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Volumn 12, Issue 5, 2013, Pages 388-404

Advances in the development of new tuberculosis drugs and treatment regimens

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMINOSALICYLIC ACID PLUS ISONIAZID; AMOXICILLIN PLUS CLAVULANIC ACID; CAPREOMYCIN; CILASTATIN PLUS IMIPENEM; CLARITHROMYCIN; CLOFAZIMINE; CYCLOSERINE; ETHAMBUTOL; ETHIONAMIDE; ISONIAZID; KANAMYCIN; LEVOFLOXACIN; LINEZOLID; MOXIFLOXACIN; OFLOXACIN; OXAZOLIDINONE DERIVATIVE; PROTIONAMIDE; PYRAZINAMIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFABUTIN; RIFAMPICIN; RIFAMYCIN; RIFAPENTINE; STREPTOMYCIN; TERIZIDONE; THIOACETAZONE; UNINDEXED DRUG; VIOMYCIN;

EID: 84877267006     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4001     Document Type: Review
Times cited : (734)

References (130)
  • 3
    • 0033581124 scopus 로고    scopus 로고
    • Consensus statement. Global burden of tuberculosis: Estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project
    • Dye, C., Scheele, S., Dolin, P., Pathania, V. & Raviglione, M. C. Consensus statement. Global burden of tuberculosis: estimated incidence, prevalence, and mortality by country. WHO Global Surveillance and Monitoring Project. JAMA 282, 677-686 (1999).
    • (1999) JAMA , vol.282 , pp. 677-686
    • Dye, C.1    Scheele, S.2    Dolin, P.3    Pathania, V.4    Raviglione, M.C.5
  • 4
    • 84880142045 scopus 로고    scopus 로고
    • Old ideas to innovate TB control: Preventive treatment to achieve elimination
    • 8 Feb 2013 (doi:10.1183/09031936.00205512)
    • Diel, R. et al. Old ideas to innovate TB control: preventive treatment to achieve elimination. Eur. Respir. J. 8 Feb 2013 (doi:10.1183/09031936. 00205512).
    • Eur. Respir. J
    • Diel, R.1
  • 5
    • 84861029136 scopus 로고    scopus 로고
    • Scaling up interventions to achieve global tuberculosis control: Progress and new developments
    • Raviglione, M. et al. Scaling up interventions to achieve global tuberculosis control: progress and new developments. Lancet 379, 1902-1913 (2012).
    • (2012) Lancet , vol.379 , pp. 1902-1913
    • Raviglione, M.1
  • 8
    • 84865498579 scopus 로고    scopus 로고
    • Modelling tuberculosis trends in the USA
    • Hill, A. N., Becerra, J. & Castro, K. G. Modelling tuberculosis trends in the USA. Epidemiol. Infect. 140, 1862-1872 (2012).
    • (2012) Epidemiol. Infect. , vol.140 , pp. 1862-1872
    • Hill, A.N.1    Becerra, J.2    Castro, K.G.3
  • 9
    • 84872131305 scopus 로고    scopus 로고
    • Infectious disease. Approval of novel TB drug celebrated-with restraint
    • Cohen, J. Infectious disease. Approval of novel TB drug celebrated-with restraint. Science 339, 130 (2013).
    • (2013) Science , vol.339 , pp. 130
    • Cohen, J.1
  • 11
    • 33744910897 scopus 로고    scopus 로고
    • Tuberculosis Coalition for Technical Assistance, Tuberculosis Coalition for Technical Assistance
    • Tuberculosis Coalition for Technical Assistance. International Standards for Tuberculosis Care (ISTC) 2nd edn (Tuberculosis Coalition for Technical Assistance, 2009)
    • (2009) International Standards for Tuberculosis Care (ISTC) 2nd Edn
  • 12
    • 69949099207 scopus 로고    scopus 로고
    • Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion
    • Johnson, J. L. et al. Shortening treatment in adults with noncavitary tuberculosis and 2-month culture conversion. Am. J. Respir. Crit. Care Med. 180, 558-563 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.180 , pp. 558-563
    • Johnson, J.L.1
  • 13
    • 79953853899 scopus 로고    scopus 로고
    • Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: The study C randomized controlled trial
    • Lienhardt, C. et al. Efficacy and safety of a 4-drug fixed-dose combination regimen compared with separate drugs for treatment of pulmonary tuberculosis: the study C randomized controlled trial. JAMA 305, 1415-1423 (2011).
    • (2011) JAMA , vol.305 , pp. 1415-1423
    • Lienhardt, C.1
  • 14
    • 84864425173 scopus 로고    scopus 로고
    • Old drugs, new purpose: Retooling existing drugs for optimized treatment of resistant tuberculosis
    • Dooley, K. E. et al. Old drugs, new purpose: retooling existing drugs for optimized treatment of resistant tuberculosis. Clin. Infect. Dis. 55, 572-581 (2012).
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 572-581
    • Dooley, K.E.1
  • 15
    • 80053067126 scopus 로고    scopus 로고
    • WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update
    • Falzon, D. et al. WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update. Eur. Respir. J. 38, 516-528 (2011).
    • (2011) Eur. Respir. J. , vol.38 , pp. 516-528
    • Falzon, D.1
  • 16
    • 84875602728 scopus 로고    scopus 로고
    • Advances in tuberculosis diagnostics: The Xpert MTB/RIF assay and future prospects for a point-of-care test
    • Lawn, S. D. & Zumla, A. Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test. Lancet Infect. Dis. 13, 349-361 (2013).
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 349-361
    • Lawn, S.D.1    Zumla, A.2
  • 17
    • 84880151052 scopus 로고    scopus 로고
    • Rapid molecular TB diagnosis: Evidence, policy-making and global implementation of Xpert®MTB/RIF
    • 22 Nov 2012 (doi:10.1183/09031936.00157212)
    • Weyer, K. et al. Rapid molecular TB diagnosis: evidence, policy-making and global implementation of Xpert®MTB/RIF. Eur. Respir. J. 22 Nov 2012 (doi:10.1183/09031936.00157212).
