-
1
-
-
84874010711
-
Tuberculosis
-
Zumla, A., Raviglione, M., Hafner, R. & von Reyn, C. F. Tuberculosis. N. Engl. J. Med. 368, 745-755 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 745-755
-
-
Zumla, A.1
Raviglione, M.2
Hafner, R.3
Von Reyn, C.F.4
-
3
-
-
0033581124
-
Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
-
Dye, C., Scheele, S., Dolin, P., Pathania, V. & Raviglione, M. C. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 282, 677-686 (1999).
-
(1999)
JAMA
, vol.282
, pp. 677-686
-
-
Dye, C.1
Scheele, S.2
Dolin, P.3
Pathania, V.4
Raviglione, M.C.5
-
4
-
-
84880142045
-
Old ideas to innovate TB control: Preventive treatment to achieve elimination
-
8 Feb 2013 (doi:10.1183/09031936.00205512)
-
Diel, R. et al. Old ideas to innovate TB control: preventive treatment to achieve elimination. Eur. Respir. J. 8 Feb 2013 (doi:10.1183/09031936. 00205512).
-
Eur. Respir. J
-
-
Diel, R.1
-
5
-
-
84861029136
-
Scaling up interventions to achieve global tuberculosis control: Progress and new developments
-
Raviglione, M. et al. Scaling up interventions to achieve global tuberculosis control: progress and new developments. Lancet 379, 1902-1913 (2012).
-
(2012)
Lancet
, vol.379
, pp. 1902-1913
-
-
Raviglione, M.1
-
8
-
-
84865498579
-
Modelling tuberculosis trends in the USA
-
Hill, A. N., Becerra, J. & Castro, K. G. Modelling tuberculosis trends in the USA. Epidemiol. Infect. 140, 1862-1872 (2012).
-
(2012)
Epidemiol. Infect.
, vol.140
, pp. 1862-1872
-
-
Hill, A.N.1
Becerra, J.2
Castro, K.G.3
-
9
-
-
84872131305
-
Infectious disease. Approval of novel TB drug celebrated-with restraint
-
Cohen, J. Infectious disease. Approval of novel TB drug celebrated-with restraint. Science 339, 130 (2013).
-
(2013)
Science
, vol.339
, pp. 130
-
-
Cohen, J.1
-
11
-
-
33744910897
-
-
Tuberculosis Coalition for Technical Assistance, Tuberculosis Coalition for Technical Assistance
-
Tuberculosis Coalition for Technical Assistance. International Standards for Tuberculosis Care (ISTC) 2nd edn (Tuberculosis Coalition for Technical Assistance, 2009)
-
(2009)
International Standards for Tuberculosis Care (ISTC) 2nd Edn
-
-
-
12
-
-
69949099207
-
Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion
-
Johnson, J. L. et al. Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion. Am. J. Respir. Crit. Care Med. 180, 558-563 (2009).
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.180
, pp. 558-563
-
-
Johnson, J.L.1
-
13
-
-
79953853899
-
Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: The study C randomized controlled trial
-
Lienhardt, C. et al. Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the study C randomized controlled trial. JAMA 305, 1415-1423 (2011).
-
(2011)
JAMA
, vol.305
, pp. 1415-1423
-
-
Lienhardt, C.1
-
14
-
-
84864425173
-
Old drugs, new purpose: Retooling existing drugs for optimized treatment of resistant tuberculosis
-
Dooley, K. E. et al. Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis. Clin. Infect. Dis. 55, 572-581 (2012).
-
(2012)
Clin. Infect. Dis.
, vol.55
, pp. 572-581
-
-
Dooley, K.E.1
-
15
-
-
80053067126
-
WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
-
Falzon, D. et al. WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. Eur. Respir. J. 38, 516-528 (2011).
-
(2011)
Eur. Respir. J.
, vol.38
, pp. 516-528
-
-
Falzon, D.1
-
16
-
-
84875602728
-
Advances in tuberculosis diagnostics: The Xpert MTB/RIF assay and future prospects for a point-of-care test
-
Lawn, S. D. & Zumla, A. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect. Dis. 13, 349-361 (2013).
-
(2013)
Lancet Infect. Dis.
, vol.13
, pp. 349-361
-
-
Lawn, S.D.1
Zumla, A.2
-
17
-
-
84880151052
-
Rapid molecular TB diagnosis: Evidence, policy-making and global implementation of Xpert®MTB/RIF
-
22 Nov 2012 (doi:10.1183/09031936.00157212)
-
Weyer, K. et al. Rapid molecular TB diagnosis: evidence, policy-making and global implementation of Xpert®MTB/RIF. Eur. Respir. J. 22 Nov 2012 (doi:10.1183/09031936.00157212).
-
Eur. Respir. J
-
-
Weyer, K.1
-
18
-
-
33750629139
-
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
-
Gandhi, N. R. et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368, 1575-1580 (2006).
-
(2006)
Lancet
, vol.368
, pp. 1575-1580
-
-
Gandhi, N.R.1
-
19
-
-
77952547476
-
Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: A retrospective cohort study
-
Dheda, K. et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet 375, 1798-1807 (2010).
