-
1
-
-
84887627398
-
Antibiotic resistance-the need for global solutions
-
Laxminarayan, R., et al. 2013. Antibiotic resistance-the need for global solutions. Lancet Infect. Dis 13: 1057-1098.
-
(2013)
Lancet Infect. Dis
, vol.13
, pp. 1057-1098
-
-
Laxminarayan, R.1
-
2
-
-
78751477224
-
Challenges of antibacterial discovery
-
Silver, L.L. 2011. Challenges of antibacterial discovery. Clin. Microbiol. Rev. 24: 71-109.
-
(2011)
Clin. Microbiol. Rev.
, vol.24
, pp. 71-109
-
-
Silver, L.L.1
-
3
-
-
77953715540
-
Chemical genomic approaches to study model microbes
-
Barker, C.A., M.A. Farha & E.D. Brown . 2010. Chemical genomic approaches to study model microbes. Chem. Biol. 17: 624-632.
-
(2010)
Chem. Biol.
, vol.17
, pp. 624-632
-
-
Barker, C.A.1
Farha, M.A.2
Brown, E.D.3
-
4
-
-
0036500993
-
Systems biology: a brief overview
-
Kitano, H. 2002. Systems biology: a brief overview. Science 295: 1662-1664.
-
(2002)
Science
, vol.295
, pp. 1662-1664
-
-
Kitano, H.1
-
7
-
-
80051703609
-
Discovery research: the scientific challenge of finding new antibiotics
-
Livermore, D.M. 2011. Discovery research: the scientific challenge of finding new antibiotics. J. Antimicrob. Chemother. 66: 1941-1944.
-
(2011)
J. Antimicrob. Chemother.
, vol.66
, pp. 1941-1944
-
-
Livermore, D.M.1
-
8
-
-
17044373269
-
Finding the target after screening the phenotype
-
Hart, C.P. 2005. Finding the target after screening the phenotype. Drug Discov. Today 10: 513-519.
-
(2005)
Drug Discov. Today
, vol.10
, pp. 513-519
-
-
Hart, C.P.1
-
9
-
-
84865421796
-
A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents
-
Testa, C.A. & L.J. Johnson . 2012. A whole-cell phenotypic screening platform for identifying methylerythritol phosphate pathway-selective inhibitors as novel antibacterial agents. Antimicrob. Agents Chemother. 56: 4906-4913.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 4906-4913
-
-
Testa, C.A.1
Johnson, L.J.2
-
10
-
-
84874291605
-
Discovery of wall teichoic acid inhibitors as potential anti-MRSA beta-lactam combination agents
-
Wang, H., et al. 2013. Discovery of wall teichoic acid inhibitors as potential anti-MRSA beta-lactam combination agents. Chem. Biol. 20: 272-284.
-
(2013)
Chem. Biol.
, vol.20
, pp. 272-284
-
-
Wang, H.1
-
11
-
-
84912571892
-
A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria
-
Fan, J., et al. 2014. A novel high-throughput cell-based assay aimed at identifying inhibitors of DNA metabolism in bacteria. Antimicrob. Agents Chemother. 58: 7264-7272.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 7264-7272
-
-
Fan, J.1
-
12
-
-
84901261858
-
Discovery of novel cell wall-active compounds using P ywaC, a sensitive reporter of cell wall stress, in the model gram-positive bacterium Bacillus subtilis
-
Czarny, T.L., et al. 2014. Discovery of novel cell wall-active compounds using P ywaC, a sensitive reporter of cell wall stress, in the model gram-positive bacterium Bacillus subtilis. Antimicrob. Agents Chemother. 58: 3261-3269.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 3261-3269
-
-
Czarny, T.L.1
-
13
-
-
84893515743
-
Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa
-
Navarro, G., et al. 2014. Image-based 384-well high-throughput screening method for the discovery of skyllamycins A to C as biofilm inhibitors and inducers of biofilm detachment in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 58: 1092-1099.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 1092-1099
-
-
Navarro, G.1
-
14
-
-
79952662163
-
An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae
-
Peach, K.C., et al. 2011. An image-based 384-well high-throughput screening method for the discovery of biofilm inhibitors in Vibrio cholerae. Mol. Biosyst. 7: 1176-1184.