    • Eur. Respir. J
    • Weyer, K.1
  • 18
    • 33750629139 scopus 로고    scopus 로고
    • Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa
    • Gandhi, N. R. et al. Extensively drug-resistant tuberculosis as a cause of death in patients co-infected with tuberculosis and HIV in a rural area of South Africa. Lancet 368, 1575-1580 (2006).
    • (2006) Lancet , vol.368 , pp. 1575-1580
    • Gandhi, N.R.1
  • 19
    • 77952547476 scopus 로고    scopus 로고
    • Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: A retrospective cohort study
    • Dheda, K. et al. Early treatment outcomes and HIV status of patients with extensively drug-resistant tuberculosis in South Africa: a retrospective cohort study. Lancet 375, 1798-1807 (2010).
    • (2010) Lancet , vol.375 , pp. 1798-1807
    • Dheda, K.1
  • 20
    • 77953771813 scopus 로고    scopus 로고
    • Treatment outcomes among patients with extensively drug-resistant tuberculosis: Systematic review and meta-analysis
    • Jacobson, K. R., Tierney, D. B., Jeon, C. Y., Mitnick, C. D. & Murray, M. B. Treatment outcomes among patients with extensively drug-resistant tuberculosis: systematic review and meta-analysis. Clin. Infect. Dis. 51, 6-14 (2010).
    • (2010) Clin. Infect. Dis. , vol.51 , pp. 6-14
    • Jacobson, K.R.1    Tierney, D.B.2    Jeon, C.Y.3    Mitnick, C.D.4    Murray, M.B.5
  • 21
    • 84880158505 scopus 로고    scopus 로고
    • Drug resistance beyond XDR-TB: Results from a large individual patient data meta-analysis
    • 11 Oct 2012 (doi:10.1183/09031936.00136312)
    • Migliori, G. B. et al. Drug resistance beyond XDR-TB: results from a large individual patient data meta-analysis. Eur. Respir. J. 11 Oct 2012 (doi:10.1183/09031936.00136312).
    • Eur. Respir. J
    • Migliori, G.B.1
  • 24
    • 80053902179 scopus 로고    scopus 로고
    • New tuberculosis drugs on the horizon
    • Cole, S. T. & Riccardi, G. New tuberculosis drugs on the horizon. Curr. Opin. Microbiol. 14, 570-576 (2011).
    • (2011) Curr. Opin. Microbiol. , vol.14 , pp. 570-576
    • Cole, S.T.1    Riccardi, G.2
  • 25
    • 79251589638 scopus 로고    scopus 로고
    • The challenge of new drug discovery for tuberculosis
    • Koul, A., Arnoult, E., Lounis, N., Guillemont, J. & Andries, K. The challenge of new drug discovery for tuberculosis. Nature 469, 483-490 (2011)
    • (2011) Nature , vol.469 , pp. 483-490
    • Koul, A.1    Arnoult, E.2    Lounis, N.3    Guillemont, J.4    Andries, K.5
  • 26
    • 0034982047 scopus 로고    scopus 로고
    • Tuberculosis. Scientific blueprint for tuberculosis drug development
    • Global-Alliance for TB Drug Development
    • Global-Alliance for TB Drug Development. Tuberculosis. Scientific blueprint for tuberculosis drug development. Tuberculosis (Edinb.) 81, (Suppl. 1), 1-52 (2001).
    • (2001) Tuberculosis (Edinb.) , vol.81 , Issue.SUPPL. 1 , pp. 1-52
  • 27
    • 70449705831 scopus 로고    scopus 로고
    • The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
    • Barry, C. E. et al. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nature Rev. Microbiol. 7, 845-855 (2009).
    • (2009) Nature Rev. Microbiol. , vol.7 , pp. 845-855
    • Barry, C.E.1
  • 28
    • 0038628994 scopus 로고    scopus 로고
    • Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days
    • Jindani, A., Doré, C. J. & Mitchison, D. A. Bactericidal and sterilizing activities of antituberculosis drugs during the first 14 days. Am. J. Respir. Crit. Care Med. 167, 1348-1354 (2003).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 1348-1354
    • Jindani, A.1    Doré, C.J.2    Mitchison, D.A.3
  • 29
    • 50649089808 scopus 로고    scopus 로고
    • The early bactericidal activity of anti-tuberculosis drugs: A literature review
    • Donald, P. R. & Diacon, A. H. The early bactericidal activity of anti-tuberculosis drugs: a literature review. Tuberculosis (Edinb.) 88, (Suppl. 1), 75-83 (2008).
    • (2008) Tuberculosis (Edinb.) , vol.88 , Issue.SUPPL. 1 , pp. 75-83
    • Donald, P.R.1    Diacon, A.H.2
  • 30
    • 1642537638 scopus 로고    scopus 로고
    • Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis
    • Nuermberger, E. L. et al. Moxifloxacin-containing regimen greatly reduces time to culture conversion in murine tuberculosis. Am. J. Respir. Crit. Care Med. 169, 421-426 (2004).
    • (2004) Am. J. Respir. Crit. Care Med. , vol.169 , pp. 421-426
    • Nuermberger, E.L.1
  • 31
    • 77953475812 scopus 로고    scopus 로고
    • Global tuberculosis drug development pipeline: The need and the reality
    • Ma, Z., Lienhardt, C., McIlleron, H., Nunn, A. J. & Wang, X. Global tuberculosis drug development pipeline: the need and the reality. Lancet 375, 2100-2109 (2010).
    • (2010) Lancet , vol.375 , pp. 2100-2109
    • Ma, Z.1    Lienhardt, C.2    McIlleron, H.3    Nunn, A.J.4    Wang, X.5
  • 32
    • 38049038389 scopus 로고    scopus 로고
    • Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model
    • Rosenthal, I. M. et al. Daily dosing of rifapentine cures tuberculosis in three months or less in the murine model. PLoS Med. 4, e344 (2007).
    • (2007) PLoS Med. , vol.4
    • Rosenthal, I.M.1
  • 33
    • 83155182847 scopus 로고    scopus 로고
    • Three months of rifapentine and isoniazid for latent tuberculosis infection
    • Sterling, T. R. et al. Three months of rifapentine and isoniazid for latent tuberculosis infection. N. Engl. J. Med. 365, 2155-2166 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 2155-2166
    • Sterling, T.R.1
  • 34
    • 34547620711 scopus 로고    scopus 로고
    • Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears
    • Diacon, A. H. et al. Early bactericidal activity of high-dose rifampin in patients with pulmonary tuberculosis evidenced by positive sputum smears. Antimicrob. Agents Chemother. 51, 2994-2996 (2007).
