Antagonism of chemical genetic interaction networks resensitize MRSA to β-lactam antibiotics

Chemistry and Biology

Volumn 18, Issue 11, 2011, Pages 1379-1389

  Lee, Sang Ho ^a   Jarantow, Lisa Wang ^a   Wang, Hao ^a   Sillaots, Susan ^a   Cheng, Henry ^a   Meredith, Timothy C ^a,b   Thompson, John ^a   Roemer, Terry ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BETA LACTAM; COMPLEMENTARY DNA; PEPTIDOGLYCAN;

ANTIBIOTIC RESISTANCE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECT; METABOLISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; DNA, ANTISENSE; DRUG RESISTANCE, BACTERIAL; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PEPTIDOGLYCAN;

EID: 82255181188     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2011.08.015     Document Type: Article

References (48)

1. D.W. Adams, and J. Errington Bacterial cell division: assembly, maintenance and disassembly of the Z ring Nat. Rev. Microbiol. 7 2009 642 653
2. D. Amsterdam Susceptibility testing of antimicrobials in liquid media V. Lorian, Antibiotics in Laboratory Medicine 2005 Lippincott Williams & Wilkins Philadelphia, PA 89 93
3. M.L. Atilano, P.M. Pereira, J. Yates, P. Reed, H. Veiga, M.G. Pinho, and S.R. Filipe Teichoic acids are temporal and spatial regulators of peptidoglycan cross-linking in Staphylococcus aureus Proc. Natl. Acad. Sci. USA 107 2010 18991 18996
4. E.A. Bancroft Antimicrobials resistance: It's not just for hospitals JAMA 298 2007 1803 1804 (Pubitemid 47598451)
5. C.A. Barker, M.A. Farha, and E.D. Brown Chemical genomic approaches to study model microbes Chem. Biol. 17 2010 624 632
6. A.M. Beltramini, C.D. Mukhopadhyay, and V. Pancholi Modulation of cell wall structure and antimicrobial susceptibility by a Staphylococcus aureus eukaryote-like serine/threonine kinase and phosphatase Infect. Immun. 77 2009 406 416
7. B. Berger-Bächi, and S. Rohrer Factors influencing methicillin resistance in Staphylococci Arch. Microbiol. 178 2002 165 171 (Pubitemid 34985297)
8. J. Campbell, A.K. Singh, J.P. Santa Maria, Y. Kim, S. Brown, J.G. Swoboda, E. Mylonakis, B.J. Wilkinson, and S. Walker Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus ACS Chem. Biol. 6 2011 106 116
9. H. Chmara, S. Milewski, R. Andruszkiewicz, F. Mignini, and E. Borowski Antibacterial action of dipeptides containing an inhibitor of glucosamine-6-phosphate isomerase Microbiology 144 1998 1349 1358 (Pubitemid 28233839)
10. M. Costanzo, A. Baryshnikova, J. Bellay, Y. Kim, E.D. Spear, C.S. Sevier, H. Ding, J.L. Koh, K. Toufighi, and S. Mostafavi The genetic landscape of a cell Science 327 2010 425 431
11. K.M. Cregg, I. Wilding, and M.T. Black Molecular cloning and expression of the spsB gene encoding an essential type I signal peptidase from Staphylococcus aureus J. Bacteriol. 178 1996 5712 5718 (Pubitemid 26327673)
12. M.Z. David, and R.S. Daum Community-associated methicillin-resistant Staphylococcus aureus: epidemiology and clinical consequences of an emerging epidemic Clin. Microbiol. Rev. 23 2010 616 687
13. H. de Lencastre, and A. Tomasz Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus Antimicrob. Agents Chemother. 38 1994 2590 2598 (Pubitemid 24332592)
14. H. de Lencastre, D. Oliveira, and A. Tomasz Antibiotic resistant Staphylococcus aureus: a paradigm of adaptive power Curr. Opin. Microbiol. 10 2007 428 435 (Pubitemid 350052684)
15. H. de Lencastre, S.W. Wu, M.G. Pinho, A.M. Ludovice, S. Filipe, S. Gardete, R. Sobral, S. Gill, M. Chung, and A. Tomasz Antibiotic resistance as a stress response: complete sequencing of a large number of chromosomal loci in Staphylococcus aureus strain COL that impact on the expression of resistance to methicillin Microb. Drug Resist. 5 1999 163 175 (Pubitemid 29519892)