-
(2010)
Lancet
, vol.375
, pp. 1798-1807
-
-
Dheda, K.1
-
20
-
-
77953771813
-
Treatment outcomes among patients with extensively drug-resistant tuberculosis: Systematic review and meta-analysis
-
Jacobson, K. R., Tierney, D. B., Jeon, C. Y., Mitnick, C. D. & Murray, M. B. Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis. Clin. Infect. Dis. 51, 6-14 (2010).
-
(2010)
Clin. Infect. Dis.
, vol.51
, pp. 6-14
-
-
Jacobson, K.R.1
Tierney, D.B.2
Jeon, C.Y.3
Mitnick, C.D.4
Murray, M.B.5
-
21
-
-
84880158505
-
Drug resistance beyond XDR-TB: Results from a large individual patient data meta-analysis
-
11 Oct 2012 (doi:10.1183/09031936.00136312)
-
Migliori, G. B. et al. Drug resistance beyond XDR-TB: results from a large individual patient data meta-analysis. Eur. Respir. J. 11 Oct 2012 (doi:10.1183/09031936.00136312).
-
Eur. Respir. J
-
-
Migliori, G.B.1
-
22
-
-
84856711991
-
Totally drug-resistant tuberculosis in India
-
Udwadia, Z. F., Amale, R. A., Ajbani, K. K. & Rodrigues, C. Totally drug-resistant tuberculosis in India. Clin. Infect. Dis. 54, 579-581 (2012).
-
(2012)
Clin. Infect. Dis.
, vol.54
, pp. 579-581
-
-
Udwadia, Z.F.1
Amale, R.A.2
Ajbani, K.K.3
Rodrigues, C.4
-
24
-
-
80053902179
-
New tuberculosis drugs on the horizon
-
Cole, S. T. & Riccardi, G. New tuberculosis drugs on the horizon. Curr. Opin. Microbiol. 14, 570-576 (2011).
-
(2011)
Curr. Opin. Microbiol.
, vol.14
, pp. 570-576
-
-
Cole, S.T.1
Riccardi, G.2
-
25
-
-
79251589638
-
The challenge of new drug discovery for tuberculosis
-
Koul, A., Arnoult, E., Lounis, N., Guillemont, J. & Andries, K. The challenge of new drug discovery for tuberculosis. Nature 469, 483-490 (2011)
-
(2011)
Nature
, vol.469
, pp. 483-490
-
-
Koul, A.1
Arnoult, E.2
Lounis, N.3
Guillemont, J.4
Andries, K.5
-
26
-
-
0034982047
-
Tuberculosis. Scientific blueprint for tuberculosis drug development
-
Global-Alliance for TB Drug Development
-
Global-Alliance for TB Drug Development. Tuberculosis. Scientific blueprint for tuberculosis drug development. Tuberculosis (Edinb.) 81, (Suppl. 1), 1-52 (2001).
-
(2001)
Tuberculosis (Edinb.)
, vol.81
, Issue.SUPPL. 1
, pp. 1-52
-
-
-
27
-
-
70449705831
-
The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
-
Barry, C. E. et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Rev. Microbiol. 7, 845-855 (2009).
-
(2009)
Nature Rev. Microbiol.
, vol.7
, pp. 845-855
-
-
Barry, C.E.1
-
28
-
-
0038628994
-
Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days
-
Jindani, A., Doré, C. J. & Mitchison, D. A. Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days. Am. J. Respir. Crit. Care Med. 167, 1348-1354 (2003).
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 1348-1354
-
-
Jindani, A.1
Doré, C.J.2
Mitchison, D.A.3
-
29
-
-
50649089808
-
The early bactericidal activity of anti-tuberculosis drugs: A literature review
-
Donald, P. R. & Diacon, A. H. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis (Edinb.) 88, (Suppl. 1), 75-83 (2008).
-
(2008)
Tuberculosis (Edinb.)
, vol.88
, Issue.SUPPL. 1
, pp. 75-83
-
-
Donald, P.R.1
Diacon, A.H.2
-
30
-
-
1642537638
-
Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis
-
Nuermberger, E. L. et al. Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis. Am. J. Respir. Crit. Care Med. 169, 421-426 (2004).
-
(2004)
Am. J. Respir. Crit. Care Med.
, vol.169
, pp. 421-426
-
-
Nuermberger, E.L.1
-
31
-
-
77953475812
-
Global tuberculosis drug development pipeline: The need and the reality
-
Ma, Z., Lienhardt, C., McIlleron, H., Nunn, A. J. & Wang, X. Global tuberculosis drug development pipeline: the need and the reality. Lancet 375, 2100-2109 (2010).
-
(2010)
Lancet
, vol.375
, pp. 2100-2109
-
-
Ma, Z.1
Lienhardt, C.2
McIlleron, H.3
Nunn, A.J.4
Wang, X.5
-
32
-
-
38049038389
-
Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model
-
Rosenthal, I. M. et al. Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med. 4, e344 (2007).
-
(2007)
PLoS Med.
, vol.4
-
-
Rosenthal, I.M.1
-
33
-
-
83155182847
-
Three months of rifapentine and isoniazid for latent tuberculosis infection
-
Sterling, T. R. et al. Three months of rifapentine and isoniazid for latent tuberculosis infection. N. Engl. J. Med. 365, 2155-2166 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 2155-2166
-
-
Sterling, T.R.1
-
34
-
-
34547620711
-
Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears
-
Diacon, A. H. et al. Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob. Agents Chemother. 51, 2994-2996 (2007).
