Interactions between sleep, circadian function, and glucose metabolism: Implications for risk and severity of diabetes

Annals of the New York Academy of Sciences

Volumn 1311, Issue 1, 2014, Pages 151-173

  Reutrakul, Sirimon ^a   Van Cauter, Eve ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Circadian rhythms; Diabetes; Glucose metabolism; Sleep; Sleep apnea

Indexed keywords

GROWTH HORMONE;

ADIPOCYTE; ADRENERGIC SYSTEM; ARTICLE; CELL FUNCTION; CIRCADIAN RHYTHM; DIABETES CONTROL; DIABETES MELLITUS; DISEASE SEVERITY; GLUCOSE METABOLISM; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; INFLAMMATION; INSOMNIA; INSULIN RESISTANCE; INSULIN SENSITIVITY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; POSITIVE END EXPIRATORY PRESSURE; PREGNANCY; PREGNANCY DIABETES MELLITUS; REM SLEEP; SLEEP; SLEEP DISORDER; SLEEP DISORDERED BREATHING; SLEEP QUALITY; SLEEP TIME;

CIRCADIAN RHYTHMS; DIABETES; GLUCOSE METABOLISM; SLEEP; SLEEP APNEA;

BLOOD GLUCOSE; CIRCADIAN RHYTHM; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; SLEEP; SLEEP APNEA, OBSTRUCTIVE; SLEEP DEPRIVATION;

EID: 84898410889     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/nyas.12355     Document Type: Article

References (203)

1. Spiegel, K., R. Leproult & E. Van Cauter. 1999. Impact of sleep debt on metabolic and endocrine function. Lancet 354: 1435-1439.
2. Leproult, R. & E. Van Cauter. 2010. Role of sleep and sleep loss in hormonal release and metabolism. Endocr. Dev. 17: 11-21.
3. Broussard, J.L., D.A. Ehrmann, E. Van Cauter, et al. 2012. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann. Intern. Med. 157: 549-557.
4. Nedeltcheva, A.V., L. Kessler, J. Imperial & P.D. Penev. 2009. Exposure to recurrent sleep restriction in the setting of high caloric intake and physical inactivity results in increased insulin resistance and reduced glucose tolerance. J. Clin. Endocrinol. Metab. 94: 3242-3250.
5. Buxton, O.M., M. Pavlova, E.W. Reid, et al. 2010. Sleep restriction for 1 week reduces insulin sensitivity in healthy men. Diabetes 59: 2126-2133.
6. Van Leeuwen, W.M., C. Hublin, M. Sallinen, et al. 2010. Prolonged sleep restriction affects glucose metabolism in healthy young men. Int. J. Endocrinol. 2010: 108641.
7. Killick, R., C.M. Hoyos, K. Melehan, et al. 2013. The effects of 'Catch-Up' sleep on insulin sensitivity in men with lifestyle driven, chronic, intermittent sleep restriction [abstract]. The Annual Endocrine Society Meeting, San Francisco.
8. Knutson, K.L. & E. Van Cauter. 2008. Associations between sleep loss and increased risk of obesity and diabetes. Ann. N Y. Acad. Sci. 1129: 287-304.
9. Ayas, N.T., D.P. White, W.K. Al-Delaimy, et al. 2003. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care 26: 380-384.
10. Bjorkelund, C., D. Bondyr-Carlsson, L. Lapidus, et al. 2005. Sleep disturbances in midlife unrelated to 32-year diabetes incidence: the prospective population study of women in Gothenburg. Diabetes Care 28: 2739-2744.
11. Mallon, L., J.E. Broman & J. Hetta. 2005. High incidence of diabetes in men with sleep complaints or short sleep duration: a 12-year follow-up study of a middle-aged population. Diabetes Care 28: 2762-2767.
12. Yaggi, H.K., A.B. Araujo & J.B. Mckinlay. 2006. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care 29: 657-661.
13. Gangwisch, J.E., S.B. Heymsfield, B. Boden-Albala, et al. 2007. Sleep duration as a risk factor for diabetes incidence in a large U.S. sample. Sleep 30: 1667-1673.
14. Hayashino, Y., S. Fukuhara, Y. Suzukamo, et al. 2007. Relation between sleep quality and quantity, quality of life, and risk of developing diabetes in healthy workers in Japan: the High-risk and Population Strategy for Occupational Health Promotion (HIPOP-OHP) Study Bmc. Public Health 7: 129.
15. Chaput, J.P., J.P. Despres, C. Bouchard, et al. 2009. Sleep duration as a risk factor for the development of type 2 diabetes or impaired glucose tolerance: analyses of the Quebec Family Study. Sleep Med. 10: 919-924.
16. Beihl, D.A., A.D. Liese & S.M. Haffner. 2009. Sleep duration as a risk factor for incident type 2 diabetes in a multiethnic cohort. Ann. Epidemiol. 19: 351-357.
17. Xu, Q., Y. Song, A. Hollenbeck, et al. 2010. Day napping and short night sleeping are associated with higher risk of diabetes in older adults. Diabetes Care 33: 78-83.
18. Rafalson, L., R.P. Donahue, S. Stranges, et al. 2010. Short sleep duration is associated with the development of impaired fasting glucose: the Western New York Health Study. Ann. Epidemiol. 20: 883-889.
19. Cappuccio, F.P., L. D'Elia, P. Strazzullo & M.A. Miller. 2010. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 33: 414-420.
