL, Drescher AA, Smith TW, Quan SF: Associations of dietary intake and physical activity with sleep disordered breathing in the Apnea Positive Pressure Long- Term Efficacy Study (APPLES). J Clin Sleep Med 2008;4:411-418.
175. Peppard PE, Szklo- Coxe M, Hla KM, Young T: Longitudinal association of sleep- related breathing disorder and depression. Arch Intern Med 2006;166: 1709-1715. (Pubitemid 44414457)
176. De Fronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol 1979;237: E214-E223. (Pubitemid 9249478)
177. Bergman RN, Finegood DT, Ader M: Assessment of insulin sensitivity in vivo. Endocr Rev 1985;6:45-86.
178. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, Corgnati A, Muggeo M: Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. J Clin Endocrinol Metab 1989;68:374-378. (Pubitemid 19052880)
179. Akinmokun A, Selby PL, Ramaiya K, Alberti KG: The short insulin tolerance test for determination of insulin sensitivity: a comparison with the euglycaemic clamp. Diabet Med 1992;9:432-437.
180. Hirst S, Phillips DI, Vines SK, Clark PM, Hales CN. Reproducibility of the short insulin tolerance test. Diabet Med 1993;10:839-842. (Pubitemid 23326836)
181. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC: Homeostasis model assessment: insulin resistance and beta- cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)
182. Standards of medical care in diabetes - 2007. Diabetes Care 2007;30(suppl 1):S4-S41.
183. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006;29(suppl 1):S43-S48.
184. Shaw JE, Punjabi NM, Wilding JP, Alberti KG, Zimmet PZ: Sleep- disordered breathing and type 2 diabetes: a report from the International Diabetes Federation Task Force on Epidemiology and Prevention. Diabetes Res Clin Pract 2008;81:2-12. (Pubitemid 351778429)
185. Elmasry A, Lindberg E, Berne C, Janson C, Gislason T, Awad Tageldin M, Boman G: Sleep- disordered breathing and glucose metabolism in hypertensive men: a population- based study. J Intern Med 2001; 249:153-161. (Pubitemid 32202505)
186. Meslier N, Gagnadoux F, Giraud P, Person C, Ouksel H, Urban T, Racineux JL: Impaired glucose- insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J 2003;22:156-160. (Pubitemid 36896486)
187. Einhorn D, Stewart DA, Erman MK, Gordon N, Philis- Tsimikas A, Casal E: Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus. Endocr Pract 2007;13:355-362.
188. Laaban JP, Daenen S, Leger D, Pascal S, Bayon V, Slama G, Elgrably F: Prevalence and predictive factors of sleep apnoea syndrome in type 2 diabetic patients. Diabetes Metab 2009;35:372-377.
189. Tasali E, Ip MS: Obstructive sleep apnea and metabolic syndrome: alterations in glucose metabolism and inflammation. Proc Am Thorac Soc 2008;5: 207-217. (Pubitemid 351237880)
190. Levy P, Bonsignore MR, Eckel J: Sleep, sleepdisordered breathing and metabolic consequences. Eur Respir J 2009;34:243-260.
191. Tassone F, Lanfranco F, Gianotti L, Pivetti S, Navone F, Rossetto R, Grottoli S, Gai V, Ghigo E, Maccario M: Obstructive sleep apnoea syndrome impairs insulin sensitivity independently of anthropometric variables. Clin Endocrinol (Oxf) 2003;59:374-379. (Pubitemid 37046992)
192. Coughlin SR, Mawdsley L, Mugarza JA, Calverley PM, Wilding JP: Obstructive sleep apnoea is independently associated with an increased prevalence of metabolic syndrome. Eur Heart J 2004;25:735-741. (Pubitemid 38647933)
193. Peled N, Kassirer M, Shitrit D, Kogan Y, Shlomi D, Berliner AS, Kramer MR: The association of OSA with insulin resistance, inflammation and metabolic syndrome. Respir Med 2007;101:1696-1701. (Pubitemid 46947878)
194. Peltier AC, Consens FB, Sheikh K, Wang L, Song Y, Russell JW: Autonomic dysfunction in obstructive sleep apnea is associated with impaired glucose regulation. Sleep Med 2007;8:149-155. (Pubitemid 46206836)
195. Kono M, Tatsumi K, Saibara T, Nakamura A, Tanabe N, Takiguchi Y, Kuriyama T: Obstructive sleep apnea syndrome is associated with some components of metabolic syndrome. Chest 2007;131:1387-1392. (Pubitemid 46762343)
196. Polotsky VY, Patil SP, Savransky V, Laffan A, Fonti S, Frame LA, Steele KE, Schweizter MA, Clark JM, Torbenson MS, Schwartz AR: Obstructive sleep apnea, insulin resistance, and steatohepatitis in severe obesity. Am J Respir Crit Care Med 2009;179: 228-234.
197. Punjabi NM, Beamer BA: Alterations in Glucose Disposal in Sleep- disordered Breathing. Am J Respir Crit Care Med 2009;179:235-240.
198. Keckeis M, Lattova Z, Maurovich- Horvat E, Beitinger PA, Birkmann S, Lauer CJ, Wetter TC, Wilde- Frenz J, Pollmacher T: Impaired glucose tolerance in sleep disorders. PLoS One 2010;5:e9444.
199. Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS: Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med 2002;165:670-676. (Pubitemid 34194755)
200. Punjabi NM, Sorkin JD, Katzel LI, Goldberg AP, Schwartz AR, Smith PL: Sleep- disordered breathing and insulin resistance in middle- aged and overweight men. Am J Respir Crit Care Med 2002;165: 677-682. (Pubitemid 34194756)
201. Punjabi NM, Shahar E, Redline S, Gottlieb DJ, Givelber R, Resnick HE: Sleep- disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am J Epidemiol 2004;160: 521-530. (Pubitemid 39215628)
202. Lam JC, Lam B, Lam CL, Fong D, Wang JK, Tse HF, Lam KS, Ip MS: Obstructive sleep apnea and the metabolic syndrome in community- based Chinese adults in Hong Kong. Respir Med 2006;100:980-987.
203. Okada M, Takamizawa A, Tsushima K, Urushihata K, Fujimoto K, Kubo K: Relationship between sleepdisordered breathing and lifestyle- related illnesses in subjects who have undergone health- screening. Intern Med 2006;45:891-896. (Pubitemid 44323005)
204. Sulit L, Storfer- Isser A, Kirchner HL, Redline S: Differences in polysomnography predictors for hypertension and impaired glucose tolerance. Sleep 2006;29:777-783. (Pubitemid 43895046)
205. Seicean S, Kirchner HL, Gottlieb DJ, Punjabi NM, Resnick H, Sanders M, Budhiraja R, Singer M, Redline S: Sleep- disordered breathing and impaired glucose metabolism in normal- weight and overweight/ obese individuals: the Sleep Heart Health Study. Diabetes Care 2008;31:1001-1006.
206. Stamatakis K, Sanders MH, Caffo B, Resnick HE, Gottlieb DJ, Mehra R, Punjabi NM: Fasting glycemia in sleep disordered breathing: lowering the threshold on oxyhemoglobin desaturation. Sleep 2008;31:1018-1024. (Pubitemid 351956941)
207. Theorell- Haglow J, Berne C, Janson C, Lindberg E: Obstructive sleep apnoea is associated with decreased insulin sensitivity in females. Eur Respir J 2008;31:1054-1060.
208. Botros N, Concato J, Mohsenin V, Selim B, Doctor K, Yaggi HK: Obstructive sleep apnea as a risk factor for type 2 diabetes. Am J Med 2009;122:1122-1127.
209. Barcelo A, Barbe F, de la Pena M, Martinez P, Soriano JB, Pierola J, Agusti AG: Insulin resistance and daytime sleepiness in patients with sleep apnoea. Thorax 2008;63:946-950.
210. Ronksley PE, Hemmelgarn BR, Heitman SJ, Hanly PJ, Faris PD, Quan H, Tsai WH: Obstructive sleep apnoea is associated with diabetes in sleepy subjects. Thorax 2009;64:834-839.
211. Davies RJ, Turner R, Crosby J, Stradling JR: Plasma insulin and lipid levels in untreated obstructive sleep apnoea and snoring: their comparison with matched controls and response to treatment. J Sleep Res 1994;3:180-185. (Pubitemid 24311373)
212. Barcelo A, Barbe F, Llompart E, Mayoralas LR, Ladaria A, Bosch M, Agusti AG: Effects of obesity on C- reactive protein level and metabolic disturbances in male patients with obstructive sleep apnea. Am J Med 2004;117:118-121. (Pubitemid 38953732)
213. Mahmood K, Akhter N, Eldeirawi K, Onal E, Christman JW, Carley DW, Herdegen JJ: Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi- ethnic sample. J Clin Sleep Med 2009;5:215-221.
214. Reichmuth KJ, Austin D, Skatrud JB, Young T: Association of sleep apnea and type II diabetes: a population- based study. Am J Respir Crit Care Med 2005;172:1590-1595. (Pubitemid 43076551)
215. Marshall NS, Wong KK, Phillips CL, Liu PY, Knuiman MW, Grunstein RR: Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study? J Clin Sleep Med 2009;5:15-20.
216. Papanas N, Steiropoulos P, Nena E, Tzouvelekis A, Maltezos E, Trakada G, Bouros D: HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men. Vasc Health Risk Manag 2009;5:751-756.
217. Steiropoulos P, Papanas N, Nena E, Maltezos E, Bouros D: Continuous positive airway pressure treatment in patients with sleep apnoea: does it really improve glucose metabolism? Curr Diabetes Rev 2010;6:156-166.
218. Punjabi NM, Polotsky VY: Disorders of glucose metabolism in sleep apnea. J Appl Physiol 2005;99: 1998-2007. (Pubitemid 41547203)
219. Babu AR, Herdegen J, Fogelfeld L, Shott S, Mazzone T: Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea. Arch Intern Med 2005;165:447-452. (Pubitemid 40280202)
220. Dorkova Z, Petrasova D, Molcanyiova A, Popovnakova M, Tkacova R: Effects of continuous positive airway pressure on cardiovascular risk profile in patients with severe obstructive sleep apnea and metabolic syndrome. Chest 2008;134:686-692.
221. Schahin SP, Nechanitzky T, Dittel C, Fuchs FS, Hahn EG, Konturek PC, Ficker JH, Harsch IA: Long- term improvement of insulin sensitivity during CPAP therapy in the obstructive sleep apnoea syndrome. Med Sci Monit 2008;14:CR117- CR121.