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 2994-2996
-
-
Diacon, A.H.1
-
35
-
-
79953905145
-
Why do we use 600 mg of rifampicin in tuberculosis treatment?
-
van Ingen, J. et al. Why do we use 600 mg of rifampicin in tuberculosis treatment? Clin. Infect. Dis. 52, e194-e199 (2011).
-
(2011)
Clin. Infect. Dis.
, vol.52
-
-
Van Ingen, J.1
-
36
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
Andries, K. et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223-227 (2005).
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
-
37
-
-
84872371975
-
Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: A systematic review and meta-analysis
-
Dey, T. et al. Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis. J. Antimicrob. Chemother. 68, 284-293 (2013).
-
(2013)
J. Antimicrob. Chemother.
, vol.68
, pp. 284-293
-
-
Dey, T.1
-
38
-
-
77952365008
-
Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis
-
Van Deun, A. et al. Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis. Am. J. Respir. Crit. Care Med. 182, 684-692 (2010).
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.182
, pp. 684-692
-
-
Van Deun, A.1
-
39
-
-
84872859798
-
Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice
-
Verma, R. K. et al. Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice. Antimicrob. Agents Chemother. 57, 1050-1052 (2013).
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 1050-1052
-
-
Verma, R.K.1
-
40
-
-
84868007876
-
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
-
Zhang, M. et al. Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis. Antimicrob. Agents Chemother. 56, 5782-5789 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5782-5789
-
-
Zhang, M.1
-
41
-
-
0025992490
-
Oxazolidinone, a new class of synthetic antituberculosis agent: In vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis
-
Ashtekar, D. R. et al. Oxazolidinone, a new class of synthetic antituberculosis agent: in vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis. Diagn. Microbiol. Infect. Dis. 14, 465-471 (1991).
-
(1991)
Diagn. Microbiol. Infect. Dis.
, vol.14
, pp. 465-471
-
-
Ashtekar, D.R.1
-
42
-
-
24044461782
-
Linezolid for the treatment of multidrug-resistant tuberculosis
-
Fortun, J. et al. Linezolid for the treatment of multidrug-resistant tuberculosis. J. Antimicrob. Chemother. 56, 180-185 (2005).
-
(2005)
J. Antimicrob. Chemother.
, vol.56
, pp. 180-185
-
-
Fortun, J.1
-
43
-
-
84867614599
-
Linezolid for treatment of chronic extensively drug-resistant tuberculosis
-
Lee, M. et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N. Engl. J. Med. 367, 1508-1518 (2012)
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1508-1518
-
-
Lee, M.1
-
44
-
-
84864518733
-
Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: Systematic review and meta-analysis
-
Sotgiu, G. et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur. Respir. J. 40, 1430-1442 (2012).
-
(2012)
Eur. Respir. J.
, vol.40
, pp. 1430-1442
-
-
Sotgiu, G.1
-
45
-
-
78751693374
-
Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis
-
Wallis, R. S. et al. Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis. Antimicrob. Agents Chemother. 55, 567-574 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.55
, pp. 567-574
-
-
Wallis, R.S.1
-
46
-
-
77955706291
-
Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers
-
Wallis, R. S. et al. Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. J. Infect. Dis. 202, 745-751 (2010).
-
(2010)
J. Infect. Dis.
, vol.202
, pp. 745-751
-
-
Wallis, R.S.1
-
47
-
-
84855928950
-
Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide
-
Wallis, R. S. et al. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide. PLoS ONE 7, e30479 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Wallis, R.S.1
-
48
-
-
84877251559
-
A 14-day multiple ascending dose study: AZD5847 is well tolerated at predicted exposure for treatment of tuberculosis (TB) (Abstract A1-1735)
-
[online]
-
Reele, S. et al. A 14-day multiple ascending dose study: AZD5847 is well tolerated at predicted exposure for treatment of tuberculosis (TB) (Abstract A1-1735). 51st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy [online], http://www.abstractsonline.com/plan/ViewAbstract.asp x?mID=2789&sKey=0b498641-f10a-4936-b80c-d 274ffe4b143&cKey=2271e63a- 2cdc-4956-b7b0-6f7dc642b346&mKey=%7B0C918954-D607-46A7-8 073-44F4B537A439%7D (2011).
-
(2011)
51st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Reele, S.1
-
49
-
-
61349183785
-
Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
-
Hugonnet, J. E. et al. Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 323, 1215-1218 (2009).
-
(2009)
Science
, vol.323
, pp. 1215-1218
-
-
Hugonnet, J.E.1
-
50
-
-
84867471468
-
Meropenem inhibits D, D-carboxypeptidase activity in Mycobacterium tuberculosis
-
Kumar, P. et al. Meropenem inhibits D, D-carboxypeptidase activity in Mycobacterium tuberculosis. Mol. Microbiol. 86, 367-381 (2012).
-
(2012)
Mol. Microbiol.