20. American Diabetes Association. 2013. Clinical practice recommendations 2013. Diabetes Care 36: S1-S110.
21. Knutson, K.L., A.M. Ryden, B.A. Mander & E. Van Cauter. 2006. Role of sleep duration and quality in the risk and severity of type 2 diabetes mellitus. Arch. Intern. Med. 166: 1768-1774.
22. Ohkuma, T., H. Fujii, M. Iwase, et al. 2013. Impact of sleep duration on obesity and the glycemic level in patients with type 2 diabetes: the Fukuoka diabetes registry. Diabetes Care 36: 611-617.
23. Bergman, R.N. 1989. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach. Diabetes 38: 1512-1527.
24. Tasali, E., R. Leproult, D.A. Ehrmann & E. Van Cauter. 2008. Slow-wave sleep and the risk of type 2 diabetes in humans. Proc. Natl. Acad. Sci. U. S. A. 105: 1044-1049.
25. Stamatakis, K.A. & N.M. Punjabi. 2010. Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest 137: 95-101.
26. Kawakami, N., N. Takatsuka & H. Shimizu. 2004. Sleep disturbance and onset of type 2 diabetes. Diabetes Care 27: 282-283.
27. Meisinger, C., M. Heier & H. Loewel. 2005. Sleep disturbance as a predictor of type 2 diabetes mellitus in men and women from the general population. Diabetologia 48: 235-241.
28. Nilsson, P.M., M. Roost, G. Engstrom, et al. 2004. Incidence of diabetes in middle-aged men is related to sleep disturbances. Diabetes Care 27: 2464-2469.
29. Knowler, W.C., D.J. Pettitt, P.J. Savage & P.H. Bennett. 1981. Diabetes incidence in Pima Indians: contributions of obesity and parental diabetes. Am. J. Epidemiol. 113: 144-156.
30. Shaten, B.J., G.D. Smith, L.H. Kuller & J.D. Neaton. 1993. Risk factors for the development of type Ii diabetes among men enrolled in the usual care group of the Multiple Risk Factor Intervention Trial. Diabetes Care 16: 1331-1339.
31. Burchfiel, C.M., J.D. Curb, B.L. Rodriguez, et al. 1995. Incidence and predictors of diabetes in Japanese-American men. The Honolulu Heart Program. Ann. Epidemiol. 5: 33-43.
32. Sargeant, L.A., N.J. Wareham & K.T. Khaw. 2000. Family history of diabetes identifies a group at increased risk for the metabolic consequences of obesity and physical inactivity in Epic-Norfolk: a population-based study. The European Prospective Investigation into Cancer Int. J. Obes. Relat. Metab. Disord. 24: 1333-1339.
33. Harrison, T.A., L.A. Hindorff, H. Kim, et al. 2003. Family history of diabetes as a potential public health tool. Am. J. Prev. Med. 24: 152-159.
34. Erasmus, R.T., B.E. Blanco, A.B. Okesina, et al. 2001. Importance of family history in type 2 black South African diabetic patients. Postgrad. Med. J. 77: 323-325.
35. Eriksson, A.K., A. Ekbom, F. Granath, et al. 2008. Psychological distress and risk of pre-diabetes and Type 2 diabetes in a prospective study of Swedish middle-aged men and women. Diabet. Med. 25: 834-842.
36. Rod, N.H., J. Vahtera, H. Westerlund, et al. 2011. Sleep disturbances and cause-specific mortality: Results from the Gazel cohort study. Am. J. Epidemiol. 173: 300-309.
37. Sorensen, M., Z.J. Andersen, R.B. Nordsborg, et al. 2013. Long-term exposure to road traffic noise and incident diabetes: a cohort study. Environ. Health Perspect. 121: 217-222.
38. Tsai, Y.W., N.H. Kann, T.H. Tung, et al. 2012. Impact of subjective sleep quality on glycemic control in type 2 diabetes mellitus. Fam. Pract. 29: 30-35.
39. Knutson, K.L., E. Van Cauter, P. Zee, et al. 2011. Cross-sectional associations between measures of sleep and markers of glucose metabolism among subjects with and without diabetes: the Coronary Artery Risk Development in Young Adults (Cardia) Sleep Study. Diabetes Care 34: 1171-1176.
40. Kushida, C.A., A. Chang, C. Gadkary, et al. 2001. Comparison of actigraphic, polysomnographic, and subjective assessment of sleep parameters in sleep-disordered patients. Sleep Med. 2: 389-396.
41. Trento, M., F. Broglio, F. Riganti, et al. 2008. Sleep abnormalities in type 2 diabetes may be associated with glycemic control. Acta Diabetol. 45: 225-229.
42. Vgontzas, A.N., D. Liao, S. Pejovic, et al. 2010. Insomnia with short sleep duration and mortality: the Penn State cohort. Sleep 33: 1159-1164.
43. Vgontzas, A.N., D. Liao, S. Pejovic, et al. 2009. Insomnia with objective short sleep duration is associated with type 2 diabetes: a population-based study. Diabetes Care 32: 1980-1985.
44. Young, T., M. Palta, J. Dempsey, et al. 1993. The occurrence of sleep-disordered breathing among middle-aged adults. N. Engl. J. Med. 328: 1230-1235.