222. Steiropoulos P, Papanas N, Nena E, Tsara V, Fitili C, Tzouvelekis A, Christaki P, Maltezos E, Bouros D: Markers of glycemic control and insulin resistance in non- diabetic patients with obstructive sleep apnea hypopnea syndrome: does adherence to CPAP treatment improve glycemic control? Sleep Med 2009;10:887-891.
223. Harsch IA, Schahin SP, Bruckner K, Radespiel- Troger M, Fuchs FS, Hahn EG, Konturek PC, Lohmann T, Ficker JH: The effect of continuous positive airway pressure treatment on insulin sensitivity in patients with obstructive sleep apnoea syndrome and type 2 diabetes. Respiration 2004;71: 252-259. (Pubitemid 38608343)
224. Harsch IA, Hahn EG, Pour Schahin S: Effect of CPAP on insulin resistance in patients with obstructive sleep apnoea and type 2 diabetes. Thorax 2008;63:384-385, author reply 385. (Pubitemid 351497956)
225. Lam JC, Lam B, Yao TJ, Lai AY, Ooi CG, Tam S, Lam KS, Ip MS: A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. Eur Respir J 2010;35:138-145.
226. Brooks B, Cistulli PA, Borkman M, Ross G, McGhee S, Grunstein RR, Sullivan CE, Yue DK: Obstructive sleep apnea in obese noninsulin- dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin responsiveness. J Clin Endocrinol Metab 1994;79:1681-1685.
227. Harsch IA, Schahin SP, Radespiel- Troger M, Weintz O, Jahreiss H, Fuchs FS, Wiest GH, Hahn EG, Lohmann T, Konturek PC, Ficker JH: Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med 2004;169:156-162. (Pubitemid 38114528)
228. Lindberg E, Berne C, Elmasry A, Hedner J, Janson C: CPAP treatment of a population- based sample - what are the benefits and the treatment compliance? Sleep Med 2006;7:553-560. (Pubitemid 44480744)
229. Dawson A, Abel SL, Loving RT, Dailey G, Shadan FF, Cronin JW, Kripke DF, Kline LE: CPAP therapy of obstructive sleep apnea in type 2 diabetics improves glycemic control during sleep. J Clin Sleep Med 2008;4:538-542.
230. Pallayova M, Donic V, Tomori Z: Beneficial effects of severe sleep apnea therapy on nocturnal glucose control in persons with type 2 diabetes mellitus. Diabetes Res Clin Pract 2008;81:e8-e11.
231. Hassaballa HA, Tulaimat A, Herdegen JJ, Mokhlesi B: The effect of continuous positive airway pressure on glucose control in diabetic patients with severe obstructive sleep apnea. Sleep Breath 2005;9:176-180. (Pubitemid 44184314)
232. Czupryniak L, Loba J, Pawlowski M, Nowak D, Bialasiewicz P: Treatment with continuous positive airway pressure may affect blood glucose levels in nondiabetic patients with obstructive sleep apnea syndrome. Sleep 2005;28:601-603. (Pubitemid 40677374)
233. Coughlin SR, Mawdsley L, Mugarza JA, Wilding JP, Calverley PM: Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur Respir J 2007;29:720-727. (Pubitemid 46554622)
234. Comondore VR, Cheema R, Fox J, Butt A, John Mancini GB, Fleetham JA, Ryan CF, Chan S, Ayas NT: The impact of CPAP on cardiovascular biomarkers in minimally symptomatic patients with obstructive sleep apnea: a pilot feasibility randomized crossover trial. Lung 2009;187:17-22.
235. Patruno V, Aiolfi S, Costantino G, Murgia R, Selmi C, Malliani A, Montano N: Fixed and autoadjusting continuous positive airway pressure treatments are not similar in reducing cardiovascular risk factors in patients with obstructive sleep apnea. Chest 2007;131:1393-1399. (Pubitemid 46762344)
236. Shoelson SE, Lee J, Goldfine AB: Inflammation and insulin resistance. J Clin Invest 2006;116:1793-1801. (Pubitemid 44033299)
237. Tilg H, Moschen AR: Inflammatory mechanisms in the regulation of insulin resistance. Mol Med 2008;14:222-231. (Pubitemid 351481853)
238. Williams A, Scharf SM: Obstructive sleep apnea, cardiovascular disease, and inflammation - is NFkappaB the key? Sleep Breath 2007;11:69-76. (Pubitemid 46745858)
239. Ramasamy R, Yan SF, Schmidt AM: The RAGE axis and endothelial dysfunction: maladaptive roles in the diabetic vasculature and beyond. Trends Cardiovasc Med 2005;15:237-243. (Pubitemid 41437905)
240. Koyama H, Yamamoto H, Nishizawa Y: RAGE and soluble RAGE: potential therapeutic targets for cardiovascular diseases. Mol Med 2007;13:625-635. (Pubitemid 350228723)
241. Yan SF, D'Agati V, Schmidt AM, Ramasamy R: Receptor for advanced glycation endproducts (RAGE): a formidable force in the pathogenesis of the cardiovascular complications of diabetes and aging. Curr Mol Med 2007;7:699-710.