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 2994-2996
    • Diacon, A.H.1
  • 35
    • 79953905145 scopus 로고    scopus 로고
    • Why do we use 600 mg of rifampicin in tuberculosis treatment?
    • van Ingen, J. et al. Why do we use 600 mg of rifampicin in tuberculosis treatment? Clin. Infect. Dis. 52, e194-e199 (2011).
    • (2011) Clin. Infect. Dis. , vol.52
    • Van Ingen, J.1
  • 36
    • 19944429772 scopus 로고    scopus 로고
    • A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
    • Andries, K. et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307, 223-227 (2005).
    • (2005) Science , vol.307 , pp. 223-227
    • Andries, K.1
  • 37
    • 84872371975 scopus 로고    scopus 로고
    • Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: A systematic review and meta-analysis
    • Dey, T. et al. Outcomes of clofazimine for the treatment of drug-resistant tuberculosis: a systematic review and meta-analysis. J. Antimicrob. Chemother. 68, 284-293 (2013).
    • (2013) J. Antimicrob. Chemother. , vol.68 , pp. 284-293
    • Dey, T.1
  • 38
    • 77952365008 scopus 로고    scopus 로고
    • Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis
    • Van Deun, A. et al. Short, highly effective, and inexpensive standardized treatment of multidrug-resistant tuberculosis. Am. J. Respir. Crit. Care Med. 182, 684-692 (2010).
    • (2010) Am. J. Respir. Crit. Care Med. , vol.182 , pp. 684-692
    • Van Deun, A.1
  • 39
    • 84872859798 scopus 로고    scopus 로고
    • Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice
    • Verma, R. K. et al. Inhaled microparticles containing clofazimine are efficacious in treatment of experimental tuberculosis in mice. Antimicrob. Agents Chemother. 57, 1050-1052 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 1050-1052
    • Verma, R.K.1
  • 40
    • 84868007876 scopus 로고    scopus 로고
    • Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
    • Zhang, M. et al. Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis. Antimicrob. Agents Chemother. 56, 5782-5789 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5782-5789
    • Zhang, M.1
  • 41
    • 0025992490 scopus 로고
    • Oxazolidinone, a new class of synthetic antituberculosis agent: In vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis
    • Ashtekar, D. R. et al. Oxazolidinone, a new class of synthetic antituberculosis agent: in vitro and in vivo activities of DuP-721 against Mycobacterium tuberculosis. Diagn. Microbiol. Infect. Dis. 14, 465-471 (1991).
    • (1991) Diagn. Microbiol. Infect. Dis. , vol.14 , pp. 465-471
    • Ashtekar, D.R.1
  • 42
    • 24044461782 scopus 로고    scopus 로고
    • Linezolid for the treatment of multidrug-resistant tuberculosis
    • Fortun, J. et al. Linezolid for the treatment of multidrug-resistant tuberculosis. J. Antimicrob. Chemother. 56, 180-185 (2005).
    • (2005) J. Antimicrob. Chemother. , vol.56 , pp. 180-185
    • Fortun, J.1
  • 43
    • 84867614599 scopus 로고    scopus 로고
    • Linezolid for treatment of chronic extensively drug-resistant tuberculosis
    • Lee, M. et al. Linezolid for treatment of chronic extensively drug-resistant tuberculosis. N. Engl. J. Med. 367, 1508-1518 (2012)
    • (2012) N. Engl. J. Med. , vol.367 , pp. 1508-1518
    • Lee, M.1
  • 44
    • 84864518733 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: Systematic review and meta-analysis
    • Sotgiu, G. et al. Efficacy, safety and tolerability of linezolid containing regimens in treating MDR-TB and XDR-TB: systematic review and meta-analysis. Eur. Respir. J. 40, 1430-1442 (2012).
    • (2012) Eur. Respir. J. , vol.40 , pp. 1430-1442
    • Sotgiu, G.1
  • 45
    • 78751693374 scopus 로고    scopus 로고
    • Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis
    • Wallis, R. S. et al. Biomarker-assisted dose selection for safety and efficacy in early development of PNU-100480 for tuberculosis. Antimicrob. Agents Chemother. 55, 567-574 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.55 , pp. 567-574
    • Wallis, R.S.1
  • 46
    • 77955706291 scopus 로고    scopus 로고
    • Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers
    • Wallis, R. S. et al. Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. J. Infect. Dis. 202, 745-751 (2010).
    • (2010) J. Infect. Dis. , vol.202 , pp. 745-751
    • Wallis, R.S.1
  • 47
    • 84855928950 scopus 로고    scopus 로고
    • Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide
    • Wallis, R. S. et al. Rapid evaluation in whole blood culture of regimens for XDR-TB containing PNU-100480 (sutezolid), TMC207, PA-824, SQ109, and pyrazinamide. PLoS ONE 7, e30479 (2012).
    • (2012) PLoS ONE , vol.7
    • Wallis, R.S.1
  • 48
    • 84877251559 scopus 로고    scopus 로고
    • A 14-day multiple ascending dose study: AZD5847 is well tolerated at predicted exposure for treatment of tuberculosis (TB) (Abstract A1-1735)
    • [online]
    • Reele, S. et al. A 14-day multiple ascending dose study: AZD5847 is well tolerated at predicted exposure for treatment of tuberculosis (TB) (Abstract A1-1735). 51st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy [online], http://www.abstractsonline.com/plan/ViewAbstract.asp x?mID=2789&sKey=0b498641-f10a-4936-b80c-d 274ffe4b143&cKey=2271e63a- 2cdc-4956-b7b0-6f7dc642b346&mKey=%7B0C918954-D607-46A7-8 073-44F4B537A439%7D (2011).
    • (2011) 51st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy
    • Reele, S.1
  • 49
    • 61349183785 scopus 로고    scopus 로고
    • Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis
    • Hugonnet, J. E. et al. Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis. Science 323, 1215-1218 (2009).