45. Peppard, P.E., T. Young, J.H. Barnet, et al. 2013. Increased prevalence of sleep-disordered breathing in adults. Am. J. Epidemiol. 177: 1006-1014.
46. Young, T., P.E. Peppard & S. Taheri. 2005. Excess weight and sleep-disordered breathing. J. Appl. Physiol. 99: 1592-1599.
47. Louis, M. & N.M. Punjabi. 2009. Effects of acute intermittent hypoxia on glucose metabolism in awake healthy volunteers. J. Appl. Physiol. 106: 1538-1544.
48. Pamidi, S., K. Wroblewski, J. Broussard, et al. 2012. Obstructive sleep apnea in young lean men: impact on insulin sensitivity and secretion. Diabetes Care 35: 2384-2389.
49. Seicean, S., H.L. Kirchner, D.J. Gottlieb, et al. 2008. Sleep-disordered breathing and impaired glucose metabolism in normal-weight and overweight/obese individuals: the Sleep Heart Health Study. Diabetes Care 31: 1001-1006.
50. Meslier, N., F. Gagnadoux, P. Giraud, et al. 2003. Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur. Respir. J. 22: 156-160.
51. Pamidi, S., R.S. Aronsohn & E. Tasali. 2010. Obstructive sleep apnea: role in the risk and severity of diabetes. Best. Pract. Res. Clin. Endocrinol. Metab. 24: 703-715.
52. Priou, P., V.M. Le, N. Meslier, et al. 2012. Independent association between obstructive sleep apnea severity and glycated hemoglobin in adults without diabetes. Diabetes Care 35: 1902-1906.
53. Punjabi, N.M., E. Shahar, S. Redline, et al. 2004. Sleep-disordered breathing, glucose intolerance, and insulin resistance: the Sleep Heart Health Study. Am. J. Epidemiol. 160: 521-530.
54. Papanas, N., P. Steiropoulos, E. Nena, et al. 2009. HbA1c is associated with severity of obstructive sleep apnea hypopnea syndrome in nondiabetic men. Vasc. Health Risk Manag. 5: 751-756.
55. Punjabi, N.M. & B.A. Beamer. 2009. Alterations in glucose disposal in sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 179: 235-240.
56. Pamidi, S. & E. Tasali. 2012. Obstructive sleep apnea and type 2 diabetes: is there a link? Front Neurol. 3: 126.
57. Reichmuth, K.J., D. Austin, J.B. Skatrud & T. Young. 2005. Association of sleep apnea and type Ii diabetes: a population-based study. Am. J. Respir. Crit. Care Med. 172: 1590-1595.
58. Mahmood, K., N. Akhter, K. Eldeirawi, et al. 2009. Prevalence of type 2 diabetes in patients with obstructive sleep apnea in a multi-ethnic sample. J. Clin. Sleep. Med. 5: 215-221.
59. Ronksley, P.E., B.R. Hemmelgarn, S.J. Heitman, et al. 2009. Obstructive sleep apnoea is associated with diabetes in sleepy subjects. Thorax 64: 834-839.
60. Fredheim, J.M., J. Rollheim, T. Omland, et al. 2011. Type 2 diabetes and pre-diabetes are associated with obstructive sleep apnea in extremely obese subjects: a cross-sectional study. Cardiovasc. Diabetol. 10: 84.
61. Lindberg, E., J. Theorell-Haglow, M. Svensson, et al. 2012. Sleep apnea and glucose metabolism: a long-term follow-up in a community-based sample. Chest 142: 935-942.
62. Botros, N., J. Concato, V. Mohsenin, et al. 2009. Obstructive sleep apnea as a risk factor for type 2 diabetes. Am. J. Med. 122: 1122-1127.
63. Marshall, N.S., K.K. Wong, C.L. Phillips, et al. 2009. Is sleep apnea an independent risk factor for prevalent and incident diabetes in the Busselton Health Study? J. Clin. Sleep Med. 5: 15-20.
64. Muraki, I., T. Tanigawa, K. Yamagishi, et al. 2010. Nocturnal intermittent hypoxia and metabolic syndrome; the effect of being overweight: the CIRCS study. J. Atheroscler. Thromb. 17: 369-377.
65. Celen, Y.T., J. Hedner, J. Carlson & Y. Peker. 2010. Impact of gender on incident diabetes mellitus in obstructive sleep apnea: a 16-year follow-up. J. Clin. Sleep Med. 6: 244-250.
66. Wang, X., Y. Bi, Q. Zhang & F. Pan. 2013. Obstructive sleep apnoea and the risk of type 2 diabetes: a meta-analysis of prospective cohort studies. Respirology. 18: 140-146.
67. Aronsohn, R.S., H. Whitmore, E. Van Cauter & E. Tasali. 2010. Impact of untreated obstructive sleep apnea on glucose control in type 2 diabetes. Am. J. Respir. Crit. Care Med. 181: 507-513.
68. Foster, G.D., M.H. Sanders, R. Millman, et al. 2009. Obstructive sleep apnea among obese patients with type 2 diabetes. Diabetes Care 32: 1017-1019.
69. Resnick, H.E., S. Redline, E. Shahar, et al. 2003. Diabetes and sleep disturbances: findings from the Sleep Heart Health Study. Diabetes Care 26: 702-709.
70. Laaban, J.P., S. Daenen, D. Leger, et al. 2009. Prevalence and predictive factors of sleep apnoea syndrome in type 2 diabetic patients. Diabetes Metab. 35: 372-377.