242. Meerwaldt R, Links T, Zeebregts C, Tio R, Hillebrands JL, Smit A: The clinical relevance of assessing advanced glycation endproducts accumulation in diabetes. Cardiovasc Diabetol 2008;7:29.
243. Tan KC, Chow WS, Lam JC, Lam B, Bucala R, Betteridge J, Ip MS: Advanced glycation endproducts in nondiabetic patients with obstructive sleep apnea. Sleep 2006;29:329-333. (Pubitemid 44019955)
244. Veasey S: Obstructive sleep apnea: rapidly AGE- ing us all. Sleep 2006;29:280-281. (Pubitemid 44019948)
245. Oltmanns KM, Gehring H, Rudolf S, Schultes B, Rook S, Schweiger U, Born J, Fehm HL, Peters A: Hypoxia causes glucose intolerance in humans. Am J Respir Crit Care Med 2004;169:1231-1237. (Pubitemid 38680401)
246. Louis M, Punjabi NM: Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J Appl Physiol 2009;106:1538-1544.
247. Iiyori N, Alonso LC, Li J, Sanders MH, Garcia- Ocana A, O'Doherty RM, Polotsky VY, O'Donnell CP: Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. Am J Respir Crit Care Med 2007;175:851-857. (Pubitemid 46631798)
248. Jun J, Polotsky VY: Sleep disordered breathing and metabolic effects: evidence from animal models. Sleep Med Clin 2007;2:263-277.
249. Paquot N, Schneiter P, Jequier E, Tappy L: Effects of glucocorticoids and sympathomimetic agents on basal and insulin- stimulated glucose metabolism. Clin Physiol 1995;15:231-240.
250. Navegantes LC, Sjostrand M, Gudbjornsdottir S, Strindberg L, Elam M, Lonnroth P: Regulation and counterregulation of lipolysis in vivo: different roles of sympathetic activation and insulin. J Clin Endocrinol Metab 2003;88:5515-5520. (Pubitemid 37452764)
251. Grassi G, Arenare F, Quarti- Trevano F, Seravalle G, Mancia G: Heart rate, sympathetic cardiovascular influences, and the metabolic syndrome. Prog Cardiovasc Dis 2009;52:31-37.
252. Bloch- Damti A, Bashan N: Proposed mechanisms for the induction of insulin resistance by oxidative stress. Antioxid Redox Signal 2005;7:1553-1567. (Pubitemid 41767991)
253. Robertson RP: Oxidative stress and impaired insulin secretion in type 2 diabetes. Curr Opin Pharmacol 2006;6:615-619. (Pubitemid 44660951)
254. Mullington JM, Haack M, Toth M, Serrador JM, Meier- Ewert HK: Cardiovascular, inflammatory, and metabolic consequences of sleep deprivation. Prog Cardiovasc Dis 2009;51:294-302.
255. Tuomilehto H, Peltonen M, Partinen M, Seppa J, Saaristo T, Korpi- Hyovalti E, Oksa H, Puolijoki H, Saltevo J, Vanhala M, Tuomilehto J: Sleep duration is associated with an increased risk for the prevalence of type 2 diabetes in middle- aged women - the FIN- D2D survey. Sleep Med 2008;9:221-227. (Pubitemid 351387098)
256. Hayashino Y, Fukuhara S, Suzukamo Y, Okamura T, Tanaka T, Ueshima H: Relation between sleep quality and quantity, quality of life, and risk of developing diabetes in healthy workers in Japan: the High- Risk and Population Strategy for Occupational Health Promotion (HIPOP- OHP) Study. BMC Public Health 2007;7:129.
257. Cappuccio FP, D'Elia L, Strazzullo P, Miller MA: Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta- analysis. Diabetes Care 2010;33:414-420.
258. Xu Q, Song Y, Hollenbeck A, Blair A, Schatzkin A, Chen H: Day napping and short night sleeping are associated with higher risk of diabetes in older adults. Diabetes Care 2010;33:78-83.
259. Bergman RN, Ader M, Huecking K, Van Citters G: Accurate assessment of beta- cell function: the hyperbolic correction. Diabetes 2002;51(suppl 1):S212-S220. (Pubitemid 34761518)
260. Prigeon RL, Kahn SE, Porte D Jr: Changes in insulin sensitivity, glucose effectiveness, and B- cell function in regularly exercising subjects. Metabolism 1995;44:1259-1263. (Pubitemid 26087786)
261. Resnick HE, Redline S, Shahar E, Gilpin A, Newman A, Walter R, Ewy GA, Howard BV, Punjabi NM: Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care 2003;26: 702-709. (Pubitemid 36929331)
262. West SD, Nicoll DJ, Stradling JR: Prevalence of obstructive sleep apnoea in men with type 2 diabetes. Thorax 2006;61:945-950. (Pubitemid 44787163)
263. Aronsohn RS, Whitmore H, Van Cauter E, Tasali E: Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am J Respir Crit Care Med 2010;181:507-513.