-
(2011)
Mol. Biosyst.
, vol.7
, pp. 1176-1184
-
-
Peach, K.C.1
-
15
-
-
84931280756
-
Discovery of a small molecule that inhibits bacterial ribosome biogenesis
-
Stokes, J.M., et al. 2014. Discovery of a small molecule that inhibits bacterial ribosome biogenesis. eLife. 3: e03574.
-
(2014)
eLife
, vol.3
, pp. e03574
-
-
Stokes, J.M.1
-
16
-
-
84892678751
-
Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis
-
Falconer, S.B., et al. 2014. Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis. Chem. Biol. 21: 136-145.
-
(2014)
Chem. Biol.
, vol.21
, pp. 136-145
-
-
Falconer, S.B.1
-
17
-
-
0034088491
-
Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system
-
Alksne, L.E., et al. 2000. Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system. Antimicrob. Agents Chemother. 44: 1418-1427.
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 1418-1427
-
-
Alksne, L.E.1
-
18
-
-
84858952632
-
A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway
-
Crowther, G.J., et al. 2012. A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the Sec pathway. J. Biomol. Screen. 17: 535-541.
-
(2012)
J. Biomol. Screen.
, vol.17
, pp. 535-541
-
-
Crowther, G.J.1
-
19
-
-
53349117642
-
An inhibitor of gram-negative bacterial virulence protein secretion
-
Felise, H.B., et al. 2008. An inhibitor of gram-negative bacterial virulence protein secretion. Cell Host Microbe 4: 325-336.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 325-336
-
-
Felise, H.B.1
-
20
-
-
69049093794
-
A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds
-
Donald, R.G., et al. 2009. A Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds. Chem. Biol. 16: 826-836.
-
(2009)
Chem. Biol.
, vol.16
, pp. 826-836
-
-
Donald, R.G.1
-
21
-
-
82255181188
-
Antagonism of chemical genetic interaction networks resensitize MRSA to beta-lactam antibiotics
-
Lee, S.H., et al. 2011. Antagonism of chemical genetic interaction networks resensitize MRSA to beta-lactam antibiotics. Chem. Biol. 18: 1379-1389.
-
(2011)
Chem. Biol.
, vol.18
, pp. 1379-1389
-
-
Lee, S.H.1
-
22
-
-
0036271625
-
A genome-wide strategy for the identification of essential genes in Staphylococcus aureus
-
Forsyth, R.A., et al. 2002. A genome-wide strategy for the identification of essential genes in Staphylococcus aureus. Mol. Microbiol. 43: 1387-1400.
-
(2002)
Mol. Microbiol
, vol.43
, pp. 1387-1400
-
-
Forsyth, R.A.1
-
23
-
-
0035929121
-
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA
-
Ji, Y., et al. 2001. Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science 293: 2266-2269.
-
(2001)
Science
, vol.293
, pp. 2266-2269
-
-
Ji, Y.1
-
24
-
-
69049091879
-
Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus
-
Huber, J., et al. 2009. Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus. Chem. Biol. 16: 837-848.
-
(2009)
Chem. Biol.
, vol.16
, pp. 837-848
-
-
Huber, J.1
-
25
-
-
33744994317
-
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
-
Wang, J., et al. 2006. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441: 358-361.
-
(2006)
Nature
, vol.441
, pp. 358-361
-
-
Wang, J.1
-
26
-
-
31944450795
-
Discovery of FabH/FabF inhibitors from natural products
-
Young, K., et al. 2006. Discovery of FabH/FabF inhibitors from natural products. Antimicrob. Agents. Chemother. 50: 519-526.
-
(2006)
Antimicrob. Agents. Chemother.
, vol.50
, pp. 519-526
-
-
Young, K.1
-
27
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
Payne, D.J., et al. 2007. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6: 29-40.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
-
28
-
-
75149125686
-
Recent advances and method development for drug target identification
-
Chan, J.N., C. Nislow & A. Emili . 2010. Recent advances and method development for drug target identification. Trends Pharmacol. Sci. 31: 82-88.
-
(2010)
Trends Pharmacol. Sci.