71. Einhorn, D., D.A. Stewart, M.K. Erman, et al. 2007. Prevalence of sleep apnea in a population of adults with type 2 diabetes mellitus. Endocr. Pract. 13: 355-362.
72. Harada, Y., T. Oga, K. Chin, et al. 2012. Differences in relationships among sleep apnoea, glucose level, sleep duration and sleepiness between persons with and without type 2 diabetes. J. Sleep Res. 21: 410-418.
73. Pillai, A., G. Warren, W. Gunathilake & I. Idris. 2011. Effects of sleep apnea severity on glycemic control in patients with type 2 diabetes prior to continuous positive airway pressure treatment. Diabetes Technol. Ther. 13: 945-949.
74. Heffner, J.E., Y. Rozenfeld, M. Kai, et al. 2012. Prevalence of diagnosed sleep apnea among patients with type 2 diabetes in primary care. Chest 141: 1414-1421.
75. St-Onge, M.P., G. Zammit, D.M. Reboussin, et al. 2012. Associations of sleep disturbance and duration with metabolic risk factors in obese persons with type 2 diabetes: data from the Sleep AHEAD Study. Nat. Sci. Sleep 4: 143-150.
76. Kosseifi, S., B. Bailey, R. Price, et al. 2010. The association between obstructive sleep apnea syndrome and microvascular complications in well-controlled diabetic patients. Mil. Med. 175: 913-916.
77. Tahrani, A.A., A. Ali, N.T. Raymond, et al. 2012. Obstructive sleep apnea and diabetic neuropathy: a novel association in patients with type 2 diabetes. Am. J. Respir. Crit. Care Med. 186: 434-441.
78. Rudrappa, S., G. Warren & I. Idris. 2012. Obstructive sleep apnoea is associated with the development and progression of diabetic retinopathy, independent of conventional risk factors and novel biomarkers for diabetic retinopathy. Br. J. Ophthalmol. 96: 1535.
79. Fenik, V.B., R.O. Davies & L. Kubin. 2005. REM sleep-like atonia of hypoglossal (XII) motoneurons is caused by loss of noradrenergic and serotonergic inputs. Am. J. Respir. Crit. Care Med. 172: 1322-1330.
80. Mokhlesi, B. & N.M. Punjabi. 2012. "REM-related" obstructive sleep apnea: an epiphenomenon or a clinically important entity? Sleep 35: 5-7.
81. Findley, L.J., S.C. Wilhoit & P.M. Suratt. 1985. Apnea duration and hypoxemia during REM sleep in patients with obstructive sleep apnea. Chest 87: 432-436.
82. Grimaldi, D., G. Beccuti, C. Touma, et al. 2013. Association of obstructive sleep apnea in REM sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care. doi:10.2337/dc13-0933.
83. Rodway, G.W., T.E. Weaver, C. Mancini, et al. 2010. Evaluation of sham-CPAP as a placebo in CPAP intervention studies. Sleep 33: 260-266.
84. Coughlin, S.R., L. Mawdsley, J.A. Mugarza, et al. 2007. Cardiovascular and metabolic effects of CPAP in obese males with OSA. Eur. Respir. J. 29: 720-727.
85. West, S.D., D.J. Nicoll, T.M. Wallace, et al. 2007. Effect of CPAP on insulin resistance and HbA1c in men with obstructive sleep apnoea and type 2 diabetes. Thorax 62: 969-974.
86. Nguyen, P.K., C.K. Katikireddy, M.V. Mcconnell, et al. 2010. Nasal continuous positive airway pressure improves myocardial perfusion reserve and endothelial-dependent vasodilation in patients with obstructive sleep apnea. J. Cardiovasc. Magn. Reson. 12: 50.
87. Kohler, M., A.C. Stoewhas, L. Ayers, et al. 2011. Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am. J. Respir. Crit. Care Med. 184: 1192-1199.
88. Sivam, S., C.L. Phillips, M.I. Trenell, et al. 2012. Effects of 8 weeks of continuous positive airway pressure on abdominal adiposity in obstructive sleep apnoea. Eur. Respir. J. 40: 913-918.
89. Hoyos, C.M., R. Killick, B.J. Yee, et al. 2012. Cardiometabolic changes after continuous positive airway pressure for obstructive sleep apnoea: a randomised sham-controlled study. Thorax 67: 1081-1089.
90. Lam, J.C., B. Lam, T.J. Yao, et al. 2010. A randomised controlled trial of nasal continuous positive airway pressure on insulin sensitivity in obstructive sleep apnoea. Eur. Respir. J. 35: 138-145.
91. Weinstock, T.G., X. Wang, M. Rueschman, et al. 2012. A controlled trial of CPAP therapy on metabolic control in individuals with impaired glucose tolerance and sleep apnea. Sleep 35: 617-625B.
92. Iftikhar, I.H. & R.P. Blankfield. 2012. Effect of continuous positive airway pressure on hemoglobin A(1c) in patients with obstructive sleep apnea: a systematic review and meta-analysis. Lung 190: 605-611.
93. Yang, D., Z. Liu, H. Yang & Q. Luo. 2013. Effects of continuous positive airway pressure on glycemic control and insulin resistance in patients with obstructive sleep apnea: a meta-analysis. Sleep Breath. 17: 33-38.