264. Mondini S, Guilleminault C: Abnormal breathing patterns during sleep in diabetes. Ann Neurol 1985;17:391-395. (Pubitemid 15079068)
265. Ficker JH, Dertinger SH, Siegfried W, Konig HJ, Pentz M, Sailer D, Katalinic A, Hahn EG: Obstructive sleep apnoea and diabetes mellitus: the role of cardiovascular autonomic neuropathy. Eur Respir J 1998;11:14-19. (Pubitemid 28081789)
266. Tasali E, Mokhlesi B, Van Cauter E: Obstructive sleep apnea and type 2 diabetes: interacting epidemics. Chest 2008;133:496-506. (Pubitemid 351272411)
267. Li J, Thorne LN, Punjabi NM, Sun CK, Schwartz AR, Smith PL, Marino RL, Rodriguez A, Hubbard WC, O'Donnell CP, Polotsky VY: Intermittent hypoxia induces hyperlipidemia in lean mice. Circ Res 2005;97:698-706. (Pubitemid 41416339)
268. Li J, Savransky V, Nanayakkara A, Smith PL, O'Donnell CP, Polotsky VY: Hyperlipidemia and lipid peroxidation are dependent on the severity of chronic intermittent hypoxia. J Appl Physiol 2007; 102:557-563. (Pubitemid 46220883)
269. Savransky V, Bevans S, Nanayakkara A, Li J, Smith PL, Torbenson MS, Polotsky VY: Chronic intermittent hypoxia causes hepatitis in a mouse model of diet- induced fatty liver. Am J Physiol Gastrointest Liver Physiol 2007;293:G871-G877. (Pubitemid 47605939)
270. Savransky V, Jun J, Li J, Nanayakkara A, Fonti S, Moser AB, Steele KE, Schweitzer MA, Patil SP, Bhanot S, Schwartz AR, Polotsky VY: Dyslipidemia and atherosclerosis induced by chronic intermittent hypoxia are attenuated by deficiency of stearoyl coenzyme A desaturase. Circ Res 2008;103:1173-1180.
271. Jun J, Polotsky VY: Metabolic consequences of sleep- disordered breathing. ILAR J 2009;50:289-306.
272. Drager LF, Jun J, Polotsky VY: Obstructive sleep apnea and dyslipidemia: implications for atherosclerosis. Curr Opin Endocrinol Diabetes Obes 2010;17:161-165.
273. Borgel J, Sanner BM, Bittlinsky A, Keskin F, Bartels NK, Buechner N, Huesing A, Rump LC, Mugge A: Obstructive sleep apnoea and its therapy influence high- density lipoprotein cholesterol serum levels. Eur Respir J 2006;27:121-127. (Pubitemid 43092675)
274. Roche F, Sforza E, Pichot V, Maudoux D, Garcin A, Celle S, Picard- Kossovsky M, Gaspoz JM, Barthelemy JC: Obstructive sleep apnoea/hypopnea influences high- density lipoprotein cholesterol in the elderly. Sleep Med 2009;10:882-886.
275. Czerniawska J, Bielen P, Plywaczewski R, Czystowska M, Korzybski D, Sliwinski P, Gorecka D: Metabolic abnormalities in obstructive sleep apnea patients. Pneumonol Alergol Pol 2008;76:340-347.
276. Tan KC, Chow WS, Lam JC, Lam B, Wong WK, Tam S, Ip MS: HDL dysfunction in obstructive sleep apnea. Atherosclerosis 2006;184:377-382. (Pubitemid 43049723)
277. Steiropoulos P, Tsara V, Nena E, Fitili C, Kataropoulou M, Froudarakis M, Christaki P, Bouros D: Effect of continuous positive airway pressure treatment on serum cardiovascular risk factors in patients with obstructive sleep apnea- hypopnea syndrome. Chest 2007;132:843-851.
278. Robinson GV, Pepperell JC, Segal HC, Davies RJ, Stradling JR: Circulating cardiovascular risk factors in obstructive sleep apnoea: data from randomized controlled trials. Thorax 2004;59:777-782. (Pubitemid 39215375)
279. Drager LF, Bortolotto LA, Figueiredo AC, Krieger EM, Lorenzi GF: Effects of continuous positive airway pressure on early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2007;176:706-712. (Pubitemid 47503079)
280. Baguet JP, Nadra M, Barone- Rochette G, Ormezzano O, Pierre H, Pepin JL: Early cardiovascular abnormalities in newly diagnosed obstructive sleep apnea. Vasc Health Risk Manag 2009;5:1063-1073.
281. Wilcox I, McNamara SG, Collins FL, Grunstein RR, Sullivan CE: 'Syndrome Z': the interaction of sleep apnoea, vascular risk factors and heart disease. Thorax 1998;53(suppl 3):S25-S28.
282. Vgontzas AN, Bixler EO, Chrousos GP: Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005;9:211-224. (Pubitemid 40694188)
283. Nieto FJ, Peppard PE, Young TB: Sleep disordered breathing and metabolic syndrome. WMJ 2009;108: 263-265.
284. Nock NL, Li L, Larkin EK, Patel SR, Redline S: Empirical evidence for 'syndrome Z': a hierarchical 5- factor model of the metabolic syndrome incorporating sleep disturbance measures. Sleep 2009;32: 615-622.