    • (2009) Science , vol.323 , pp. 1215-1218
    • Hugonnet, J.E.1
  • 50
    • 84867471468 scopus 로고    scopus 로고
    • Meropenem inhibits D, D-carboxypeptidase activity in Mycobacterium tuberculosis
    • Kumar, P. et al. Meropenem inhibits D, D-carboxypeptidase activity in Mycobacterium tuberculosis. Mol. Microbiol. 86, 367-381 (2012).
    • (2012) Mol. Microbiol. , vol.86 , pp. 367-381
    • Kumar, P.1
  • 51
    • 85027929829 scopus 로고    scopus 로고
    • Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis
    • Dauby, N., Muylle, I., Mouchet, F., Sergysels, R. & Payen, M. C. Meropenem/clavulanate and linezolid treatment for extensively drug-resistant tuberculosis. Pediatr. Infect. Dis. J. 30, 812-813 (2011).
    • (2011) Pediatr. Infect. Dis. J. , vol.30 , pp. 812-813
    • Dauby, N.1    Muylle, I.2    Mouchet, F.3    Sergysels, R.4    Payen, M.C.5
  • 52
    • 84870747517 scopus 로고    scopus 로고
    • Efficacy and safety of meropenem/clavunate added to linezolid containing regimens in the treatment of M/XDR-TB
    • 20 Sept 2012 (doi:10.1183/09031936.00124312)
    • De Lorenzo, S. et al. Efficacy and safety of meropenem/clavunate added to linezolid containing regimens in the treatment of M/XDR-TB. Eur. Respir. J. 20 Sept 2012 (doi:10.1183/09031936.00124312).
    • Eur. Respir. J
    • De Lorenzo, S.1
  • 53
    • 34248998479 scopus 로고    scopus 로고
    • Diarylquinolines target subunit c of mycobacterial ATP synthase
    • Koul, A. et al. Diarylquinolines target subunit c of mycobacterial ATP synthase. Nature Chem. Biol. 3, 323-324 (2007).
    • (2007) Nature Chem. Biol. , vol.3 , pp. 323-324
    • Koul, A.1
  • 54
    • 62949223223 scopus 로고    scopus 로고
    • Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue
    • Haagsma, A. C. et al. Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towards the eukaryotic homologue. Antimicrob. Agents Chemother. 53, 1290-1292 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 1290-1292
    • Haagsma, A.C.1
  • 55
    • 77149123917 scopus 로고    scopus 로고
    • Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor
    • Huitric, E. et al. Rates and mechanisms of resistance development in Mycobacterium tuberculosis to a novel diarylquinoline ATP synthase inhibitor. Antimicrob. Agents Chemother. 54, 1022-1028 (2009).
    • (2009) Antimicrob. Agents Chemother. , vol.54 , pp. 1022-1028
    • Huitric, E.1
  • 56
    • 84872038902 scopus 로고    scopus 로고
    • 0 ATP synthase and a novel model for mechanism of action of the TB drug TMC207
    • 0 ATP synthase and a novel model for mechanism of action of the TB drug TMC207. Antimicrob. Agents Chemother. 57, 168-176 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 168-176
    • Biukovic, G.1
  • 57
    • 54449084104 scopus 로고    scopus 로고
    • Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis
    • Koul, A. et al. Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis. J. Biol. Chem. 283, 25273-25280 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 25273-25280
    • Koul, A.1
  • 58
    • 50149113470 scopus 로고    scopus 로고
    • The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis
    • Rao, S. P., Alonso, S., Rand, L., Dick, T. & Pethe, K. The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 105, 11945-11950 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 11945-11950
    • Rao, S.P.1    Alonso, S.2    Rand, L.3    Dick, T.4    Pethe, K.5
  • 59
    • 66649090346 scopus 로고    scopus 로고
    • The diarylquinoline TMC207 for multidrug-resistant tuberculosis
    • Diacon, A. H. et al. The diarylquinoline TMC207 for multidrug-resistant tuberculosis. N. Engl. J. Med. 360, 2397-2405 (2009).
    • (2009) N. Engl. J. Med. , vol.360 , pp. 2397-2405
    • Diacon, A.H.1
  • 60
    • 58349103319 scopus 로고    scopus 로고
    • A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis
    • Veziris, N. et al. A once-weekly R207910-containing regimen exceeds activity of the standard daily regimen in murine tuberculosis. Am. J. Respir. Crit. Care Med. 179, 75-79 (2009).
    • (2009) Am. J. Respir. Crit. Care Med. , vol.179 , pp. 75-79
    • Veziris, N.1
  • 61
    • 49049106807 scopus 로고    scopus 로고
    • Prevention of drug carryover effects in studies assessing antimycobacterial efficacy of TMC207
    • Lounis, N. et al. Prevention of drug carryover effects in studies assessing antimycobacterial efficacy of TMC207. J. Clin. Microbiol. 46, 2212-2215 (2008).
    • (2008) J. Clin. Microbiol. , vol.46 , pp. 2212-2215
    • Lounis, N.1
  • 62
    • 84865540183 scopus 로고    scopus 로고
    • Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques
    • Lin, P. L. et al. Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques. Proc. Natl Acad. Sci. USA 109, 14188-14193 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 14188-14193
    • Lin, P.L.1
  • 63
    • 0034702247 scopus 로고    scopus 로고
    • A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
    • Stover, C. K. et al. A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis. Nature 405, 962-966 (2000).
    • (2000) Nature , vol.405 , pp. 962-966
    • Stover, C.K.1
  • 64
    • 33845323336 scopus 로고    scopus 로고
    • OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
    • Matsumoto, M. et al. OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med. 3, e466 (2006).
    • (2006) PLoS Med. , vol.3
    • Matsumoto, M.1
  • 65
    • 31044452898 scopus 로고    scopus 로고
    • Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
    • Manjunatha, U. H. et al. Identification of a nitroimidazo-oxazine- specific protein involved in PA-824 resistance in Mycobacterium tuberculosis. Proc. Natl Acad. Sci. USA 103, 431-436 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 431-436
    • Manjunatha, U.H.1
  • 66
    • 57149099588 scopus 로고    scopus 로고
    • PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release
    • Singh, R. et al. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release. Science 322, 1392-1395 (2008).