94. Hecht, L., R. Mohler & G. Meyer. 2011. Effects of CPAP-respiration on markers of glucose metabolism in patients with obstructive sleep apnoea syndrome: a systematic review and meta-analysis. Ger. Med. Sci. 9: Doc20.
95. Pien, G.W. & R.J. Schwab. 2004. Sleep disorders during pregnancy. Sleep 27: 1405-1417.
96. Hedman, C., T. Pohjasvaara, U. Tolonen, et al. 2002. Effects of pregnancy on mothers' sleep. Sleep Med. 3: 37-42.
97. Lee, K.A., M.E. Zaffke & G. Mcenany. 2000. Parity and sleep patterns during and after pregnancy. Obstet. Gynecol. 95: 14-18.
98. Driver, H.S. & C.M. Shapiro. 1992. A longitudinal study of sleep stages in young women during pregnancy and postpartum. Sleep 15: 449-453.
99. Hertz, G., A. Fast, S.H. Feinsilver, et al. 1992. Sleep in normal late pregnancy. Sleep 15: 246-251.
100. Mindell, J.A. & B.J. Jacobson. 2000. Sleep disturbances during pregnancy. J. Obstet Gynecol. Neonatal. Nurs. 29: 590-597.
101. O'Brien, L.M., A.S. Bullough, J.T. Owusu, et al. 2012. Pregnancy-onset habitual snoring, gestational hypertension, and preeclampsia: prospective cohort study. Am. J. Obstet Gynecol. 207: 487-489.
102. Bourjeily, G., C.A. Raker, M. Chalhoub & M.A. Miller. 2010. Pregnancy and fetal outcomes of symptoms of sleep-disordered breathing. Eur. Respir. J. 36: 849-855.
103. Maasilta, P., A. Bachour, K. Teramo, O. Polo & L.A. Laitinen. 2001. Sleep-related disordered breathing during pregnancy in obese women. Chest 120: 1448-1454.
104. Facco, F.L., D. Ouyang, W. Grobman, et al. 2013. Sleep apnea is associated with an increased risk of gestational diabetes. Sleep 36: 123.
105. Facco, F.L., C.S. Liu, A.A. Cabello, et al. 2012. Sleep-disordered breathing: a risk factor for adverse pregnancy outcomes? Am. J. Perinatol. 29: 277-282.
106. Facco, F.L., W.A. Grobman, J. Kramer, et al. 2010. Self-reported short sleep duration and frequent snoring in pregnancy: impact on glucose metabolism. Am. J. Obstet Gynecol. 203: 142-145.
107. O'Brien, L.M., A.S. Bullough & M.C. Chames. 2013. Sleep duration and glucose levels in pregnant women. Sleep 36: 400.
108. Qiu, C., D. Enquobahrie, I.O. Frederick, et al. 2010. Glucose intolerance and gestational diabetes risk in relation to sleep duration and snoring during pregnancy: a pilot study BMC. Womens Health 10: 17.
109. Bourjeily, G., S.R. El, P. Sawan, et al. 2013. Epworth sleepiness scale scores and adverse pregnancy outcomes. Sleep Breath. 17: 1179-1186.
110. Ugur, M.G., K. Boynukalin, Z. Atak, et al. 2012. Sleep disturbances in pregnant patients and the relation to obstetric outcome. Clin. Exp. Obstet Gynecol. 39: 214-217.
111. Reutrakul, S., N. Zaidi, K. Wroblewski, et al. 2011. Sleep disturbances and their relationship to glucose tolerance in pregnancy. Diabetes Care 34: 2454-2457.
112. Chen, Y.H., J.H. Kang, C.C. Lin, et al. 2012. Obstructive sleep apnea and the risk of adverse pregnancy outcomes. Am. J. Obstet Gynecol. 206: 136-5.
113. Izci-Balserak, B. & G.W. Pien. 2010. Sleep-disordered breathing and pregnancy: potential mechanisms and evidence for maternal and fetal morbidity. Curr. Opin. Pulm. Med. 16: 574-582.
114. Herring, S.J., D.B. Nelson, G.W. Pien, et al. 2014. Objectively-measured sleep duration and hyperglycemia in pregnancy. Sleep Med. 15: 51-55.
115. Reutrakul, S., N. Zaidi, K. Wroblewski, et al. 2013. Interactions between pregnancy, obstructive sleep apnea, and gestational diabetes mellitus. J. Clin. Endocrinol. Metab. 98: 4195-4202.
116. Louis, J.M., D. Auckley, R.J. Sokol & B.M. Mercer. 2010. Maternal and neonatal morbidities associated with obstructive sleep apnea complicating pregnancy. Am. J. Obstet. Gynecol. 202: 261-265.
117. Champagne, K., K. Schwartzman, L. Opatrny, et al. 2009. Obstructive sleep apnoea and its association with gestational hypertension. Eur. Respir. J. 33: 559-565.
118. O'Keeffe, M. & M.P. St-Onge. 2013. Sleep duration and disorders in pregnancy: implications for glucose metabolism and pregnancy outcomes. Int. J. Obes. (Lond.) 37: 765-770.
119. Guilleminault, C., M. Kreutzer & J.L. Chang. 2004. Pregnancy, sleep disordered breathing and treatment with nasal continuous positive airway pressure. Sleep Med. 5: 43-51.
120. Thomas, M., H. Sing, G. Belenky, et al. 2000. Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity. J. Sleep Res. 9: 335-352.