285. Eckel RH, Grundy SM, Zimmet PZ: The metabolic syndrome. Lancet 2005;365:1415-1428. (Pubitemid 40523737)
286. Wolk R, Somers VK: Sleep and the metabolic syndrome. Exp Physiol 2007;92:67-78. (Pubitemid 46096254)
287. Lam JC, Ip MS: Obstructive sleep apnea and the metabolic syndrome. Expert Rev Respir Med 2009;3:177-186.
288. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, Fruchart JC, James WP, Loria CM, Smith SC Jr: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention, National Heart, Lung and Blood Institute, American Heart Association, World Heart Federation, International Atherosclerosis Society and International Association for the Study of Obesity. Circulation 2009;120:1640-1645.
289. Alberti KG, Zimmet P, Shaw J: The metabolic syndrome - a new worldwide definition. Lancet 2005;366:1059-1062. (Pubitemid 41338752)
290. Gale EA: Should we dump the metabolic syndrome? Yes. BMJ 2008;336:640.
291. Kahn R: Metabolic syndrome - what is the clinical usefulness? Lancet 2008;371:1892-1893.
292. Sattar N, McConnachie A, Shaper AG, Blauw GJ, Buckley BM, de Craen AJ, Ford I, Forouhi NG, Freeman DJ, Jukema JW, Lennon L, Macfarlane PW, Murphy MB, Packard CJ, Stott DJ, Westendorp RG, Whincup PH, Shepherd J, Wannamethee SG: Can metabolic syndrome usefully predict cardiovascular disease and diabetes? Outcome data from two prospective studies. Lancet 2008;371:1927-1935.
293. Alberti KG, Zimmet PZ: Definition, diagnosis and classification of diabetes mellitus and its complications. 1. Diagnosis and classification of diabetes mellitus: provisional report of a WHO consultation. Diabet Med 1998;15:539-553. (Pubitemid 28319935)
294. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III): final report. Circulation 2002;106:3143-3421.
295. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F: Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-2752. (Pubitemid 41532612)
296. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356-359. (Pubitemid 34251969)
297. Cameron AJ, Shaw JE, Zimmet PZ: The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am 2004;33:351-375. (Pubitemid 38680634)
298. Ford ES: Prevalence of the metabolic syndrome defined by the International Diabetes Federation among adults in the US. Diabetes Care 2005;28: 2745-2749. (Pubitemid 43951170)
299. Hu G, Qiao Q, Tuomilehto J, Balkau B, Borch- Johnsen K, Pyorala K: Prevalence of the metabolic syndrome and its relation to all- cause and cardiovascular mortality in nondiabetic European men and women. Arch Intern Med 2004;164:1066-1076. (Pubitemid 38668985)
300. Gruber A, Horwood F, Sithole J, Ali NJ, Idris I: Obstructive sleep apnoea is independently associated with the metabolic syndrome but not insulin resistance state. Cardiovasc Diabetol 2006;5:22.
301. Sasanabe R, Banno K, Otake K, Hasegawa R, Usui K, Morita M, Shiomi T: Metabolic syndrome in Japanese patients with obstructive sleep apnea syndrome. Hypertens Res 2006;29:315-322. (Pubitemid 43965112)
302. Parish JM, Adam T, Facchiano L: Relationship of metabolic syndrome and obstructive sleep apnea. J Clin Sleep Med 2007;3:467-472. (Pubitemid 47378249)
303. Chin K, Oga T, Takahashi K, Takegami M, Nakayama- Ashida Y, Wakamura T, Sumi K, Nakamura T, Horita S, Oka Y, Minami I, Fukuhara S, Kadotani H: Associations between obstructive sleep apnea, metabolic syndrome, and sleep duration, as measured with an actigraph, in an urban male working population in Japan. Sleep 2010;33: 89-95.
304. Drager LF, Bortolotto LA, Maki- Nunes C, Trombetta IC, Alves MJ, Fraga RF, Negrao CE, Krieger EM, Lorenzi- Filho G: The incremental role of obstructive sleep apnoea on markers of atherosclerosis in patients with metabolic syndrome. Atherosclerosis 2010;208:490-495.
305. Drager LF, Bortolotto LA, Maki- Nunes C, Trombetta IC, Negrao CE, Krieger EM, Lorenzi- Filho G: Atherosclerosis in obstructive sleep apnoea: it does not matter whether patients are sleepy or not. Atherosclerosis 2010;211:30-31.
306. Saletu M, Sauter C, Lalouschek W, Saletu B, Kapfhammer G, Benesch T, Zeitlhofer J: Is excessive daytime sleepiness a predictor of carotid atherosclerosis in sleep apnea? Atherosclerosis 2008;196: 810-816.
307. Mota PC, Drummond M, Winck JC, Santos AC, Almeida J, Marques JA: APAP impact on metabolic syndrome in obstructive sleep apnea patients. Sleep Breath 2010, E- pub ahead of print.
308. Ip MS, Lam B, Lauder IJ, Tsang KW, Chung KF, Mok YW, Lam WK: A community study of sleepdisordered breathing in middle- aged Chinese men in Hong Kong. Chest 2001;119:62-69. (Pubitemid 32150548)
309. Netzer NC, Stoohs RA, Netzer CM, Clark K, Strohl KP: Using the Berlin Questionnaire to identify patients at risk for the sleep apnea syndrome. Ann Intern Med 1999;131:485-491. (Pubitemid 29482391)
310. Drager LF, Genta PR, Pedrosa RP, Nerbass FB, Gonzaga CC, Krieger EM, Lorenzi- Filho G:Characteristics and predictors of obstructive sleep apnea in patients with systemic hypertension. Am J Cardiol 2010;105:1135-1139.