    • (2008) Science , vol.322 , pp. 1392-1395
    • Singh, R.1
  • 67
    • 33749513414 scopus 로고    scopus 로고
    • Mycobacterium leprae is naturally resistant to PA-824
    • Manjunatha, U. H. et al. Mycobacterium leprae is naturally resistant to PA-824. Antimicrob. Agents Chemother. 50, 3350-3354 (2006).
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 3350-3354
    • Manjunatha, U.H.1
  • 68
    • 54549121616 scopus 로고    scopus 로고
    • A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents
    • Hurdle, J. G. et al. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. J. Antimicrob. Chemother. 62, 1037-1045 (2008).
    • (2008) J. Antimicrob. Chemother. , vol.62 , pp. 1037-1045
    • Hurdle, J.G.1
  • 69
    • 77951298792 scopus 로고    scopus 로고
    • The mechanism of action of PA-824: Novel insights from transcriptional profiling
    • Manjunatha, U., Boshoff, H. I. & Barry, C. E. The mechanism of action of PA-824: Novel insights from transcriptional profiling. Commun. Integr. Biol. 2, 215-218 (2009).
    • (2009) Commun. Integr. Biol. , vol.2 , pp. 215-218
    • Manjunatha, U.1    Boshoff, H.I.2    Barry, C.E.3
  • 70
    • 84861124193 scopus 로고    scopus 로고
    • Phase II dose-ranging trial of the early bactericidal activity of PA-824; Antimicrob
    • Diacon, A. et al. Phase II dose-ranging trial of the early bactericidal activity of PA-824; Antimicrob. Agents Chemother. 56, 3027-3031 (2012).
    • (2012) Agents Chemother. , vol.56 , pp. 3027-3031
    • Diacon, A.1
  • 71
    • 84866177379 scopus 로고    scopus 로고
    • 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: A randomised trial
    • Diacon, A. H. et al. 14-day bactericidal activity of PA-824, bedaquiline, pyrazinamide, and moxifloxacin combinations: a randomised trial. Lancet 380, 986-993 (2012)
    • (2012) Lancet , vol.380 , pp. 986-993
    • Diacon, A.H.1
  • 72
    • 79958718650 scopus 로고    scopus 로고
    • Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients
    • Diacon, A. H. et al. Early bactericidal activity of delamanid (OPC-67683) in smear-positive pulmonary tuberculosis patients. Int. J. Tuberc. Lung Dis. 15, 949-954 (2011).
    • (2011) Int. J. Tuberc. Lung Dis. , vol.15 , pp. 949-954
    • Diacon, A.H.1
  • 73
    • 84861864703 scopus 로고    scopus 로고
    • Delamanid for multidrug-resistant pulmonary tuberculosis
    • Gler, M. T. et al. Delamanid for multidrug-resistant pulmonary tuberculosis. N. Engl. J. Med. 366, 2151-2160 (2012).
    • (2012) N. Engl. J. Med. , vol.366 , pp. 2151-2160
    • Gler, M.T.1
  • 74
    • 84878776777 scopus 로고    scopus 로고
    • Delamanid improves outcomes and reduces mortality for multidrug-resistant tuberculosis
    • 27 Sept 2012 (doi:10.1183/09031936.00125812)
    • Skripconoka, V. et al. Delamanid improves outcomes and reduces mortality for multidrug-resistant tuberculosis. Eur. Respir. J. 27 Sept 2012 (doi:10.1183/09031936.00125812).
    • Eur. Respir. J
    • Skripconoka, V.1
  • 75
    • 0038700567 scopus 로고    scopus 로고
    • Combinatorial lead optimization of [1, 2]-diamines based on ethambutol as potential antituberculosis preclinical candidates
    • Lee, R. E. et al. Combinatorial lead optimization of [1, 2]-diamines based on ethambutol as potential antituberculosis preclinical candidates. J. Comb. Chem. 5, 172-187 (2003).
    • (2003) J. Comb. Chem. , vol.5 , pp. 172-187
    • Lee, R.E.1
  • 76
    • 84863404695 scopus 로고    scopus 로고
    • SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
    • Tahlan, K. et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56, 1797-1809 (2012)
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1797-1809
    • Tahlan, K.1
  • 77
    • 77953797826 scopus 로고    scopus 로고
    • In vitro interactions between new antitubercular drug candidates SQ109 and TMC207
    • Reddy, V. M., Einck, L., Andries, K. & Nacy, C. A. In vitro interactions between new antitubercular drug candidates SQ109 and TMC207. Antimicrob. Agents Chemother. 54, 2840-2846 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 2840-2846
    • Reddy, V.M.1    Einck, L.2    Andries, K.3    Nacy, C.A.4
  • 78
    • 84858677107 scopus 로고    scopus 로고
    • Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
    • Grzegorzewicz, A. E. et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nature Chem. Biol. 8, 334-341 (2012).
    • (2012) Nature Chem. Biol. , vol.8 , pp. 334-341
    • Grzegorzewicz, A.E.1
  • 79
    • 84455173193 scopus 로고    scopus 로고
    • MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
    • La Rosa, V. et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob. Agents Chemother. 56, 324-331 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 324-331
    • La Rosa, V.1
  • 80
    • 84865253965 scopus 로고    scopus 로고
    • Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening
    • Stanley, S. A. et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem. Biol. 7, 1377-1384 (2012).
    • (2012) ACS Chem. Biol. , vol.7 , pp. 1377-1384
    • Stanley, S.A.1
  • 81
    • 65649096556 scopus 로고    scopus 로고
    • Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
    • Makarov, V. et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324, 801-804 (2009).
    • (2009) Science , vol.324 , pp. 801-804
    • Makarov, V.1
  • 82
    • 77950141431 scopus 로고    scopus 로고
    • Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones
    • Pasca, M. R. et al. Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones. Antimicrob. Agents Chemother. 54, 1616-1618 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1616-1618
    • Pasca, M.R.1
  • 83
    • 84868032303 scopus 로고    scopus 로고
    • In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis
    • Lechartier, B., Hartkoorn, R. C. & Cole, S. T. In vitro combination studies of benzothiazinone lead compound BTZ043 against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56, 5790-5793 (2012).