121. Grassi, G., R. Dell'Oro, F. Quarti-Trevano, et al. 2005. Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 48: 1359-1365.
122. Tentolouris, N., G. Argyrakopoulou & N. Katsilambros. 2008. Perturbed autonomic nervous system function in metabolic syndrome. Neuromolecular. Med. 10: 169-178.
123. Irwin, M., J. Thompson, C. Miller, et al. 1999. Effects of sleep and sleep deprivation on catecholamine and interleukin-2 levels in humans: clinical implications. J. Clin. Endocrinol. Metab. 84: 1979-1985.
124. Reynolds, A.C., J. Dorrian, P.Y. Liu, et al. 2012. Impact of five nights of sleep restriction on glucose metabolism, leptin and testosterone in young adult men. PLoS. One. 7: e41218.
125. Leproult, R., G. Copinschi, O. Buxton & E. Van Cauter. 1997. Sleep loss results in an elevation of cortisol levels the next evening. Sleep 20: 865-870.
126. Plat, L., R. Leproult, M.L'Hermite-Baleriaux, et al. 1999. Metabolic effects of short-term elevations of plasma cortisol are more pronounced in the evening than in the morning. J. Clin. Endocrinol. Metab. 84: 3082-3092.
127. Mullington, J.M., N.S. Simpson, H.K. Meier-Ewert & M. Haack. 2010. Sleep loss and inflammation. Best. Pract. Res. Clin. Endocrinol. Metab. 24: 775-784.
128. Boudjeltia, K.Z., B. Faraut, P. Stenuit, et al. 2008. Sleep restriction increases white blood cells, mainly neutrophil count, in young healthy men: a pilot study. Vasc. Health Risk Manag. 4: 1467-1470.
129. Faraut, B., K.Z. Boudjeltia, M. Dyzma, et al. 2011. Benefits of napping and an extended duration of recovery sleep on alertness and immune cells after acute sleep restriction. Brain Behav. Immun. 25: 16-24.
130. Boyum, A., P. Wiik, E. Gustavsson, et al. 1996. The effect of strenuous exercise, calorie deficiency and sleep deprivation on white blood cells, plasma immunoglobulins and cytokines. Scand. J. Immunol. 43: 228-235.
131. Vgontzas, A.N., E. Zoumakis, E.O. Bixler, et al. 2004. Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines. J. Clin. Endocrinol. Metab. 89: 2119-2126.
132. Irwin, M.R., M. Wang, C.O. Campomayor, et al. 2006. Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation. Arch. Intern. Med. 166: 1756-1762.
133. Van Leeuwen, W.M., M. Lehto, P. Karisola, et al. 2009. Sleep restriction increases the risk of developing cardiovascular diseases by augmenting proinflammatory responses through Il-17 and Crp. PLoS One. 4: e4589.
134. Shearer, W.T., J.M. Reuben, J.M. Mullington, et al. 2001. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight. J. Allergy Clin. Immunol. 107: 165-170.
135. Wieser, V., A.R. Moschen & H. Tilg. 2013. Inflammation, cytokines and insulin resistance: a clinical perspective. Arch. Immunol. Ther. Exp. (Warsz.) 61: 119-125.
136. Spiegel, K., E. Tasali, P. Penev & E. Van Cauter. 2004. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann. Intern. Med. 141: 846-850.
137. Morselli, L.L., A. Guyon & K. Spiegel. 2012. Sleep and metabolic function. Pflugers Arch. 463: 139-160.
138. Killick, R., S. Banks & P.Y. Liu. 2012. Implications of sleep restriction and recovery on metabolic outcomes. J. Clin. Endocrinol. Metab. 97: 3876-3890.
139. Guilleminault, C., N.B. Powell, S. Martinez, et al. 2003. Preliminary observations on the effects of sleep time in a sleep restriction paradigm. Sleep Med. 4: 177-184.
140. Spiegel, K., R. Leproult, M. L'Hermite-Baleriaux, et al. 2004. Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin. J. Clin. Endocrinol. Metab. 89: 5762-5771.
141. Mullington, J.M., J.L. Chan, H.P. Van Dongen, et al. 2003. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men. J. Neuroendocrinol. 15: 851-854.
142. Nedeltcheva, A.V., J.M. Kilkus, J. Imperial, et al. 2010. Insufficient sleep undermines dietary efforts to reduce adiposity. Ann. Intern. Med. 153: 435-441.
143. Omisade, A., O.M. Buxton & B. Rusak. 2010. Impact of acute sleep restriction on cortisol and leptin levels in young women. Physiol. Behav. 99: 651-656.
144. Schmid, S.M., M. Hallschmid, K. Jauch-Chara, et al. 2008. A single night of sleep deprivation increases ghrelin levels and feelings of hunger in normal-weight healthy men. J. Sleep Res. 17: 331-334.
145. Knutson, K.L., G. Galli, X. Zhao, et al. 2011. No association between leptin levels and sleep duration or quality in obese adults. Obesity (Silver Spring) 19: 2433-2435.
146. Nedeltcheva, A.V., J.M. Kilkus, J. Imperial, et al. 2009. Sleep curtailment is accompanied by increased intake of calories from snacks. Am. J. Clin. Nutr. 89: 126-133.
147. Bosy-Westphal, A., S. Hinrichs, K. Jauch-Chara, et al. 2008. Influence of partial sleep deprivation on energy balance and insulin sensitivity in healthy women. Obes. Facts. 1: 266-273.