311. Dixon JB, Bhathal PS, O'Brien PE: Nonalcoholic fatty liver disease: predictors of nonalcoholic steatohepatitis and liver fibrosis in the severely obese. Gastroenterology 2001;121:91-100. (Pubitemid 32591518)
312. Kim CH, Younossi ZM: Nonalcoholic fatty liver disease: a manifestation of the metabolic syndrome. Cleve Clin J Med 2008;75:721-728.
313. Shifflet A, Wu GY: Non- alcoholic steatohepatitis: an overview. J Formos Med Assoc 2009;108:4-12.
314. Vanni E, Bugianesi E, Kotronen A, De Minicis S, Yki- Jarvinen H, Svegliati- Baroni G: From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis 2010;42:320-330.
315. Ahmed MH, Byrne CD: Obstructive sleep apnea syndrome and fatty liver: association or causal link? World J Gastroenterol 2010;16:4243-4252.
316. Tian JL, Zhang Y, Chen BY: Sleep apnea hypopnea syndrome and liver injury. Chin Med J (Engl) 2010;123:89-94.
317. Tanne F, Gagnadoux F, Chazouilleres O, Fleury B, Wendum D, Lasnier E, Lebeau B, Poupon R, Serfaty L: Chronic liver injury during obstructive sleep apnea. Hepatology 2005;41:1290-1296. (Pubitemid 40770281)
318. Kallwitz ER, Herdegen J, Madura J, Jakate S, Cotler SJ: Liver enzymes and histology in obese patients with obstructive sleep apnea. J Clin Gastroenterol 2007;41:918-921. (Pubitemid 350307079)
319. Savransky V, Nanayakkara A, Vivero A, Li J, Bevans S, Smith PL, Torbenson MS, Polotsky VY: Chronic intermittent hypoxia predisposes to liver injury. Hepatology 2007;45:1007-1013. (Pubitemid 46631569)
320. Kohler M, Pepperell JC, Davies RJ, Stradling JR: Continuous positive airway pressure and liver enzymes in obstructive sleep apnoea: data from a randomized controlled trial. Respiration 2009;78: 141-146.
321. Day CP, James OF: Steatohepatitis: a tale of two 'hits'? Gastroenterology 1998;114:842-845.
322. Day CP, Saksena S: Non- alcoholic steatohepatitis: definitions and pathogenesis. J Gastroenterol Hepatol 2002;17(suppl 3):S377-S384. (Pubitemid 35454314)
323. Browning JD, Horton JD: Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 2004; 114:147-152. (Pubitemid 39071617)
324. Diehl AM: Lessons from animal models of NASH. Hepatol Res 2005;33:138-144. (Pubitemid 41799792)
325. Clark JM, Diehl AM: Nonalcoholic fatty liver disease: an underrecognized cause of cryptogenic cirrhosis. JAMA 2003;289:3000-3004. (Pubitemid 37430103)
326. Clark JM, Diehl AM: Defining nonalcoholic fatty liver disease: implications for epidemiologic studies. Gastroenterology 2003;124:248-250. (Pubitemid 36055357)
327. Day CP: Natural history of NAFLD: remarkably benign in the absence of cirrhosis. Gastroenterology 2005;129:375-378. (Pubitemid 41002070)
328. McCullough AJ: Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol 2006;40(suppl 1):S17-S29. (Pubitemid 44309539)
329. Chin K, Nakamura T, Takahashi K, Sumi K, Ogawa Y, Masuzaki H, Muro S, Hattori N, Matsumoto H, Niimi A, Chiba T, Nakao K, Mishima M, Ohi M: Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients. Am J Med 2003;114:370-376. (Pubitemid 36513685)
330. Jouet P, Sabate JM, Maillard D, Msika S, Mechler C, Ledoux S, Harnois F, Coffin B: Relationship between obstructive sleep apnea and liver abnormalities in morbidly obese patients: a prospective study. Obes Surg 2007;17:478-485. (Pubitemid 46850187)
331. Norman D, Bardwell WA, Arosemena F, Nelesen R, Mills PJ, Loredo JS, Lavine JE, Dimsdale JE: Serum aminotransferase levels are associated with markers of hypoxia in patients with obstructive sleep apnea. Sleep 2008;31:121-126.
332. Tatsumi K, Saibara T: Effects of obstructive sleep apnea syndrome on hepatic steatosis and nonalcoholic steatohepatitis. Hepatol Res 2005;33:100-104. (Pubitemid 41799784)
333. Mishra P, Nugent C, Afendy A, Bai C, Bhatia P, Afendy M, Fang Y, Elariny H, Goodman Z, Younossi ZM: Apnoeic- hypopnoeic episodes during obstructive sleep apnoea are associated with histological nonalcoholic steatohepatitis. Liver Int 2008;28:1080-1086.