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5790-5793
    • Lechartier, B.1    Hartkoorn, R.C.2    Cole, S.T.3
  • 84
    • 84865960733 scopus 로고    scopus 로고
    • Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis
    • Neres, J. et al. Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Sci. Transl. Med. 4, 150ra121 (2012).
    • (2012) Sci. Transl. Med. , vol.4
    • Neres, J.1
  • 85
    • 77957310736 scopus 로고    scopus 로고
    • Benzothiazinones: Prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis
    • Trefzer, C. et al. Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2′-epimerase DprE1 of Mycobacterium tuberculosis. J. Am. Chem. Soc. 132, 13663-13665 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 13663-13665
    • Trefzer, C.1
  • 86
    • 84855948516 scopus 로고    scopus 로고
    • Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1
    • Trefzer, C. et al. Benzothiazinones are suicide inhibitors of mycobacterial decaprenylphosphoryl-β-D-ribofuranose 2′-oxidase DprE1. J. Am. Chem. Soc. 134, 912-915 (2012).
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 912-915
    • Trefzer, C.1
  • 87
    • 73649143180 scopus 로고    scopus 로고
    • High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors
    • Christophe, T. et al. High content screening identifies decaprenyl-phosphoribose 2' epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog. 5, e1000645 (2009).
    • (2009) PLoS Pathog. , vol.5
    • Christophe, T.1
  • 88
    • 78049483746 scopus 로고    scopus 로고
    • Leads for antitubercular compounds from kinase inhibitor library screens
    • Magnet, S. et al. Leads for antitubercular compounds from kinase inhibitor library screens. Tuberculosis (Edinb.) 90, 354-360 (2010).
    • (2010) Tuberculosis (Edinb.) , vol.90 , pp. 354-360
    • Magnet, S.1
  • 89
    • 77049123034 scopus 로고    scopus 로고
    • Timing of relapse in short-course chemotherapy trials for tuberculosis
    • Nunn, A. J., Phillips, P. P. & Mitchison, D. A. Timing of relapse in short-course chemotherapy trials for tuberculosis. Int. J. Tuberc. Lung Dis. 14, 241-242 (2010).
    • (2010) Int. J. Tuberc. Lung Dis. , vol.14 , pp. 241-242
    • Nunn, A.J.1    Phillips, P.P.2    Mitchison, D.A.3
  • 90
    • 84861123740 scopus 로고    scopus 로고
    • A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: Design issues and lessons learnt from the gatifloxacin for TB (OFLOTUB) project
    • Merle, C. S. et al. A pivotal registration phase III, multicenter, randomized tuberculosis controlled trial: design issues and lessons learnt from the gatifloxacin for TB (OFLOTUB) project. Trials 13, 61 (2012).
    • Trials , vol.13 , Issue.61 , pp. 2012
    • Merle, C.S.1
  • 91
    • 84860385130 scopus 로고    scopus 로고
    • Innovative trial designs are practical solutions for improving the treatment of tuberculosis
    • Phillips, P. P. et al. Innovative trial designs are practical solutions for improving the treatment of tuberculosis. J. Infect. Dis. 205, (Suppl. 2), 250-257 (2012).
    • (2012) J. Infect. Dis. , vol.205 , Issue.SUPPL. 2 , pp. 250-257
    • Phillips, P.P.1
  • 92
    • 84875595918 scopus 로고    scopus 로고
    • Tuberculosis biomarkers discovery: Developments, needs and challenges
    • Wallis, R. et al. Tuberculosis biomarkers discovery: developments, needs and challenges. Lancet Infect. Dis. 13, 362-372 (2013).
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 362-372
    • Wallis, R.1
  • 93
    • 77952473253 scopus 로고    scopus 로고
    • Sputum monitoring during tuberculosis treatment for predicting outcome: Systematic review and meta-analysis
    • Horne, D. J. et al. Sputum monitoring during tuberculosis treatment for predicting outcome: systematic review and meta-analysis. Lancet Infect. Dis. 10, 387-394 (2010).
    • (2010) Lancet Infect. Dis. , vol.10 , pp. 387-394
    • Horne, D.J.1
  • 95
    • 84860356467 scopus 로고    scopus 로고
    • Tuberculosis diagnostics and biomarkers: Needs, challenges, recent advances, and opportunities
    • McNerney, R. et al. Tuberculosis diagnostics and biomarkers: needs, challenges, recent advances, and opportunities. J. Infect. Dis. 205 (Suppl. 2), 147-158 (2012).
    • (2012) J. Infect. Dis. , vol.205 , Issue.SUPPL. 2 , pp. 147-158
    • McNerney, R.1
  • 96
    • 80054693304 scopus 로고    scopus 로고
    • CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap
    • Nahid, P. et al. CDC/NIH Workshop. Tuberculosis biomarker and surrogate endpoint research roadmap. Am. J. Respir. Crit. Care Med. 184, 972-979 (2011).
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , pp. 972-979
    • Nahid, P.1
  • 97
    • 84861880367 scopus 로고    scopus 로고
    • Alarming levels of drug-resistant tuberculosis in Belarus: Results of a survey in Minsk
    • Skrahina, A. et al. Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk. Eur. Respir. J. 39, 1425-1431 (2012).
    • (2012) Eur. Respir. J. , vol.39 , pp. 1425-1431
    • Skrahina, A.1
  • 98
    • 84878434964 scopus 로고    scopus 로고
    • Drug resistant tuberculosis: Time for visionary political leadership
    • 24 Mar 2013 (doi:10.1016/S1473-3099(13) 70030-6)
    • Abubakar, I. et al. Drug resistant tuberculosis: time for visionary political leadership. Lancet Infect. Dis. 24 Mar 2013 (doi:10.1016/S1473- 3099(13) 70030-6).
    • Lancet Infect. Dis
    • Abubakar, I.1
  • 99
    • 84964134387 scopus 로고
    • A substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria
    • Schatz, A., Bugie, E. & Waksman, S. A. Streptomycin, a substance exhibiting antibiotic activity against Gram-positive and Gram-negative bacteria. Proc. Soc. Exp. Biol. Med. 55, 66-69 (1944).
