Cardiovascular and cerebrovascular responses to acute hypoxia following exposure to intermittent hypoxia in healthy humans

Journal of Physiology

Volumn 587, Issue 13, 2009, Pages 3287-3299

  Foster, Glen E ^a,b   Brugniaux, Julien V ^a,b   Pialoux, Vincent ^a,b   Duggan, Cailean T C ^a,b   Hanly, Patrick J ^a,b   Ahmed, Sofia B ^a,c   Poulin, Marc J ^a,b,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF CALGARY   (Canada)

^c LIBIN CARDIOVASCULAR INSTITUTE OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

ACTIMETRY; ADULT; ARTICLE; BIOAVAILABILITY; BLOOD PRESSURE REGULATION; BODY MASS; BRAIN BLOOD FLOW; BRAIN FUNCTION; BRAIN VASCULAR RESISTANCE; CARDIOVASCULAR FUNCTION; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPOXEMIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRESSOR RESPONSE; PRIORITY JOURNAL; SLEEP APNEA SYNDROME; CONTROLLED STUDY; EXPERIMENTAL MODEL; INTERMITTENT HYPOXIA;

ACUTE DISEASE; ADULT; ANOXIA; BLOOD PRESSURE; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; HUMANS; HYPERCAPNIA; MALE; MODELS, BIOLOGICAL; SLEEP APNEA, OBSTRUCTIVE; TIME FACTORS; VASCULAR RESISTANCE; YOUNG ADULT;

EID: 67650524761     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2009.171553     Document Type: Article

References (57)