16. R.G.K. Donald, S. Skwish, R.A. Forsyth, J.W. Anderson, T. Zhong, C. Burns, S. Lee, X. Meng, L. LoCastro, and L.W. Jarantow A novel Staphylococcus aureus fitness test platform for mechanism-based profiling of antibacterial compounds Chem. Biol. 16 2009 826 836
17. R.A. Forsyth, R.J. Haselbeck, K.L. Ohlsen, R.T. Yamamoto, H. Xu, J.D. Trawick, D. Wall, L. Wang, V. Brown-Driver, and J.M. Froelich A genome-wide strategy for the identification of essential genes in Staphylococcus aureus Mol. Microbiol. 43 2002 1387 1400 (Pubitemid 34595533)
18. T.R. Fritsche, H.S. Sader, and R.N. Jones Antimicrobial activity of ceftobiprole, a novel anti-methicillin-resistant Staphylococcus aureus cephalosporin, tested against contemporary pathogens: results from the SENTRY Antimicrobial Surveillance Program (2005-2006) Diagn. Microbiol. Infect. Dis. 61 2008 86 95 (Pubitemid 351509753)
19. S. Gardete, S.W. Wu, S. Gill, and A. Tomasz Role of VraSR in antibiotic resistance and antibiotic-induced stress response in Staphylococcus aureus Antimicrob. Agents Chemother. 50 2006 3424 3434 (Pubitemid 44527519)
20. S. Gardete, A.M. Ludovice, R.G. Sobral, S.R. Filipe, H. de Lencastre, and A. Tomasz Role of murE in the Expression of beta-lactam antibiotic resistance in Staphylococcus aureus J. Bacteriol. 186 2004 1705 1713 (Pubitemid 38314516)
21. H.S. Girgis, A.K. Hottes, and S. Tavazoie Genetic architecture of intrinsic antibiotic susceptibility PLoS ONE 4 2009 e5629
22. M.J. Gomez, and A.A. Neyfakh Genes involved in intrinsic antibiotic resistance of Acinetobacter baylyi Antimicrob. Agents Chemother. 50 2006 3562 3567 (Pubitemid 44684866)
23. J. Huber, R.G. Donald, S.H. Lee, L.W. Jarantow, M.J. Salvatore, X. Meng, R. Painter, R.H. Onishi, J. Occi, and K. Dorso Chemical genetic identification of peptidoglycan inhibitors potentiating carbapenem activity against methicillin-resistant Staphylococcus aureus Chem. Biol. 16 2009 837 848
24. D.S. Jo, C.P. Montgomery, S. Yin, S. Boyle-Vavra, and R.S. Daum Improved oxacillin treatment outcomes in experimental skin and lung infection by methicillin-resistant staphylococcus aureus containing a vraSR operon deletion Antimicrob. Agents Chemother. 55 2011 2818 2823
25. L. Kalan, and G.D. Wright Antibiotic adjuvants: multicomponent anti-infective strategies Expert Rev. Mol. Med. 23 2011 13:e5
26. T. Katsube, S. Matsumoto, M. Takatsuka, M. Okuyama, Y. Ozeki, M. Naito, Y. Nishiuchi, N. Fujiwara, M. Yoshimura, and T. Tsuboi Control of cell wall assembly by a histone-like protein in Mycobacteria J. Bacteriol. 189 2007 8241 8249 (Pubitemid 350178936)
27. R.M. Klevens, M.A. Morrison, J. Nadle, S. Petit, K. Gershman, S. Ray, L.H. Harrison, R. Lynfield, G. Dumyati, and J.M. Townes Invasive methicillin-resistant Staphylococcus aureus infections in the United States JAMA 298 2007 1763 1771 (Pubitemid 47598444)
28. H. Komatsuzawa, T. Fujiwara, H. Nishi, S. Yamada, M. Ohara, N. McCallum, B. Berger-Bächi, and M. Sugai The gate controlling cell wall synthesis in Staphylococcus aureus Mol. Microbiol. 53 2004 1221 1231 (Pubitemid 39120441)
29. M. Kuroda, H. Kuroda, T. Oshima, F. Takeuchi, H. Mori, and K. Hiramatsu Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus Mol. Microbiol. 49 2003 807 821 (Pubitemid 36918698)
30. M. Matsuhashi, M.D. Song, F. Ishino, M. Wachi, M. Doi, M. Inoue, K. Ubukata, N. Yamashita, and M. Konno Molecular cloning of the gene of a penicillin-binding protein supposed to cause high resistance to beta-lactam antibiotics in Staphylococcus aureus J. Bacteriol. 167 1986 975 980 (Pubitemid 16045033)