    • (1944) Proc. Soc. Exp. Biol. Med. , vol.55 , pp. 66-69
    • Schatz, A.1    Bugie, E.2    Streptomycin, A.W.S.3
  • 100
    • 33646890251 scopus 로고
    • Pulmonary tuberculosis
    • Wassersug, J. D. Pulmonary tuberculosis. N. Engl. J. Med. 235, 220-229 (1946).
    • (1946) N. Engl. J. Med. , vol.235 , pp. 220-229
    • Wassersug, J.D.1
  • 101
    • 84877297344 scopus 로고
    • Streptomycin in the treatment of pulmonary tuberculosis. A Medical Research Council investigation
    • Marshall, G. Streptomycin in the treatment of pulmonary tuberculosis. A Medical Research Council investigation. BMJ 1, 382-386 (1949).
    • (1949) BMJ , vol.1 , pp. 382-386
    • Marshall, G.1
  • 102
    • 0037441632 scopus 로고    scopus 로고
    • Treatment of tuberculosis
    • American Thoracic Society
    • American Thoracic Society. Treatment of tuberculosis. Am. J. Respir. Crit. Care Med. 167, 603-662 (2003).
    • (2003) Am. J. Respir. Crit. Care Med. , vol.167 , pp. 603-662
  • 103
    • 79958802504 scopus 로고    scopus 로고
    • Initiating antiretrovirals during tuberculosis treatment: A drug safety review
    • Gengiah, T. N., Gray, A. L., Naidoo, K. & Karim, Q. A. Initiating antiretrovirals during tuberculosis treatment: a drug safety review. Expert Opin. Drug Saf. 10, 559-574 (2011).
    • (2011) Expert Opin. Drug Saf. , vol.10 , pp. 559-574
    • Gengiah, T.N.1    Gray, A.L.2    Naidoo, K.3    Karim, Q.A.4
  • 104
    • 80054721877 scopus 로고    scopus 로고
    • Timing of antiretroviral therapy for HIV-1 infection and tuberculosis
    • Havlir, D. V. et al. Timing of antiretroviral therapy for HIV-1 infection and tuberculosis. N. Engl. J. Med. 365, 1482-1491 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1482-1491
    • Havlir, D.V.1
  • 105
    • 80054742528 scopus 로고    scopus 로고
    • Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis
    • Blanc, F. X. et al. Earlier versus later start of antiretroviral therapy in HIV-infected adults with tuberculosis. N. Engl. J. Med. 365, 1471-1481 (2011).
    • (2011) N. Engl. J. Med. , vol.365 , pp. 1471-1481
    • Blanc, F.X.1
  • 106
    • 84874742048 scopus 로고    scopus 로고
    • When to start ART in Africa-an urgent research priority
    • De Cock, K. M. & El-Sadr, W. M. When to start ART in Africa-an urgent research priority. N. Engl. J. Med. 368, 886-889 (2013).
    • (2013) N. Engl. J. Med. , vol.368 , pp. 886-889
    • De Cock, K.M.1    El-Sadr, W.M.2
  • 107
    • 80053452071 scopus 로고    scopus 로고
    • Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs
    • Subbian, S. et al. Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs. PLoS Pathog. 7, e1002262 (2011).
    • (2011) PLoS Pathog. , vol.7
    • Subbian, S.1
  • 108
    • 84856693171 scopus 로고    scopus 로고
    • Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections
    • Tobin, D. M. et al. Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148, 434-446 (2012).
    • (2012) Cell , vol.148 , pp. 434-446
    • Tobin, D.M.1
  • 109
    • 84862980932 scopus 로고    scopus 로고
    • Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas
    • Skerry, C., Harper, J., Klunk, M., Bishai, W. R. & Jain, S. K. Adjunctive TNF inhibition with standard treatment enhances bacterial clearance in a murine model of necrotic TB granulomas. PLoS ONE 7, e39680 (2012).
    • (2012) PLoS ONE , vol.7
    • Skerry, C.1    Harper, J.2    Klunk, M.3    Bishai, W.R.4    Jain, S.K.5
  • 110
    • 81755161197 scopus 로고    scopus 로고
    • Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis
    • Napier, R. J. et al. Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis. Cell Host Microbe 10, 475-485 (2012).
    • (2012) Cell Host Microbe , vol.10 , pp. 475-485
    • Napier, R.J.1
  • 111
    • 84879392633 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs for adjunctive tuberculosis treatment
    • 5 Apr 2013 (doi:10.1093/infdis/jit153)
    • Ivanyi, I. & Zumla, A. Non-steroidal anti-inflammatory drugs for adjunctive tuberculosis treatment. J. Infect. Dis. 5 Apr 2013 (doi:10.1093/infdis/jit153).
    • J. Infect. Dis
    • Ivanyi, I.1    Zumla, A.2
  • 112
    • 34447542162 scopus 로고    scopus 로고
    • Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps
    • Amaral, L., Martins, M. & Viveiros, M. Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps. J. Antimicrob. Chemother. 59, 1237-1246 (2007).
    • (2007) J. Antimicrob. Chemother. , vol.59 , pp. 1237-1246
    • Amaral, L.1    Martins, M.2    Viveiros, M.3
  • 113
    • 79953279193 scopus 로고    scopus 로고
    • Drug tolerance in replicating mycobacteria mediate macrophage-induced efflux mechanism
    • Adams, K. N. et al. Drug tolerance in replicating mycobacteria mediate macrophage-induced efflux mechanism. Cell 145, 39-53 (2011).
    • (2011) Cell , vol.145 , pp. 39-53
    • Adams, K.N.1
  • 114
    • 84872842061 scopus 로고    scopus 로고
    • Anthelmintic avermectins kill M. tuberculosis, including multidrug-resistant clinical strains
    • Lim, L. E. et al. Anthelmintic avermectins kill M. tuberculosis, including multidrug-resistant clinical strains. Antimicrob. Agents Chemother. 57, 1040-1046 (2013).