1. American Academy of Sleep Medicine (1999). Sleep-related breathing disorders in adults: Recommendations for syndrome definition and measurement techniques in clinical research. The Report of an American Academy of Sleep Medicine Task Force. Sleep 22, 667-689.
2. Ainslie PN & Poulin MJ (2004). Ventilatory, cerebrovascular, and cardiovascular interactions in acute hypoxia: Regulation by carbon dioxide. J Appl Physiol 97, 149-159.
3. Arzt M, Young T, Finn L, Skatrud JB & Bradley TD (2005). Association of sleep-disordered breathing and the occurrence of stroke. Am J Respir Crit Care Med 172, 1447-1451.
4. Balfors EM & Franklin KA (1994). Impairment of cerebral perfusion during obstructive sleep apneas. Am J Respir Crit Care 150, 1587-1591.
5. Choi S, Bennett LS, Mullins R, Davies RJ & Stradling JR (2000). Which derivative from overnight oximetry best predicts symptomatic response to nasal continuous positive airway pressure in patients with obstructive sleep apnoea? Respir Med 94, 895-899.
6. Clapp BR, Hingorani AD, Kharbanda RK, Mohamed-Ali V, Stephens JW, Vallance P & MacAllister RJ (2004). Inflammation-induced endothelial dysfunction involves reduced nitric oxide bioavailability and increased oxidant stress. Cardiovasc Res 64, 172-178.
7. Cohen RA (1995). The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog Cardiovasc Dis 38, 105-128.
8. Collins R, Peto R, MacMahon S, Hebert P, Fiebach NH, Eberlein KA, Godwin J, Qizilbash N, Taylor JO & Hennekens CH (1990). Blood pressure, stroke, and coronary heart disease. Part 2. Short-term reductions in blood pressure: Overview of randomised drug trials in their epidemiological context. Lancet 335, 827-838.
9. Fletcher EC (2000). Effect of episodic hypoxia on sympathetic activity and blood pressure. Respir Physiol 119, 189-197.
10. Fletcher EC, Bao G & Li R (1999). Renin activity and blood pressure in response to chronic episodic hypoxia. Hypertension 34, 309-314.
11. Fletcher EC, Lesske J, Behm R, Miller CC 3rd, Stauss H & Unger T (1992a). Carotid chemoreceptors, systemic blood pressure, and chronic episodic hypoxia mimicking sleep apnea. J Appl Physiol 72, 1978-1984.
12. Fletcher EC, Lesske J, Culman J, Miller CC & Unger T (1992b). Sympathetic denervation blocks blood pressure elevation in episodic hypoxia. Hypertension 20, 612-619.
13. Fletcher EC, Lesske J, Qian W, Miller CC 3rd & Unger T (1992c). Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 19, 555-561.
14. Fletcher EC, Orolinova N & Bader M (2002). Blood pressure response to chronic episodic hypoxia: The renin-angiotensin system. J Appl Physiol 92, 627-633.
15. Foster GE, Hanly PJ, Ostrowski M & Poulin MJ (2007a). Effects of continuous positive airway pressure on cerebral vascular response to hypoxia in patients with obstructive sleep apnea. Am J Resp Crit Care Med 175, 720-725.
16. Foster GE, Hanly PJ, Ostrowski M & Poulin MJ (2009). Ventilatory and cerebrovascular responses to hypercapnia in patients with obstructive sleep apnoea: Effect of CPAP therapy. Respir Physiol Neurobiol 165, 73-81.
17. Foster GE, McKenzie DC, Milsom WK & Sheel AW (2005). Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia. J Physiol 567, 689-699.
18. Foster GE, Poulin MJ & Hanly PJ (2007b). Intermittent hypoxia and vascular function: Implications for obstructive sleep apnoea. Exp Physiol 92, 51-65.
19. 15 N]nitrate in biological fluids. Anal Biochem 126, 131-138.
20. Hackenthal E, Paul M, Ganten D & Taugner R (1990). Morphology, physiology, and molecular biology of renin secretion. Physiol Rev 70, 1067-1116.
21. Heintz A, Koch T & Deussen A (2005). Intact nitric oxide production is obligatory for the sustained flow response during hypercapnic acidosis in guinea pig heart. Cardiovasc Res 66, 55-63.
22. Hla KM, Young TB, Bidwell T, Palta M, Skatrud JB & Dempsey J (1994). Sleep apnea and hypertension. A population-based study. Ann Intern Med 120, 382-388.
23. 2 in newborn pig brain microvascular endothelial cells. Am J Physiol Heart Circ Physiol 264, H1485-1492.
24. Hung J, Whitford EG, Parsons RW & Hillman DR (1990). Association of sleep apnoea with myocardial infarction in men. Lancet 336, 261-264.
25. Ip MS, Lam B, Chan LY, Zheng L, Tsang KW, Fung PC & Lam WK (2000). Circulating nitric oxide is suppressed in obstructive sleep apnea and is reversed by nasal continuous positive airway pressure. Am J Respir Crit Care Med 162, 2166-2171.
26. Katayama K, Shima N, Sato Y, Qiu JC, Ishida K, Mori S & Miyamura M (2001). Effect of intermittent hypoxia on cardiovascular adaptations and response to progressive hypoxia in humans. High Alt Med Biol 2, 501-508.
27. Klienbaum D, Kupper L, Muller K & Nizam A (1998). Applied Regression Analysis and Other Multivariable Methods. Cole, Pacific Grove, CA, USA.
28. Klingelhofer J, Hajak G, Sander D, Schulz-Varszegi M, Ruther E & Conrad B (1992). Assessment of intracranial hemodynamics in sleep apnea syndrome. Stroke 23, 1427-1433.
29. Lavie L (2003). Obstructive sleep apnoea syndrome - an oxidative stress disorder. Sleep Med Rev 7, 35-51.
30. Leuenberger UA, Brubaker D, Quraishi S, Hogeman CS, Imadojemu VA & Gray KS (2005). Effects of intermittent hypoxia on sympathetic activity and blood pressure in humans. Auton Neurosci 121, 87-93.
