Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents

Chemistry and Biology

Volumn 20, Issue 2, 2013, Pages 272-284

  Wang, Hao ^a   Gill, Charles J ^a   Lee, Sang H ^a   Mann, Paul ^a   Zuck, Paul ^a   Meredith, Timothy C ^b   Murgolo, Nicholas ^a   She, Xinwei ^a   Kales, Susan ^a   Liang, Lianzhu ^a   Liu, Jenny ^a   Wu, Jin ^a   Santa Maria, John ^c   Su, Jing ^a   Pan, Jianping ^a   Hailey, Judy ^a   McGuinness, Debra ^a   Tan, Christopher M ^a   Flattery, Amy ^a   Walker, Suzanne ^c   Black, Todd ^a   Roemer, Terry ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CILASTATIN; IMIPENEM; TEICHOIC ACID; TUNICAMYCIN; UNCLASSIFIED DRUG; WALL TEICHOIC ACID INHIBITOR;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL LOAD; BIOSYNTHESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; GENE REPRESSION; GENE SEQUENCE; IN VITRO STUDY; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN SUSCEPTIBLE STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PLASMA PROTEIN BINDING; POINT MUTATION; PRIORITY JOURNAL; STAPHYLOCOCCUS EPIDERMIDIS;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; CELL WALL; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; OSMOLAR CONCENTRATION; PHENOTYPE; SEQUENCE ANALYSIS, DNA; TEICHOIC ACIDS; TEMPERATURE;

EID: 84874291605     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.11.013     Document Type: Article

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