148. St-Onge, M.P., A.L. Roberts, J. Chen, et al. 2011. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am. J. Clin. Nutr. 94: 410-416.
149. Shechter, A., M. O'Keeffe, A.L. Roberts, et al. 2012. Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance. Am. J. Physiol. Regul. Integr. Comp. Physiol. 303: R883-R889.
150. Schmid, S.M., M. Hallschmid, K. Jauch-Chara, et al. 2009. Short-term sleep loss decreases physical activity under free-living conditions but does not increase food intake under time-deprived laboratory conditions in healthy men. Am. J. Clin. Nutr. 90: 1476-1482.
151. Benedict, C., S.J. Brooks, O.G. O'Daly, et al. 2012. Acute sleep deprivation enhances the brain's response to hedonic food stimuli: an fMRI study. J. Clin. Endocrinol. Metab. 97: E443-E447.
152. St-Onge, M.P., A. Mcreynolds, Z.B. Trivedi, et al. 2012. Sleep restriction leads to increased activation of brain regions sensitive to food stimuli. Am J. Clin. Nutr. 95: 818-824.
153. Jung, C.M., E.L. Melanson, E.J. Frydendall, et al. 2011. Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J. Physiol. 589: 235-244.
154. Markwald, R.R., E.L. Melanson, M.R. Smith, et al. 2013. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Proc. Natl. Acad. Sci. U. S. A. 110: 5695-5700.
155. Bromley, L.E., J.N. Booth, III, J.M. Kilkus, et al. 2012. Sleep restriction decreases the physical activity of adults at risk for type 2 diabetes. Sleep 35: 977-984.
156. Booth, J.N., L.E. Bromley, A.P. Darukhanavala, et al. 2012. Reduced physical activity in adults at risk for type 2 diabetes who curtail their sleep. Obesity (Silver Spring) 20: 278-284.
157. Lopez-Garcia, E., R. Faubel, L. Leon-Munoz, et al. 2008. Sleep duration, general and abdominal obesity, and weight change among the older adult population of Spain. Am. J. Clin. Nutr. 87: 310-316.
158. Hairston, K.G., M. Bryer-Ash, J.M. Norris, et al. 2010. Sleep duration and five-year abdominal fat accumulation in a minority cohort: the Iras family study. Sleep 33: 289-295.
159. Watanabe, M., H. Kikuchi, K. Tanaka & M. Takahashi. 2010. Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep 33: 161-167.
160. Chaput, J.P., J.P. Despres, C. Bouchard & A. Tremblay. 2008. The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Sleep 31: 517-523.
161. Broussard, J. & M.J. Brady. 2010. The impact of sleep disturbances on adipocyte function and lipid metabolism. Best. Pract. Res. Clin. Endocrinol. Metab. 24: 763-773.
162. Ahima, R.S., C.B. Saper, J.S. Flier & J.K. Elmquist. 2000. Leptin regulation of neuroendocrine systems. Front Neuroendocrinol. 21: 263-307.
163. Hucking, K., M. Hamilton-Wessler, M. Ellmerer & R.N. Bergman. 2003. Burst-like control of lipolysis by the sympathetic nervous system in vivo. J. Clin. Invest. 111: 257-264.
164. Knutson, K.L. & R. Leproult. 2010. Apples to oranges: comparing long sleep to short sleep. J. Sleep Res. 19: 118.
165. Drager, L.F., J.C. Jun & V.Y. Polotsky. 2010. Metabolic consequences of intermittent hypoxia: relevance to obstructive sleep apnea. Best. Pract. Res. Clin. Endocrinol. Metab. 24: 843-851.
166. Xu, J., Y.S. Long, D. Gozal & P.N. Epstein. 2009. Beta-cell death and proliferation after intermittent hypoxia: role of oxidative stress. Free Radic. Biol. Med. 46: 783-790.
167. Huang, W., K.M. Ramsey, B. Marcheva & J. Bass. 2011. Circadian rhythms, sleep, and metabolism. J. Clin. Invest. 121: 2133-2141.
168. Morris, C.J., J.N. Yang & F.A. Scheer. 2012. The impact of the circadian timing system on cardiovascular and metabolic function. Prog. Brain Res. 199: 337-358.
169. Turek, F.W., C. Joshu, A. Kohsaka, et al. 2005. Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308: 1043-1045.
170. Fonken, L.K., J.L. Workman, J.C. Walton, et al. 2010. Light at night increases body mass by shifting the time of food intake. Proc. Natl. Acad. Sci. U. S. A. 107: 18664-18669.
171. Pan, A., E.S. Schernhammer, Q. Sun & F.B. Hu. 2011. Rotating night shift work and risk of type 2 diabetes: two prospective cohort studies in women. PLoS. Med. 8: e1001141.
172. Suwazono, Y., K. Sakata, Y. Okubo, et al. 2006. Long-term longitudinal study on the relationship between alternating shift work and the onset of diabetes mellitus in male Japanese workers. J. Occup. Environ. Med. 48: 455-461.
173. Scheer, F.A., M.F. Hilton, C.S. Mantzoros & S.A. Shea. 2009. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc. Natl. Acad. Sci. U. S. A. 106: 4453-4458.
174. Buxton, O.M., S.W. Cain, S.P.O'Connor, et al. 2012. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci. Transl. Med. 4: 129ra43.