, vol.31
, pp. 82-88
-
-
Chan, J.N.1
Nislow, C.2
Emili, A.3
-
29
-
-
84891786814
-
DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements
-
Luo, H., et al. 2014. DEG 10, an update of the database of essential genes that includes both protein-coding genes and noncoding genomic elements. Nucleic Acids Res. 42: D574-580.
-
(2014)
Nucleic Acids Res
, vol.42
, pp. D574-D580
-
-
Luo, H.1
-
31
-
-
33751567092
-
Experimental and computational assessment of conditionally essential genes inEscherichia coli
-
Joyce, A.R., et al. 2006. Experimental and computational assessment of conditionally essential genes inEscherichia coli. J. Bacteriol. 188: 8259-8271.
-
(2006)
J. Bacteriol
, vol.188
, pp. 8259-8271
-
-
Joyce, A.R.1
-
32
-
-
84870479250
-
A fine scale phenotype-genotype virulence map of a bacterial pathogen
-
vanOpijnen, T. & A. Camilli . 2012. A fine scale phenotype-genotype virulence map of a bacterial pathogen. Genome Res. 22: 2541-2551.
-
(2012)
Genome Res.
, vol.22
, pp. 2541-2551
-
-
van Opijnen, T.1
Camilli, A.2
-
33
-
-
0242268400
-
Genetic requirements for mycobacterial survival during infection
-
Sassetti, C.M. & E.J. Rubin . 2003. Genetic requirements for mycobacterial survival during infection. Proc. Natl. Acad. Sci. U.S.A. 100: 12989-12994.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 12989-12994
-
-
Sassetti, C.M.1
Rubin, E.J.2
-
34
-
-
84905484563
-
Requirements for Pseudomonas aeruginosa acute burn and chronic surgical wound infection
-
Turner, K.H., et al. 2014. Requirements for Pseudomonas aeruginosa acute burn and chronic surgical wound infection. PLoS Genet. 10: e1004518.
-
(2014)
PLoS Genet
, vol.10
, pp. e1004518
-
-
Turner, K.H.1
-
35
-
-
84865768680
-
In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media
-
pii: e00113-12.
-
Umland, T.C., et al. 2012. In vivo-validated essential genes identified in Acinetobacter baumannii by using human ascites overlap poorly with essential genes detected on laboratory media. mBio. 3: pii: e00113-12.
-
(2012)
mBio
, vol.3
-
-
Umland, T.C.1
-
36
-
-
84890037649
-
Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing
-
Zhang, Y.J., et al. 2013. Tryptophan biosynthesis protects mycobacteria from CD4 T-cell-mediated killing. Cell 155: 1296-1308.
-
(2013)
Cell
, vol.155
, pp. 1296-1308
-
-
Zhang, Y.J.1
-
37
-
-
84911470344
-
Targeting bacterial central metabolism for drug development
-
Murima, P., J.D. McKinney & K. Pethe . 2014. Targeting bacterial central metabolism for drug development. Chem. Biol. 21: 1423-1432.
-
(2014)
Chem. Biol.
, vol.21
, pp. 1423-1432
-
-
Murima, P.1
McKinney, J.D.2
Pethe, K.3
-
38
-
-
84871156127
-
Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens
-
Fahnoe, K.C., et al. 2012. Non-traditional antibacterial screening approaches for the identification of novel inhibitors of the glyoxylate shunt in gram-negative pathogens. PLoS One 7: e51732.
-
(2012)
PLoS One
, vol.7
, pp. e51732
-
-
Fahnoe, K.C.1
-
39
-
-
84888004411
-
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation
-
Zlitni, S., L.F. Ferruccio & E.D. Brown . 2013. Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat. Chem. Biol. 9: 796-804.
-
(2013)
Nat. Chem. Biol.
, vol.9
, pp. 796-804
-
-
Zlitni, S.1
Ferruccio, L.F.2
Brown, E.D.3
-
41
-
-
79251537963
-
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
-
Pethe, K., et al. 2010. A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy. Nat. Commun. 1: 57.
-
(2010)
Nat. Commun.
, vol.1
, pp. 57
-
-
Pethe, K.1
-
42
-
-
84903377089
-
The future of antibiotics
-
Spellberg, B. 2014. The future of antibiotics. Crit. Care 18: 228.