334. Rashid S, Watanabe T, Sakaue T, Lewis GF: Mechanisms of HDL lowering in insulin resistant, hypertriglyceridemic states: the combined effect of HDL triglyceride enrichment and elevated hepatic lipase activity. Clin Biochem 2003;36:421-429. (Pubitemid 37083556)
335. Taskinen MR: Type 2 diabetes as a lipid disorder. Curr Mol Med 2005;5:297-308.
336. Savransky V, Nanayakkara A, Li J, Bevans S, Smith PL, Rodriguez A, Polotsky VY: Chronic intermittent hypoxia induces atherosclerosis. Am J Respir Crit Care Med 2007;175:1290-1297. (Pubitemid 46905755)
337. Cusi K: Role of insulin resistance and lipotoxicity in non- alcoholic steatohepatitis. Clin Liver Dis 2009; 13:545-563.
338. Edens MA, Kuipers F, Stolk RP: Non- alcoholic fatty liver disease is associated with cardiovascular disease risk markers. Obes Rev 2009;10:412-419.
339. Lizardi- Cervera J, Aguilar- Zapata D: Nonalcoholic fatty liver disease and its association with cardiovascular disease. Ann Hepatol 2009;8(suppl 1): S40-S43.
340. Montecucco F, Mach F: Does non- alcoholic fatty liver disease (NAFLD) increase cardiovascular risk? Endocr Metab Immune Disord Drug Targets 2008;8: 301-307.
341. Malhotra A, Loscalzo J: Sleep and cardiovascular disease: an overview. Prog Cardiovasc Dis 2009;51: 279-284.
342. Douketis JD, Paradis G, Keller H, Martineau C: Canadian guidelines for body weight classification in adults: application in clinical practice to screen for overweight and obesity and to assess disease risk. CMAJ 2005;172:995-998. (Pubitemid 40546592)
343. Arens R, Marcus CL: Pathophysiology of upper airway obstruction: a developmental perspective. Sleep 2004;27:997-1019. (Pubitemid 39095735)
344. Baeuerle PA, Baichwal VR: NF- kappa B as a frequent target for immunosuppressive and anti-inflammatory molecules. Adv Immunol 1997;65: 111-137. (Pubitemid 27323247)
345. Ghosh S, May MJ, Kopp EB: NF- kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 1998;16: 225-260. (Pubitemid 28183365)
346. Karin M, Ben- Neriah Y: Phosphorylation meets ubiquitination: the control of NF- [kappa]B activity. Annu Rev Immunol 2000;18:621-663. (Pubitemid 30365393)
347. Carmody RJ, Chen YH: Nuclear factor- kappaB: activation and regulation during Toll- like receptor signaling. Cell Mol Immunol 2007;4:31-41.
348. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, Ferrell LD, Liu YC, Torbenson MS, Unalp- Arida A, Yeh M, McCullough AJ, Sanyal AJ: Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005;41:1313-1321. (Pubitemid 40770284)
349. Appropriate body- mass index for Asian populations and its implications for policy and intervention strategies. Lancet 2004;363:157-163.
350. Obesity: preventing and managing the global epidemic. Report of a WHO consultation. World Health Organ Tech Rep Ser 2000;894:1-253.
351. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults - the evidence report. National Institutes of Health. Obes Res 1998;6(suppl 2):51S- 209S.
352. Health Canada: Canadian Guidelines for Body Weight Classification in Adults. Ottawa, Health Canada, 2003, publication ID No 4645
353. Khan NA, McAlister FA, Rabkin SW, Padwal R, Feldman RD, Campbell NR, Leiter LA, Lewanczuk RZ, Schiffrin EL, Hill MD, Arnold M, Moe G, Campbell TS, Herbert C, Milot A, Stone JA, Burgess E, Hemmelgarn B, Jones C, Larochelle P, Ogilvie RI, Houlden R, Herman RJ, Hamet P, Fodor G, Carruthers G, Culleton B, Dechamplain J, Pylypchuk G, Logan AG, Gledhill N, Petrella R, Tobe S, Touyz RM: The 2006 Canadian Hypertension Education Program recommendations for the management of hypertension- II. Therapy. Can J Cardiol 2006;22: 583-593. (Pubitemid 44044214)
354. Graham I, Atar D, Borch- Johnsen K, Boysen G, Burell G, Cifkova R, Dallongeville J, De Backer G, Ebrahim S, Gjelsvik B, Herrmann- Lingen C, Hoes A, Humphries S, Knapton M, Perk J, Priori SG, Pyorala K, Reiner Z, Ruilope L, Sans- Menendez S, Op Reimer WS, Weissberg P, Wood D, Yarnell J, Zamorano JL: European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Atherosclerosis 2007;194:1-45. (Pubitemid 47470068)
355. Hara K, Matsushita Y, Horikoshi M, Yoshiike N, Yokoyama T, Tanaka H, Kadowaki T: A proposal for the cutoff point of waist circumference for the diagnosis of metabolic syndrome in the Japanese population. Diabetes Care 2006;29:1123-1124. (Pubitemid 44115258)
356. Oka R, Kobayashi J, Yagi K, Tanii H, Miyamoto S, Asano A, Hagishita T, Mori M, Moriuchi T, Kobayashi M, Katsuda S, Kawashiri MA, Nohara A, Takeda Y, Mabuchi H, Yamagishi M: Reassessment of the cutoff values of waist circumference and visceral fat area for identifying Japanese subjects at risk for the metabolic syndrome. Diabetes Res Clin Pract 2008;79:474-481. (Pubitemid 351273461)
357. New criteria for 'obesity disease' in Japan. Circ J 2002;66:987-992.