175. Wittmann, M., J. Dinich, M. Merrow & T. Roenneberg. 2006. Social jetlag: misalignment of biological and social time. Chronobiol. Int. 23: 497-509.
176. Horne, J.A. & O. Ostberg. 1976. A self-assessment questionnaire to determine morningness-eveningness in human circadian rhythms. Int. J. Chronobiol. 4: 97-110.
177. Roenneberg, T., T. Kuehnle, M. Juda, et al. 2007. Epidemiology of the human circadian clock. Sleep Med. Rev. 11: 429-438.
178. Roenneberg, T., T. Kuehnle, P.P. Pramstaller, et al. 2004. A marker for the end of adolescence. Curr. Biol. 14: R1038-R1039.
179. Merikanto, I., T. Lahti, H. Puolijoki, et al. 2013. Associations of chronotype and sleep with cardiovascular diseases and type 2 diabetes. Chronobiol. Int. 30: 470-477.
180. Wong, P.M., K.A. Roecklein, M. Muldoon & S. Manuck. 2013. Later chronotype is associated with increased risk for the metabolic syndrome. Sleep 36: A285.
181. Finn, L., E.J. Young, E. Mignot, et al. 2013. Associations of eveningness chronotype with adverse metabolic indications in the Wisconsin Sleep Cohort [abstract]. Sleep 36: 188.
182. Garaulet, M., T.A. Esteban, Y.C. Lee, et al. 2012. SIRT1 and CLOCK 3111T>C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. Int. J. Obes. (Lond.) 36:1436-1441
183. Scott, E.M., A.M. Carter & P.J. Grant. 2008. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int. J. Obes. (Lond.) 32: 658-662.
184. Woon, P.Y., P.J. Kaisaki, J. Braganca, et al. 2007. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc. Natl. Acad. Sci. U. S. A. 104: 14412-14417.
185. Lucassen, E.A., X. Zhao, K.I. Rother, et al. 2013. Evening chronotype is associated with changes in eating behavior, more sleep apnea, and increased stress hormones in short sleeping obese individuals. PLoS. One. 8: e56519.
186. Reutrakul, S., M.M. Hood, S.J. Crowley, et al. 2013. Chronotype is independently associated with glycemic control in type 2 diabetes. Diabetes Care 36: 2523-2529.
187. Brzezinski, A. 1997. Melatonin in humans. N. Engl. J. Med. 336: 186-195.
188. Waldhauser, F. & M. Dietzel. 1985. Daily and annual rhythms in human melatonin secretion: role in puberty control. Ann. N.Y. Acad. Sci. 453: 205-214.
189. Crowley, S.J. 2013. "Assessment of circadian rhythms." In The Oxford Handbook of Infant, Child, and Adolescent Sleep and Behavior. A. Wolfson & H. Montgomery-Downs, Eds.: 204-222. New York: Oxford University Press.
190. Peschke, E. & E. Muhlbauer. 2010. New evidence for a role of melatonin in glucose regulation. Best. Pract. Res. Clin. Endocrinol. Metab. 24: 829-841.
191. Slominski, R.M., R.J. Reiter, N. Schlabritz-Loutsevitch, et al. 2012. Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol. Cell Endocrinol. 351: 152-166.
192. Mcarthur, A.J., M.U. Gillette & R.A. Prosser. 1991. Melatonin directly resets the rat suprachiasmatic circadian clock in vitro. Brain Res. 565: 158-161.
193. Ramracheya, R.D., D.S. Muller, P.E. Squires, et al. 2008. Function and expression of melatonin receptors on human pancreatic islets. J. Pineal. Res. 44: 273-279.
194. Cizza, G., M. Requena, G. Galli & J.L. De. 2011. Chronic sleep deprivation and seasonality: implications for the obesity epidemic. J. Endocrinol. Invest. 34: 793-800.
195. Sparso, T., A. Bonnefond, E. Andersson, et al. 2009. G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19, 605. Europeans Diabetes 58: 1450-1456.
196. Langenberg, C., L. Pascoe, A. Mari, et al. 2009. Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia 52: 1537-1542.
197. Prokopenko, I., C. Langenberg, J.C. Florez, et al. 2009. Variants in MTNR1B influence fasting glucose levels. Nat. Genet. 41: 77-81.
198. Lyssenko, V., C.L. Nagorny, M.R. Erdos, et al. 2009. Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat. Genet. 41: 82-88.
199. Bonnefond, A., N. Clement, K. Fawcett, et al. 2012. Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes. Nat. Genet. 44: 297-301.
200. Mcmullan, C.J., E.S. Schernhammer, E.B. Rimm, et al. 2013. Melatonin secretion and the incidence of type 2 diabetes. JAMA 309: 1388-1396.
201. Diethelm, K., L. Libuda, K. Bolzenius, et al. 2010. Longitudinal associations between endogenous melatonin production and reported sleep duration from childhood to early adulthood. Horm. Res. Paediatr. 74: 390-398.
202. Hernandez, C., J. Abreu, P. Abreu, et al. 2007. Nocturnal melatonin plasma levels in patients with OSAS: the effect of CPAP. Eur. Respir. J. 30: 496-500.
203. Garfinkel, D., M. Zorin, J. Wainstein, et al. 2011. Efficacy and safety of prolonged-release melatonin in insomnia patients with diabetes: a randomized, double-blind, crossover study. Diabetes Metab Syndr. Obes. 4: 307-313.