A mechanism-based whole-cell screening assay to identify inhibitors of protein export in Escherichia coli by the sec pathway

Journal of Biomolecular Screening

Volumn 17, Issue 4, 2012, Pages 535-541

  Crowther, Gregory J ^a   Quadri, S Arshiya ^a   Shannon Alferes, Benjamin J ^a   Van Voorhis, Wesley C ^a   Rosen, Henry ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

protein translocation; screening assay; translocase

Indexed keywords

AMIKACIN; AMPICILLIN; AZTREONAM; BETA GALACTOSIDASE; CEFAZOLIN; CEFEPIME; CEFOXITIN; CEFTRIAXONE; CLINDAMYCIN; COTRIMOXAZOLE; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; DOXYCYCLINE; ERYTHROMYCIN; GENTAMICIN; IMIPENEM; LEVOFLOXACIN; LINEZOLID; MOXIFLOXACIN; NITROFURANTOIN; OXACILLIN; PENICILLIN G; PROTEIN SYNTHESIS INHIBITOR; RIFAMPICIN; STREPTOMYCIN; SULTAMICILLIN; TETRACYCLINE; TIGECYCLINE; UNINDEXED DRUG; VANCOMYCIN;

ARTICLE; BACTERIAL SECRETION SYSTEM; BACTERIAL STRAIN; BACTERIAL TRANSLOCATION; CELL ASSAY; CELL ENGINEERING; CELL SCREENING; CONTROLLED STUDY; CYTOPLASM; DRUG SCREENING; DRUG TARGETING; ESCHERICHIA COLI; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; VALIDATION PROCESS; WHOLE CELL;

ANTI-BACTERIAL AGENTS; BETA-GALACTOSIDASE; ENZYME ASSAYS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HIGH-THROUGHPUT SCREENING ASSAYS; PROTEIN TRANSPORT; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA;

EID: 84858952632     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057111431606     Document Type: Article

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