, vol.86
, pp. 367-381
-
-
Kumar, P.1
-
51
-
-
85027929829
-
Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis
-
Dauby, N., Muylle, I., Mouchet, F., Sergysels, R. & Payen, M. C. Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis. Pediatr. Infect. Dis. J. 30, 812-813 (2011).
-
(2011)
Pediatr. Infect. Dis. J.
, vol.30
, pp. 812-813
-
-
Dauby, N.1
Muylle, I.2
Mouchet, F.3
Sergysels, R.4
Payen, M.C.5
-
52
-
-
84870747517
-
Efficacy and safety of meropenem/clavunate added to linezolid containing regimens in the treatment of M/XDR-TB
-
20 Sept 2012 (doi:10.1183/09031936.00124312)
-
De Lorenzo, S. et al. Efficacy and safety of meropenem/clavunate added to linezolid containing regimens in the treatment of M/XDR-TB. Eur. Respir. J. 20 Sept 2012 (doi:10.1183/09031936.00124312).
-
Eur. Respir. J
-
-
De Lorenzo, S.1
-
53
-
-
34248998479
-
Diarylquinolines target subunit c of mycobacterial ATP synthase
-
Koul, A. et al. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nature Chem. Biol. 3, 323-324 (2007).
-
(2007)
Nature Chem. Biol.
, vol.3
, pp. 323-324
-
-
Koul, A.1
-
54
-
-
62949223223
-
Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue
-
Haagsma, A. C. et al. Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue. Antimicrob. Agents Chemother. 53, 1290-1292 (2009).
-
(2009)
Antimicrob. Agents Chemother.
, vol.53
, pp. 1290-1292
-
-
Haagsma, A.C.1
-
55
-
-
77149123917
-
Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor
-
Huitric, E. et al. Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor. Antimicrob. Agents Chemother. 54, 1022-1028 (2009).
-
(2009)
Antimicrob. Agents Chemother.
, vol.54
, pp. 1022-1028
-
-
Huitric, E.1
-
56
-
-
84872038902
-
0 ATP synthase and a novel model for mechanism of action of the TB drug TMC207
-
0 ATP synthase and a novel model for mechanism of action of the TB drug TMC207. Antimicrob. Agents Chemother. 57, 168-176 (2013).
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 168-176
-
-
Biukovic, G.1
-
57
-
-
54449084104
-
Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
-
Koul, A. et al. Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J. Biol. Chem. 283, 25273-25280 (2008).
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 25273-25280
-
-
Koul, A.1
-
58
-
-
50149113470
-
The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
-
Rao, S. P., Alonso, S., Rand, L., Dick, T. & Pethe, K. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 105, 11945-11950 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 11945-11950
-
-
Rao, S.P.1
Alonso, S.2
Rand, L.3
Dick, T.4
Pethe, K.5
-
59
-
-
66649090346
-
The diarylquinoline TMC207 for multidrug-resistant tuberculosis
-
Diacon, A. H. et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360, 2397-2405 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 2397-2405
-
-
Diacon, A.H.1
-
60
-
-
58349103319
-
A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis
-
Veziris, N. et al. A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis. Am. J. Respir. Crit. Care Med. 179, 75-79 (2009).
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.179
, pp. 75-79
-
-
Veziris, N.1
-
61
-
-
49049106807
-
Prevention of drug carryover effects in studies assessing antimycobacterial efficacy of TMC207
-
Lounis, N. et al. Prevention of drug carryover effects in studies assessing antimycobacterial efficacy of TMC207. J. Clin. Microbiol. 46, 2212-2215 (2008).
-
(2008)
J. Clin. Microbiol.
, vol.46
, pp. 2212-2215
-
-
Lounis, N.1
-
62
-
-
84865540183
-
Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
-
Lin, P. L. et al. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proc. Natl Acad. Sci. USA 109, 14188-14193 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 14188-14193
-
-
Lin, P.L.1
-
63
-
-
0034702247
-
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
-
Stover, C. K. et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 405, 962-966 (2000).
-
(2000)
Nature
, vol.405
, pp. 962-966
-
-
Stover, C.K.1
-
64
-
-
33845323336
-
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
-
Matsumoto, M. et al. OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 3, e466 (2006).
-
(2006)
PLoS Med.
, vol.3
-
-
Matsumoto, M.1
-
65
-
-
31044452898
-
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
-
Manjunatha, U. H. et al. Identification of a nitroimidazo-oxazine- specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 103, 431-436 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 431-436
-
-
Manjunatha, U.H.1
-
66
-
-
57149099588
-
PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
-
Singh, R. et al. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science 322, 1392-1395 (2008).
-
(2008)
Science
, vol.322
, pp. 1392-1395
-
-
Singh, R.1
-
67
-
-
33749513414
-
Mycobacterium leprae is naturally resistant to PA-824
-
Manjunatha, U. H. et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob. Agents Chemother. 50, 3350-3354 (2006).
-
(2006)
Antimicrob. Agents Chemother.
, vol.50
, pp. 3350-3354
-
-
Manjunatha, U.H.1
-
68
-
-
54549121616
-
A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
-
Hurdle, J. G. et al. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. J. Antimicrob. Chemother. 62, 1037-1045 (2008).