-
(2014)
Crit. Care
, vol.18
, pp. 228
-
-
Spellberg, B.1
-
44
-
-
33845607284
-
Persister cells, dormancy and infectious disease
-
Lewis, K. 2007. Persister cells, dormancy and infectious disease. Nat. Rev. Microbiol. 5: 48-56.
-
(2007)
Nat. Rev. Microbiol.
, vol.5
, pp. 48-56
-
-
Lewis, K.1
-
45
-
-
34248191157
-
Recurrent upper airway infections and bacterial biofilms
-
Galli, J., et al. 2007. Recurrent upper airway infections and bacterial biofilms. J. Laryngol. Otol. 121: 341-344.
-
(2007)
J. Laryngol. Otol.
, vol.121
, pp. 341-344
-
-
Galli, J.1
-
46
-
-
78650293305
-
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections
-
Hurdle, J.G., et al. 2011. Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections. Nat. Rev. Microbiol. 9: 62-75.
-
(2011)
Nat. Rev. Microbiol.
, vol.9
, pp. 62-75
-
-
Hurdle, J.G.1
-
47
-
-
11144250804
-
Tuberculosis-metabolism and respiration in the absence of growth
-
Boshoff, H.I. & C.E. Barry, 3rd. 2005. Tuberculosis-metabolism and respiration in the absence of growth. Nat. Rev. Microbiol. 3: 70-80.
-
(2005)
Nat. Rev. Microbiol
, vol.3
, pp. 70-80
-
-
Boshoff, H.I.1
Barry, C.E.2
-
48
-
-
0037252098
-
The curious characteristics of pyrazinamide: a review
-
Zhang, Y. & D. Mitchison . 2003. The curious characteristics of pyrazinamide: a review. Int. J. Tuberc. Lung Dis. 7: 6-21.
-
(2003)
Int. J. Tuberc. Lung Dis.
, vol.7
, pp. 6-21
-
-
Zhang, Y.1
Mitchison, D.2
-
49
-
-
0242437861
-
Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid
-
Zhang, Y., et al. 2003. Mode of action of pyrazinamide: disruption of Mycobacterium tuberculosis membrane transport and energetics by pyrazinoic acid. J. Antimicrob. Chemother. 52: 790-795.
-
(2003)
J. Antimicrob. Chemother.
, vol.52
, pp. 790-795
-
-
Zhang, Y.1
-
50
-
-
81155160151
-
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis
-
Shi, W., et al. 2011. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science 333: 1630-1632.
-
(2011)
Science
, vol.333
, pp. 1630-1632
-
-
Shi, W.1
-
51
-
-
84877267006
-
Advances in the development of new tuberculosis drugs and treatment regimens
-
Zumla, A., P. Nahid & S.T. Cole . 2013. Advances in the development of new tuberculosis drugs and treatment regimens. Nat. Rev. Drug Discov. 12: 388-404.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 388-404
-
-
Zumla, A.1
Nahid, P.2
Cole, S.T.3
-
52
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries, K., et al. 2005. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307: 223-227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
-
54
-
-
84864128973
-
A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis
-
Mak, P.A., et al. 2012. A high-throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem. Biol. 7: 1190-1197.
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1190-1197
-
-
Mak, P.A.1
-
55
-
-
84886571125
-
Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model
-
Grant, S.S., et al. 2013. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem. Biol. 8: 2224-2234.
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 2224-2234
-
-
Grant, S.S.1
-
56
-
-
34247143197
-
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis
-
Cho, S.H., et al. 2007. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51: 1380-1385.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 1380-1385
-
-
Cho, S.H.1
-
57
-
-
70349647606
-
Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance
-
deCarvalho, L.P., et al. 2009. Nitazoxanide kills replicating and nonreplicating Mycobacterium tuberculosis and evades resistance. J. Med. Chem. 52: 5789-5792.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5789-5792
-
-
de Carvalho, L.P.1
-
58
-
-
36749066063
-
Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis
-
Byrne, S.T., et al. 2007. Pyrrolidine dithiocarbamate and diethyldithiocarbamate are active against growing and nongrowing persister Mycobacterium tuberculosis. Antimicrob. Agents. Chemother. 51: 4495-4497.