31. G. Memmi, S.R. Filipe, M.G. Pinho, Z. Fu, and A. Cheung Staphylococcus aureus PBP4 is essential for β-lactam resistance in community-acquired methicillin-resistant strains Antimicrob. Agents Chemother. 52 2008 3955 3966
32. B. Moyá, L. Zamorano, C. Juan, Y. Ge, and A. Oliver Affinity of the new cephalosporin CXA-101 to penicillin-binding proteins of Pseudomonas aeruginosa Antimicrob. Agents Chemother. 54 2010 3933 3937
33. M.G. Pinho, and J. Errington Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery Mol. Microbiol. 50 2003 871 881 (Pubitemid 37372250)
34. M.G. Pinho, and J. Errington Recruitment of penicillin-binding protein PBP2 to the division site of Staphylococcus aureus is dependent on its transpeptidation substrates Mol. Microbiol. 55 2005 799 807 (Pubitemid 40203695)
35. M.G. Pinho, H. de Lencastre, and A. Tomasz Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus J. Bacteriol. 182 2000 1074 1079 (Pubitemid 30075031)
36. M.G. Pinho, H. de Lencastre, and A. Tomasz An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant Staphylococci Proc. Natl. Acad. Sci. USA 98 2001 10886 10891 (Pubitemid 32878714)
37. M.G. Pinho, S.R. Filipe, H. de Lencastre, and A. Tomasz Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus J. Bacteriol. 183 2001 6525 6531 (Pubitemid 33026741)
38. L.D. Sabath, C. Garner, C. Wilcox, and M. Finland Effect of inoculum and of beta-lactamase on the anti-staphylococcal activity of thirteen penicillins and cephalosporins Antimicrob. Agents Chemother. 8 1975 344 349
39. D.J. Scheffers, and M.G. Pinho Bacterial cell wall synthesis: new insights from localization studies Microbiol. Mol. Biol. Rev. 69 2005 585 607 (Pubitemid 41798464)
40. T. Schneider, M.M. Senn, B. Berger-Bächi, A. Tossi, H.G. Sahl, and I. Wiedemann In vitro assembly of a complete, pentaglycine interpeptide bridge containing cell wall precursor (lipid II-Gly5) of Staphylococcus aureus Mol. Microbiol. 53 2004 675 685 (Pubitemid 38998184)
41. R.G. Sobral, A.M. Ludovice, S. Gardete, K. Tabei, H. De Lencastre, and A. Tomasz Normally functioning murF is essential for the optimal expression of methicillin resistance in Staphylococcus aureus Microb. Drug Resist. 9 2003 231 241 (Pubitemid 37048544)
42. M.D. Song, M. Wachi, M. Doi, F. Ishino, and M. Matsuhashi Evolution of an inducible penicillin-target protein in methicillin-resistant Staphylococcus aureus by gene fusion FEBS Lett. 221 1987 167 171 (Pubitemid 17124049)
43. D. Styers, D.J. Sheehan, P. Hogan, and D.F. Sahm Laboratory-based surveillance of current antimicrobial resistance patterns and trends among Staphylococcus aureus: 2005 status in the United States Ann. Clin. Microbiol. Antimicrob. 5 2006 1 9
44. C. Tamae, A. Liu, K. Kim, D. Sitz, J. Hong, E. Becket, A. Bui, P. Solaimani, K.P. Tran, and H. Yang Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli J. Bacteriol. 190 2008 5981 5988
45. J. van Heijenoort Recent advances in the formation of the bacterial peptidoglycan monomer unit Nat. Prod. Rep. 18 2001 503 519 (Pubitemid 33016991)
46. C. Walsh Antibiotics: Actions, Origins, Resistance 2003 ASM Press Washington, DC pp. 345
47. J. Wang, S.M. Soisson, K. Young, W. Shoop, S. Kodali, A. Galgoci, R. Painter, G. Parthasarathy, Y.S. Tang, and R. Cummings Platensimycin is a selective FabF inhibitor with potent antibiotic properties Nature 441 2006 358 361 (Pubitemid 44050201)
48. H.H. Xu, J.D. Trawick, R.J. Haselbeck, R.A. Forsyth, R.T. Yamamoto, R. Archer, J. Patterson, M. Allen, J.M. Froelich, and I. Taylor Staphylococcus aureus TargetArray: comprehensive differential essential gene expression as a mechanistic tool to profile antibacterials Antimicrob. Agents Chemother. 54 2010 3659 3670