Discovery of a small molecule that inhibits bacterial ribosome biogenesis

eLife

Volumn 3, Issue , 2014, Pages e03574-

  Stokes, Jonathan M ^a   Davis, Joseph H ^a   Mangat, Chand S ^a   Williamson, James R ^a   Brown, Eric D ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

biochemistry; cold sensitivity; E. coli; infectious disease; lamotrigine; microbiology; ribosome biogenesis; translation initiation factor IF2

Indexed keywords

INITIATION FACTOR 2; LAMOTRIGINE; MOLECULAR LIBRARY; TRIAZINE DERIVATIVE;

AMINO ACID SEQUENCE; CHEMISTRY; COLD; DRUG EFFECTS; ESCHERICHIA COLI; LARGE RIBOSOMAL SUBUNIT; METABOLISM; MOLECULAR GENETICS; MOLECULAR LIBRARY; PHARMACOLOGY; PHYSIOLOGICAL STRESS; PROTEIN SYNTHESIS; RIBOSOME; SMALL RIBOSOMAL SUBUNIT;

AMINO ACID SEQUENCE; COLD TEMPERATURE; ESCHERICHIA COLI; MOLECULAR SEQUENCE DATA; PROKARYOTIC INITIATION FACTOR-2; PROTEIN BIOSYNTHESIS; RIBOSOME SUBUNITS, LARGE, BACTERIAL; RIBOSOME SUBUNITS, SMALL, BACTERIAL; RIBOSOMES; SMALL MOLECULE LIBRARIES; STRESS, PHYSIOLOGICAL; TRIAZINES;

EID: 84931280756     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.03574     Document Type: Article

References (0)