31. Lusina SJ, Kennedy PM, Inglis JT, McKenzie DC, Ayas NT & Sheel AW (2006). Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans. J Physiol 575, 961-970.
32. Moller DS, Lind P, Strunge B & Pedersen EB (2003). Abnormal vasoactive hormones and 24-hour blood pressure in obstructive sleep apnea. Am J Hypertens 16, 274-280.
33. Morrell MJ, Finn L, Kim H, Peppard PE, Badr MS & Young T (2000). Sleep fragmentation, awake blood pressure, and sleep-disordered breathing in a population-based study. Am J Respir Crit Care Med 162, 2091-2096.
34. Narkiewicz K, van de Borne PJ, Cooley RL, Dyken ME & Somers VK (1998a). Sympathetic activity in obese subjects with and without obstructive sleep apnea. Circulation 98, 772-776.
35. Narkiewicz K, van de Borne PJ, Montano N, Dyken ME, Phillips BG & Somers VK (1998b). Contribution of tonic chemoreflex activation to sympathetic activity and blood pressure in patients with obstructive sleep apnea. Circulation 97, 943-945.
36. Nieto FJ, Young TB, Lind BK, Shahar E, Samet JM, Redline S, D'Agostino RB, Newman AB, Lebowitz MD & Pickering TG (2000). Association of sleep-disordered breathing, sleep apnea, and hypertension in a large community-based study. Sleep Heart Health Study. JAMA 283, 1829-1836.
37. O'Connor C, Thornley KS & Hanly PJ (2000). Gender differences in the polysomnographic features of obstructive sleep apnea. Am J Respir Crit Care Med 161, 1465-1472.
38. Ohta M, Nanri H, Matsushima Y, Sato Y & Ikeda M (2005). Blood pressure-lowering effects of lifestyle modification: Possible involvement of nitric oxide bioavailability. Hypertens Res 28, 779-786.
39. Peppard PE, Young T, Palta M & Skatrud J (2000). Prospective study of the association between sleep-disordered breathing and hypertension. N Engl J Med 342, 1378-1384.
40. Phillips BG, Narkiewicz K, Pesek CA, Haynes WG, Dyken ME & Somers VK (1999). Effects of obstructive sleep apnea on endothelin-1 and blood pressure. J Hypertens 17, 61-66.
41. Phillips SA, Olson EB, Morgan BJ & Lombard JH (2004). Chronic intermittent hypoxia impairs endothelium-dependent dilation in rat cerebral and skeletal muscle resistance arteries. Am J Physiol Heart Circ Physiol 286, H388-H393.
42. Placidi F, Diomedi M, Cupini LM, Bernardi G & Silvestrini M (1998). Impairment of daytime cerebrovascular reactivity in patients with obstructive sleep apnoea syndrome. J Sleep Res 7, 288-292.
43. Querido JS, Godwin JB & Sheel AW (2008). Intermittent hypoxia reduces cerebrovascular sensitivity to isocapnic hypoxia in humans. Respir Physiol Neurobiol 161, 1-9.
44. Ray CJ, Abbas MR, Coney AM & Marshall JM (2002). Interactions of adenosine, prostaglandins and nitric oxide in hypoxia-induced vasodilatation: In vivo and in vitro studies. J Physiol 544, 195-209.
45. Sahlin C, Sandberg O, Gustafson Y, Bucht G, Carlberg B, Stenlund H & Franklin KA (2008). Obstructive sleep apnea is a risk factor for death in patients with stroke: A 10-year follow-up. Arch Intern Med 168, 297-301.
46. Schulz R, Schmidt D, Blum A, Lopes-Ribeiro X, Lucke C, Mayer K, Olschewski H, Seeger W & Grimminger F (2000). Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnoea: Response to CPAP therapy. Thorax 55, 1046-1051.
47. 2 dissociation computations. J Appl Physiol 46, 599-602.
48. Shahar E, Whitney CW, Redline S, Lee ET, Newman AB, Javier Nieto F, O'Connor GT, Boland LL, Schwartz JE & Samet JM (2001). Sleep-disordered breathing and cardiovascular disease: Cross-sectional results of the Sleep Heart Health Study. Am Respir Crit Care Med 163, 19-25.
49. Somers VK, Dyken ME, Clary MP & Abboud FM (1995). Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 96, 1897-1904.
50. Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S, Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M & Young T (2008). Sleep apnea and cardiovascular disease: An American Heart Association/American College of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education Committee, Council on Clinical Cardiology, Stroke Council, and Council on Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood Institute National Center on Sleep Disorders Research (National Institutes of Health). Circulation 118, 1080-1111.
51. Tahawi Z, Orolinova N, Joshua IG, Bader M & Fletcher EC (2001). Altered vascular reactivity in arterioles of chronic intermittent hypoxic rats. J Appl Physiol 90, 2007-2013.
52. Tamisier R, Nieto L, Anand A, Cunnington D & Weiss JW (2004). Sustained muscle sympathetic activity after hypercapnic but not hypocapnic hypoxia in normal humans. Respir Physiol Neurobiol 141, 145-155.
53. Urbano F, Roux F, Schindler J & Mohsenin V (2008). Impaired cerebral autoregulation in obstructive sleep apnea. J Appl Physiol 105, 1852-1857.
54. ATP channels in vascular smooth muscles. Circ Res 92, 1225-1232.
55. Xie A, Skatrud JB, Puleo DS & Morgan BJ (2001). Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 91, 1555-1562.
56. Yaggi HK, Concato J, Kernan WN, Lichtman JH, Brass LM & Mohsenin V (2005). Obstructive sleep apnea as a risk factor for stroke and death. N Engl J Med 353, 2034-2041.
57. Young T, Peppard P, Palta M, Hla KM, Finn L, Morgan B & Skatrud J (1997). Population-based study of sleep-disordered breathing as a risk factor for hypertension. Arch Intern Med 157, 1746-1752.