-
(2008)
J. Antimicrob. Chemother.
, vol.62
, pp. 1037-1045
-
-
Hurdle, J.G.1
-
69
-
-
77951298792
-
The mechanism of action of PA-824: Novel insights from transcriptional profiling
-
Manjunatha, U., Boshoff, H. I. & Barry, C. E. The mechanism of action of PA-824: Novel insights from transcriptional profiling. Commun. Integr. Biol. 2, 215-218 (2009).
-
(2009)
Commun. Integr. Biol.
, vol.2
, pp. 215-218
-
-
Manjunatha, U.1
Boshoff, H.I.2
Barry, C.E.3
-
70
-
-
84861124193
-
Phase II dose-ranging trial of the early bactericidal activity of PA-824; Antimicrob
-
Diacon, A. et al. Phase II dose-ranging trial of the early bactericidal activity of PA-824; Antimicrob. Agents Chemother. 56, 3027-3031 (2012).
-
(2012)
Agents Chemother.
, vol.56
, pp. 3027-3031
-
-
Diacon, A.1
-
71
-
-
84866177379
-
14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: A randomised trial
-
Diacon, A. H. et al. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986-993 (2012)
-
(2012)
Lancet
, vol.380
, pp. 986-993
-
-
Diacon, A.H.1
-
72
-
-
79958718650
-
Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients
-
Diacon, A. H. et al. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 15, 949-954 (2011).
-
(2011)
Int. J. Tuberc. Lung Dis.
, vol.15
, pp. 949-954
-
-
Diacon, A.H.1
-
73
-
-
84861864703
-
Delamanid for multidrug-resistant pulmonary tuberculosis
-
Gler, M. T. et al. Delamanid for multidrug-resistant pulmonary tuberculosis. N. Engl. J. Med. 366, 2151-2160 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2151-2160
-
-
Gler, M.T.1
-
74
-
-
84878776777
-
Delamanid improves outcomes and reduces mortality for multidrug-resistant tuberculosis
-
27 Sept 2012 (doi:10.1183/09031936.00125812)
-
Skripconoka, V. et al. Delamanid improves outcomes and reduces mortality for multidrug-resistant tuberculosis. Eur. Respir. J. 27 Sept 2012 (doi:10.1183/09031936.00125812).
-
Eur. Respir. J
-
-
Skripconoka, V.1
-
75
-
-
0038700567
-
Combinatorial lead optimization of [1, 2]-diamines based on ethambutol as potential antituberculosis preclinical candidates
-
Lee, R. E. et al. Combinatorial lead optimization of [1, 2]-diamines based on ethambutol as potential antituberculosis preclinical candidates. J. Comb. Chem. 5, 172-187 (2003).
-
(2003)
J. Comb. Chem.
, vol.5
, pp. 172-187
-
-
Lee, R.E.1
-
76
-
-
84863404695
-
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
-
Tahlan, K. et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56, 1797-1809 (2012)
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 1797-1809
-
-
Tahlan, K.1
-
77
-
-
77953797826
-
In vitro interactions between new antitubercular drug candidates SQ109 and TMC207
-
Reddy, V. M., Einck, L., Andries, K. & Nacy, C. A. In vitro interactions between new antitubercular drug candidates SQ109 and TMC207. Antimicrob. Agents Chemother. 54, 2840-2846 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 2840-2846
-
-
Reddy, V.M.1
Einck, L.2
Andries, K.3
Nacy, C.A.4
-
78
-
-
84858677107
-
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
-
Grzegorzewicz, A. E. et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nature Chem. Biol. 8, 334-341 (2012).
-
(2012)
Nature Chem. Biol.
, vol.8
, pp. 334-341
-
-
Grzegorzewicz, A.E.1
-
79
-
-
84455173193
-
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
-
La Rosa, V. et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob. Agents Chemother. 56, 324-331 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 324-331
-
-
La Rosa, V.1
-
80
-
-
84865253965
-
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening
-
Stanley, S. A. et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem. Biol. 7, 1377-1384 (2012).
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
-
81
-
-
65649096556
-
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
-
Makarov, V. et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324, 801-804 (2009).
-
(2009)
Science
, vol.324
, pp. 801-804
-
-
Makarov, V.1
-
82
-
-
77950141431
-
Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones
-
Pasca, M. R. et al. Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones. Antimicrob. Agents Chemother. 54, 1616-1618 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 1616-1618
-
-
Pasca, M.R.1
-
83
-
-
84868032303
-
In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis
-
Lechartier, B., Hartkoorn, R. C. & Cole, S. T. In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56, 5790-5793 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5790-5793
-
-
Lechartier, B.1
Hartkoorn, R.C.2
Cole, S.T.3
-
84
-
-
84865960733
-
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
-
Neres, J. et al. Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci. Transl. Med. 4, 150ra121 (2012).
-
(2012)
Sci. Transl. Med.
, vol.4
-
-
Neres, J.1
-
85
-
-
77957310736
-
Benzothiazinones: Prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
-
Trefzer, C. et al. Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis. J. Am. Chem. Soc. 132, 13663-13665 (2010).
-
(2010)
J. Am. Chem. Soc.
, vol.132
, pp. 13663-13665
-
-
Trefzer, C.1
-
86
-
-
84855948516
-
Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1
-
Trefzer, C. et al. Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1. J. Am. Chem. Soc. 134, 912-915 (2012).