-
(2007)
Antimicrob. Agents. Chemother.
, vol.51
, pp. 4495-4497
-
-
Byrne, S.T.1
-
59
-
-
77955642555
-
A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections
-
Hu, Y., et al. 2010. A new approach for the discovery of antibiotics by targeting non-multiplying bacteria: a novel topical antibiotic for staphylococcal infections. PLoS One. 5: e11818.
-
(2010)
PLoS One
, vol.5
, pp. e11818
-
-
Hu, Y.1
-
60
-
-
80054682562
-
Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells
-
Kim, J.S., et al. 2011. Selective killing of bacterial persisters by a single chemical compound without affecting normal antibiotic-sensitive cells. Antimicrob. Agents. Chemother. 55: 5380-5383.
-
(2011)
Antimicrob. Agents. Chemother.
, vol.55
, pp. 5380-5383
-
-
Kim, J.S.1
-
61
-
-
0037311481
-
Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis
-
Hu, Y., A.R. Coates & D.A. Mitchison . 2003. Sterilizing activities of fluoroquinolones against rifampin-tolerant populations of Mycobacterium tuberculosis. Antimicrob. Agents. Chemother. 47: 653-657.
-
(2003)
Antimicrob. Agents. Chemother.
, vol.47
, pp. 653-657
-
-
Hu, Y.1
Coates, A.R.2
Mitchison, D.A.3
-
62
-
-
84864349736
-
Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals
-
Grant, S.S., et al. 2012. Eradication of bacterial persisters with antibiotic-generated hydroxyl radicals. Proc. Natl. Acad. Sci. U.S.A. 109: 12147-12152.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 12147-12152
-
-
Grant, S.S.1
-
63
-
-
79955886933
-
Metabolite-enabled eradication of bacterial persisters by aminoglycosides
-
Allison, K.R., M.P. Brynildsen & J.J. Collins . 2011. Metabolite-enabled eradication of bacterial persisters by aminoglycosides. Nature 473: 216-220.
-
(2011)
Nature
, vol.473
, pp. 216-220
-
-
Allison, K.R.1
Brynildsen, M.P.2
Collins, J.J.3
-
64
-
-
84884512993
-
Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus
-
Farha, M.A., et al. 2013. Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus. Chem. Biol. 20: 1168-1178.
-
(2013)
Chem. Biol.
, vol.20
, pp. 1168-1178
-
-
Farha, M.A.1
-
65
-
-
33747792090
-
Rapid test for distinguishing membrane-active antibacterial agents
-
Prakash Singh, M. 2006. Rapid test for distinguishing membrane-active antibacterial agents. J. Microbiol. Methods. 67: 125-130.
-
(2006)
J. Microbiol. Methods.
, vol.67
, pp. 125-130
-
-
Prakash Singh, M.1
-
68
-
-
84895732971
-
Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth
-
Stanley, S.A., et al. 2014. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 10: e1003946.
-
(2014)
PLoS Pathog
, vol.10
, pp. e1003946
-
-
Stanley, S.A.1
-
69
-
-
84865253965
-
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening
-
Stanley, S.A., et al. 2012. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem. Biol. 7: 1377-1384.
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
-
70
-
-
84923253954
-
Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model
-
Jayamani, E., et al. 2015. Insect-derived cecropins display activity against Acinetobacter baumannii in a whole-animal high-throughput Caenorhabditis elegans model. Antimicrob. Agents Chemother. 59: 1728-1737.
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 1728-1737
-
-
Jayamani, E.1
-
71
-
-
33745912507
-
Identification of novel antimicrobials using a live-animal infection model
-
Moy, T.I., et al. 2006. Identification of novel antimicrobials using a live-animal infection model. Proc. Natl. Acad. Sci. U.S.A. 103: 10414-10419.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 10414-10419
-
-
Moy, T.I.1
-
72
-
-
67650787333
-
High-throughput screen for novel antimicrobials using a whole animal infection model
-
Moy, T.I., et al. 2009. High-throughput screen for novel antimicrobials using a whole animal infection model. ACS Chem. Biol. 4: 527-533.
-
(2009)
ACS Chem. Biol.
