Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage

Chemistry and Biology

Volumn 22, Issue 2, 2015, Pages 175-185

  Tam, John ^a   Beilhartz, Greg L ^a   Auger, Anick ^a   Gupta, Pulkit ^b   Therien, Alex G ^b   Melnyk, Roman A ^a,c  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; CLOSTRIDIUM DIFFICILE TOXIN B; CYTOPROTECTIVE AGENT; MEPACRINE; BACTERIAL PROTEIN; BACTERIAL TOXIN; BIFLAVONOID; CATECHIN; CHOLIC ACID DERIVATIVE; EPIGALLOCATECHIN GALLATE; GALLIC ACID; METHYL CHOLATE; MOLECULAR LIBRARY; PHLORETIN; PROTEIN BINDING; THEAFLAVIN DIGALLATE; TOXB PROTEIN, CLOSTRIDIUM DIFFICILE;

ACIDIFICATION; ARTICLE; BIOLOGICAL ACTIVITY; CELL DAMAGE; CELL DEATH; CELL STRUCTURE; CHANNEL GATING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; ENDOSOME; FIBROBLAST; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; LYSOSOME; NECROSIS; PH; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; THERMOSTABILITY; WESTERN BLOTTING; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; CHEMISTRY; CHLOROCEBUS AETHIOPS; DRUG EFFECTS; KINETICS; METABOLISM; MOLECULAR LIBRARY; PEPTOCLOSTRIDIUM DIFFICILE; VERO CELL LINE;

CLOSTRIDIUM DIFFICILE;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; BIFLAVONOIDS; CATECHIN; CELL LINE; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; CHOLATES; CLOSTRIDIUM DIFFICILE; GALLIC ACID; HUMANS; KINETICS; NECROSIS; PHLORETIN; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; VERO CELLS;

EID: 84923139085     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.12.010     Document Type: Article

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