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 912-915
-
-
Trefzer, C.1
-
87
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors
-
Christophe, T. et al. High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5, e1000645 (2009).
-
(2009)
PLoS Pathog.
, vol.5
-
-
Christophe, T.1
-
88
-
-
78049483746
-
Leads for antitubercular compounds from kinase inhibitor library screens
-
Magnet, S. et al. Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis (Edinb.) 90, 354-360 (2010).
-
(2010)
Tuberculosis (Edinb.)
, vol.90
, pp. 354-360
-
-
Magnet, S.1
-
89
-
-
77049123034
-
Timing of relapse in short-course chemotherapy trials for tuberculosis
-
Nunn, A. J., Phillips, P. P. & Mitchison, D. A. Timing of relapse in short-course chemotherapy trials for tuberculosis. Int. J. Tuberc. Lung Dis. 14, 241-242 (2010).
-
(2010)
Int. J. Tuberc. Lung Dis.
, vol.14
, pp. 241-242
-
-
Nunn, A.J.1
Phillips, P.P.2
Mitchison, D.A.3
-
90
-
-
84861123740
-
A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: Design issues and lessons learnt from the gatifloxacin for TB (OFLOTUB) project
-
Merle, C. S. et al. A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the gatifloxacin for TB (OFLOTUB) project. Trials 13, 61 (2012).
-
Trials
, vol.13
, Issue.61
, pp. 2012
-
-
Merle, C.S.1
-
91
-
-
84860385130
-
Innovative trial designs are practical solutions for improving the treatment of tuberculosis
-
Phillips, P. P. et al. Innovative trial designs are practical solutions for improving the treatment of tuberculosis. J. Infect. Dis. 205, (Suppl. 2), 250-257 (2012).
-
(2012)
J. Infect. Dis.
, vol.205
, Issue.SUPPL. 2
, pp. 250-257
-
-
Phillips, P.P.1
-
92
-
-
84875595918
-
Tuberculosis biomarkers discovery: Developments, needs and challenges
-
Wallis, R. et al. Tuberculosis biomarkers discovery: developments, needs and challenges. Lancet Infect. Dis. 13, 362-372 (2013).
-
(2013)
Lancet Infect. Dis.
, vol.13
, pp. 362-372
-
-
Wallis, R.1
-
93
-
-
77952473253
-
Sputum monitoring during tuberculosis treatment for predicting outcome: Systematic review and meta-analysis
-
Horne, D. J. et al. Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis. Lancet Infect. Dis. 10, 387-394 (2010).
-
(2010)
Lancet Infect. Dis.
, vol.10
, pp. 387-394
-
-
Horne, D.J.1
-
94
-
-
79955480087
-
Immunological biomarkers of tuberculosis
-
Walzl, G., Ronacher, K., Hanekom, W., Scriba, T. J. & Zumla, A. Immunological biomarkers of tuberculosis. Nature Rev. Immunol. 11, 343-354 (2011).
-
(2011)
Nature Rev. Immunol.
, vol.11
, pp. 343-354
-
-
Walzl, G.1
Ronacher, K.2
Hanekom, W.3
Scriba, T.J.4
Zumla, A.5
-
95
-
-
84860356467
-
Tuberculosis diagnostics and biomarkers: Needs, challenges, recent advances, and opportunities
-
McNerney, R. et al. Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities. J. Infect. Dis. 205 (Suppl. 2), 147-158 (2012).
-
(2012)
J. Infect. Dis.
, vol.205
, Issue.SUPPL. 2
, pp. 147-158
-
-
McNerney, R.1
-
96
-
-
80054693304
-
CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap
-
Nahid, P. et al. CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap. Am. J. Respir. Crit. Care Med. 184, 972-979 (2011).
-
(2011)
Am. J. Respir. Crit. Care Med.
, vol.184
, pp. 972-979
-
-
Nahid, P.1
-
97
-
-
84861880367
-
Alarming levels of drug-resistant tuberculosis in Belarus: Results of a survey in Minsk
-
Skrahina, A. et al. Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk. Eur. Respir. J. 39, 1425-1431 (2012).
-
(2012)
Eur. Respir. J.
, vol.39
, pp. 1425-1431
-
-
Skrahina, A.1
-
98
-
-
84878434964
-
Drug resistant tuberculosis: Time for visionary political leadership
-
24 Mar 2013 (doi:10.1016/S1473-3099(13) 70030-6)
-
Abubakar, I. et al. Drug resistant tuberculosis: time for visionary political leadership. Lancet Infect. Dis. 24 Mar 2013 (doi:10.1016/S1473- 3099(13) 70030-6).
-
Lancet Infect. Dis
-
-
Abubakar, I.1
-
99
-
-
84964134387
-
A substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria
-
Schatz, A., Bugie, E. & Waksman, S. A. Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proc. Soc. Exp. Biol. Med. 55, 66-69 (1944).
-
(1944)
Proc. Soc. Exp. Biol. Med.