, vol.4
, pp. 527-533
-
-
Moy, T.I.1
-
73
-
-
84864296849
-
An in vivo platform for rapid high-throughput antitubercular drug discovery
-
Takaki, K., et al. 2012. An in vivo platform for rapid high-throughput antitubercular drug discovery. Cell Rep. 2: 175-184.
-
(2012)
Cell Rep
, vol.2
, pp. 175-184
-
-
Takaki, K.1
-
74
-
-
84876549670
-
Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death
-
Slater, L.H., et al. 2013. Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death. ACS Chem. Biol. 8: 812-822.
-
(2013)
ACS Chem. Biol
, vol.8
, pp. 812-822
-
-
Slater, L.H.1
-
75
-
-
84923139085
-
Small molecule inhibitors of clostridium difficile toxin b-induced cellular damage
-
Tam, J., et al. 2015. Small molecule inhibitors of clostridium difficile toxin b-induced cellular damage. Chem. Biol. 22: 175-185.
-
(2015)
Chem. Biol.
, vol.22
, pp. 175-185
-
-
Tam, J.1
-
76
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors
-
Christophe, T., et al. 2009. High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5: e1000645.
-
(2009)
PLoS Pathog
, vol.5
, pp. e1000645
-
-
Christophe, T.1
-
77
-
-
84883824094
-
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
-
Pethe, K., et al. 2013. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 19: 1157-1160.
-
(2013)
Nat. Med
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
-
78
-
-
0142167588
-
Zebrafish-based small molecule discovery
-
MacRae, C.A. & R.T. Peterson . 2003. Zebrafish-based small molecule discovery. Chem. Biol. 10: 901-908.
-
(2003)
Chem. Biol.
, vol.10
, pp. 901-908
-
-
MacRae, C.A.1
Peterson, R.T.2
-
79
-
-
84928046813
-
Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane
-
Hamamoto, H., et al. 2015. Lysocin E is a new antibiotic that targets menaquinone in the bacterial membrane. Nat. Chem. Biol. 11: 127-133.
-
(2015)
Nat. Chem. Biol.
, vol.11
, pp. 127-133
-
-
Hamamoto, H.1
-
80
-
-
1842684987
-
The use of zebrafish to understand immunity
-
Trede, N.S., et al. 2004. The use of zebrafish to understand immunity. Immunity 20: 367-379.
-
(2004)
Immunity
, vol.20
, pp. 367-379
-
-
Trede, N.S.1
-
81
-
-
63149102055
-
Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants
-
Clatworthy, A.E., et al. 2009. Pseudomonas aeruginosa infection of zebrafish involves both host and pathogen determinants. Infect. Immun. 77: 1293-1303.
-
(2009)
Infect. Immun.
, vol.77
, pp. 1293-1303
-
-
Clatworthy, A.E.1
-
82
-
-
84903934442
-
Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model
-
Torraca, V., et al. 2014. Macrophage-pathogen interactions in infectious diseases: new therapeutic insights from the zebrafish host model. Dis. Model Mech. 7: 785-797.
-
(2014)
Dis. Model Mech
, vol.7
, pp. 785-797
-
-
Torraca, V.1
-
83
-
-
79958082128
-
Host-pathogen interactions made transparent with the zebrafish model
-
Meijer, A.H. & H.P. Spaink . 2011. Host-pathogen interactions made transparent with the zebrafish model. Curr. Drug Targets 12: 1000-1017.
-
(2011)
Curr. Drug Targets
, vol.12
, pp. 1000-1017
-
-
Meijer, A.H.1
Spaink, H.P.2
-
85
-
-
33747620519
-
Systems biology and combination therapy in the quest for clinical efficacy
-
Fitzgerald, J.B., et al. 2006. Systems biology and combination therapy in the quest for clinical efficacy. Nat. Chem. Biol. 2: 458-466.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 458-466
-
-
Fitzgerald, J.B.1
-
86
-
-
33845762340
-
Multi-target therapeutics: when the whole is greater than the sum of the parts
-
Zimmermann, G.R., J. Lehar & C.T. Keith . 2007. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov. Today 12: 34-42.
