Lysocin e is a new antibiotic that targets menaquinone in the bacterial membrane

Nature Chemical Biology

Volumn 11, Issue 2, 2015, Pages 127-133

  Hamamoto, Hiroshi ^a   Urai, Makoto ^a,h   Ishii, Kenichi ^a   Yasukawa, Jyunichiro ^a   Paudel, Atmika ^a   Murai, Motoki ^a   Kaji, Takuya ^a   Kuranaga, Takefumi ^a   Hamase, Kenji ^b   Katsu, Takashi ^c   Su, Jie ^a   Adachi, Tatsuo ^a   Uchida, Ryuji ^d   Tomoda, Hiroshi ^d   Yamada, Maki ^e,f   Souma, Manabu ^g   Kurihara, Hiroki ^e,f   Inoue, Masayuki ^a   Sekimizu, Kazuhisa ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c YASUDA WOMEN'S UNIVERSITY   (Japan)

^d KITASATO UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g MASIS Inc   (Japan)

^h NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CYCLOPEPTIDE; FARNOQUINONE; LYSOCIN E;

ANIMAL; ANTAGONISTS AND INHIBITORS; BACTERIOLYSIS; BOMBYX; CELL MEMBRANE; CHEMICAL STRUCTURE; DISEASE MODEL; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; GRAM POSITIVE BACTERIUM; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; LYSOBACTER; MEMBRANE POTENTIAL; METABOLISM; MICROBIAL SENSITIVITY TEST; MICROBIOLOGY; MOUSE; PROCEDURES; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BACTERIOLYSIS; BOMBYX; CELL MEMBRANE; DISEASE MODELS, ANIMAL; DRUG DISCOVERY; GRAM-POSITIVE BACTERIA; LYSOBACTER; MEMBRANE POTENTIALS; MICE; MICE, INBRED ICR; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PEPTIDES, CYCLIC; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VITAMIN K 2;

EID: 84928046813     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1710     Document Type: Article

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