, vol.55
, pp. 66-69
-
-
Schatz, A.1
Bugie, E.2
Streptomycin, A.W.S.3
-
100
-
-
33646890251
-
Pulmonary tuberculosis
-
Wassersug, J. D. Pulmonary tuberculosis. N. Engl. J. Med. 235, 220-229 (1946).
-
(1946)
N. Engl. J. Med.
, vol.235
, pp. 220-229
-
-
Wassersug, J.D.1
-
101
-
-
84877297344
-
Streptomycin in the treatment of pulmonary tuberculosis. A Medical Research Council investigation
-
Marshall, G. Streptomycin in the treatment of pulmonary tuberculosis. A Medical Research Council investigation. BMJ 1, 382-386 (1949).
-
(1949)
BMJ
, vol.1
, pp. 382-386
-
-
Marshall, G.1
-
102
-
-
0037441632
-
Treatment of tuberculosis
-
American Thoracic Society
-
American Thoracic Society. Treatment of tuberculosis. Am. J. Respir. Crit. Care Med. 167, 603-662 (2003).
-
(2003)
Am. J. Respir. Crit. Care Med.
, vol.167
, pp. 603-662
-
-
-
103
-
-
79958802504
-
Initiating antiretrovirals during tuberculosis treatment: A drug safety review
-
Gengiah, T. N., Gray, A. L., Naidoo, K. & Karim, Q. A. Initiating antiretrovirals during tuberculosis treatment: a drug safety review. Expert Opin. Drug Saf. 10, 559-574 (2011).
-
(2011)
Expert Opin. Drug Saf.
, vol.10
, pp. 559-574
-
-
Gengiah, T.N.1
Gray, A.L.2
Naidoo, K.3
Karim, Q.A.4
-
104
-
-
80054721877
-
Timing of antiretroviral therapy for HIV-1 infection and tuberculosis
-
Havlir, D. V. et al. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N. Engl. J. Med. 365, 1482-1491 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 1482-1491
-
-
Havlir, D.V.1
-
105
-
-
80054742528
-
Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis
-
Blanc, F. X. et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N. Engl. J. Med. 365, 1471-1481 (2011).
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 1471-1481
-
-
Blanc, F.X.1
-
106
-
-
84874742048
-
When to start ART in Africa-an urgent research priority
-
De Cock, K. M. & El-Sadr, W. M. When to start ART in Africa-an urgent research priority. N. Engl. J. Med. 368, 886-889 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 886-889
-
-
De Cock, K.M.1
El-Sadr, W.M.2
-
107
-
-
80053452071
-
Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs
-
Subbian, S. et al. Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog. 7, e1002262 (2011).
-
(2011)
PLoS Pathog.
, vol.7
-
-
Subbian, S.1
-
108
-
-
84856693171
-
Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections
-
Tobin, D. M. et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148, 434-446 (2012).
-
(2012)
Cell
, vol.148
, pp. 434-446
-
-
Tobin, D.M.1
-
109
-
-
84862980932
-
Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas
-
Skerry, C., Harper, J., Klunk, M., Bishai, W. R. & Jain, S. K. Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas. PLoS ONE 7, e39680 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Skerry, C.1
Harper, J.2
Klunk, M.3
Bishai, W.R.4
Jain, S.K.5
-
110
-
-
81755161197
-
Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis
-
Napier, R. J. et al. Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis. Cell Host Microbe 10, 475-485 (2012).
-
(2012)
Cell Host Microbe
, vol.10
, pp. 475-485
-
-
Napier, R.J.1
-
111
-
-
84879392633
-
Non-steroidal anti-inflammatory drugs for adjunctive tuberculosis treatment
-
5 Apr 2013 (doi:10.1093/infdis/jit153)
-
Ivanyi, I. & Zumla, A. Non-steroidal anti-inflammatory drugs for adjunctive tuberculosis treatment. J. Infect. Dis. 5 Apr 2013 (doi:10.1093/infdis/jit153).
-
J. Infect. Dis
-
-
Ivanyi, I.1
Zumla, A.2
-
112
-
-
34447542162
-
Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps
-
Amaral, L., Martins, M. & Viveiros, M. Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps. J. Antimicrob. Chemother. 59, 1237-1246 (2007).
-
(2007)
J. Antimicrob. Chemother.
, vol.59
, pp. 1237-1246
-
-
Amaral, L.1
Martins, M.2
Viveiros, M.3
-
113
-
-
79953279193
-
Drug tolerance in replicating mycobacteria mediate macrophage-induced efflux mechanism
-
Adams, K. N. et al. Drug tolerance in replicating mycobacteria mediate macrophage-induced efflux mechanism. Cell 145, 39-53 (2011).
-
(2011)
Cell
, vol.145
, pp. 39-53
-
-
Adams, K.N.1
-
114
-
-
84872842061
-
Anthelmintic avermectins kill M. tuberculosis, including multidrug-resistant clinical strains
-
Lim, L. E. et al. Anthelmintic avermectins kill M. tuberculosis, including multidrug-resistant clinical strains. Antimicrob. Agents Chemother. 57, 1040-1046 (2013).