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 1040-1046
    • Lim, L.E.1
  • 115
    • 84856526748 scopus 로고    scopus 로고
    • Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model
    • Maiga, M. et al. Successful shortening of tuberculosis treatment using adjuvant host-directed therapy with FDA-approved phosphodiesterase inhibitors in the mouse model. PLoS ONE 7, e30749 (2012).
    • (2012) PLoS ONE , vol.7
    • Maiga, M.1
  • 116
    • 84860380066 scopus 로고    scopus 로고
    • Adjunct immunotherapies for tuberculosis
    • Uhlin, M., Andersson, J., Zumla, A. & Maeurer, M. Adjunct immunotherapies for tuberculosis. J. Infect. Dis. 205 (Suppl. 2), 325-334 (2012).
    • (2012) J. Infect. Dis. , vol.205 , Issue.SUPPL. 2 , pp. 325-334
    • Uhlin, M.1    Andersson, J.2    Zumla, A.3    Maeurer, M.4
  • 117
    • 84867290598 scopus 로고    scopus 로고
    • Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages
    • Bruns, H. et al. Abelson tyrosine kinase controls phagosomal acidification required for killing of Mycobacterium tuberculosis in human macrophages. J. Immunol. 189, 4069-4078 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 4069-4078
    • Bruns, H.1
  • 118
    • 36749030024 scopus 로고    scopus 로고
    • Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1
    • Kuijl, C. et al. Intracellular bacterial growth is controlled by a kinase network around PKB/AKT1. Nature. 450, 725-730 (2007).
    • (2007) Nature. , vol.450 , pp. 725-730
    • Kuijl, C.1
  • 119
    • 11144250804 scopus 로고    scopus 로고
    • Tuberculosis-metabolism and respiration in the absence of growth
    • Boshoff, H. I. & Barry, C. E. 3rd. Tuberculosis-metabolism and respiration in the absence of growth. Nature Rev. Microbiol. 3, 70-80 (2005).
    • (2005) Nature Rev. Microbiol. , vol.3 , pp. 70-80
    • Boshoff, H.I.1    Barry III, C.E.2
  • 121
    • 81155160151 scopus 로고    scopus 로고
    • Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis
    • Shi, W. et al. Pyrazinamide inhibits trans-translation in Mycobacterium tuberculosis. Science 333, 1630-1632 (2011).
    • (2011) Science , vol.333 , pp. 1630-1632
    • Shi, W.1
  • 122
    • 84871927537 scopus 로고    scopus 로고
    • Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis
    • Chakraborty, S., Gruber, T., Barry, C. E. 3rd, Boshoff, H. I. & Rhee, K. Y. Para-aminosalicylic acid acts as an alternative substrate of folate metabolism in Mycobacterium tuberculosis. Science 339, 88-91 (2013).
    • (2013) Science , vol.339 , pp. 88-91
    • Chakraborty, S.1    Gruber, T.2    Barry III, C.E.3    Boshoff, H.I.4    Rhee, K.Y.5
  • 123
    • 84859565524 scopus 로고    scopus 로고
    • GyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis
    • Sirgel, F. A. et al. gyrA mutations and phenotypic susceptibility levels to ofloxacin and moxifloxacin in clinical isolates of Mycobacterium tuberculosis. J. Antimicrob. Chemother. 67, 1088-1093 (2012).
    • (2012) J. Antimicrob. Chemother. , vol.67 , pp. 1088-1093
    • Sirgel, F.A.1
  • 124
    • 84859568104 scopus 로고    scopus 로고
    • Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis
    • Sirgel, F. A. et al. Mutations in the rrs A1401G gene and phenotypic resistance to amikacin and capreomycin in Mycobacterium tuberculosis. Microb. Drug Resist. 18, 193-197 (2012).
    • (2012) Microb. Drug Resist. , vol.18 , pp. 193-197
    • Sirgel, F.A.1
  • 125
    • 84869214331 scopus 로고    scopus 로고
    • Structure-activity relationships among the kanamycin aminoglycosides: Role of ring i hydroxyl and amino groups
    • Salian, S. et al. Structure-activity relationships among the kanamycin aminoglycosides: role of ring I hydroxyl and amino groups. Antimicrob. Agents Chemother. 56 6104-6108 (2012)
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 6104-6108
    • Salian, S.1
  • 126
    • 84877254418 scopus 로고    scopus 로고
    • Global alliance for TB drug development
    • Global Alliance for TB Drug Development. Cycloserine. Tuberculosis (Edinb.) 88, 100-101 (2008).
    • (2008) Cycloserine. Tuberculosis (Edinb.) , vol.88 , pp. 100-101
  • 127
    • 78650666677 scopus 로고    scopus 로고
    • Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine
    • Bruning, J. B., Murillo, A. C., Chacon, O., Barletta, R. G. & Sacchettini, J. C. Structure of the Mycobacterium tuberculosis D-alanine:D-alanine ligase, a target of the antituberculosis drug D-cycloserine. Antimicrob. Agents Chemother. 55, 291-301 (2010).
    • (2010) Antimicrob. Agents Chemother. , vol.55 , pp. 291-301
    • Bruning, J.B.1    Murillo, A.C.2    Chacon, O.3    Barletta, R.G.4    Sacchettini, J.C.5
  • 128
    • 0037125569 scopus 로고    scopus 로고
    • Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: A randomised clinical trial
    • Benator, D. et al. Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial. Lancet 360, 528-534 (2002).
    • (2002) Lancet , vol.360 , pp. 528-534
    • Benator, D.1
  • 129
    • 79951643988 scopus 로고    scopus 로고
    • Higher-dose rifampin for the treatment of pulmonary tuberculosis: A systematic review
    • Steingart, K. R., et al. Higher-dose rifampin for the treatment of pulmonary tuberculosis: a systematic review. Int. J. Tuber. Lung Dis. 15, 305-316 (2011).
    • (2011) Int. J. Tuber. Lung Dis. , vol.15 , pp. 305-316
    • Steingart, K.R.1
  • 130
    • 84863919677 scopus 로고    scopus 로고
    • Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors
    • Batt, S. M., et al. Structural basis of inhibition of Mycobacterium tuberculosis DprE1 by benzothiazinone inhibitors. Proc. Natl Acad. Sci. USA 109, 11354-11359 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 11354-11359
    • Batt, S.M.1


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