-
(2007)
Drug Discov. Today
, vol.12
, pp. 34-42
-
-
Zimmermann, G.R.1
Lehar, J.2
Keith, C.T.3
-
87
-
-
33746622984
-
Strategies for optimizing combinations of molecularly targeted anticancer agents
-
Dancey, J.E. & H.X. Chen . 2006. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat. Rev. Drug Discov. 5: 649-659.
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 649-659
-
-
Dancey, J.E.1
Chen, H.X.2
-
88
-
-
33645452696
-
Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application
-
Millan, M.J. 2006. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol. Ther. 110: 135-370.
-
(2006)
Pharmacol. Ther.
, vol.110
, pp. 135-370
-
-
Millan, M.J.1
-
89
-
-
0038610570
-
Systematic discovery of multicomponent therapeutics
-
Borisy, A.A., et al. 2003. Systematic discovery of multicomponent therapeutics. Proc. Natl. Acad. Sci. U.S.A. 100: 7977-7982.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 7977-7982
-
-
Borisy, A.A.1
-
90
-
-
79960302847
-
Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen
-
Ramon-Garcia, S., et al. 2011. Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen. Antimicrob. Agents Chemother. 55: 3861-3869.
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 3861-3869
-
-
Ramon-Garcia, S.1
-
91
-
-
84868149433
-
A forward chemical screen identifies antibiotic adjuvants in Escherichia coli
-
Taylor, P.L., et al. 2012. A forward chemical screen identifies antibiotic adjuvants in Escherichia coli. ACS Chem. Biol. 7: 1547-1555.
-
(2012)
ACS Chem. Biol
, vol.7
, pp. 1547-1555
-
-
Taylor, P.L.1
-
92
-
-
84872572985
-
Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to beta-lactams
-
Farha, M.A., et al. 2013. Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to beta-lactams. ACS Chem. Biol. 8: 226-233.
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 226-233
-
-
Farha, M.A.1
-
93
-
-
84903457328
-
Aspergillomarasmine A overcomes metallo-beta-lactamase antibiotic resistance
-
King, A.M., et al. 2014. Aspergillomarasmine A overcomes metallo-beta-lactamase antibiotic resistance. Nature 510: 503-506.
-
(2014)
Nature
, vol.510
, pp. 503-506
-
-
King, A.M.1
-
94
-
-
79956107885
-
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
-
Ejim, L., et al. 2011. Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat. Chem. Biol. 7: 348-350.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 348-350
-
-
Ejim, L.1
-
95
-
-
84864369297
-
Mechanism-independent method for predicting response to multidrug combinations in bacteria
-
Wood, K., et al. 2012. Mechanism-independent method for predicting response to multidrug combinations in bacteria. Proc. Natl. Acad. Sci. U.S.A. 109: 12254-12259.
-
(2012)
Proc. Natl. Acad. Sci. U.S.A.
, vol.109
, pp. 12254-12259
-
-
Wood, K.1
-
96
-
-
33847643207
-
Chemical combination effects predict connectivity in biological systems
-
Lehar, J., et al. 2007. Chemical combination effects predict connectivity in biological systems. Mol. Syst. Biol. 3: 80.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 80
-
-
Lehar, J.1
-
97
-
-
84898877069
-
Predicting selective drug targets in cancer through metabolic networks
-
Folger, O., et al. 2011. Predicting selective drug targets in cancer through metabolic networks. Mol. Syst. Biol. 7: 501.
-
(2011)
Mol. Syst. Biol.
, vol.7
, pp. 501
-
-
Folger, O.1
-
98
-
-
84855272311
-
Prediction of drug combinations by integrating molecular and pharmacological data
-
Zhao, X.M., et al. 2011. Prediction of drug combinations by integrating molecular and pharmacological data. PLoS Comput. Biol. 7: e1002323.
-
(2011)
PLoS Comput. Biol.
, vol.7
, pp. e1002323
-
-
Zhao, X.M.1
-
99
-
-
84892778654
-
A network inference method for large-scale unsupervised identification of novel drug-drug interactions
-
Guimera, R. & M. Sales-Pardo . 2013. A network inference method for large-scale unsupervised identification of novel drug-drug interactions. PLoS Comput. Biol. 9: e1003374.
-
(2013)
PLoS Comput. Biol.
, vol.9
, pp. e1003374
-
-
Guimera, R.1
Sales-Pardo, M.2
|