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 1040-1046
-
-
Lim, L.E.1
-
115
-
-
84856526748
-
Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model
-
Maiga, M. et al. Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model. PLoS ONE 7, e30749 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Maiga, M.1
-
116
-
-
84860380066
-
Adjunct immunotherapies for tuberculosis
-
Uhlin, M., Andersson, J., Zumla, A. & Maeurer, M. Adjunct immunotherapies for tuberculosis. J. Infect. Dis. 205 (Suppl. 2), 325-334 (2012).
-
(2012)
J. Infect. Dis.
, vol.205
, Issue.SUPPL. 2
, pp. 325-334
-
-
Uhlin, M.1
Andersson, J.2
Zumla, A.3
Maeurer, M.4
-
117
-
-
84867290598
-
Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages
-
Bruns, H. et al. Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages. J. Immunol. 189, 4069-4078 (2012).
-
(2012)
J. Immunol.
, vol.189
, pp. 4069-4078
-
-
Bruns, H.1
-
118
-
-
36749030024
-
Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
-
Kuijl, C. et al. Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature. 450, 725-730 (2007).
-
(2007)
Nature.
, vol.450
, pp. 725-730
-
-
Kuijl, C.1
-
119
-
-
11144250804
-
Tuberculosis-metabolism and respiration in the absence of growth
-
Boshoff, H. I. & Barry, C. E. 3rd. Tuberculosis-metabolism and respiration in the absence of growth. Nature Rev. Microbiol. 3, 70-80 (2005).
-
(2005)
Nature Rev. Microbiol.
, vol.3
, pp. 70-80
-
-
Boshoff, H.I.1
Barry III, C.E.2
-
120
-
-
84873118897
-
-
eds Wax, R. G., Lewis, K., Salyers, A. A. & Taber, H., CRC
-
Pym, A. S. & Cole, S. T. in Bacterial Resistance to Antimicrobials 2nd Edn (eds Wax, R. G., Lewis, K., Salyers, A. A. & Taber, H.) 313-342 (CRC, 2008).
-
(2008)
Bacterial Resistance to Antimicrobials 2nd Edn
, pp. 313-342
-
-
Pym, A.S.1
Cole, S.T.2
-
121
-
-
81155160151
-
Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis
-
Shi, W. et al. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science 333, 1630-1632 (2011).
-
(2011)
Science
, vol.333
, pp. 1630-1632
-
-
Shi, W.1
-
122
-
-
84871927537
-
Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
-
Chakraborty, S., Gruber, T., Barry, C. E. 3rd, Boshoff, H. I. & Rhee, K. Y. Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis. Science 339, 88-91 (2013).
-
(2013)
Science
, vol.339
, pp. 88-91
-
-
Chakraborty, S.1
Gruber, T.2
Barry III, C.E.3
Boshoff, H.I.4
Rhee, K.Y.5
-
123
-
-
84859565524
-
GyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis
-
Sirgel, F. A. et al. gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 67, 1088-1093 (2012).
-
(2012)
J. Antimicrob. Chemother.
, vol.67
, pp. 1088-1093
-
-
Sirgel, F.A.1
-
124
-
-
84859568104
-
Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis
-
Sirgel, F. A. et al. Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis. Microb. Drug Resist. 18, 193-197 (2012).
-
(2012)
Microb. Drug Resist.
, vol.18
, pp. 193-197
-
-
Sirgel, F.A.1
-
125
-
-
84869214331
-
Structure-activity relationships among the kanamycin aminoglycosides: Role of ring i hydroxyl and amino groups
-
Salian, S. et al. Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups. Antimicrob. Agents Chemother. 56 6104-6108 (2012)
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 6104-6108
-
-
Salian, S.1
-
126
-
-
84877254418
-
Global alliance for TB drug development
-
Global Alliance for TB Drug Development. Cycloserine. Tuberculosis (Edinb.) 88, 100-101 (2008).
-
(2008)
Cycloserine. Tuberculosis (Edinb.)
, vol.88
, pp. 100-101
-
-
-
127
-
-
78650666677
-
Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine
-
Bruning, J. B., Murillo, A. C., Chacon, O., Barletta, R. G. & Sacchettini, J. C. Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine. Antimicrob. Agents Chemother. 55, 291-301 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.55
, pp. 291-301
-
-
Bruning, J.B.1
Murillo, A.C.2
Chacon, O.3
Barletta, R.G.4
Sacchettini, J.C.5
-
128
-
-
0037125569
-
Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: A randomised clinical trial
-
Benator, D. et al. Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet 360, 528-534 (2002).
-
(2002)
Lancet
, vol.360
, pp. 528-534
-
-
Benator, D.1
-
129
-
-
79951643988
-
Higher-dose rifampin for the treatment of pulmonary tuberculosis: A systematic review
-
Steingart, K. R., et al. Higher-dose rifampin for the treatment of pulmonary tuberculosis: a systematic review. Int. J. Tuber. Lung Dis. 15, 305-316 (2011).
-
(2011)
Int. J. Tuber. Lung Dis.
, vol.15
, pp. 305-316
-
-
Steingart, K.R.1
-
130
-
-
84863919677
-
Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
-
Batt, S. M., et al. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc. Natl Acad. Sci. USA 109, 11354-11359 (2012).
-
(2012)
Proc. Natl Acad. Sci. USA
, vol.109
, pp. 11354-11359
-
-
Batt, S.M.1
|